Matches 201 - 250 out of 398 < 1 2 3 4 5 6 7 8 >
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5254579 N-(5-thioxo-L-prolyl)-L-cysteine, derivatives thereof, processes for the preparation thereof and pharmaceutical compositions containing them  
N-(5-thioxo-L-prolyl)-L-cysteine and derivatives thereof, having interesting mucolytic-expectorant, antioxidant (radical-scavenger), antielastase, antiemphysema, immunostimulating and...
5252746 Process for the preparation of insecticidal, nematicidal and acaricidal 2-halo-3-substituted-5-arylpyrrole compounds  
There is provided a process for the preparation of 2-halo-3-substituted-5-arylpyrrole compounds which are useful as insecticidal, nematicidal and acaricidal agents.
5232980 N-substituted carbonyloxyalkylpyrrole insecticidal, acaricidal and molluscicidal agents  
There are provided N-substituted carbonyloxyalkylpyrrole compounds of formula I ##STR1## and their use for the control of insects, acarina and mollusks. Further provided are compositions and...
5227496 Pyroglutamic acid derivatives as enhancers of learning processes and memory and pharmaceutical compositions comprising same  
Orally or parenterally administrable pharmaceutical compositions in unit dosage form comprise from about 100 to about 500 mg of one of the compounds of formula (I). ##STR1## wherein R is selected...
5223530 Arylcycloalkanepolyalkylamine ligands  
Novel arylcycloalkanepolyalkylamines useful as anti-psychotic, anti-ischemia, anti-stroke, anti-dementia and anti-convulsant agents. These arylcycloalkanepolyalkylamines are selective high-affinity...
5223529 N-phenylamides and medicinal products containing them  
Compounds of formula: ##STR1## in which R 1 is (a) a phenyl radical or a substituted phenyl radical, (b) a chain --CH(R 8 )--COOR 4 , (c) a chain --CH 2 --CO--NR 5 R 6 or (d) a phenylalkyl...
5218116 Procedure for the preparation of nitroxyl radicals of sterically hindered amines  
Procedure for the preparation of nitroxyl radicals of sterically hindered amines, consisting of the reaction of amines with hydrogen peroxide in the presence of a titanium containing catalyst,...
5216174 Process for trans-6-[12-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis  
An improved process for the preparation of trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-ones by a novel synthesis is described where 1,6-heptadien4-ol is converted in eight operations to the...
5206384 Actinonin derivatives and pharmaceutically acceptable salts thereof  
A novel actinonin derivative and a salt thereof are provided, which are useful as enzyme inhibitors and particularly have strong inhibitory activities against enkephalinase and...
5194588 Aminoalcohol intermediates for peptide derivatives  
The invention concerns pharmaceutically useful trifluoromethyl ketone substituted di-, tri- and tetra-peptide derivatives of the formulae Ia, Ib, Ic set out hereinafter, and salts thereof, which...
5189055 Phenylpyrrolic compounds used as drugs, their preparation and application  
The present invention relates to phenylpyrrole compounds, pharmaceutical compositions, preparation and to their application as an active principle, especially as a drug having antimitotic activity.
5173557 Crosslinkable rubber composition  
It is sometimes desirable to cure rubber compositions utilizing non-sulfur curing agents. The subject invention reveals rubber compositions which can be cured without utilizing sulfur or sulfur...
5155152 Substitute aminopyrroles as stabilizers for chlorine-containing polymers  
The compounds of formula I ##STR1## wherein n is 1 or 2, R 1 is C 1 -C 4 alkyl, R 2 and R 3 are, for example, alkanoyl or alkanoyloxy or R 3 may also be, for example, alkanedioyl, are...
5138071 Process for preparing peptides with N-terminal non-proteinogenous amino acids  
A process for preparing dipeptides with N-terminal non-proteinogenous amino acids of the formula ##STR1## in which R 1 to R 6 have the meaning stated in the description, from compounds of the...
5120738 Pantothenic acid derivatives  
Compounds represented by general formula (I) below ##STR1## wherein R 1 and R 2 , which are the same or different, each represent a hydrogen atom or a protective group for a hydroxyl group; R 3...
5117057 Insecticidal N' substituted-N-N'-disubstituted-hydrazines  
This invention relates to insecticidal compositions containing N'-substituted-N,N'-disubstitutedhydrazines, methods of using such compositions and N'-substituted-N, N'-disubstitutedhydrazines....
5115098 End-blocked peptides inhibiting binding capacity of gp120  
A C- and N-blocked prolyl-alanine compound having the structure ##STR1## in which X is --OCH 2 --B or ##STR2## in which A and B are hydrogen or phenyl and Y is isobutyl inhibits binding capacity...
5110797 Peptide compound and a pharmaceutically acceptable salt thereof  
Peptide compounds of formula (I): ##STR1## wherein A is hydrogen or an amino-protecting group; X is a member selected from the group consisting of Gly, Glu, Tyr, Asp, Phe, Ile, Ala, Pro, Leu, Hyp,...
5110986 Synthesis of N-t-alkyl-1,2-diacylhydrazines  
This application relates to a process for preparing a N-t-alkyl-1,2-diacylhydrazine by reacting a 1,3,4-oxadiazole with a tertiary alkyl cation precursor in the presence of a strong acid catalyst....
5110936 Process for the preparation of 3-(lpyroglutamyl)-L-thiazolidine-4-carboxylic acid derivatives  
3-(L-pyroglutamyl)-L-thiazolidine-4-carboxylic acid and derivatives thereof are prepared by condensing L-pyroglutamic acid or its substitution products, either in the presence of...
5101043 Process for the preparation of 3-carboxamido-5-vinyl-2-pyrrolidone  
The preparation of 3-carboxamido-5-vinyl-2-pyrrolidone from a 2-vinylcyclopropyl-1,1-dicarboxylic acid dialkyl ester and ammonia is improved with respect to yield and purity of the end product by...
5087752 Synthesis of nitroxides using dioxiranes  
The subject invention relates to a method of synthesizing nitroxides from secondary amines. This method uses a suitable dioxirane compound such as dimethyldioxirane (DMD), which is relatively...
5086054 Novel arylcycloalkanepolyalkylamines  
Novel arylcycloalkanepolyalkylamines useful as anti-psychotic, anti-ischemia, anti-stroke, anti-dementia and anti-convulsant agents. These arylcycloalkanepolyalkylamines are selective high-affinity...
5075452 Process for the preparation of 5-membered nitrogen containing heteroaromatics  
Compounds of the formula I ##STR1## in which A and X 1 have the meaning given in patent claim 1 can be prepared in a simple manner, in a one-pot process and in high yields.
5063208 Peptidyl aminodiol renin inhibitors  
A renin inhibiting compound having an aminodiol functional group is useful for treating hypertension, congestive heart failure and glaucoma and inhibits retroviral protease.
5053504 Process for benzazepine intermediates  
A process is disclosed for providing benzazepine intermediates of the formulae ##STR1## wherein R 3 , R 4 and Y are as defined herein, which intermediates are useful in a process for the...
5053548 Biphenyl derivative composition for nerve cell degeneration repairing or protective agent and process for preparing a phenyl derivative contained in the composition  
There is disclosed a biphenyl derivative of the formula (B): ##STR1## wherein R 1 , R 3 , R 4 , R 5 and R c are as defined or its salt, a composition for nerve cell degeneration repairing or...
5047541 2-azacyclocarboxamide derivatives  
Compounds are provided of the following general structure: ##STR1## wherein A is 2-pyrrolidinyl, 2-piperidinyl or 4-thiazolidinyl and R and R 1 are independently selected from hydrogen and methyl....
5047555 4-aminophenol derivatives and processes for preparing the same  
There are disclosed a 4-aminophenol derivative of the formula: ##STR1## (wherein R 1 and R 2 each represent a lower alkyl group, Y represents a single bonding arm, a lower alkylene group or a...
5043349 Substituted pyrrole angiotensin II antagonists  
Substituted pyrroles, pyrazoles and triazoles such as ##STR1## and their pharmaceutically suitable salts are useful as antihypertensive agents and for treatment of congestive heart failure.
5041442 Pyrrolo(1,2-a)pyrazines as inhibitors of gastric acid secretion  
This invention is directed to compounds of formula (I): ##STR1## wherein R 1 is thiocyano, --CH 2 CN, --NH 2 , --NHR 5 , or --CH 2 OR 5 where R 5 is lower alkyl; R 2 is hydrogen, halo,...
5039683 Azetidinyl quinolone carboxylic acids and esters  
Compounds of the formula ##STR1## wherein R 1 is hydrogen, alkyl of 1 to 6 carbon atoms, or NR 4 R 5 , wherein R 4 and R 5 are independently selected from hydrogen and alkyl of 1 to 6 carbon...
5032600 Alkyl diamine derivatives  
The invention refers to new diamines of the Formula I ##STR1## wherein R stands for ##STR2## or --NH--COA 1 --R 4 or ##STR3## wherein A stands for C 1 -5 alkylene which can be substituted by...
5032577 Peptidylaminodiols  
A renin inhibiting compound of the formula: ##STR1## wherein A is a substituent; W is CO or CHOH; U is CH 2 or NR 2 , provided that when W is CHOH then U is CH 2 ; R 1 is loweralkyl,...
5030732 Aminoethylphosphinic acid derivatives  
Disclosed are some new aminoethylphosphinic acid derivatives useful as antibacterial agents.
5028704 (2,5-dihydro 5-phenyl-2-oxo-3-furanyl)amines, methods of manufacture, and use thereof in the production of angiotensin converting enzyme inhibitors  
The present invention relates to compounds of the formula ##STR1## wherein R c is carboxy, esterified carboxy or amidated carboxy; R 2 is hydrogen or lower alkyl or joins with R a and R b ...
5002964 S-nitrosocaptopril compounds and the use thereof  
The invention relates to novel nitroso compounds having the formula: ##STR1## wherein, R is hydroxy, NH 2 , NHR 4 , NR 4 R 5 or C 1 -C 7 alkoxy, wherein R 4 and R 5 are C 1 -C 4 alkyl,...
4971993 Dipeptide derivatives and antihypertensive drugs containing them  
There are disclosed dipeptide derivatives represented by the general formula: ##STR1## wherein R 1 is a radical selected from the group consisting of alkyl, aralkyl and aryl groups optionally...
4966901 Pyrrole derivatives, their preparation and their use as pharmaceutical active compounds  
Pyrrole derivatives of the general formula I ##STR1## wherein R denotes alkyl which is substituted by --NH 2 or acylamino, R 1 and R 2 independently of one another denote hydrogen or alkyl...
4960787 Certain pyrrolyl-substituted hydroxamic acid derivatives  
The invention relates to the pyrrolyl-substituted hydroxamic acid derivatives of the formula ##STR1## wherein R represents aryl, aryl-lower alkyl, cycloalkyl, bicycloalkyl or adamantyl; R 1 and R...
4958030 Process for the preparation of 3-phenylpyrrole derivatives  
3-Phenylpyrrole derivatives of formula I ##STR1## wherein X is cyano, --CO--R 3 , --CO--OR 3 or ##STR2## R 1 and R 2 are each independently of the other hydrogen, C 1 -C 6 alkyl, C 1 -C 6 ...
4956504 Novel spergualin-related compounds and process for producing the same  
The present invention relates to novel Spergualin-related compounds represented by the general formula [I] ##STR1## (wherein X is ##STR2## R is --H or --CH 2 OH; R 1 is --H, ##STR3## R 2 is a...
4933354 2-pyrrolidone-5-carboxylic acid compounds useful for the treatment of mental disorders  
In one embodiment this invention provides novel 2-pyrrolidone-5-carboxylic acid compounds, and pharmaceutically acceptable salts thereof, represented by the formula: ##STR1## where n is an integer...
4923890 Difluoro keto compounds and their use as HLE inhibitors  
The invention relates to selected difluoro compounds of formulae Ia, Ib and Ic (set out hereinafter) which are useful as inhibitors of human leukocyte elastase.
4912128 Novel pyrrolidine-2-(1,3-dicarbonyl) derivatives, a process for their preparation, agents containing them, and their use  
Novel pyrrolidine-2-(1,3-dicarbonyl) derivatives, a process for their preparation, agents containing them, and their use The invention relates to pyrrolidine derivatives of the general formula...
4910190 Peptide derivatives  
The invention concerns pharmaceutically useful trifluoromethyl ketone substituted di-, tri- and tetra-peptide derivatives of the formulae Ia, Ib, Ic set out hereinafter, and salts thereof, which...
4904679 Pyrrolophenylalkanolamines as animal yield promoters  
Pyrrolophenylalkanolamines of the formula ##STR1## R 1 and R 2 represent hydrogen or various radicals, R 3 represents hydrogen, acyl or trialkylsilyl, R 4 represents hydrogen or alkyl, R...
4900839 precursors to Quinolone inotropic agents  
A series of novel heterocyclic-substituted 2-(1H)-quinolone compounds have been prepared, including the 3,4-dihydro derivatives thereof, wherein the heterocyclic ring moiety is a pyrrolyl,...
4898930 Peptide derivatives and processes for their preparation  
Peptide ester and amide derivatives of the general formula I: ##STR1## in which X is H or an acyl, A and B are structurally defined amino acid residues, n is an integer of from 1 to 3, R 1 is H or...
4879410 Preparation of primary aralkyl urethanes and ureas and isocyanates derived therefrom  
A process is disclosed for the preparation of aralkyl mono- and diurethanes or ureas by carbamylmethylation, or acid-catalyzed addition at a temperature of 40° C. to about 100° C. of formaldehyde...
Matches 201 - 250 out of 398 < 1 2 3 4 5 6 7 8 >