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7417062 Substituted arylamides  
Substituted benzamide compounds are provided along with methods for the use of those compounds for treating cancer.
7402606 Derivatives of 1-(oxoaminoacetyl) pentylcarbamate as cathepsin K inhibitors for the treatment of bone loss  
Heterocycle substituted ketoamide derivatives of Formula (I), wherein the substitutes A, D, A and R are defined as in claim in, which are useful as cathepsin K inhibitors are described herein. The...
7361755 Transition-metal-catalyzed process for the conversion of alkenes to sterically hindered substituted n-alkoxyamines  
This invention pertains to a novel process for preparing sterically hindered N-substituted alkyloxyamines from alkenes by the transition-metal-catalyzed reaction of a intermediate alkylborane with...
7361663 N-acylpyrrolidin-2-ylalkylbenzamidine derivatives as inhibitors of factor Xa  
This invention is directed to N-acylpyrrolidin-2-ylalkylbenzamidine derivatives which useful for inhibiting the activity of Factor Xa, by contacting said derivatives with a composition containing...
7335679 Wortmannin analogs and methods of using same  
Novel Wortmannin analogs and their use in inhibiting inhibiting PI-3-kinase activity in mammals as well as tumor formation in a subject are described herein.
7314875 Tricyclic aromatic and bis-phenyl sulfinyl derivatives  
The present invention provides compounds of the structure: wherein the constituent members are defined herein, including pharmaceutical compositions thereof and methods of treating diseases...
7304168 Photo-caged fluorescent molecules  
A class of photo-caged and cell permeable fluorescent molecules having high uncaging cross sections, robust fluorescence enhancement, and flexible chemistry for bioconjugation. Some of the...
7304081 Amido compounds and their use as pharmaceuticals  
The present invention relates to inhibitors of 11-β hydroxyl steroid dehydrogenase type 1, antagonists of the mineralocorticoid receptor (MR), and pharmaceutical compositions thereof. The...
7271193 Inhibitors of cyclin-dependent kinases and their use  
The present invention relates to novel compounds for the inhibition of cyclin-dependent kinases, and more particularly, to chromenone derivatives of formula (Ia), wherein R 1 , R 2 , R 3 , R 4...
7247646 Benzopyranone compounds, compositions thereof, and methods of treatment therewith  
Benzopyranone Compounds having the following structure: wherein R 1 , R 2 , X, Y and n are as defined herein, are disclosed. The Benzopyranone Compounds are useful for treating or...
7208491 N-monoacylated o-phenylenediamines  
Mono-acylated o-phenylendiamines derivatives of formula I wherein X and R are as described herein, have been found useful for the treatment of diseases mediated by the inhibition of histone...
7189758 Glucocorticoid mimetics, methods of making them, pharmaceutical formulations, and uses thereof  
A compound of Formula (I) wherein R 1 , R 2 , R 3 , R 4 , R 5 , and R 6 are as defined herein, or a tautomer, prodrug, solvate, or salt thereof; pharmaceutical compositions containing such...
7186722 2-heteroaryl-3,4-dihydro-2h-pyrrole derivatives and the use thereof as pesticides  
Novel Δ 1 -pyrrolines of the Formula (I) in which R 1 , R 2 , R 3 and Het have the meanings given in the description, a plurality of processes for preparing these compounds and their use...
7160877 Aliphatic nitrogen-containing 5-membered ring compound  
The present invention is to provide an aliphatic nitrogen-containing 5-membered ring compound represented by the formula [I]: wherein A represents —CH 2 — or —S—, R 1 represents...
7157489 HIV protease inhibitors  
Compounds useful for inhibiting HIV protease are disclosed. Methods of making the compounds, and their use as therapeutic agents, for example, in treating wild-type HIV and of multidrug-resistant...
7157454 Derivatives of n-(arylsulfonyl)beta-aminoacids comprising a substituted aminomethyl group, the preparation method thereof and the pharmaceutical compositions containing same  
The invention relates to compounds of formula: These compounds show affinity for the bradykinin receptors with selectivity towards the B 1 receptors; they may be used for the preparation of...
7119214 Thio-substituted tricyclic and bicyclic aromatic methanesulfinyl derivatives  
The present invention is related to chemical compositions, processes for the preparation thereof and uses of the composition. Particularly, the present invention relates to compositions of...
7112684 Compounds and methods for fluorescent labeling  
Dye reagents useful in labeling biological materials are provided along with methods for their use.
7102027 Adamantanetricarboxylic acid derivatives  
An adamantanetricarboxylic acid derivative is represented by following Formula (1): wherein X is a hydrogen atom or a hydrocarbon group; and R 1 , R 2 and R 3 may be the same as or different...
7098202 Amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors  
Selected amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such...
7034051 Fused bicyclic carboxamide derivatives and methods of their use  
Fused bicyclic carboxamide derivatives are disclosed. Pharmaceutical compositions containing the compounds and methods for their use are also disclosed.
6989446 Process for the preparation of 3-aryl-benzofuranones  
Process for the preparation of compounds of formula I wherein the general symbols are as defined in claim 1, which process comprises reacting a compound of formula V wherein the general...
6989384 Antipicornaviral compounds and compositions, their pharmaceutical uses, and materials for their synthesis  
Compounds of the formula: where the formula variables are as defined in the disclosure, advantageously inhibit or block the biological activity of the picomaviral 3C protease. These compounds,...
6967216 Amino substituted dibenzothiophene derivatives for the treatment of disorders mediated by NP Y5 receptor  
Compounds of formula (I): wherein: X is a group of formula (A) or (B): and R 1 , R 2 , R 3 , R 4 , n, x, y and z are as defined within are described. Processes for their...
6962942 Azacycloalkanone serine protease inhibitors  
The present invention is directed to non-peptidic factor Xa inhibitors which are useful for the treatment of arterial and venous thrombotic occlusive disorders, inflammation, cancer, and...
6951950 Quaternary ammonium compounds  
The invention features quaternary ammonium compounds of formula I, described herein, and their use in treating asthma, chronic obstructive pulmonary disorder, allergic rhinitis, and infectious...
6930188 Stable hydrate of a muscarinic receptor antagonist  
A stable solid hydrate of a muscarinic receptor antagonist is useful in the treatment of irritable bowel syndrome, diverticular disease, oesophageal achalasia, chronic obstructive airways disease,...
6897211 Thienodibenzoazulene compounds as tumor necrosis factor inhibitors  
The present invention relates to the dibenzoazulene compounds represented by formula I as well as to their pharmaceutical preparations for the inhibition of tumor necrosis factor alpha (TNF-α) and...
6881733 Serotonergic benzofurans  
The present invention provides serotonergic benzofurans of Formula (I): where A, R, R 1 , R 2 , R 3 , and R 4 are as described in the specification.
6863843 Naphthopyran compounds, photoresponsive compositions and lenses  
A photochromic [1,2-b] naphthopyran having a fluoro substituent in at least one of the 7-position or the 9-position of the naphthopyran provides a stable photochromic compound with a narrow range...
6858227 Vitamin E conjugates  
Vitamin E conjugates, methods for their preparation, and compositions that include the conjugates. The vitamin E conjugates include a tocopherol moiety covalently coupled through a linker moiety to...
6846817 Nicotine receptor ligands  
The invention provides nicotine receptor agonists of formula I: wherein R 1 , x, y, and n have any of the values given in the specification, or a pharmaceutically acceptable salt thereof, as...
6844336 4-fluoroalkyl-2h-benzopyrans with anti-estogenic activity  
This invention describes the new 4-fluoroalkyl-2H-benzopyrans of general formula I, in which Z is a straight-chain or branched-chain alkyl group with up to 5 carbon atoms that is...
6835727 Cathepsin cysteine protease inhibitors  
This invention relates to a novel class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of Cathepsins K and L. These compounds are useful for treating...
6822101 Process for preparing amine-substituted benzofurans  
The present invention relates to processes for preparing amine substituted benzofurans, and more particularly 4-(2-{2-[(2R)-2-methyl-1-pyrrolidinyl]ethyl}-1-benzofuran-5- yl)benzonitrile, and salts...
6784167 17-beta-hydroxysteroid dehydrogenase-II inhibitors  
17-beta-hydroxysteroid dehydrogenase-II inhibitors having the structural formula wherein the phenyl group labeled A and the group —C(R 4 )(R 6 )Y are oriented cis to each other; W represents O...
6750243 Amidino derivatives and their use as thrombin inhibitors  
There is provided compounds of formula I wherein R 1 , R x , Y, R y , n and B have meanings given in the description which are useful as competitive inhibitors of trypsin-like proteases, such as...
6740649 Cyclic hydroxamic acids as inhibitors of matrix metalloproteinases and/or TNF- α converting enzyme (TACE)  
The present application describes novel cyclic hydroxamic acids of formula I: or pharmaceutically acceptable salt forms thereof, wherein ring B is a 5-7 membered cyclic system containing from...
6736998 Indeno-fused photochromic naphthopyrans  
Described are novel reversible photochromic indenonaphthopyran compounds, examples of which are 2H-naphtho[1,2-b]pyrans characterized by having a substituted or unsubstituted indeno group fused at...
6734206 3-oxa-8-azaprostaglandin analogs as agents for lowering intraocular pressure  
The present invention provides a method of treating ocular hypertension or glaucoma which comprises administering to an animal having ocular hypertension or glaucoma therapeutically effective...
6716987 Derivatives of benzofuran or benzodioxazole compounds  
An oxygen-containing heterocyclic compound represented by following Formula (I): wherein R 1 and R 2 independently represent hydrogen, lower alkyl, cyano, —(CH 2 ) n —E 1 —CO—G 1 ...
6703407 Benzofuran compounds, compositions, and methods  
The present invention provides novel, reduced benzothiophenes of formula I wherein R is —H, —OH, —O(C 1 -C 4 alkyl), —O—CO—(C 1 -C 6 alkyl), —O—CO—Ar in which Ar is...
6653479 Crystalline form of 6-hydroxy-3-(4-&lsqb 2-(piperidin-1-yl)ethoxy&rsqb phenoxy)-2-(4-methoxyphenyl)benzo&lsqb b&rsqb thiophene hydrochloride  
The present invention is directed to a novel crystalline hydrate of 6-hydroxy-3-(4-[2-(piperidin-1-yl)ethoxy]phenoxy)-2-(4-metho xyphenyl)benzo[b]thiophene hydrochloride and uses for same,...
6653328 3-benzyl-benzothiophenes  
This invention relates to the fields of pharmaceutical and organic chemistry and provides novel 3-benzyl-benzothiophenes which are α-substituted with ether, thioether amino, cyano or halo that are...
6632833 2-(2-methylphenyl)-3,4-dihydro-2H-pyrrole derivatives  
The invention relates to novel 2-(2-methylphenyl)-3,4-dihydro-2H-pyrrole derivatives of the formula (I) in which Ar represents substituted phenyl, to a plurality of processes for their...
6632825 Antipicornaviral compounds and compositions, their pharmaceutical uses, and materials for their synthesis  
Compounds of the formula: where the formula variables are as defined in the disclosure, advantageously inhibit or block the biological activity of the picornaviral 3C protease. These compounds,...
6620838 Benzopyrazone compounds, compositions thereof, and methods of treatment therewith  
Benzopyranone compounds having the following structure: wherein R 1 , X, Y and n are as defined here, are disclosed. The compounds of formula (I), wherein R 1 is H, can be prepared by...
6620837 Antithrombotic agents  
This application relates to novel compounds of formula (I) (and their pharmaceutically acceptable salts), as defined herein, processes and intermediates for their preparation, pharmaceutical...
6610737 Non-psychotropic cannabinoids  
Novel non-psychotropic cannabinoids are disclosed and pharmaceutical compositions comprising these novel compounds are described for preventing neurotoxicity, neuroinflammation, immune or...
6608089 Derivatives of flavones, xanthones and coumarins  
Compounds having the formula (I) Z—OCH 2 —C≡CCH 2 —NRR 1 (I) or a pharmaceutically acceptable salt or solvate thereof wherein Z can represent the formula (1A) or (1B). The compounds...
Matches 1 - 50 out of 1006 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 >