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7094872 |
Activated polyethylene glycol esters
The present invention relates to the preparation of polyethylene glycol carbonate active esters useful for the PEGylation of biological active and pharmaceutically useful peptides and proteins. The...
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7091285 |
Adducts of mid-range vinylidene content polyisobutylene polymer products and methods for making the same
A reaction product comprising an adduct of a mid-range vinylidene content PIB polymer composition and maleic anhydride, a phenolic compound or a compound having a reactive site for subsequent...
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6706892 |
Pulmonary delivery for bioconjugation
Methods of and compositions for pulmonary delivery of therapeutic agents which are capable of forming covalent bonds with a site of interest or which have formed a covalent bond with a pulmonary...
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6218536 |
1,2-bis-adducts of stable nitroxides with substituted ethylenes and stabilized compositions
1,2-Bis-adducts of stable hindered nitroxide compounds with substituted ethylenes are prepared by reacting two equivalents of nitroxyl compound with an ethylenically unsaturated compound such as...
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6005069 |
Production of polysuccinimide and derivatives thereof in a sulfur-containing solvent
Polysuccinimide of varying molecular weight has been prepared in a solvent system by heat polymerization of aspartic acid. The solvent system includes a sulfur oxygen acid and a sulfur oxygen acid...
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5985815 |
Bleach activators
New compounds useful as bleach activators as well as new percarboxylic acids, which may be formed as intermediates upon reaction of such activators with peroxygen bleach source in aqueous solution,...
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5976783 |
Bis-maleimido cross-linking agents
Formation of an intramolecular cross-link in enzyme donor polypeptide fragments of β-galactosidase, thereby forming a cyclic enzyme donor which is hindered from complementation with an enzyme...
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5925651 |
Inhibitors of farnesyl-protein transferase
The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to...
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5880070 |
Cross-linked succinimides from an acid derivative, a polyamine, and a polycarboxylic acid derivative
A polyalkylene succinimide composition prepared by reacting a mixture of an acid derivative, a polycarboxylic acid derivative; and a polyamine under reactive conditions. The acid derivative can be...
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5872191 |
Process for producing a polyoxyalkylene derivatives substituted with succinimidyl group
A process for producing a polyoxyalkylene derivative substituted with succinimidyl group which comprises reacting a polyoxyalkylene compound having carboxyl group at ends with N-hydroxysuccinimide...
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5856427 |
Process for the production of polysuccinimide
There is disclosed a process for preparing polysuccinimide by the thermal polycondensation of amino acids such as L-aspartic acid in the presence of an acidic catalyst for the polycondensation...
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5808096 |
Process for preparing active carbonates of polyalkylene oxides for modification of polypeptides
Poly(ethylene glycol)-N-succinimide carbonate and its preparation are disclosed. Polyethylene glycol (PEG) is converted into its N-succinimide carbonate derivative. This form of the polymer reacts...
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5777012 |
Polysulfides of n-methylpyrrolidinone
The present invention relates polysulfides of N-methylpyrrolidinone and to rubber compositions containing such polysulfides. Addition of the polysulfides to rubber improves the hysteresis,...
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5767284 |
Process for producing a polyoxyalkylene derivative substituted with succinimidyl group
A process for producing a polyoxyalkylene derivative substituted with succinimidyl group which comprises reacting a polyoxyalkylene compound having carboxyl group at ends with N-hydroxysuccinimide...
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5650234 |
Electrophilic polyethylene oxides for the modification of polysaccharides, polypeptides (proteins) and surfaces
Several poly(ethylene glycol) mixed carbonates and their preparation are closed. These carbonates are synthesized by conversion of polyethylene glycol first to the chloroformate then by reaction...
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5644001 |
Resin-free succinimides process of making, and compositions containing same
This invention relates to novel pure hydrocarbyl succinylating agents, substantially pure derivatives thereof, to a method of preparation of pure substituted succinylating agents and their...
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5630996 |
Two-step pretargeting methods using improved biotin-active agent conjugates
Methods, compounds, compositions and kits that relate to pretargeted delivery of diagnostic and therapeutic agents are disclosed. In particular, methods for radiometal labeling of biotin and for...
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5612460 |
Active carbonates of polyalkylene oxides for modification of polypeptides
Poly(ethylene glycol)-N-succinimide carbonate and its preparation are disclosed. Polyethylene glycol (PEG) is converted into its N-succinimide carbonate derivative. This form of the polymer reacts...
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5610318 |
Imidocarboxylic acid activators and sulfimidocarboxylic acid activators processes for their preparation and their use
This invention is directed to a process for preparing a compound containing a persalt activators and salts thereof which are derived from imidocarboxylic acids and sulfimidocarboxylic acids of the...
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5556976 |
Reactive cyclic N-sulfatoimides and cellulose crosslinked with the imides
A method of forming a crosslinked cellulose product is disclosed wherein cellulose fibers are exposed to a solution that includes a catalyst and a crosslinking agent selected from the group...
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5523417 |
Resin-free succinimides
This invention relates to novel pure hydrocarbyl succinylating agents, substantially pure derivatives thereof, to a method of preparation of pure substituted succinylating agents and their...
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5508434 |
Production of a polysuccinimide and derivatives thereof in the presence of a sulfur-containing dehydrating agent
Polysuccinimide of varying molecular weight has been prepared by heat polymerization of aspartic acid in the presence of a sulfur-containing dehydrating agent employing a variety of reaction...
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5504128 |
Thermoplastic resin composition and a method of molding the same
This invention provides a thermoplastic resin composition comprising a thermoplastic resin and 0.1 to 100 parts by weight, per 100 parts by weight of the thermoplastic resin, of an imide compound...
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5491213 |
Production of polysuccinimide
Polysuccinimide is prepared by reacting an unsaturated C 2 dicarboxylic acid or anhydride thereof, e.g., maleic acid, fumaric acid, and maleic anhydride, with a particulate ammonium salt that is...
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5484945 |
Preparation process of polysuccinimide
In the process for preparing polysuccinimide by dehydration condensation of aspartic acid in an organic solvent, polysuccinimide can be obtained simply and suitably in industry by removing a...
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5468404 |
Lubricating oil additives, their preparation and use
A lubricating oil soluble compound suitable for use as a dispersant additive is obtainable by reacting at elevated temperature a polyepoxide with a dispersant having at least one reactive...
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5466387 |
Oil-soluble adducts of disuccinimides and anhydrides of unsaturated bicarboxylic aliphatic acids
Oil-soluble additives with dispersant properties inert towards fluoroelastomers are described, prepared by reacting an alkyl or alkenyl disuccinimide with an anhydride of an unsaturated...
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5464549 |
Oil soluble dispersants suitable for use in fuels and lubricants
The dispersants are formed by reacting (a) at least one dispersant having at least one primary or secondary amino group and/or at least one hydroxyl group, with (b) at least one polyolefinic...
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5424445 |
Alkoxylation products
Alkoxylation products which are suitable as dispersants and are of the general formula I ##STR1## where A is oxygen or --CO--O-- when x and y are each 1 or is nitrogen when x+y=3, B is...
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5405966 |
Trichothecene conjugates
Conjugates of trichothecenes and agents that bind to a defined population of cells are disclosed. Preferred are conjugates of trichothecene molecules with polyclonal or monoclonal antibodies or...
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5399715 |
Polyamino oligomers and polymaleimide compounds
The polyamino oligomers of this invention are obtained by reacting diisopropenylbenzenes or bis(α-hydroxyisopropyl)benzenes and anilines in the presence of an acid catalyst and characterized by...
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5391764 |
Polyaspartic acid manufacture
Polyaspartic acid is produced by hydrolysis of anhydropolyaspartic acid that has been produced by thermal condensation polymerization of L-aspartic acid. Conversion in excess of 80 percent is...
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5380873 |
Homobifunctional agents for coupling enzymes and the like to antibodies and the like
A coupling agent useful in conducting immunoassays, particularly assays for B12, is disclosed. The coupling agent has the formula ##STR1## Z and Z' can be the same or different and each is ##STR2##...
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5356885 |
Substituted oxotremorine derivatives and pharmaceutical use thereof
This disclosure describes novel substituted oxotremorine derivatives of formula I having nitrogen, oxygen or sulfur groups and the prodrug forms of these derivatives. The compounds have cholinergic...
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5346910 |
Maleimide derivatives of oxotremorine
Maleimide derivatives of oxotremorine and their alkylthiol addition products having the general formulae: ##STR1## wherein R 1 and R 2 are independently alkyl, hydroxyalkyl, acyloxy,...
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5329020 |
Preparation of polysuccinimide
The present invention relates to a process for the production of polysuccinimide by the thermal condensation of aspartic acid wherein the rate of reaction is increased by contacting the aspartic...
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5283317 |
Intermediates for conjugation of polypeptides with high molecular weight polyalkylene glycols
A biologically persistent, water-soluble, substantially non-immunogenic, substantially non-antigenic conjugate of superoxide dismutase is prepared by coupling one to five strands of a polyalkylene...
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5281698 |
Preparation of an activated polymer ester for protein conjugation
The present invention is a process for preparing an activated ester of polyethylene glycol or a polyoxyethylated polyol. After the activated ester is prepared, it can be reacted with a protein to...
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5266081 |
Multifunctional ashless dispersants
A fuel additive is the reaction product of an intermediate reaction product of a hydrocarbon-substituted succinic anhydride and an aminosalicylic acid, preferably a 4-aminosalicylic acid. The...
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5264004 |
Multifunctional ashless detergent additives for fuels and lubricants
An ashless detergent additive having antioxidant and metal surface protection properties for lubricants or fuels is made from a Mannich condensation reaction between a hydrocarbylbissuccinimide,...
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5235067 |
Continuous process for alkenyl succinimides
A continuous process has been found for producing hydroxyacylated alkenyl-substituted mono- and bis- succinimides. The Mannich phenol coupled compositions are produced continuously as well. In the...
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5234476 |
Polynitrogen compound having two terminal cycles of the imide type, their preparations and uses
Polynitrogen compound having two terminal cycles of the imide type, its preparation by conventional organic chemistry methods and its use as an additive for engine fuel. This compound complies with...
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5230817 |
Polyanhydride modified adducts or reactants and oleaginous compositions containing same
An oil soluble dispersant additive useful in oleaginous compositions selected from fuels and lubricating oils comprising the reaction products of: (i) at least one intermediate adduct comprised...
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5205945 |
Multifunctional additives
A multifunctional antioxidant, antiwear and dispersancy additive for fuels and lubricants is a reaction product of a thiol-substituted diazole, such as aminomercaptothiadiazole (AMTD) or...
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5186853 |
Polyacrylate-modified bis-succinimide lubricant additives
A lubricating oil soluble compound suitable for use as a dispersant additive is obtainable by reacting at elevated temperature a polyacrylate with a dispersant having at least one reactive...
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5182392 |
Process for producing bistrimellitic imide
A process for producing a bistrimellitic imide of the formula (2) ##STR1## wherein X is an aliphatic group having at least 2 carbon atoms, an alicyclic group or an aromatic group, which comprises...
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5175285 |
Polymers derived from polysuccinimide, used as surface coatings for medicinals and foods
A conversion product of polysuccinimide useful as coating material for medicinal preparations and foodstuffs having the structure: ##STR1## wherein A is hydrogen or a straight or branched alkyl or...
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5156654 |
Detergent, dispersant and anti-rust additive for fuels and lubricating oils
An additive for fuels and lubricating oils with detergent, dispersant and anti-rust properties is described, consisting essentially of the product of condensing a mixture of alkenylsuccinic acids...
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5147414 |
Process for producing ORI control additives
An improvement in a method of producing an ORI control additive which is the reaction product of a polybutenyl succinic anhydride and a polyoxyalkylene diamine, wherein the improvement comprises...
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5145984 |
Bis-succinimide derivatives
A process for producing a lubricating oil dispersant additive comprises: step (1) reacting compound (A), wherein compound (A) is a hydrocarbyl-substituted or a substituted...
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