Patents in Class 548/517

Matches 1 - 50 out of 707

Match	Document	Document Title
1	7638550	Pyrrolic derivatives with histone deacetylase inhibitory activity The invention describes new compounds derived from formula I pyrroles, methods for obtaining them and their application as drugs in pharmaceutical compositions for the treatment of cancer due to...
2	7625932	Pyrrole and pyrazole derivatives as potentiators of glutamate receptors The present invention relates to pyrrole and pyrazole compounds of formula (I) and their pharmaceutically acceptable salts, and further relates to their use in treating schizophrenia, cognitive...
3	7608592	HCV inhibitors The present invention is directed to compounds that are antiviral agents. Specifically the compounds of the present invention inhibit replication of HCV and are therefore useful in treating...
4	7601752	Pyrrolidine derivatives The invention is concerned with novel pyrrolidine derivatives of formula (I) wherein X, Y, R 1 , R 2 and R 3 are as defined in the description and in the claims, as well as physiologically...
5	7589119	Methods for treating or preventing metastatic cancer using benzopyranone compounds This invention relates to Benzopyranone Compounds, compositions comprising a Benzopyranone Compound and methods for treating or preventing cancer or inhibiting the growth of a cancer cell or...
6	7585882	Phosphodiesterase 4 inhibitors Selective PDE4 inhibition is achieved by novel compounds, e.g., 4-(substituted-phenyl)-2-pyrrolidinone compounds. The compounds of the present invention are of formula I: wherein R 1 , R 2 ,...
7	7582749	Photochromic compounds Various non-limiting embodiments disclosed herein relate generally to photochromic compounds, which may be thermally reversible or non-thermally reversible, and articles made therefrom. Other...
8	7576102	Biaryl substituted nitrogen containing heterocycle inhibitors of LTA4H for treating inflammation The present invention relates to a chemical genus of biaryl substituted nitrogen-attached heterocycles that are inhibitors of LTA4H (leukotriene A4 hydrolase). The compounds have the general...
9	7572824	Methods for minimizing thioamide impurities Methods for minimizing the formation of thioamide compounds using decoy agents during reactions, such as thionations of carbonyl compounds containing nitrile groups, and the products thereby are...
10	7563910	Heterocyclic cannabinoid receptor antagonists The present invention relates to compounds of formula I and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prophylaxis of diseases which are...
11	7553861	Dipeptidyl peptidase-IV inhibitors The present invention relates generally to pyrrolidine and thiazolidine DPP-IV inhibitor compounds. The present invention also provides synthetic methods for preparation of such compounds, methods...
12	7550487	Pyrrolidine-3,4-dicarboxamide derivatives The invention is concerned with novel pyrrolidine-3,4-dicarboxamide derivatives of formula (I) wherein R 1 to R 9 and X are as defined in the description and in the claims, as well as...
13	7547694	Selected CGRP-antagonists, process for preparing them and their use as pharmaceutical compositions The present invention relates to the CGRP antagonists of general formula wherein A and R 1 to R 3 are defined as in claim 1 , the tautomers, the diastereomers, the enantiomers, the hydrates...
14	7538138	Amines as histamine-3 receptor ligands and their therapeutic applications Compounds of formula (I) or a pharmaceutically acceptable salts or prodrug thereof which are useful for the modulation of the histamine-3 receptors in mammals and which are useful for the...
15	7534810	Salt forms of [R—(R,R)]-2-(4-fluorophenyl)-β, δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid Novel salt forms of [R-(R,R)]-2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylet hyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptano ic acid characterized by their X-ray powder diffraction...
16	7528156	Compounds The invention provides compounds of general formula (D wherein m, n, Q, Z1, Z2, R1, R2, R3, R4, R5, R6, R7, and R8 are as defined in the specification, processes for their preparation,...
17	7521470	Factor Xa inhibitors The present invention is directed to compounds represented by Formula I and pharmaceutically acceptable salts, solvates, hydrates, and prodrugs thereof which are inhibitors of Factor Xa. The...
18	RE40667	[R-(RR)]-2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid, its lactone form and salts thereof [R-(R,R)]-2-(4-fluorophenyl)-β,δ-dihydroxy-5-((1-methyle thyl)-3-phenyl-4-[(phenylamino)-carbonyl)]-1H-pyrrole-1-hept anoic acid or...
19	7504243	Methods for the production of biliverdin The present invention relates to compositions and methods for the production of biliverdin. In particular, the invention concerns methods for producing biliverdin in yeast, especially Candida...
20	7482475	Therapeutic lactams Disclosed herein is a compound having a structure Therapeutic methods, compositions, and medicaments related thereto are also disclosed.
21	7476747	Substituted gamma lactams as therapeutic agents A compound comprising or a pharmaceutically acceptable salt, prodrug, or a metabolite thereof is disclosed herein. Y, A, and B are as described herein. Methods, compositions, and medicaments...
22	7456164	3- or 4-monosubtituted phenol and thiophenol derivatives useful as H3 ligands The invention relates to 3- or 4-monosubstituted phenol and thiophenol derivatives of formula (I) and to processes for the preparation of, intermediates used in the preparation of, compositions...
23	7456209	IAP binding compounds IAP binding molecules and compositions including these are disclosed. The IAP binding molecules interact with IAPs (inhibitor of apoptosis proteins) in cells and may be used to modify apoptosis in...
24	RE40525	Hepatitis C inhibitor tri-peptides A racemate diastereoisomer and optical isomer of a compound of formula (I): wherein B is H, a C 6 or C 10 aryl, C 7-16 aralkyl; Het or (lower alkyl)-Het, all of which may be optionally...
25	7425575	Spirocyclic 3-phenyl-3-substituted 4-ketolactams and 4-ketolactones The present invention relates to novel phenyl-substituted 4-ketolactams and -lactones of the formula (I) in which A, B, Q, G, W, X, Y, Z and R 3 are as defined above, to processes and...
26	7423061	Substitute thiophenes and uses thereof This invention relates to novel compounds having the structural formula (I) and to their pharmaceutical salts, compositions and methods of use. These novel compounds provide a treatment or...
27	7417062	Substituted arylamides Substituted benzamide compounds are provided along with methods for the use of those compounds for treating cancer.
28	7414141	Process and intermediate compounds useful in the preparation of statins, particularly atorvastatin There is provided a process for the preparation of a compound of formula (7) or salts thereof: wherein R 1 represents a hydrogen or a hydrocarbyl group, R 2 represents a hydrogen or substituent...
29	7399773	Process for the synthesis of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid and phenylamide An improved process for the preparation of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro- pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxy lic acid phenylamide by a novel...
30	7396851	Heterocyclic and benzoheterocyclic polyamides structurally related to the natural antibiotic distamycin A for the treatment of β-thalassaemia The invention relates to the use of structural analogues of distamycin having the general formula (I), (II), (III), (IV) or (V) or their pharmaceutically acceptable salts, for the preparation of a...
31	7388007	Gamma-lactams as beta-secretase inhibitors There is provided a series of novel substituted gamma-lactams of Formula (I) or a stereoisomer; or a pharmaceutically acceptable salt thereof, wherein R 1 , R 2 , R 4 , R 5 and R 6 as defined...
32	7381741	3-amino-2-phenylpyrrolidine derivatives 3-amino-2-phenylpyrrolidine compounds useful as NK-1 antagonists, with pharmaceutical compositions and methods of treatment comprising same, are disclosed.
33	7378436	Compounds A compound of Formula (I) and pharmaceutically and/or veterinarily acceptable derivatives thereof, wherein R 1 is H, C 1-6 alkyl, —C(X)Y, C 3-8 cycloalkyl, aryl, het, aryl-C 1-4 alkyl or...
34	7365092	Inhibitors of serine proteases, particularly HCV NS3-NS4A protease The present invention relates to compounds of formula I: or pharmaceutically acceptable salts thereof that inhibit serine protease activity, particularly the activity of hepatitis C virus...
35	7361771	Process for the synthesis of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide An improved process for the preparation of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro- pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxy lic acid phenylamide by a novel...
36	7361755	Transition-metal-catalyzed process for the conversion of alkenes to sterically hindered substituted n-alkoxyamines This invention pertains to a novel process for preparing sterically hindered N-substituted alkyloxyamines from alkenes by the transition-metal-catalyzed reaction of a intermediate alkylborane with...
37	7358273	Inhibitors of caspases The present invention relates to novel classes of compounds which are caspase inhibitors, in particular interleukin-1β converting enzyme (“ICE”) inhibitors. This invention also relates to...
38	7358274	Methods for treating or preventing cancer using Benzopyranone Compounds This invention relates to Benzopyranone Compounds, compositions comprising a Benzopyranone Compound and methods for treating or preventing cancer or inhibiting the growth of a cancer cell or...
39	7348346	Pharmaceutical compositions as inhibitors of dipeptidyl peptidase-IV (DPP-IV) The present invention relates to compounds of formula (I), which inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II...
40	7329762	Prodrugs of mitotic kinesin inhibitors The present invention relates to phosphate ester prodrugs of dihydropyrrole compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP...
41	7319132	Polymer compounds containing oxetane and maleimide functionality Polymeric compounds containing an oxetane functionality and a maleimide functionality have the structure in which polymer is a polymeric backbone, m and n are integers from 2 to 500, R 1 is...
42	7319148	Combinatorial production of nucleotide and nucleoside (XiTP) analogues The invention concerns novel nucleotide analogues comprising a reactive hydrazide function used as initial synthons for preparing compounds (formula I) capable of inducing mutations or capable of...
43	7317064	Phenolic resin systems for fiber reinforced composite manufacture The invention includes formulations useful for creating reinforced composites based on 1) novolac resin compositions, and, 2) non-formaldehyde hardeners, as well as processes for manufacturing...
44	7317063	Phenolic resins The invention herein disclosed comprises the use of oxazolidines, nitroalcohols, nitroamines, aminonitroalcohols, imines, hexahydropyrimidines, nitrones, hydroxylamines, nitro-olefins and...
45	7312336	Compounds with analgesic effect Compounds of general formula (I) are disclosed and claimed in the present application, as well as their pharmaceutically acceptable salts, pharmaceutical compositions comprising the novel...
46	7304087	1-acyl-pyrrolidine derivatives for the treatment of viral infections Anti-viral agents of Formula (I) wherein: A represents hydroxy; D represents aryl or heteroaryl; E represents hydrogen, C 1-6 alkyl, aryl, heteroaryl or heterocyclyl; G represents hydrogen or...
47	7282510	Small molecule inhibitors of rotamase enzyme activity This invention relates to neurotrophic N-glyoxyl-prolyl ester compounds having an affinity for FKBP-type immunophilins, their preparation and use as inhibitors of the enzyme activity associated...
48	7276531	G-lactam derivatives as prostaglandin agonists A gamma-lactam diene of Formula I: which is particularly useful as a medicament for the treatment of various disorders such as asthma, hypertension, osteoporosis, sexual dysfunction and...
49	7259179	Kinase inhibitors A compound of the general formula: or pharmaceutically acceptable salts, hydrates, solvates, crystal forms or diastereomers thereof is described. A method of treating protein kinase-associated...
50	7250519	Method for the production of arylamines The invention relates to a method for the production of tertiary amines by reaction of secondary amines with aromatics or heteroaromatics in the presence of a base, a nickel or palladium compound...

Matches 1 - 50 out of 707

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