Patents in Class 548/516

Matches 1 - 50 out of 100

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Match	Document	Document Title
1	7605168	PDE4B inhibitors Compounds are described that are active on PDE4. Also described are crystal structures of PDE4B determined using X-ray crystallography, the use of PDE4B crystals and structural information for...
2	7531672	Preparation of heterocyclic ketones The present invention relates to a process for preparing heterocyclic ketones of the formulae (I) and (la), by reacting a heterocyclic compound of the formula (II), with an α, β-unsaturated...
3	7365061	2-Amino-3-functionalized tetralin derivatives and related glycogen phosphorylase inhibitors Novel compounds are provided which are glycogen phosphorylase inhibitors which are useful in treating, preventing or slowing the progression of diseases requiring glycogen phosphorylase inhibitor...
4	7226942	2-amino-4-functionalized tetralin derivatives and related glycogen phosphorylase inhibitors Novel compounds are provided which are glycogen phosphorylase inhibitors which are useful in treating, preventing or slowing the progression of diseases requiring glycogen phosphorylase inhibitor...
5	7223786	2-aminonaphthalene derivatives and related glycogen phosphorylase inhibitors Novel compounds are provided which are glycogen phosphorylase inhibitors which are useful in treating, preventing or slowing the progression of diseases requiring glycogen phosphorylase inhibitor...
6	7214704	2-Amino-1-functionalized tetralin derivatives and related glycogen phosphorylase inhibitors Novel compounds are provided which are glycogen phosphorylase inhibitors which are useful in treating, preventing or slowing the progression of diseases requiring glycogen phosphorylase inhibitor...
7	7199148	Broadspectrum substituted oxindole sulfonamide HIV protease inhibitors The present invention concerns the compounds having the formula N-oxides, salts, stereoisomeric forms, racemic mixtures, prodrugs, esters and metabolites thereof, wherein R 1 and R 8 each are...
8	7078535	Method for the production of 6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1h-pyrrolizin-5-ylacetic acid The invention relates to a process for the preparation of 6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrr olizin-5-ylacetic acid, in which 5-benzyl-3,3-dimethyl-3,4-dihydro-2H-pyrrole...
9	6936632	Fused pyrrole compounds, pharmaceutical agents containing the same, and the use thereof The present invention relates to fused pyrrole compounds of the formula 1. in which at least one of the radicals R1, R2, R3 is 4-sulphur-substituted phenyl. These compounds are in particular...
10	6930190	Process for the preparation of heterocyclic pentalene derivatives A process for preparing heterocyclic pentalene derivative having formula (I): wherein w is a sulfur atom (S), an oxygen atom (O) or a NR or PR group, wherein R is an hydrocarbon group; R 1 , R 2 ,...
11	6878738	Anti-inflammatory oxo derivatives and hydroxy derivatives of pyrrolizines, and their pharmaceutical use The present invention relates to compounds of the formula I in which one of the radicals R8 and R9 is a hydrogen atom or an alkyl group and the other is hydroxyl, alkoxy or acyloxy or where R8...
12	6559319	Synthesis of compounds useful in the manufacture of ketorolac A multi-step method of synthesizing ketorolac, an analgesic compound, is shown. Several of the reactions and intermediate compounds are novel. The reaction sequence begins with the known compound...
13	6548532	Indolecarboxylic compounds for treating seborrhea and complications thereof Indolecarboxylic acid compounds and derivatives thereof are useful for treating seboarhea and the dermatitides associated therewith, especially acne and/or blackheads and/or comedones.
14	6541507	Indolecarboxylic compounds for inducing/stimulating hair growth and/or retarding hair loss Indolecarboxylic acid compounds and derivatives thereof, notably 4,6-dimethoxyindole-2-carboxylic acid and derivatives thereof, are especially useful for inducing/stimulating mammalian hair growth...
15	6448243	1,4-substituted cyclic amine derivatives A novel 1,4-substituted cyclic amine derivative represented by the following formula or a pharmacologically acceptable salt thereof: (wherein A, B, C, D, T, Y and Z represent each methine or...
16	6433199	Quinone derivatives The invention relates to a quinone derivative of the following formula: which is capable of converting into two alkylating agents upon bioreduction. Substituents A, B, C, and D are as described...
17	6417371	Process for preparing 6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl-acetic acid The present invention relates to a process process for the preparation of the compound of the formula I where the compound of the formula III is reacted with oxalyl chloride and the product...
18	6395766	Tetrahydroindolone derivatives as gabaaalpha5 ligands for enhancing cognition Compounds according to Formula (I) or a pharmaceutically acceptable salt thereof are GABA-A Alpha 5 ligands useful for enhancing cognition: where A is C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl,...
19	6391917	Dialkyl ureas as calcitonin mimetics Dialkyl urea compounds are described which act as calcitonin mimetics. These compounds are useful in the treatment of diseases which are associated with bone resorption. The calcitonin mimetics of...
20	6323344	Preparation of ketorolac 5-Benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxamides of the formula ##STR1## where R 1 is alkyl and R 2 is optionally substituted phenyl; and the method for their preparation and their conversion...
21	6218419	Aminoiminoquinone and aminoquinone alkaloid compounds and methods of use The subject application concerns novel compounds with useful biological properties. For example, these compounds can be used as antinflammatory, anti-proliferative, immunomodulatory, and/or...
22	5969133	Bioreductive cytotoxic agents A compound which consists of a proactive alkylating moiety containing an electron-withdrawing group, a bioreductive moiety containing at least two double bonds, and a linker joining the proactive...
23	5958943	A!-anellated pyrrole derivatives and their use in pharmacology The present invention relates to heterocyclic compounds of the formula ##STR1## in which R 1 -R 7 , B, a and X have the meanings recited in the specification. These compounds are usable in the...
24	5952316	2-amino-1,3-propanediol compound and immunosuppressant 2-Amino-1,3-propanediol compounds of the formula (I) ##STR1## wherein R is an optionally substituted straight- or branched carbon chain, an optionally substituted aryl, an optionally substituted...
25	5942535	a!-Annelated pyrrole derivatives and pharmaceutical use thereof The present invention relates to heterocyclic compounds of the formula ##STR1## in which R 1 -R 7 , B, a and X have the meanings recited in the specification. These compounds are usable in the...
26	5925770	Certain fused pyrrolecarboxanilides; a new class of gaba brain receptor ligands The present invention encompasses structures of the formula: ##STR1## or the pharmaceutically acceptable non-toxic salts thereof wherein: ##STR2## wherein: W represents substituted or unsubstituted...
27	5684160	3-aminopyrroles, methods for their synthesis and for their pharmaceutical use The invention is directed to 3-aminopyrroles of formula I, which are largely new, to methods for the preparation and to their use as medicinal agents and preparations, as well as to anti-convulsive...
28	5580888	Styryl derivatives as anti-inflammatory agents Compounds of general formula (1) ##STR1## are described wherein Y is a halogen atom or a group --OR 1 , wherein R 1 is an optionally substituted alkyl group; X is --O--, --S-- or --N(R 6 )--,...
29	5543423	Amino acid derivatives with improved multi-drug resistance activity The present invention relates to compounds that can maintain, increase, or restore sensitivity of cells to therapeutic or prophylactic agents. This invention also relates to pharmaceutical...
30	5523306	Amino acid derivatives cyclized at the C-terminal Novel α-substituted Trp dipeptoid derivatives cyclized at the C-terminal useful as agents in the treatment of obesity, hypersecretion of gastric acid in the gut, gastrin-dependent tumors, or as...
31	5516784	Anti-HIV (AIDS) agents Compounds of formula ##STR1## wherein Ar, W, Z, Q, R 1 , U, and T are as set forth herein, are described. These compounds are active as agents against retroviruses and in particular against HIV.
32	5484944	Certain fused pyrrolecarboxanilides and their use as GABA brain receptor ligands The present invention encompasses structures of the formula I: ##STR1## and the pharmaceutically acceptable non-toxic salts thereof wherein: ##STR2## wherein: W represents substituted or...
33	5482942	(3,4-dioxocyclobuten-1-yl)chromene, indene, and dihydronaphthalenone derivatives as smooth muscle relaxants This invention relates to novel 4-(3,4-dioxocyclobuten-1-yl)chromenes and dihydronaphthalenones and 3-(3,4-dioxocyclobuten-1-yl)indenes and salts thereof having smooth muscle relaxing activity, to...
34	RE34918	Azaazulene compounds which are useful as antiallergic and antiinflammatory agents An azaazulene derivative having the general formula (I): ##STR1## wherein R 1 is hydrogen atom or isopropyl group; the bond C N between C at the 2-position and N at the 1-position is single bond...
35	5354891	Method of producing aromatic amine derivatives Disclosed is a method for producing aromatic amine derivatives in a high yield at a low price, which comprises inducing an aromatic hydroxamic acid derivative to undergo a rearrangement reaction...
36	5017213	1-phenylpyrroles Herbicidal 1-phenylpyrroles of the formula ##STR1## wherein each R 1 represents methyl or together form a tetramethylene group, R 2 represents hydrogen, C 1 -6 alkyl, cyclopropylmethyl, C 1 -4...
37	4853149	Heterocyclic liquid crystal compounds Heterocyclic liquid crystal compounds containing the structural element ##STR1## wherein M is H, CN,, NCS, halogen or an alkyl group with 1-5 C atoms, X is CR 4 or N, Y is CHR 4 , O, S or NR...
38	4737519	Substituted naphthalenes, indoles, benzofurans, and benzothiophenes as lipoxygenase inhibitors The present invention provides certain novel substituted naphthalenes, indoles, benzofurans, and benzothiophenes of Formula I which are useful as inhibitors of leukotriene biosynthesis and as...
39	4736043	Process for the preparation of indole derivatives The present invention provides a process for the preparation of 4-hydroxyindole derivatives of the general formula: ##STR1## in which R 1 is a hydrogen atom or an alkyl radical containing up to 6...
40	4666934	Prostaglandin analogs The compound 6,9-deepoxy-6,9-(phenylimino)-Δ 6 ,8 -prostaglandin I 1 , potassium salt and compositions thereof.
41	4521606	5-Indolyl substituted aminoethanols Herein is disclosed bicyclic-substituted aminoethanol derivatives, therapeutically acceptable acid addition salts thereof, processes for their preparation, methods of using the derivatives and...
42	4496742	Analogs of 5,6-dihydro PGI.sub.2 Novel structural analogues of 5,6-dihydro PGI 2 of the formula: ##STR1## and the corresponding 10,11-didehydro-11-deoxy derivatives are useful as antiallergy agents.
43	4442291	1,2,3,4,4a,7-Hexahydro-6,8-dimethoxy-2-methyl isoquinoline The present invention is directed to a compound having the formula ##STR1## which is used as an intermediate in the preparation of octahydro-1H-pyrrolo[2,3-g]isoquinolines.
44	4383112	Chiral amino-alcohol complexes Chiral Schiff bases according to the general formula: ##STR1## and transition metal complexes thereof, wherein C * is an asymmetric carbon atom, R 1 and R 2 , which may be the same or different...
45	4344943	6-Chloro- or 6-bromo-1,2-dihydro-3H-pyrrolo[1,2-a]-pyrrole-1-carboxylic acids and derivatives thereof Novel 5-aroyl-6-chloro- or 6-bromo-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-7-carboxylic acids represented by the formula ##STR1## and the pharmaceutically acceptable, non-toxic esters and salts...
46	4336202	1,3-Cyclohexanedione derivatives Novel cyclohexanone derivatives of general formula: ##STR1## (wherein R 1 is a hydrocarbon group of 1 to 15 carbon atoms) and new cyclohexanone derivatives of general formula: ##STR2## (wherein R...
47	4316850	Tertiary aminoacids New α-(cyclic tert. aminophenyl)-aliphatic acids, e.g. those of the formula ##STR1## and functional derivatives thereof, are anti-inflammatory agents.
48	4294759	Structural analogues of 5,6,-dihydro PG.sub.1 Novel structural analogues of 5,6-dihydro PGI 1 of the formula: ##STR1## useful as antiallergy agents.
49	4260762	Octahydro-1H-pyrrolo[2,3-g]isoquinolines Neuroleptically active octahydro-1H-pyrrolo[2,3-g]isoquinolines of the formula ##STR1## wherein R 1 , R 2 , R 3 , R 4 and X are as hereinafter set forth, are described.
50	4087539	5-(2-Furoyl)-, 5-(2-thenoyl)-, 5-(3-furoyl)- and 5-(3-thenoyl)-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid derivatives and process for the production thereof Novel 5-substituted-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxy lic acid compounds represented by the formulas ##STR1## and the pharmaceutically acceptable, non-toxic esters and salts thereof,...

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