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7446122 |
Substituted indole derivatives
Provided herein are indole derivatives, pharmaceutical compositions containing them, methods for their use, and methods for preparing these compounds.
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7314886 |
Tetrahydropyrano-indole derivatives
Provided herein are indole derivatives, pharmaceutical compositions containing them, methods for their use, and methods for preparing these compounds.
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7151100 |
Indole compounds useful for the treatment of cancer
The present invention provides novel indole derivatives useful to inhibit cancer or sensitize cancer cells to chemotherapeutic agents, radiation or other anti-cancer treatments.
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7078533 |
Method for the racemization of etodolic acid
A method for the resolution of etodolic acid by crystallization of its salt with optically active 1-phenylethylamine and subsequent recovery of the (R,S) etodolic acid from the mother liquors of...
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6964979 |
R-enantiomers of pyranoindole derivatives and the use thereof for the treatment of hepatitis C virus infection or disease
The invention is directed to a compound and a pharmaceutical composition of the formula:
Wherein substitutions at R 1 , R 2 , R 3 -R 12 , and Y are set forth in the specification.
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6514984 |
Treatment for alzheimer's disease
A method is disclosed for the prevention and treatment of Alzheimer's disease by administering to a human in need thereof an effective amount of a substituted tricyclic sPLA 2 inhibitor.
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6469171 |
Syntheses of a variety of lamellarin compounds and analogues
The present invention relates to methods for preparing a variety of Lamellarin compounds and analogues via a synthetic intermediate, which methods involved the step of performing an intramolecular...
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6331638 |
Process for the preparation of 1,8-disubstituted-1,3,4,9-tetrahydropyrano (3,4-B)-indole-1-acetic acid esters
A process for the preparation of the esters of 1,8-disubstituted-1,3,4,9-tetrahydropyrano (3,4-b)-indole-1-acetic acid is delineated.
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6110955 |
Metabolically stabilized oxyalkylene esters and uses thereof
This invention relates to compositions for and methods of treating, preventing or ameliorating cancer and other proliferative diseases as well as methods of inducing wound healing, treating...
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6071946 |
Tricyclic urea compounds
A compound selected from those of formula (I): ##STR1## in which A, Y, R 1 , R 2 and R 3 are as defined in the Specification, and pharmaceutical compositions containing the same, which are useful...
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6066741 |
Process for the preparation of etodolac
Process for the preparation of etodolac, comprising the following steps: a) reacting 7-ethyl-tryptophol of formula (II) with methyl 3-oxo-pentanoate of formula (III) thereby obtaining methyl...
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5998461 |
Tricyclic amide compounds
This invention relates to benzofuran/pyran derivatives of a new tricyclic amide compound, their composition and method of use for treating disorders of the melatoninergic system.
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5756320 |
Bioactive substances K93-0711 I-1 and I-2 and process for production thereof
Bioactive substances K93-0711 I-1 and I-2 having inhibitory action on IL-6 activity, are produced by culturing a microorganism belonging to the genus Streptomyces in a medium, whereby the bioactive...
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5750556 |
2-(aminomethyl)-3,4,7,9-tetrahydro-2H-pyrano- 2,3-E!indol-8-ones and derivatives
Compounds of Formula I are selective autoreceptor agonists useful in treating disease states involving hyperactivity of dopamine systems: ##STR1## in which X is --(CH 2 ) n --; n is 1-3; R 1 is...
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5696130 |
Tricyclic steroid receptor modulator compounds and methods
Non-steroidal compounds which are high affinity, high selectivity modulators for steroid receptors are disclosed. Also disclosed are pharmaceutical compositions incorporating such compounds,...
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5639778 |
Indoletetralins having dopaminergic activity
A compound of formula (I) and pharmaceutically acceptable salts thereof, where Z is R 3 and X and Y form (a), or X is R 3 and Y and Z form (a) or (b); R 1 and R 2 are independently hydrogen, C...
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5621000 |
Nitric esters having a pharmacological activity and process for their preparation
Nitric esters with pharmacological activity having general formula (I), their pharmaceutical utilisation and process for their preparation. ##STR1##
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5599946 |
3-(2-trialkylsilyloxy)ethyl-7-ethyl-1H-indoles and method for their preparation
The present invention relates to novel trialkylsilyloxy derivatives of 7-ethyltryptophol useful in the preparation of etodolac, and methods of making them, and methods of using them to prepare...
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5585499 |
Cyclopropylbenzindole-containing cytotoxic drugs
Novel cytotoxic agents comprising a cell binding agent chemically linked to one or more analogue or derivative of CC-1065 are described. The therapeutic use of the cytotoxic agents is also...
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5578734 |
Method for the preparation of S-(+)-ethodolic acid and saline derivatives
Method for optically resolving an enantiomeric mixture of ethodolic acid to produce the S (+) enantiomer is provided wherein the enantiomeric mixture is salified with at least 0.5 moles per mole of...
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5491163 |
(Thia)cycloalkyl[B]indoles
The invention relates to a compound selected from those of formula (I): ##STR1## in which R 1 , R 2 , R 3 and A are as defined in the description, and medicinal product containing the same in...
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5330981 |
Arylalkyl esters of 4,5-dihydroxy-9,10-dihydro-9,10-dioxo-2-anthracenecarboxylic acid having therapeutical activity
This application describes 3-arylalkyl esters of 4,5-dihydro-9,10-dioxo-2-anthracenecarboxylic acid and a process for making them. Also described is a method of using the compounds in the treatment...
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5137909 |
Indole derivative and method of production thereof
An indole derivative represented by the general formula (I) ##STR1## wherein R is hydrogen, lower alkyl having 1 to 6 carbons, carboxymethyl, or substituted or unsubstituted aralkyl; R 1 , R 2 , R...
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5128363 |
Trifluoromethoxy substituted 1,3,4,9-tetrahydropyrano-[3,4-b]indole-1-acetic acids
Indole derivatives characterized by having a 1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid nucleus bearing a trifluoromethoxy substituent in the 5-, 6-, 7-, or 8-position, and methods for...
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5071853 |
Polycyclic amines useful as cerebrovascular agents
A novel series of polycyclic amines, derivatives, methods of making the compounds, novel intermediates, compositions containing them, and methods for using them in the treatment and prevention of...
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5030646 |
Novel tricyclic indole compound
The invention relates to compounds of general formula: ##STR1## in which A, B, G, D which may be identical or different, each denote a hydrogen atom or a halogen atom, a lower alkoxy group or...
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4925955 |
Resolution of (1S,4R)-1-ethyl-1,3,4,9-tetrahydro-4-(phenylmethyl) pyrano[3,4-B]indole-1-acetic acid using brucine
This invention relates to a process for resolving (±)-cis-1-ethyl-1,3,4,9-tetrahydro-4-(phenylmethyl)pyrano[3
,4-b]indole- 1-acetic acid (pemedolac) usinig brucine to obtain the corresponding...
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4910318 |
Tetrahydrothiopyrano(3,2-b)-indole derivatives
Tetrahydrothiopyrano[3,2-b]indole derivatives represented by the formula I: ##STR1## wherein R 1 is hydrogen, C 1 -4 alkyl, C 2 -4 alkenyl, C 2 -4 alkynyl, phenyl-C 1 -4 alkyl, C 2 -5 alkanoyl, or...
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4897493 |
Production of substituted 1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acids
Process for the production of substituted 1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acids having useful analgesic and anti-inflammatory activity.
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4886886 |
Substituted 1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acids
Indole derivatives characterized by having a 1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid nucleus bearing a substituent in position 1-, 4-, 5-, 6-, 7- and 8- are disclosed. The derivatives...
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4855445 |
Substituted-8-alkenyl-1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acids
Indole derivatives characterized by having a 1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid nucleus bearing substituents in position 1-,5-,6-, 7- and 8- are disclosed. The derivatives are...
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4826994 |
Production of substituted 1,3,4,9-tetrahydropyrano(3,4-B)indole-1-acetic acids
Production of indole derivatives characterized by having a 1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid nucleus bearing a substituent in position 1 and 4. The nucleus may be optionally...
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4822893 |
Production of substituted 1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acids
Process for the production of substituted 1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid having useful analgesic and anti-inflammatory activity.
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4810699 |
Substituted 1,3,4,9-tetrahydropyrano[3,4,-b]indole-1-acetic acids, pharmaceutical compositions containing them, and methods for treating inflammatory conditions and for analgesic purposes using them
Indole derivatives characterized by having a 1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid nucleus bearing a substituent in position 1,5, 6, 7 and 8. The derivatives are useful...
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4748252 |
Substituted 1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acids
Indole derivatives characterized by having a 1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid nucleus bearing a substituent in position 1 and 4. The nucleus may be optionally substituted at...
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4748174 |
Water soluble salts of an NSAID with meglumine/glucamine
The water soluble acid addition salts of an NSAID, such as acetylsalicylic acid, fenbufen, diflunisal, piroxicam, naproxen, or the like, with either glucamine or meglumine (N-methylglucamine) are...
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4604469 |
Process for the resolution of pyrano[3,4-b]indole-1-acetic acids
Mixtures of racemic (+)pyrano[3,4-b]indole-1-acetic acids are resolved with (-)-borneol to obtain the substantially pure (+) and (-)-enantiomers. The resolution involves the formation of a mixture...
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4585877 |
Process for preparing 1,8-diethyl-1,3,4,9-tetrahydropyrano(3,4-b)-indole-1-acetic acid, etodolac
A process for preparing 1,8-diethyl-1,3,4,9-tetrahydro[3,4-b]-indole-1-acetic acid (etodolac) is disclosed. Etodolac is a useful antiinflammatory and analgesic agent.
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4520203 |
Resolution of (±)-1,8-diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid using cinchonine
Racemic (±)-1,8-diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indole-1-ace
tic acid is resolved with cinchonine to obtain directly the pure salt of the (+)-enantiomer with cinchonine and converting the...
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4515961 |
Resolution of (±)-1,8-diethyl-1,3,4,9-tetrahydropyrano[3,4,-b] indole-1-acetic acid using enrichment crystallization
Racemic (±)-1,8-diethyl-1,3,4,9-tetrahydroprano[3,4-b]indole-1-acet
ic acid is resolved using enrichment crystallization to obtain directly the (+)-enantiomer.
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4309348 |
Tricyclic indole derivatives
Indole derivatives characterized by having a 1,3,4,9-tetrahydropyrano[3,4-b]indole or 1,3,4,9-tetrahydrothiopyrano[3,4-b]indole nucleus with a hydroxyalkanamine or lower alkoxyalkanamine...
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4226860 |
Spiroindolones
Herein is disclosed spiroindolone derivatives of the formula ##STR1## in which R 1 is lower alkyl or carboxy(lower)alkyl, R 2 is lower alkyl, R 3 is lower alkyl or phenyl(lower)alkyl, and X is...
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4179503 |
1-Hydroxyalkanamine pyrano[3,4-b]indole derivatives
Indole derivatives characterized by having a 1,3,4,9-tetrahydropyrano[3,4-b]indole or 1,3,4,9-tetrahydrothiopyrano[3,4-b]indole nucleus with a hydroxyalkanamine or lower alkoxyalkanamine...
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4171443 |
10B-Azafluoranthene derivatives and precursors thereof
10b-Azafluoranthene derivatives characterized by having a 1,2,3,3a,5,6-hexahydro-4-oxa(or thia)-10b-azafluoranthene nucleus having an alkanamine substituent at position 3 or 3a are disclosed. The...
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4118395 |
Method for the production of indolyl lactones
A method for the production of indolyl lactones of the formula ##STR1## wherein R 1 is hydrogen, halogen, or an alkoxy group having 1 to 4 C atoms and R 3 is hydrogen, characterized in the manner...
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4118394 |
Pyrano- and thiopyranoindole derivatives
Pyranoindole and thiopyranoindole derivatives characterized by having an amino(lower)alkyl radical attached to either or both the 1 and 9 position of a pyrano[3,4-b]indole or...
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4100277 |
4,1-Benzoxazonine derivatives and process therefor
4,1-Benzoxazonine derivatives characterized by having an alkyl radical at the 3-position as well as being further substituted at the 3-position are disclosed. The derivatives are optionally further...
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4076831 |
Pyrano[3,4-b]-indole derivatives, pharmaceutical compositions and methods of use
Indole derivatives characterized by having a 1,3,4,9-tetrahydropyrano[3,4-b]indole or 1,3,4,9-tetrahydrothiopyrano[3,4-b]indole nucleus bearing a substituent in position 1, said substituent...
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4070371 |
Derivatives of 1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid
Indole derivatives characterized by having a 1,3,4,9-tetrahydropyrano[3,4-b]indole or 1,3,4,9-tetrahydrothiopyrano[3,4-b]indole nucleus bearing a substituent in position 1, said substituent...
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4056537 |
Process for making pyrano- and thiopyranoindole derivatives
Pyranoindole and thiopyranoindole derivatives characterized by having an amino(lower)alkyl radical attached to either or both the 1 and 9 position of a pyrano[3,4-b]indole or...
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