|
Match
|
Document |
Document Title |
|
|
7303760 |
Method for treating multi-drug resistant tumors
Methods for administering mitomycin C to a multi-drug resistant cell and for reducing the toxicity of the compound are described. In the methods, mitoymic C is provided in the form of a prodrug...
|
|
|
6713633 |
Compounds capable of cleaving double-stranded DNA and method of utilization of the same
Novel chemical species capable of simultaneously alkylating double-stranded DNA and cleaving the same; methods for alkylating and cleaving DNA by using these species; and anticancer agents with the...
|
|
|
6576780 |
Hydroxyamidino derivatives useful as nitric oxide synthase inhibitors
The current invention discloses hydroxyamidino derivatives useful as nitric oxide synthase inhibitors.
|
|
|
6429212 |
Medicinal composition
It is to provide a cyclic imide derivative which is useful as an active ingredient of a pharmaceutical composition. A pharmaceutical composition which comprises, a cyclic imide derivative...
|
|
|
6355820 |
Chiral molecular magnet and manufacturing method of the same
There is disclosed a chiral molecular magnet having characteristics exhibiting a monocrystal, a magnetic property, an optical activity, a transparent color and a relatively high transition...
|
|
|
5780585 |
Bacterial nitroreductase for the reduction of CB 1954 and analogues thereof to a cytotoxic form
A prodrug of the formula (I): ##STR1## where R 1 is a group such that the compound R--NH 2 represents actinomycin D, doxorubicin, mitomycin C, or a nitrogen mustard of the formula (IV): ##STR2##...
|
|
|
5776962 |
Lactone compounds for treating patient with precancerous lesions
Substituted lactone compounds are useful in the treatment of precancerous lesions and neoplasms.
|
|
|
5776907 |
Mitomycin oligonucleotide conjugates
The present invention provides conjugates of mitomycin C or derivatives thereof and oligonucleotides. A conjugate of the present invention corresponds to formula I, below: ##STR1## where R is H, CH...
|
|
|
5703111 |
Stable injectable formulation of BMY-25067
This invention relates to a stable, easy to constitute, injectable formulation of anticancer agent BMY-25067. More specifically, the present invention concerns a formulation of BMY-25067 obtained...
|
|
|
5629427 |
2,7-diaminomitosene analogues
The present invention relates to analogues of 2,7-diaminomitosene, a mitomycin C metabolite, useful as antitumor, antimicrobial and/or antiviral agents. These analogues involve functionalization of...
|
|
|
5559245 |
Intermediates to 4-amino- hexahydrobenz (cd) indoles and processes therefor
New intermediates, and processes therefor, provide an efficient method for deriving 4-amino-1,2,2a,3,4,5-hexahydrobenz[cd]indoles, which are themselves intermediates to useful CNS agents, from the...
|
|
|
5523411 |
Synthesis of mitomycin and its analogs
The present invention relates to the synthesis of mitomycin and analogs thereof that are useful as anticancer antibiotics. The invention further relates to analogs of mitomycin, which can be...
|
|
|
5374739 |
Mitomycin analogs
The present invention provides novel mitomycin analogs containing a cyclic acetal or thioacetal group. These compounds are mitomycin C analogs in which the 7-amino group bears a 5-membered...
|
|
|
5352798 |
Process for preparing dithio-ethylanino 9A-methoxymitosanes
7-(Diphenylmethyl)oxy-9a-methoxymitosane is a novel intermediate for conversion into 7-amino and 7-oxy-9a-methoxymitosanes and is also useful for inhibiting mammalian tumor growth. The compound is...
|
|
|
5334611 |
6-ethyl mitomycin derivatives
Novel mitomycin derivatives represented by the formula (I) are obtained by introducing a substituent at the 6-position. The mitomycin derivatives of the present invention have an antitumor activity.
|
|
|
5218126 |
Halogen substituted mitomycin derivatives
Disclosed are mitomycin derivatives of formula (I): ##STR1## where W represents halogen; X represents methoxy, amino or ethylenimino; Y represents hydrogen or methyl; Z represents hydrogen or...
|
|
|
5180670 |
Method for purification of mitomycin C
A method for purification of mitomycin C comprises; a. a step of treating the culture of a mitomycin C-producing microorganism with reverse phase adsorption resin to adsorb mitomycin C onto the...
|
|
|
5175303 |
Preparation of 7-(diphenylmethyl)oxy-9A-methoxymitosane
7-(Diphenylmethyl)oxy-9a-methoxymitosane is a novel intermediate for conversion into 7-amino and 7-oxy-9a-methoxymitosanes and is also useful for inhibiting mammalian tumor growth. The compound is...
|
|
|
5103018 |
Mitomycin derivatives
Mitomycin derivatives containing substituted dithioethylamino groups at the 7th position are provided. The mitomycin derivatives according to the present invention are superior to mitomycin C with...
|
|
|
5099016 |
Substituted 7-oxomitosanes
The present invention provides novel mitomycin analogs containing a disulfide group and processes for the preparation thereof. These compounds are mitomycin A analogs in which the 7-alkoxy group...
|
|
|
5098926 |
6-substituted mitomycin analogs
Novel methods for treatment of neoplastic disease states in animals, which methods comprise administering a therapeutically effective amount of a compound of the formula IV, ##STR1## wherein: Y is...
|
|
|
5091523 |
Mitomycin derivatives having reduced bone marrow toxicity, processes for their preparation, and the uses thereof
The invention relates to certain derivatives of mitomycins A and C and the use thereof to treat bacterial infections and to supress the growth of cancer cells. The invention also relates to...
|
|
|
5075454 |
7-(diphenylmethyl)oxy-9a-methoxymitosane
7-(Diphenylmethyl)oxy-9a-methoxymitosane is a novel intermediate for conversion into 7-amino and 7-oxy-9a-methoxymitosanes and is also useful for inhibiting mammalian tumor growth. The compound is...
|
|
|
5068349 |
Mitomycin derivatives
Novel mitomycin derivatives are characterized by a substituent on the C 6 -methyl group. The mitomycin derivatives exhibit anti-tumor and antibacterial activity and have low toxicity.
|
|
|
5021423 |
Mitomycin derivatives and intermediates therefor
Mitomycin derivatives having the formula ##STR1## wherein X is acyl, lower alkyl, alkoxycarbonyl aryloxycarbonyl or aralkoxycarbonyl; Y is hydrogen or methyl; Z is hydrogen, methyl, acyl or...
|
|
|
4880825 |
Mitomycin derivatives
Mitomycin derivatives having potent anti-tumor activity having the formula: ##STR1## wherein one of R 1 and R 2 represents carbamoyloxymethyl and the other represents hydrogen or R 1 and R 2 ...
|
|
|
4874779 |
Mitomycin phosphate derivatives
Disclosed herein are N 7 -alkylphosphate derivatives of mitomycin C and porfiromycin showing antitumor activity against transplanted human tumor and reduced toxicity relative to the parent N 7 ...
|
|
|
4866180 |
Amino disulfide thiol exchange products
This invention refers to 7-amino mitosane analogs (mitomycin C) in which the 7-amino group bears an organic substituent incorporating a disulfide group and to a novel thiol exchange process for...
|
|
|
4863935 |
Mitomycin compounds having useful anti-tumor activity
Mitomycin derivatives having potent anti-tumor activity against solid sarcoma 180 tumors and lymphocytic leukemia P-388 tumors.
|
|
|
4853385 |
7-N,8-N-Ethylenemitomycin 8-imines
7-N,8-N-Ethylenemitomycin 8-imines represented by the formula ##STR1## wherein one of the R 1 and R 2 represents carbamoyloxymethyl and another represents hydrogen or both are combined together...
|
|
|
4820824 |
Mitomaycin compounds
Mitomycin compound having potent antitumour activity having the formula: ##STR1## wherein ##STR2## (wherein Ra, Rb and Rc each independently represent lower alkyl, cycloalkyl having 3-7 carbon...
|
|
|
4814445 |
Process for preparing mitomycin analogs
The present invention provides novel mitomycin analogs containing a disulfide group and processes for the preparation thereof. These compounds are mitomycin A analogs in which the 7-alkoxy group...
|
|
|
4803212 |
Amino disulfides
The present invention refers to mitomycin analogs containing a disulfide group. These compounds are mitromycin C derivatives in which the 7-amino group bears an organic substituent incorporating a...
|
|
|
4791130 |
Mitomycin derivatives as antileukemia agents
Mitomycin derivatives having potent antitumour activity have the formula: ##STR1## wherein R represents lower alkyl, cycloalkyl or unsubstituted or substituted aralkyl; X represents hydrogen or...
|
|
|
4771068 |
Mitomycin derivatives having anti-tumor and antibacterial utility
Mitomycin derivatives of the formula: ##STR1## wherein X is ##STR2## [wherein R 3 is alkyl, cycloalkyl or optionally substituted phenyl; and R 4 is alkyl or cycloalkyl]; n is an integer of 2 to...
|
|
|
4748251 |
7-n-aminomethylenemitomycin derivative
Mitomycin derivatives represented by the formula (I): ##STR1## wherein R 1 and R 2 may be the same or different, and represent a hydrogen atom or a lower alkyl group; R 3 and R 4 mean that when...
|
|
|
4720543 |
1a-7-substituted derivatives of mitomycin and uses thereof
This invention discloses 1a- and 7-substituted derivatives of mitosanes containing thiocarbamoyl and glycosyl residues. The compounds possess antibacterial and antitumor activity, with a...
|
|
|
4691024 |
New mitomycin derivatives, preparation thereof and pharmaceutical compositions containing them
The present invention provides new mitomycin derivatives of general formula (I) ##STR1## [wherein Y and Z, which may be the same or different, each represents a hydrogen atom or a methyl group; ...
|
|
|
4642352 |
Acylamino mitosanes
7-Acylamino-9a-methoxymitosanes having enhanced capacity to inhibit animal tumors in vivo relative to mitomycin C are produced by N 7 -acylation of 7-amino-9a-methoxymitosane, or N 1a ,N 7 ...
|
|
|
4639528 |
Crystalline form of 7-(dimethylaminomethylene-amino-9a-methoxymitosane
There is disclosed a new crystalline form of 7-(dimethylaminomethylene)amino-9a-methoxymitosane having an infra-red spectrogram as disclosed in the drawing. This new crystalline form is...
|
|
|
4590074 |
Bis-amidines
Symmetrical bis-amidine derivatives of mitomycin C may be converted to unsymmetrical bis-amidine analogs by reaction with secondary amines. The compounds are active anti-tumor agents in...
|
|
|
4567256 |
Amidine process
9a-Methoxymitosane derivatives having the amidino group at one or both of the 7-position and the carbamoyl-N positions are prepared by reaction of mitomycin A, mitomycin C, or an N 1a -substituted...
|
|
|
4487769 |
Amidines
Mitomycin A, mitomycin C, and porfiromycin react with amide acetals and other amide derivatives to produce amidine derivatives having antitumor activity against experimental animal tumors. The...
|
|
|
4395558 |
9-Epi-mitomycin B and D compounds
Mitomycin compounds of the general formula (I): ##STR1## wherein X is selected from an alkoxy group having 1 to 4 carbon atoms and amino group; and Z is selected from --OH, --OCONH 2 and --OCO 2 ...
|
|
|
4374774 |
Mitomycins
New mitomycins are produced by synthetic processes. The compounds exhibit broad spectrum antibacterial activity and are useful as antibacterial agents.
|
|
|
4264504 |
Mitomycin derivatives
New mitomycin derivatives having antibacterial activity are produced by semi-synthetic processes and also by a fermentative method. ##STR1##
|
|
|
4231936 |
Mitomycin C derivatives
The present invention provides new derivatives of mitomycin C, represented by the formula: ##STR1## wherein R represents a hydroxy group in which case the composition is designated as...
|
|
|
4021449 |
Derivatives of mitomycin C
1A-Higher aliphatic acyl derivatives of mitomycin C have been found to have superior anti-tumor activity and lipid-solubility as compared with known 1a-acyl derivatives of mitomycin C. Also, the...
|
|
|
3514452 |
NOVEL DERIVATIVES OF MITOMYCIN A,MITOMYCIN B,AND MITOMYCIN C
|
|
|
3506681 |
DERIVATIVES OF MITOMYCIN AND PREPARATION OF THE SAME
|