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7598395 |
Heterocyclocarboxamide derivatives
The invention relates to a fungicidally active compound of formula (I): where Het is a 5- or 6-membered heterocyclic ring containing one to three heteroatoms, each independently selected from...
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7585981 |
Method for producing trimer of indole derivative, and trimer of indole derivative and laminated structure thereof
The present invention provides an industrial method that allows to produce an indole derivative trimer with high purity in mass, as well as novel indole derivative trimers obtainable by the method,...
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7582770 |
Viral polymerase inhibitors
An enantiomer, diastereoisomer or tautomer of a compound, represented by formula I:
wherein A, B, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , and R 10 are as defined herein, or a...
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7504520 |
Antagonists of the vanilloid receptor subtype 1 (VR1) and use thereof
The present invention is directed to compounds of formula (I)
wherein variables W, X, Y, D, A, n, R 1 , R 2 and R 9 are as defined in the description.
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7495111 |
Compounds useful as serotonin inhibitors and 5-HT1A agonists and antagonists
3-Amino chroman and 2-amino tetralin derivatives and compositions containing such compounds are disclosed. Such compounds are useful for modulating activity of a 5-HT 1A receptor (agonizing or...
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7491831 |
PPAR active compounds
Compounds are described that are active on PPARs, including pan-active compounds. Also described are methods for developing or identifying compounds having a desired selectivity profile.
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7482472 |
Substituted isoindoles and their use
The invention relates to coagulation of the blood. Disclosed are novel compounds of formula (I),
a method for the production of these compounds, pharmaceutical compositions containing them, and...
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7482471 |
Process for preparation of 1-[9H-carbazol-4-yloxy]-3-[{2-(2-(-methoxy)phenoxy)-ethyl}-amino]-propan-2-ol
The present invention provides a process for preparation of 1-[9H-carbazol-4-yloxy]-3-[{2-(2-(methoxy)phenoxy)-ethyl}-am
ino]-propan-2-ol,a compound of formula 1 in racemic form or in the form of...
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7468442 |
Process for the preparation of carvedilol form-II
The present invention provides a cost-effective, industrially feasible process for the manufacture of crystalline Carvedilol Form-II using novel Carvedilol salts comprising a step of reacting...
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7465811 |
Indoline compounds
Sulfonylindoline compounds of formula I,
wherein R1 through R4, Y and Z have defined meanings, a process for preparation of such compounds, and the use as pharmaceutically active substances,...
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7452641 |
Electrophotographic organophotoreceptors with novel charge transport compounds
Charge transport compounds are described that have a multiple number of hydrazone-bridged (N,N-disubstituted)arylamine groups connected by a central bridging group. Examples of charge transport...
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7452615 |
Carbazole derivative and organic light emitting device using same
Disclosed is a compound of Formula 1 and an organic light emitting device using the same.
In Formula 1, R1 to R3 and X1 to X3 are as described in the specification. The compound of Formula 1...
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7423056 |
Tricyclic heteroaryl piperazines, pyrrolidines and azetidines as serotonin receptor modulators
The present invention generally relates to a series of compounds, to pharmaceutical compositions containing the compounds, and to use of the compounds and compositions as therapeutic agents. More...
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7332520 |
Fused indoles as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes
The present invention is directed to fused indole derivatives which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DP-IV inhibitors”) and which are useful in the treatment or prevention...
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7323571 |
Heterodimeric dye composition
This invention provides for labeling reagents, labeled targets and processes for preparing labeling reagents. The labeling reagents can take the form of cyanine dyes, xanthene dyes, porphyrin dyes,...
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7312342 |
Process for the preparation of (3-cyano-1h-indol-7-yl) (4-(4-fluorophenethyl) piperazin-1-yl)-methanone and salts thereof
The present invention relates to a process for the preparation of (3-cyano-1H-indol-7-yl)[4-(4-fluorophenethyl)piperazin-1-yl]
-methanone and salts thereof, characterised in that an indole ester of...
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7291732 |
Isomeric fused pyrrolocarbazoles and isoindolones
The present invention is directed to novel fused pyrrolocarbazoles and isoindolones, including pharmaceutical compositions, diagnostic kits, assay standards or reagents containing the same, and...
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7282511 |
Isatine derivatives with neurotrophic activity
The present invention relates to novel isatin derivatives, pharmaceutical compositions comprising the isatin derivatives of the invention, methods of preparing the isatin derivatives of the...
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7262215 |
N-carbacycle monosubstituted indolocarbazoles as protein kinase inhibitors
This invention relates to N-carbacycle monosubstituted indolocarbazole compounds. Furthermore, this invention relates to medicaments comprising N-carbacycle monosubstituted indolocarbazoles...
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7247651 |
2,7-substituted indoles
The present invention provides a compound of the formula:
a pharmaceutically acceptable salt or a prodrug thereof, where R 1 , R 2 , R 3 , R 4 , and n are those defined herein. The present...
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7241897 |
Process for preparing cyanine dye labeling reagents
This invention provides for labeling reagents, labeled targets and processes for preparing labeling reagents. The labeling reagents can take the form of cyanine dyes, xanthene dyes, porphyrin dyes,...
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7214703 |
Pyrrolidinohydrochinazolines
Disclosed are compounds of formula (I):
or stereoisomers or pharmaceutically acceptable salts thereof, wherein the groups Ar 1 , Ar 2 , A, R 1 , R 2 , R 3 , E 1 , E 2 , X and n are as defined...
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7173047 |
Benzo (f) insoindol derivatives and their use as ep4 receptor ligands
Compounds of formula (I)
and pharmaceutically acceptable derivatives thereof bind with high affinity to the EP4 receptor and are of use in the treatment or prevention of conditions such as a...
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7157421 |
Piracetam and piracetam analog conjugate and a pharmaceutical composition for treatment of neuronal disorders
A compound of the formula
where R 1 is H, C 1 –C 4 alkyl and OH; R 2 in is H, C 1 –C 4 alkyl and OH; R 3 is H and C 1 –C 4 alkyl; R 4 is H and C 1 –C 4 alkyl; n is an integer...
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7122679 |
Multicyclic compounds and the use thereof
The present invention is directed to novel multicyclic molecules that mediate enzymatic activity. In particular, the compounds may be effective in the treatment of diseases or disease states...
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7118840 |
Organophotoreceptor with a charge transport material having at least three linked hydrazone groups
Improved organophotoreceptor comprises an electrically conductive substrate and a photoconductive element on the electrically conductive substrate, the photoconductive element comprising:
...
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7115751 |
Method for producing trimer of indole derivative, and trimer of indole derivative and laminated structure thereof
The present invention provides an industrial method that allows to produce an indole derivative trimer with high purity in mass, as well as novel indole derivative trimers obtainable by the method,...
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7115750 |
Melanin concentrating hormone antagonist
A melanin-concentrating hormone antagonist which comprises a compound of the formula:
wherein Ar 1 is a cyclic group which may have substituents;
X is a spacer having a main chain of 1 to 6...
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7112391 |
Electrophotographic organophotoreceptors with novel charge transport compounds
Charge transport compounds are described that have a multiple number of hydrazone-bridged (N,N-disubstituted)arylamine groups connected by a central bridging group. Examples of charge transport...
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7109229 |
Methods and compounds for treating proliferative diseases
The compounds disclosed herein are indolocarbazoles of Formula (I), which are potent CDK4 inhibitors, and are useful in the treatment of cell proliferative disorders, including cancer. Formula (I).
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7091229 |
Tricyclic lactam and sultam derivatives and their use as histone deacetylase inhibitors
A compound of formula (I)
wherein A and B are optionally substituted cyclohexenyl or phenyl groups, X is carbonyl or sulfonyl, and Y is 5–7 atoms-linker, is useful as histone deacetylase...
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7081536 |
Isoxazoline derivatives as P N ligands
The invention relates to novel ligands of the phosphanylbenzothiophenyl-dihydroisoxazoline, phosphanyl-dihydrooxazolyl-indole and phosphanyl-dihydrooxazolyl-benzofuran type, especially compounds of...
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7045360 |
Method for analysis of reaction products
The present invention provides methods, compounds, and kits useful in the analysis of reaction products and components of reaction mixtures, and in certain embodiments for the rapid and...
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7026489 |
Ketol fatty acid derivative and plant growth regulating agents
α-Ketol unsaturated fatty acid derivatives represented by the following formula (1), α-ketol unsaturated fatty acid amide derivatives represented by the following formula (6), and plant growth...
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7026338 |
Pharmaceutical nitrones
Pharmaceutical nitrone comprise condensates of an N-hydroxylamine and a physiological aldehyde, providing improved delivery and absorption, enhanced stability and reduced toxicity. Preferred...
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6916893 |
Polymerization-active transition metal complexes having bulky ligand systems
Transition metal complexes having bulky ligand systems and the formula (I)
where
R 2 , R 4 are C 4 -C 16 -heteroaryl or C 6 -C 16 -aryl bearing C 4 -C 16 -heteroaryl or C 6 -C 16 -aryl...
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6906198 |
Antipicornaviral compounds, their preparation and use
Peptido and peptidomimetic compounds of the formula:
wherein the formula variables are as defined in the disclosure, advantageously inhibit or block the biological activity of the picornaviral...
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6861441 |
Use of EP4 receptor ligands in the treatment of neuropathic pain and colon cancer
The present invention relates to the use of an EP4 receptor ligand in the manufacture of a medicament for use in the treatment of neuropathic pain, colon cancer, migraine, and for increasing the...
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6835514 |
Hydrazone-based charge transport compounds
Improved organophotoreceptor include: (a) a charge transport compound having the formula where R 1 has a structure of: in which Ar is selected form the group consisting of; R 4 is a hydrogen...
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6770638 |
Tetrahydroindolone and purine derivatives linked to arylpiperazines
Pharmaceutical composite compositions comprising tetrahydroindolones linked to arylpiperazines and derivatives thereof are disclosed. Specifically, composite compositions useful in treating...
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6713633 |
Compounds capable of cleaving double-stranded DNA and method of utilization of the same
Novel chemical species capable of simultaneously alkylating double-stranded DNA and cleaving the same; methods for alkylating and cleaving DNA by using these species; and anticancer agents with the...
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6692538 |
Use of novel indole compounds for dyeing and making up keratin materials, compositions comprising them and dyeing processes
The invention relates to the use of novel indole compounds as direct dyes in compositions intended for dyeing keratin materials, and, for example, compositions intended for dyeing human keratin...
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6686385 |
Anhydro sugar derivatives of indolocarbazoles
The present invention concerns novel sugar derivatives of indolocarbazoles and pharmaceutical formulations thereof which exhibit topoisomerase-I activity and are useful in inhibiting the...
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6686358 |
Bicyclic amino-pyrazinone compounds
A compound of formula (I): wherein: R 1 represents hydrogen, or linear or branched (C 1 -C 6 )alkyl optionally substituted by one or more identical or different groups selected from aryl,...
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6602649 |
Photoresist monomers, polymers thereof and photoresist compositions containing the same
Photoresist monomers which can be used to form photoresist polymers and photoresist compositions using the same which are suitable for photolithography processes employing a deep ultraviolet light...
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6565829 |
5-arylsulfonyl indoles useful for treating disease
The invention provides derivatives of 5-arylsulfonyl indole and 5-arylsulfonyl indoline compounds which may be in the form of pharmaceutical acceptable salts or compositions that are useful in...
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6489354 |
3-alkyl substituted pyrrolidine modulators of chemokine receptor activity
The present invention is directed to pyrrolidine compounds of the formula I: (wherein R 1 , R 2 , R 3 , R 4c , R 4d , and R 4f are defined herein) which are useful as modulators of chemokine...
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6407260 |
Indole compound
The invention relates to novel indole compounds, to their use as direct dyes in compositions intended for dyeing keratin materials and for example compositions intended for dyeing human keratin...
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6403311 |
Methods of analyzing polymers using ordered label strategies
The invention relates to methods and products for analyzing polymers. The polymers are analyzed by reconstructing sequence information from population data sets. The data sets include information...
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6140051 |
Fluorescent dibenzazole derivatives and methods related thereto
Dibenzazole compounds having the general structure: ##STR1## wherein; R 1 , R 2 , R 3 , R 4 , R 5 , R 6 are independently H or a substituent which aids in solubility of the compound or which...
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