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7618969 |
Compounds which potentiate glutamate receptor and uses thereof in medicine
Compounds of formula (I) or a pharmaceutically acceptable salt, solvate or prodrug thereof, are disclosed:
wherein R 1 is C 1-6 alkyl, haloC 1-6 alkyl, C 2-6 alkenyl, amino, monoC 1-4...
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7608635 |
Pyrazole compounds that modulate HSP90 activity
Compounds of formula (I), pharmaceutical compositions comprising compounds of formula (I) and methods of inhibiting Hsp90 in a cell, treating or preventing a proliferation disorder in a mammal and...
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7598285 |
Pyrazole derivatives, compositions containing such compounds and methods of use
Pyrazoles having a naphthyl group attached are disclosed. The compounds are useful for treating type 2 diabetes and related conditions. Pharmaceutical compositions and methods of treatment are also...
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7572922 |
Substituted pyrazoles, compositions containing such compounds and methods of use
The present invention relates to substituted pyrazoles, compositions containing such compounds and methods of treatment The compounds are glucagon receptor antagonists and thus are useful for...
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7566709 |
1,3,4-Substituted pyrazoles as 5-HT receptor antagonists for the treatment of psychoses and neurological disorders
Compounds of the formula (I) and salts and solvates thereof, in which X, R 1 , R 2 , R 5 and Q have the meanings indicated in Claim 1 , are suitable as ligands of 5 HT receptors; as well as...
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7538134 |
Substituted arylpyrazoles
This invention relates to a range of 1-aryl-4-cyclopropylpyrazoles in which the cyclopropyl ring is substituted at the angular position, and pharmaceutically acceptable salts and solvates thereof,...
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7531669 |
Methods for treating neural disorders and conditions, and compounds useful therefor
In accordance with the present invention, there are provided novel compounds that protect neurons and/or promote neuroregeneration and/or promote memory formation. Such compounds are useful for...
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7465808 |
CCK-1 receptor modulators
There are provided by the present invention certain pyrazole based CCK-1 receptor modulators.
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7452899 |
Gamma-secretase inhibitors
Compounds of Formula (I): inhibit the processing of APP by gamma-secretase, and hence are useful for treatment or prevention of Alzheimer's disease.
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7361679 |
2-phenyl-3-heteroarylpropionic acid derivative or salt thereof and medicine containing the same
The present invention relates to a 2-phenyl-3-heteroarylpropionic acid derivative or a salt thereof, and also relates to a pharmaceutical agent and a VLA-4 and/or LPAM-1 antagonist each of which...
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7247734 |
3,4-diarylpyrazoles and their use in the therapy of cancer
The present invention pertains to the use of certain 3,4-diarylpyazoles of formula (I), both in vitro and in vivo, to inhibit heat shock protein 90 (HSP90), and in the treatment of conditions...
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7244753 |
Cyclooxygenase-2 selective inhibitors, compositions and methods of use
The invention describes novel cyclooxygenase 2 (COX-2) selective inhibitors and novel compositions comprising at least one cyclooxygenase 2 (COX-2) selective inhibitor, and, optionally, at least...
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RE39708 |
Estrogen receptor modulators
Estrogen receptor-modulating pyrazole compounds are described in addition to methods and compositions for treating or preventing estrogen receptor-mediated disorders. The compounds described have...
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7202232 |
Acrylonitrile derivatives for inflammation and immune-related uses
What is claimed is a compound represented by the following structural formula:
or a pharmaceutically acceptable salt, solvate or clathrate thereof. The variables for Structural Formula (I) are...
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7183306 |
Pyrazole derivatives
A compound of the formula (I):
wherein R 1 is hydrogen or lower alkyl;
R 2 is lower alkyl, etc.; R 3 is lower alkoxy, etc.; R 4 is hydroxy, etc.; X is O, S, etc.; Y is CH or N; Z is...
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7144910 |
Sulfonamides, sulfamates and sulfamides as gamma-secretase inhibitors
Compounds of formula I:
inhibit the processing of APP by gamma-secretase, and hence are useful in treating or preventing Alzheimer's disease.
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7141678 |
Synthesis of diaryl pyrazoles
A process for the qualitative preparation of 3-haloalkyl-1H-pyrazoles suitable for efficient, high payload commercial application.
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7132544 |
Process for the preparation of tetrasubstituted imidazole derivatives and novel crystalline structures thereof
The present invention relates to a process for preparing tetrasubstituted imidazole derivatives of the general formula (I)
wherein R 1 , R 2 , R 3 and R 4 are as defined in the...
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7112601 |
Cycloalkyl heterocycles for treating hepatitis C virus
Compounds of Formula I are disclosed which inhibit hepatitis C NS5B RNA-dependent RNA polymerase and are useful for treating hepatitis C. Compositions and methods of using these compounds are also...
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7094906 |
Processes for preparing pesticidal intermediates
The present invention relates to processes for the preparation of a compound of the formula
wherein W is nitrogen or —CR 3 ; R 1 is halogen, haloalkyl, haloalkoxy, R 4 S(O) n — or —SF 5...
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6960609 |
1-diphenylmethyl-pyrazole derivatives as opioid receptor ligands
This invention relates to 1-diphenylmethyl-pyrazole derivatives of formula (I):
and pharmaceutically acceptable salts thereof; wherein R 1 , R 2 , R 3 , R 4 and R 5 are defined herein, as...
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6951949 |
Substituted pyrazolyl benzenesulfonamides for the treatment of inflammation
A class of pyrazolyl benzenesulfonamide compounds is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula II:
...
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6919462 |
Process for preparing pesticidal intermediates
A process for preparing pesticides or pesticidal intermediates, particularly 5-amino-1 aryl-3-cyanopyrazoles, having the formula
said process comprising reacting a compound having the formula...
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6916839 |
Pyrazolylarylalkines
The present invention relates to pyrazolylarylalkines and to their use, to a process for preparing pyrazolylarylalkines and also to intermediates.
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6906196 |
Processes for the preparation of 1,5-diaryl-3-substituted-pyrazoles
Provided are processes and chemical intermediates useful for preparing a compound of the formula I
wherein X is selected from the group consisting of C 1 -C 6 trihalomethyl; C 1 -C 6 ...
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6846838 |
Ureido-substituted aniline compounds useful as serine protease inhibitors
Compounds having the formula (I),
or pharmaceutically-acceptable salts, hydrates or prodrugs thereof, are effective as inhibitors of Factor VIIa.
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6825184 |
1,4-Disubstituted benzo-fused urea compounds
Disclosed are compounds of the formulas (I) & (II) shown below which are active as anti-inflammatory agents. Also disclosed are methods of using and making such compounds. wherein G, X, A and Q...
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6797723 |
Heterocycle substituted diphenyl leukotriene antagonists
The invention relates to novel heterocycle substituted diphenyl leukotriene B 4 (LTB 4 ) antagonists, to compositions containing such compounds, and to methods of using such compounds for...
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6716991 |
Process for preparing a substituted pyrazolyl benzenesulfonamide for the treatment of inflammation
A class of pyrazolyl benzenesulfonamide compounds is descrbed for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula II: ...
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6706927 |
Alkyne ketones
Provided are processes for the preparation of the compound of the formula wherein R 1 , R 3 and R 4 are independently selected from the group consisting of hydrogen, halogen, hydroxyl, nitro,...
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6673923 |
Pyrazole antimicrobial agents
The present invention provides pyrazole and pyrazolone derivatives. Preferred compounds of the invention are useful as RNA polymerase inhibitors. Further preferred compounds of the invention are...
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6617342 |
Hypoglycemic sulfonyl pyrazolones and pyrazolines
This invention provides compounds and their pharmaceutically acceptable salts, pharmaceutical formulation of said compounds and methods for treating hyperglycemia associated with non-insulin...
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6583090 |
Hetaryl-substituted benzyl phenyl ethers, method for the production thereof, and their use for combating harmful fungi and animal pests
The invention relates to hetaryl-substituted benzyl phenyl ethers of formula (I) in which the substituents have the following meanings: (Q): C(═CHOCH 3 )—COOCH 3 , C(═CHCH 3 )—COOCH 3 ,...
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6579988 |
Processes for the preparation of 1,5-diarylpyrazoles
Provided are processes for the preparation of the compound of the formula wherein R 1 , R 3 and R 4 are independently selected from the group consisting of hydrogen, halogen, hydroxyl, nitro,...
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6545031 |
Endothelin receptor antagonists
Novel pyrroles, pyrazoles and triazoles, pharmaceutical compositions containing these compounds and their use as endothelin receptor antagonists as described.
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6518266 |
1- Aryl-3-thioalkyl pyrazoles, the synthesis thereof and the use thereof as insecticides
The present invention is directed to novel pyrazole derivatives and their use as pesticidal agents. The pyrazole derivatives have Formula I: or a salt thereof, where R 1 represents R 5 O, R 5...
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6506779 |
Acetylene derivatives as anti-inflammatory/analgesic agents
The present invention relates to compounds of the formula wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , X and Y are defined as in the specification, to pharmaceutical compositions containing them...
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6482774 |
Substituted (4-brompyrazole-3-yl) benzazoles
Substituted (4-bromopyrazol-3-yl)benzazoles I and their salts where R 1 =H, C 1 -C 4 -alkyl, C 1 -C 4 -haloalkyl; R 2 =CN, C l -C 4 -alkyl, C 1 -C 4 -haloalkyl, C 1 -C 4 -alkoxy, C 1 -C 4...
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6462164 |
2-phenylimidazole-phosphoric acid salt as an accelerator for acid anhydride curatives in one-component epoxy compositions
A heat curable, a one-component epoxy protective or decorative coating or adhesive composition comprising an epoxy resin, acid anhydride latent heat activated curing agent and an accelerator for...
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6451835 |
Pesticidal fluoroethyl pyrazole derivatives
Disclosed herein are fluoroethyl pyrazole compounds of the formula: wherein X and Y are independently selected from the group consisting of hydrogen, halogen, alkyl, haloalkyl, nitro, alkylthio,...
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6414011 |
Aryl substituted pyrazoles, and pyrroles, and the use thereof
This invention relates to compounds having the Formula I: or a pharmaceutically acceptable salt, prodrug or solvate thereof, wherein Het and R 5 -R 13 are set in the specification. The...
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6409988 |
Radiolabeled 1-aryl pyrazoles, the synthesis thereof and the use thereof as pest GABA receptor ligands
The present invention is directed to radiolabeled compounds of Formula I: or salts thereof, where R 1 represents R 8 , R 8 O, R 8 SO 2 , R 8 SO or R 8 S in which R 8 is tritiated or deuterated...
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6407238 |
Process of making substituted pyrazoles
Disclosed is a process of making substituted pyrazoles from substituted benzophenone hydrazones with a variety of 1,3-bifunctional substrates under acid conditions. The pyrazole compounds are...
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6403629 |
Heterocyclic compounds for therapeutic use
A class of compounds particularly diaryl pyrazole of general formulas 1 and 2 where R and R′ represents alkyl, hydrogen, halogens, haloalkyl, cyano, nitro, formyl, carboxyl, alkoxycarbonyl,...
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6391906 |
Crystals of celecoxib
A new crystalline form of 4-[5-(4-Methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]be
nzenesulfonamide of Formula I designated as Form I and a method for its production.
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6380393 |
Ligands, transition metal complexes and methods of using same
Compositions including at least one organic ligand including a first hetero atom and a second hetero atom directly bonded to the first hetero atom or located one carbon atom away from the first...
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6358631 |
Mixed vapor deposited films for electroluminescent devices
A light emitting device (LED) structure and devices containing the same in which the LED structure contains a plurality of at least a first and a second light emitting organic device (LED) stacked...
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6359143 |
Heterocycle-bearing thio phenol compounds, intermediates for the preparation of the same and processes for the preparation of both
Novel thio phenol compounds bearing heterocyclic groups as the substituent, useful as intermediates for the preparation of agricultural chemicals, particularly herbicides; intermediates for the...
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6342510 |
Treatment of inflammation and inflammation-related disorders with a combination of a cyclooxygenase-2 inhibitors and a leukotriene B4 receptor antagonist
Combinations of a cyclooxygenase-2 inhibitor and a leukotriene B 4 receptor antagonist are described for treatment of inflammation and inflammation-related disorders.
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6316485 |
1,5-diphenylpyrazole derivatives
A compound of the formula (I): ##STR1## wherein: R 1 is chlorine, difluoromethyl, trifluoromethyl or cyano; and R 2 is a group having the formula: ##STR2## wherein: X is halogen,...
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