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5907041 |
Process for preparing pyrazole derivatives
The invention relates to a process for preparing compounds having the formula: ##STR1## wherein R 3 , R 4 , R 6 and Ar are as defined in the description, by reaction of a compound of formula (I)...
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5889058 |
Peptidyl derivatives
Methods of use for compounds of formula (I) are described wherein R represent a --CONHOH, carboxyl (--CO 2 H) or esterified carboxyl group; R 1 represents a hydrogen atom or an optionally...
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5886046 |
Dicarbonyl-containing compounds
This invention relates to chemical compounds that contain adjacent carbonyl groups, which effectively inhibit the biological, chemical, and/or physical properties of enzymes and other...
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5886175 |
7-(substituted)-8-(substituted)-9-(substitued amino)-6-demethyl-6-deoxytetracyclines
The invention provides compounds of the formulas ##STR1## which are useful as intermediates for the preparation of 6-demethyl-6-deotetracycline antibiotic agents.
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5882393 |
Dispersing agent
The invention relates to a dispersing agent or salts thereof, comprising the reaction product of: A one or more polyisocyanates with an average functionality of about 2 to about 5, with B a...
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5877196 |
N- 4-(imidazolyl or pyrazolyl)phenyl(oxy, sulfinyl, sulfenyl or sulfonyl)alkyl!carboxamides, sulfonamides or phosphoramides having antiarrhythmic properties
The present invention relates to substituted ω- phenoxy, phenylthio, phenylsulfinyl, phenylsulfonyl! alkyl, alkenyl or alkynyl!amine carboxamides, sulfonamides and phosphonylamides which are...
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5874588 |
Process for the preparation of diketopyrrolopyrrolecarboxylic acids and their esters and amides
Diketopyrrolopyrroles of formula I ##STR1## are prepared by reacting a diketopyrrolopyrrole of formula II ##STR2## with a) formic acid or b) a compound of formula III X'--H ...
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5856560 |
Preparation of a-methoxyiminocarboxylic acid methylamides and intermediates therefore
A process and intermediates for preparing α-methoxyiminocarboxylic acid methylamides (I) by Pinner reaction of a cyanoketone (II) with an alcohol and subsequent reaction of the resulting ester...
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5847154 |
Method of preparing 1,2-dimethyl-3,5-diarylpyrazolium methylsulfates
A process for the preparation of 1,2-dimethyl-3,5-diaryl-pyrazolium methylsulfates of the formula I ##STR1## where R 1 and R 2 independently of one another are hydrogen, C 1 -C 4 -alkyl, C 3 ...
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5827863 |
Pyrazole derivatives as angiotensin II antagonists
Compounds of general formula I and their salts and solvates are angiotensin II receptor antagonists and as such are useful in the treatment of hypertension, congestive heart failure and elevated...
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5817829 |
Pyrazolecarboxylic acid derivatives and plant disease control agent
The present invention provides a plant disease control agent containing as active ingredient one or more compounds of the formula 1! A--COOR 1 1!...
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5767151 |
3,3-(disubstituted) cyclohexan-1-ylidine acetate dimers and related compounds
The present invention relates to novel 3,3-(disubstituted)-cyclohexan-1-ylidene acetate dimers of Formula (I): ##STR1## and related compounds, pharmaceutical compositions containing these...
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5723473 |
Propenoic acid derivatives useful as fungicides
A fungicidal compound of formula (I): ##STR1## wherein A is hydrogen, halogen, hydroxy, C 1 -4 alkyl, C 1 -4 alkoxy, C 1 -4 haloalkyl, C 1 -4 haloalkoxy, C 1 -4 alkylcarbonyl, C 1 -4...
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5719169 |
Substituted benzoylguanidines, their use as a medicament or diagnostic, and medicament containing them
The invention relates to benzoylguanidines of the formula I: ##STR1## to pharmaceutically acceptable salts of these compounds and to a process for preparing compounds of the formula I, which...
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5703092 |
Hydroxamic acid compounds as metalloprotease and TNF inhibitors
The present invention provides novel hydroxamic acids and carbocyclic acids and derivatives thereof and to pharmaceutical compositions and methods of use of these novel compounds for the inhibition...
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5684022 |
Ether compounds, their use, and intermediates for use in their production
There are disclosed novel ether compounds of the general formula: ##STR1## wherein R 1 is halogen; A is a group of the general formula Q-1: --CH(R 2 )--(CH 2 ) m --CH (R 3 )--N(R 4...
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5675017 |
Herbicidal substituted 3-aryl-pyrazoles
The invention herein relates to certain substituted-arylpyrazole compounds, herbicidal compositions containing same, herbicidal methods of use and processes for preparing said compounds.
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5670533 |
Pyrazole derivatives, processes for preparation thereof and pharmaceutical composition comprising the same
The present invention relates to new pyrazole derivatives represented by the following general formula (I) ##STR1## wherein R 1 is aryl which is substituted with substituent(s) selected from the...
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5639777 |
1,4,5-triphenyl pyrazolyl compounds for the treatment of inflammation and inflammation-related disorders
A class of 1,4,5-triphenyl pyrazoles is described for the treatment of inflammation, including treatment of pain and disorders such as arthritis. Compounds of particular interest are of Formula II...
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5629335 |
Pesticidal 1-arylpyrazole-3-carboximidothioic acid esters
1-(Substituted phenyl)-3-(thioimidate)pyrazoles having systemic activity, arthropodicidal (especially insecticidal) and nematocidal compositions comprising same and methods for controlling...
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5606074 |
Process for the preparation of pyrazoles
The invention relates to a process for the preparation of pyrazoles of the formula (I) ##STR1## in which R represents hydrogen, alkyl, unsubstituted or substituted cycloalkyl, unsubstituted or...
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5578595 |
Cyclopropylacetic acid derivatives
Novel 2-(2,2-difluorocyclopropyl)-acetic acid derivatives of formula I ##STR1## wherein A is oxygen or --NR 1 --, B is C 2 -C 6 alkylene, D is oxygen, sulfur or --O--CH 2 --, E is...
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5554633 |
Substituted amines as tachykinin receptor antagonists
Compounds of formula (I), and salts and prodrugs thereof, wherein Q is optionally substituted phenyl or benzhydryl; X and Y are each H or together form a group=O; Z is O, S or NR 9 , where R 9 is...
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5547984 |
N-Acetonyl-substituted-amides
Certain N-acetonyl-substituted-amides of the formula: ##STR1## wherein A is a heterocycle, a phenylalkyl, a phenylalkoxy, naphthyl, cycloalkyl, alkoxyalkyl, alkyl, haloalkyl or alkenyl group; X, Y...
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5545608 |
Pyrazole-glycolic acid amide derivatives as herbicides
Pyrazole-glycolic acid amides of the following formula (1) (in which R 1 to R 5 each represent a hydrogen atom or a substituent having a broad definition), and herbicides containing them. The...
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5543433 |
Azine-substituted phenylacetic acid derivatives and fungicides containing these
Compounds of the formula I ##STR1## where X is hydrogen, halogen, alkyl, alkoxy, trifluoromethyl, cyano or nitro, Y is an amino, methylamino or dimethylamino group, Z is a group CHCH 3 ,...
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5541213 |
Propenoic acid derivatives diazole propenoic acid compounds which have useful pharmaceutical utility
A novel propenoic acid derivative which exhibits adenosine A1 antagonism is defined by the general formula (I): ##STR1## (wherein A represents an aromatic ring; R 1 represents aryl or the like; R...
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5516789 |
Lipoxygenase and cyclooxygenase inhibiting compounds
Compounds having the structure ##STR1## or a pharmaceutically acceptable salt thereof have activity as inhibitors of cylooxygenase and 5-lipoxygenase, reduce the biosynthesis of leukotrienes B 4 ,...
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5510432 |
Mixed blocked isocyanate prepolymers, a process for their production and their use for the production of flexible epoxy resin systems
Isocyanate prepolymers based on an aromatic diisocyanate and a polyether polyol in which at least 95% of the isocyanate groups are blocked by blocking agents selected from A) about 50 to about...
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5510496 |
Substituted pyrazolyl benzenesulfonamides
A class of pyrazolyl benzenesulfonamide compounds is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula I:...
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5506254 |
Pyrazoyly derivatives and their use
Pyrazolyl derivatives of the general formula I ##STR1## where the indices and the substituents have the following meanings: n is is 0, 1, 2, 3 or 4, it being possible for the radicals R 1 to be...
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5498724 |
Pyrazoleamidine compounds
A process for the production of guanidino protected ω-aminoalkyl guanidines comprising reacting a diamine selectively at one amino group with an alkoxycarbonyl or aralkoxycarbonyl protected...
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5495032 |
Process for producing 7-(substituted)-8-(substituted-9-[(substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
The invention provides a process for the production of compounds of the formula: ##STR1## wherein, R, R 3 , R 4 , X and W are defined in the specification in which a compound of the following...
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5495018 |
7-(substituted-9-(substituted amino)-6-demethyl-6-deoxytetracyclines
The invention provides compounds of the formulas ##STR1## which are useful as intermediates for the preparation of 6-demethyl-6-deotetracycline antibiotic agents.
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5495031 |
Process for the production of 7-(substituted)-9-[(substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
The invention provides a process for the production of compounds of the formula: ##STR1## wherein R, R 3 , R 4 and W are defined in the specification in which a compound of the following formula:...
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5473066 |
Process for preparing benzothiazepine derivatives
Process for stereoselectivity preparing a cis-form of 5-(aminoalkylamino)-1,5-benzothiazepine derivative represented by formula (VI): ##STR1## is provided, said process comprising carrying out a...
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5441975 |
Pyrazolo-substituted alkyl amide acat inhibitors
Pharmaceutically useful compounds having ACAT inhibitory activity of the formula ##STR1## wherein n is 0, 1, or 2, for X other than tetrazole and n=2 then R 2 =R 3 =H; R 1 is phenyl, substituted...
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5430162 |
7-(substituted)-8-(substituted)-9-substituted amino)-6-demethyl-6-deoxytetracyclines
The invention provides compounds of formula ##STR1## wherein X, R and R 1 are defined in the specification. These compounds are useful as antibiotic agents.
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5416219 |
Preparation of monoclinic metazachlor
Monoclinic 2-chloro-(2',6'-dimethyl-N-pyrazol-1-ylmethyl)-acetanilide of the formula ##STR1## which melts at 76° C. Processes for its preparation and herbicides.
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5416235 |
Preparation of substituted aryl compounds
A process for the preparation of aromatic compounds of the general formula I, Ar--X I in which Ar represents an optionally substituted aryl...
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5414122 |
Process for producing alpha-ketoamide derivative
There is disclosed an efficient process for producing α-ketoacetamide of the formula: ##STR1## which is useful as an intermediate for the production of various alkoxyiminoacetamide compounds to be...
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5410066 |
Process for the preparation of substituted pyrazolines
A new process for the preparation of pyrazolines of formula ##STR1## is provided, in which R 1 and R 3 are identical or different and each represent optionally substituted aryl or optionally...
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5391772 |
Converting an alcohol to an azide with S.sub.N 2 inversion using a phosphoryl azide
Described is a process for converting an alcohol to an azide with S N 2 inversion using a phosphoryl azide, e.g. diphenylphosphoryl azide (DPPA). Good yields of azide in high enantiomeric excess...
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5389616 |
Amino acid derivatives
The compounds of the formula ##STR1## wherein A, R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are as set forth above, are described. The compounds of formula I have an inhibitory activity on the natural...
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5387602 |
1.5-diphenyl-3-(N-hydroxycarbamoyloxyalkyl)pyrazoles
1,5-Diphenyl-3-(N-hydroxycarbamoyloxyalkyl)pyrazoles of the general formula: ##STR1## are disclosed to have anti-inflammatory activity in mammals.
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5380869 |
Regioselective synthesis of 1,5-diaryl pyrazole anti-inflammatory agents
The invention provides a process for preparing 1,5-diaryl pyrazole anti-inflammatory agents. A 6-aryl-4,6-dioxohexanoic acid is treated with acetic anhydride or acetyl chloride to produce an enol...
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5378716 |
Pyrazol-1-yl phenoxyacetic acid compounds which have useful pharmaceutical utility
We proposed a novel compound having an activity of PGI 2 receptor agonist. A phenoxyacetic acid derivative of the formula ##STR1## A is --C(R 1 )N.about.OR 2 , --CH(R)NH--OR 2 , --COE, --SO 2 ...
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5354904 |
Sulfonamides derived from 1-hydroxy-6-aminonaphthalene-3-sulfonic acid (J acid)
The sulfonamides have the formula ##STR1## where R 1 is C 1 -C 13 -lkyl, substituted or unsubstituted phenyl, C 1 -C 8 -alkanoyl or substituted or unsubstituted benzoyl, and R 2 and R 3 ...
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5321002 |
Herbicidal derivatives of 2-(1-aryl-4-cyano-5-pyrazolylmethyleneiminooxy)alkanoic acids
Herbicidal compounds, compositions containing them, and a method for controlling weeds by application of the compositions are disclosed. The herbicidal compounds are...
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5298521 |
1,5-diphenyl-3-pyrazolylalkyl-N-hydroxydithiocaramates, compositions and use
1,5-Diphenyl-3-pyrazolylalkyl-N-hydroxydithiocarbamates of the general formula: ##STR1## are disclosed to have anti-inflammatory activity in mammals.
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