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6638321 |
Cationic oxidation bases, their use for oxidation dyeing of keratin fibres, dyeing compositions and dyeing methods
The invention relates to novel monobenzene oxidation bases containing at least one cationic group Z, Z being chosen from aliphatic chains containing at least one quaternized unsaturated ring, to...
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6632830 |
ACE-2 inhibiting compounds and methods of use thereof
ACE-2 inhibiting compounds are disclosed. These compounds include compounds of formula (IV): wherein the variables are as described in the specification. Pharmaceutical compositions containing...
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6624309 |
Benzoic acid derivatives and related compounds as antiarrhythmic agents
Benzoic acid derivatives of the formula where X is oxygen, sulfur, —NH, —NR 1 , —N—CN, —N—OR 1 or —N—NO 2 ; Y is a single bond, —C═C—, or —NH; R 1 is alkyl, alkenyl,...
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6613914 |
Process for preparing 1, 5-diaryl-3-substituted pyrazoles
A process for making a compound of formula I wherein the substituents are as described in the specification comprising reacting a ketone of formula II with succinic anhydride and an alkoxide base...
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6583182 |
Compounds with chelation affinity and selectivity for first transition series elements: use in medical therapy and diagnosis
This invention involves synthesis and use of a class of compounds with chelation affinity and selectivity for first transition series elements. Administration of the free or conjugated compound, or...
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6559102 |
Substituted 3-aryl-pyrazoles
The invention relates to novel substituted 3-aryl-pyrazoles of the general formula (I) in which n, Q, R 1 , R 2 , R 3 , R 4 , R 5 and X are each as defined in the description, and also to...
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6541632 |
Process for producing heterocyclic nitriles
A carbocyclic or heterocyclic compound, ammonia and an oxygen-containing gas are subjected to fluid catalytic reaction in vapor phase in the presence of a catalyst containing alkali metal to...
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6518295 |
Utilization of aryl(or heteroaryl)azolylcarbinol derivatives in the preparation of a medicament for the treatment of troubles mediated by an excess of substance P
The present invention relates to the use of derivatives of aryl (or heteroaryl) azolylcarbinols of general formula (1) of the specification, as well as their physiologically acceptable salts, in...
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6515124 |
Dehydroamino acids
Aromatic dehydroamino acids are disclosed that are active as LFA-1 arnagonists This activity enables these compounds to prevent inflammation which is a consequence of T cell activation and...
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6495699 |
Metalloproteinase inhibitors, pharmaceutical compositions containing them, and their use
The present invention is directed to compound of the formula I: wherein R 1 , R 2 , R 3 , R 4 , R 5 , X, Y, and are as defined herein. These compounds are useful for inhibiting the activity of...
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6492421 |
Substituted phenylalanine type compounds which inhibit leukocyte adhesion mediated by VLA-4
Disclosed are compounds which bind VLA-4. Certain of these compounds aslo inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the...
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6479550 |
α-sulfenimino acid derivatives
α-Sulfenimino acid derivatives of formula I including the optical isomers thereof and mixtures of such isomers, wherein A is cycloalkyl, cycloalkenyl, aryl or heteroaryl, each optionally...
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6476202 |
5-acylamino-2-arylazo, nitro, or nitroso-4-substituted-phenol compounds and method of using them
Disclosed is a 5-acylamino-2-arylazo, nitro, or nitroso-4-substituted-phenol having the structural formula I: wherein: R* is an arylazo, nitro, or nitroso group, Y is a coupling-off group, and...
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6469041 |
Certain pyrazole derivatives as corticotropin-releasing factor CRF1 ligands
Disclosed are compounds that are highly selective partial agonists or antagonists at human CRF 1 receptors that are useful in the diagnosis and treatment of treating stress related disorders such...
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6448293 |
Diphenyl ether compounds useful in therapy
A compound of general formula (I), or pharmaceutically acceptable salts, solvates or polymorphs thereof; wherein; R 1 and R 2 , which may be the same or different, are hydrogen, C 1 -C 6 alkyl,...
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6432999 |
Pyrazole substituted hydroxamic acid derivatives as cyclooxygenase-2 and 5-lipoxygenase inhibitors
This invention is in the field of antiinflammatory pharmaceutical agents and specifically relates to compounds, compositions and methods for treating disorders mediated by cyclooxygenase-2 or...
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6420605 |
Benzamidoxim derivatives, intermediate products and methods for preparing and using them as fungicides
The invention relates to benzamidoxim derivatives of formula (I) wherein the substituents have the following meanings: R 1 represents difluoromethyl or trifluoromethyl, R 2 represents hydrogen or...
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6414005 |
Heterocyclic compounds having nos inhibitory activities
Compounds represented by the general formula (1): [wherein R 1 is typically an aminoalkyl group; R 2 is typically a hydrogen atom, a lower alkyl group, R 3 or SR 4 (where R 4 is typically a...
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6410582 |
Thienylazolylalcoxyethanamines, their preparation and their application as medicaments
The thienylazolylalkoxyethanamines (I) where R1 is a hydrogen atom, a halogen atom or a lower alkyl radical; R2, R3 and R4 represent, independently, a hydrogen atom or a lower alkyl radical; and Az...
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6410745 |
Process for preparing 1-guanylpyrazole acid adducts
1-Guanylpyrazole acid adducts of the formula: wherein R 1 , R 2 and R 3 independently of one another are hydrogen, a branched or straight-chain C 1-6 -alkyl group, a C 3-8 -cycloalkyl group or...
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6380393 |
Ligands, transition metal complexes and methods of using same
Compositions including at least one organic ligand including a first hetero atom and a second hetero atom directly bonded to the first hetero atom or located one carbon atom away from the first...
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6376502 |
Osteoporosis compounds
This invention relates to prostaglandin agonists, methods of using such prostaglandin agonists, pharmaceutical compositions containing such prostaglandin agonists and kits containing such...
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6372774 |
Derivatives of N-phenylpyrazoles
N-Phenylpyrazole derivatives of the formula: wherein R 1 represents optionally halogenated alkyl; R 2 represents halogen, cyano, nitro, cycloalkyl, alkenyl, thiocyanato, optionally alkyl...
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6339046 |
Pyrazde herbicides
Compounds of the formula I in which R 1 is C 1 -C 4 alkyl; R 2 is cyano or NH 2 C(S)—; R 3 is hydrogen, C 1 -C 4 alkyl, C 1 -C 4 haloalkyl, C 3 - or C 4 alkenyl, C 3 - or C 4 alkynyl, C 3...
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6319939 |
Retinoic acid mimetic anlides
The present invention is concerned with compounds of formula ##STR1## the N-oxides, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein X...
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6316485 |
1,5-diphenylpyrazole derivatives
A compound of the formula (I): ##STR1## wherein: R 1 is chlorine, difluoromethyl, trifluoromethyl or cyano; and R 2 is a group having the formula: ##STR2## wherein: X is halogen,...
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6294676 |
Process for the preparation of 6-(arylcarbonyl)-4-oximo-dihydrobenzothiopyran herbicides and intermediates useful therein
The present invention provides compounds of formula I and processes for the preparation and purification thereof. ##STR1## Compounds of formula I are useful as intermediates in the manufacture of...
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6268509 |
Parasiticidal pyrazoles
Compounds of formula (I) ##STR1## or pharmaceutically, veterinarily or agriculturally acceptable salts thereof, or pharmaceutically, veterinarily or agriculturally acceptable solvates of either...
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6258822 |
Urokinase inhibitors
Compounds having the formula ##STR1## are inhibitors of urokinase and are useful in the treatment of diseases in which urokinase plays a role. Also disclosed are urokinase-inhibiting compositions...
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6255327 |
Diphenyl-substituted heterocycles, processes for preparing them and their use as pharmaceutical compositions
The invention relates to new diphenyl-substituted 5-ring heterocycles of general formula (I) ##STR1## wherein A, X and the groups R 1 , R 2 , R 3 , R 4 and R 5 are defined as in the claims,...
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6255333 |
Parasiticidal compounds
Parasiticidal pyrazole derivatives of formula (I) wherein: R 1 represents CN, C 1 -6 alkoxycarbonyl, NO 2 , CHO, C 1 -6 alkanoyl, phenyl optionally substituted by one or more halogen, or C 1 -6...
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6251829 |
Herbicidal benzoyloxy carboxylates and carboxamides
This invention relates to herbicidal alpha-(2,4,5-trisubstituted)- and alpha-(2,5-disubstituted)-benzoyloxy-alpha-beta-, and/or beta-gamma-unsaturated-carboxylates and their derivatives, to...
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6187930 |
Resolution of amines
The procedure comprises reacting the mixture that comprises 2-[phenyl(1-methyl-1 H-pyrazole-5-yl)methoxy]-N,N-dimethylethanamine (I) with an enantiomer of an optically active acid to form a...
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6187944 |
Acrylonitrile compounds, process for their production and pesticides containing them
Acrylonitrile compounds having pesticidal activity of formula (I) and salts thereof. ##STR1## wherein Q is ##STR2## Y is C(R 4 )-- or N--, R 1 is alkyl, haloalkyl, etc., each of R 2 and R 3...
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6153752 |
Process for preparing heterocycles
Process for the preparation of heterocycles by reacting 2-substituted acetals of malondialdehyde with a reactant selected from hydroxylamines and their salts, hydrazines and their salts, formamid,...
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6150393 |
Small molecule modulators of non-endogenous, constitutively activated human serotonin receptors
Disclosed herein are non-endogenous, constitutively activated forms of the human 5-HT 2A and human 5-HT 2C receptors and uses of such receptors to screen candidate compounds. Further disclosed...
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6118009 |
Process for obtaining enantiomers of cis-olirtine
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6096747 |
Phenylaminocarbonyl derivatives and processes for their preparation
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6063928 |
5-lipoxygenase inhibitors
Novel compounds having the ability to inhibit 5-lipoxygenase enzyme and having the following formula I: ##STR1## and the pharmaceutically acceptable salts thereof, wherein Ar 1 is a heterocyclic...
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6011059 |
Acyl guanidine sodium/proton exchange inhibitors and method
Acyl guanidines are provided which are sodium/proton exchange (NHE) inhibitors which have the structure ##STR1## wherein n is 1 to 5; X is N or C--R 5 wherein R 5 is H, halo, alkenyl, alkynyl,...
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5994359 |
Imino oxyphenyl acetic acid derivatives, methods and intermediates for their preparation and use thereof
2-Iminooxyphenylacetic acid derivatives ##STR1## where the substituents and the index have the following meanings: R 1 is C(CO 2 CH 3 )NOCH 3 (Ia), C(CONHCH 3 )NOCH 3 (Ib), C(CONH 2...
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5972940 |
Arginine analogues having nitric oxide synthase inhibitor activity
A compound selected from the group consisting of a compound of the formula wherein A is selected from the group consisting of hydrogen, alkyl of 1 to 6 carbon atoms and --NO 2 , E is --O-- or a...
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5962489 |
Heteroaromatic compounds and crop protection agents containing them
Heteroaromatic compounds of the formulae IA and IB ##STR1## where the dashed line is a double bond between the carbon atom and a Z atom, and the index and the substituents have the following...
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5962492 |
2 cyclo(alkyl and alkenyl) phenyl-alkenylyl heteroaryl compounds and pharmaceutical compositions containing same
Compounds of general formula (1) ##STR1## are described wherein Y is a halogen atom or a group --OR 1 , wherein R 1 is an optionally substituted alkyl group; X is --O--, --S--, or --N(R 6 ),...
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5958948 |
Substituted pyrazoles as CRF antagonists
The compounds of the formula wherein A, R 1 , R 3 , X 1 , Y and Z are as defined herein, have corticotropin-releasing factor (CRF) antagonist activity. They are useful in the treatment of illnesses...
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5959120 |
Acetate ester compounds
The present invention provides an acetate ester compound of formula (III), ##STR1## a process for synthesizing compound (III), and a process for using that compound to prepare a pyrazolone...
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5948779 |
Substituted condensation products of n-benzyl-3-indenyl acetamides with heterocyclic aldehydes
Substituted condensation products of N-benzyl-3-indenylacetamides with heterocyclic aldehydes are useful for inducing or promoting apotosis and for arresting uncontrolled neoplastic cell...
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5932598 |
Prodrugs of benzenesulfonamide-containing COX-2 inhibitors
Prodrugs of COX-2 inhibitors are described as being useful in treating inflammation and inflammation-related disorders.
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5925769 |
Acetylenic 1,5-diarylpyrazoles as antiinflammatory agents
Compounds of Formula I ##STR1## wherein, R 1 through R 7 are described herein. These compounds inhibit the production of arachidonic acid products associated with 5-lipoxygenase and...
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5925631 |
Alkylated styrenes as prodrugs to COX-2 inhibitors
The invention encompasses the novel compound of Formula I useful in the treatment of cyclooxygenase-2 mediated diseases. ##STR1## The invention also encompasses certain pharmaceutical compositions...
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