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7632855 |
Pyrazole compounds as HSP90 inhibitors for the treatment of cancer
Compounds of formula (I) are inhibitors of HSP90 activity, and useful in the treatment of proliferative disease such as cancers: wherein R 1 , R 2 and R 3 are as defined in the specification, and...
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7625944 |
Inhibitors of plasma kallikrein
The present invention provides compounds that inhibit the activity of plasma kallikrein (PK) and methods of preventing and treating the formation of thrombin during or after a PK dependent disease...
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7622595 |
Substituted 1H-dihydropyrazoles, their preparation and use
This invention provides compounds of Formula I, methods for their preparation and use for preparing compounds of Formula II
wherein R 1 , R 2 , R 3 , R 5 , R 6 , X and n are as defined in...
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7615572 |
Pyrrole and pyrazole DAAO inhibitors
Methods for increasing D-Serine concentration and reducing concentration of the toxic products of D-Serine oxidation, for enhancing learning, memory and/or cognition, or for treating schizophrenia,...
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7605273 |
Aryl-substituted pyrazole-amide compounds useful as kinase inhibitors
The present invention relates to compounds having the formula,
and pharmaceutically-acceptable salts, prodrugs, solvates, isomers, and/or hydrates thereof, wherein Q is an...
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7601743 |
Cyano anthranilamide insecticides
Compounds of formula (I) wherein the substituents are as defined in claim 1 , and the agrochemically acceptable salts and all stereoisomers and tautomeric forms of the compounds of formula I can...
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7538073 |
Pyrazoylcarboxanilides as fungicides
The present invention relates to novel pyrazolylcarboxanilides of the formula (I)
in which R 1 , R 2 , G, R 3 and n are as defined in the disclosure, to a plurality of processes for...
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7528260 |
Method for preparing N-phenylpyrazole-1-carboxamides
A method is disclosed for preparing compounds of Formula 1 by combining compounds of Formulae 2 and 3 and a sulfonyl chloride.
Also disclosed are compounds of Formula 3, which are useful as...
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7521397 |
Disubstituted pyrazolyl carboxanilides
This invention relates to novel pyrazolylcarboxanilides of formula (I)
in which R, R 1 , R 2 and R 3 are as defined in the disclosure, to a plurality of processes for preparing these...
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7521471 |
4-cyanopyrazole-3-carboxamide derivatives, preparation and application thereof
The invention relates to 4-cyanopyrazole-3-carboxamide derivatives of formula (I):
in which R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 are as described herein. Also disclosed and claimed...
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7514463 |
Lonidamine analogues and their use in male contraception and cancer treatment
Novel compounds useful for inhibiting spermatogenesis and cancer treatment, and in particular as inhibitors of heat shock proteins and/or elongation factor 1 alpha.
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7511149 |
Process for the oxidation of certain substituted sulfilimines to insecticidal sulfoximines
Insecticidal sulfoximines are produced efficiently and in high yield by the oxidation of the corresponding sulfilimine with ruthenium tetraoxide or an alkali metal permanganate.
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7504518 |
Process for producing blocked isocyanate compound
Disclosed is a process for producing a blocked isocyanate compound represented by general formula (III): wherein R 1 , R 2 , Q 1 , and Q 2 are as defined in the specification, characterized by...
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7501527 |
Method for the production of fluoromethyl-substituted heterocycles
The present invention relates to a process for preparing fluoromethyl-substituted heterocycles of the formula (I)
in which R 1 , R 2 , R 3 and A are each as defined in the disclosure, by...
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7488747 |
Pyrrole and pyrazole DAAO inhibitors
Methods for increasing D-Serine concentration and reducing concentration of the toxic products of D-Serine oxidation, for enhancing learning, memory and/or cognition, or for treating schizophrenia,...
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7468367 |
Ethylene diamine derivatives and their use as orexin-receptor antagonists
This invention relates to heterocyclic substituted ethylene diamine derivatives and their use as pharmaceuticals.
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7459477 |
Substituted N-phenyl-phenoxy nicotinic acid-(thio)amides and their use as herbicides
The present invention relates to a substituted anilide derivative represented by general formula (I):
(wherein R 1 is a hydrogen atom, a (C 1 -C 6 )alkyl group, a halo(C 1 -C 6 )alkyl...
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7446121 |
Pyrazole-based HMG CoA reductase inhibitors
Novel compounds and pharmaceutical compositions useful as hypocholesterolemic and hypolipidemic agents are described. More specifically, potent inhibitors of the enzyme...
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7442801 |
Pyrazole compound
A pyrazole compound of formula (a):
wherein R 1 represents C1-C4 alkyl or trifluoromethyl, R 2 represents C1-C4 alkyl, R 3 represents hydrogen or C1-C6 alkyl; R 4 represents halogen and so...
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7425640 |
Substituted 5-carboxyamide pyrazoles and [1,2,4]triazoles as antiviral agents
The present invention provides compounds of formula I wherein X, Y, R 1 -R 7 are as defined herein. Compositions containing these compounds, and methods for inhibiting HCV RNA-dependent RNA...
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7417152 |
4-bromo-5-(2-chloro-benzoylamino)-1H-pyrazole-3-carboxylic acid amide derivatives and related compounds as bradykinin B1 receptor antagonists for the treatment of inflammatory diseases
Disclosed are compounds of formula I and II that are bradykinin B 1 receptor antagonists and are useful for treating diseases, or relieving adverse symptoms associated with disease conditions, in...
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7378448 |
Diphenylether amide derivatives as opioid receptor antagonists
A compound of the formula (I) wherein the variables X 1 , X 2 , B, D, R 1 to R 7 including R 3′ , p, y, q, and z, are as defined or a pharmaceutically acceptable salt, solvate, enantiomer,...
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7378409 |
Substituted cycloalkylamine derivatives as modulators of chemokine receptor activity
The present application describes modulators of MCP-1 of formula (I):
or pharmaceutically acceptable salt forms thereof, useful for the prevention of asthma, multiple sclerosis,...
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7358371 |
Process for the preparation of 1,5—carboxylic acid derivatives
The present invention comprises a process for the preparation of compounds that possess an affinity for the cannabinoid receptor in the human brain. These compounds are useful as immunomodulators...
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7358214 |
Pyrazolyl carboxanilides for controlling unwanted microorganisms
This invention relates to novel pyrazolylcarboxanilides of the formula (I)
in which R 1 , G and n are as defined in the disclosure, to a plurality of processes for preparing these...
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7348350 |
Pyrazolyl biphenyl carboxamides and the use thereof for controlling undesirable microorganisms
Novel pyrazolylbiphenylcarboxamides of the formula (I)
in which
R 1 , R 2 , X, m, Y and n are each as defined in the description, a plurality of processes for preparing these substances...
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7345058 |
Pyrazoles
Provided herein are compounds of the formula (I):
as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds,...
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7335780 |
Method for preparing 3-halo-4,5-dihydro-1H-pyrazoles
This invention relates to a method for preparing 3-halo-4,5-dihydro-1H-pyrazole compound of Formula (I), comprising contacting with HX 1 a different 4,5-dihydro-1H-pyrazole compound of Formula...
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7329633 |
Disubstituted pyrazolylcarboxanilides
This invention relates to novel pyrazolylcarboxanilides of formula (I)
in which R, R 1 , R 2 and R 3 are as defined in the disclosure, to a plurality of processes for preparing these...
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7319150 |
Method for preparing styryl pyrazole, isoxazole and isothiazole derivatives
The invention concerns a method for synthesizing styryl isoxazole, styryl pyrazole and styryl isothazole derivatives in a synthesis step followed by a recrystallization in a basic alcohol medium.
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7300469 |
Diaminopyrazole compounds and the use thereof in the oxidation dyeing of keratinous fibres
The invention relates to novel diaminopyrazole having formula (I), wherein: R 1 , R 2 , identical or different, represent a C 3 C 5 mono- or polyhydroxyalkyl, isopropyl, n-propyl or ethyl group,...
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7291647 |
Guanylhydrazone compounds, compositions, methods of making and using
The present invention relates to compounds having the formula:
salts thereof; compositions comprising one or more of the compounds and/or salts thereof; methods of using; and methods of...
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7288554 |
Ortho-substituted aryl amides for controlling invertebrate pests
Disclosed are compounds of Formula I, their N-oxides and agriculturally suitable salts (I) wherein J is a phenyl ring, a 5- or 6-membered heteroaromatic ring or an aromatic 8-, 9- or 10-membered...
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7247628 |
Cannabinoid receptor ligands and uses thereof
Compounds of Formula (I) that act as cannabinoid receptor ligands and their uses in the treatment diseases, conditions and/or disorders herein.
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7241721 |
Biphenyl derivatives and their use as fungicides
A fungicidally active compound of formula (I): where Het is a substituted 5- or 6-membered heterocyclic ring; R 1 is hydrogen, formyl, CO—C 1-4 alkyl, COO—C 1-4 alkyl, C 1-4 alkoxy(C 1-4...
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7227025 |
Substituted dihydro 3-halo-1H-pyrazole-T-carboxylates, their preparation and use
This invention relates to a compound of Formula I, a method for its preparation and its use in the preparation of a compound of Formula II
wherein R 1 , R 2 , R 3 , X and n are as defined in...
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7223782 |
Pyrazole-amides and -sulfonamides
Compounds, compositions and methods are provided which are useful in the treatment of diseases through the inhibition of sodium ion flux through voltage-dependent sodium channels. More...
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7223774 |
Benzamide 2-hydroxy-3-diaminoalkanes
The present invention relates to compounds of formula (I):
useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme...
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7183306 |
Pyrazole derivatives
A compound of the formula (I):
wherein R 1 is hydrogen or lower alkyl;
R 2 is lower alkyl, etc.; R 3 is lower alkoxy, etc.; R 4 is hydroxy, etc.; X is O, S, etc.; Y is CH or N; Z is...
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7176228 |
Pyrazole biphenylcarboxamides
The invention relates to biphenylcarboxamides of the formula (I)
in which A, R, Z, X, Y, m and n are each as defined in the disclosure, to a plurality of processes for preparing these...
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7173055 |
Pyrazolecarboxamide and pyrazolethioamide as fungicide
Novel pyraole derivatives of formula (I), wherein: X is oxygen or sufu, R 1 is C 1 –C 3 alkyl, C 1 –C 3 haloalkyl, C 1 –C 3 alkoxy-C 1 –C 3 alkyl or C 1 –C 3 haloalkoxy-C 1 –C 3 alkyl;...
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7157475 |
Diamide invertebrate pest control agents
Compounds of Formula (I), and their N-oxides and suitable slats, are disclosed which are useful as invertebrate pest control agents, wherein A and B are independently O or S; E is C or N; J is a...
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7135472 |
3-Heterocyclic benzylamide derivatives as potassium channel openers
The present invention provides novel 3-heterocyclic benzylamides and related derivatives having the general Formula I
wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , A and Het are as defined in the...
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7135475 |
Amide substituted xanthine derivatives
The present invention is a 1,3,8 substituted xanthine derivative of formula I
or a pharmaceutically acceptable salt thereof, wherein R 1 , R 2 and R 3 are as defined in the specification.
...
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7112601 |
Cycloalkyl heterocycles for treating hepatitis C virus
Compounds of Formula I are disclosed which inhibit hepatitis C NS5B RNA-dependent RNA polymerase and are useful for treating hepatitis C. Compositions and methods of using these compounds are also...
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7109243 |
Inhibitors of cathepsin S
The present invention provides compounds, compositions and methods for the selective inhibition of cathepsin S. In a preferred aspect, cathepsin S is selectively inhibited in the presence of at...
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7087634 |
Cyclic AMP-specific phosphodiesterase inhibitors
Pyrazole compounds that are potent and selective inhibitors of PDE4, as well as methods of making the same, are disclosed. Use of the compounds in the treatment of inflammatory diseases and other...
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7078426 |
Aryl substituted pyrazoles, triazoles, and tetrazoles, and the use thereof
This invention relates to compounds having the Formula I:
or a pharmaceutically acceptable salt, prodrug or solvate thereof, wherein Het and R 5 -R 8 are set in the specification. The...
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7009056 |
Blockade of voltage dependent sodium channels
Compounds of formula (I), and pharmaceutically acceptable salts thereof, are capable of blockading voltage-dependent sodium channels and are useful in particular, in treating glaucoma and multiple...
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6989384 |
Antipicornaviral compounds and compositions, their pharmaceutical uses, and materials for their synthesis
Compounds of the formula:
where the formula variables are as defined in the disclosure, advantageously inhibit or block the biological activity of the picomaviral 3C protease. These compounds,...
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