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7608635 |
Pyrazole compounds that modulate HSP90 activity
Compounds of formula (I), pharmaceutical compositions comprising compounds of formula (I) and methods of inhibiting Hsp90 in a cell, treating or preventing a proliferation disorder in a mammal and...
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7598389 |
Silylated carboxamides
Novel silylated carboxamides of the formula (I)
in which
R, L, R 1 , R 3 , R 3 , R 4 and A are as defined in the description, a plurality of processes for preparing these compounds and their...
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7576116 |
PDK-1/Akt signaling inhibitors
A new class of phosphoinositide-dependent kinase-1 (PDK-1) inhibitors of formula I:
wherein X is selected from the group consisting of alkyl and haloalkyl; Ar is an aryl radical selected from...
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7576115 |
Heterocyclic compounds and thrombopoietin receptor activators
A compound represented by the formula (1):
wherein A is a nitrogen atom or CR 4 , B is an oxygen atom, a sulfur atom or NR 9 (provided that when A is a nitrogen atom, B is not NH), R 1 is a C...
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7572797 |
Amino substituted pyrazine derivatives for the treatment of pain
The present invention relates to compounds of the formula
and pharmaceutically acceptable salts and solvates thereof, to processes for the preparation of, intermediates used in the preparation...
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7569516 |
Plant growth regulation
The present invention relates to a new class of plant growth regulators. In particular, the invention relates to 5-substituted-1-arylpyrazole-3-carboxylic acid derivative of general formula (I) and...
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7566716 |
Imidazopyrazines as Raf inhibitor compounds
Compounds of Formula I are useful for inhibiting Raf kinase and for treating disorders mediated thereby. Methods of using compounds of Formula I, and stereoisomers, tautomers, solvates and...
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7538134 |
Substituted arylpyrazoles
This invention relates to a range of 1-aryl-4-cyclopropylpyrazoles in which the cyclopropyl ring is substituted at the angular position, and pharmaceutically acceptable salts and solvates thereof,...
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7528260 |
Method for preparing N-phenylpyrazole-1-carboxamides
A method is disclosed for preparing compounds of Formula 1 by combining compounds of Formulae 2 and 3 and a sulfonyl chloride.
Also disclosed are compounds of Formula 3, which are useful as...
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7521471 |
4-cyanopyrazole-3-carboxamide derivatives, preparation and application thereof
The invention relates to 4-cyanopyrazole-3-carboxamide derivatives of formula (I):
in which R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 are as described herein. Also disclosed and claimed...
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7511149 |
Process for the oxidation of certain substituted sulfilimines to insecticidal sulfoximines
Insecticidal sulfoximines are produced efficiently and in high yield by the oxidation of the corresponding sulfilimine with ruthenium tetraoxide or an alkali metal permanganate.
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7511034 |
Dialkylhydroxybenzoic acid derivatives containing metal chelating groups and their therapeutic uses
Novel dialkylhydroxybenzoic acid derivatives containing metal chelating groups are disclosed. The novel compounds are used as therapeutics for treating and/or preventing various medical...
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7504518 |
Process for producing blocked isocyanate compound
Disclosed is a process for producing a blocked isocyanate compound represented by general formula (III): wherein R 1 , R 2 , Q 1 , and Q 2 are as defined in the specification, characterized by...
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7495017 |
Phosphodiesterase 4 inhibitors
Selective PDE4 inhibition is achieved by aryl and heteroaryl pyrazole compounds. The compounds exhibit improved PDE4 inhibition as compared to compounds such as rolipram and show selectivity with...
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7476687 |
Substituted furo[2,3-g]indazoles for the treatment of glaucoma
Substituted furo[2,3-g]indazoles for lowering intraocular pressure and treating glaucoma are disclosed.
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7452899 |
Gamma-secretase inhibitors
Compounds of Formula (I): inhibit the processing of APP by gamma-secretase, and hence are useful for treatment or prevention of Alzheimer's disease.
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7446121 |
Pyrazole-based HMG CoA reductase inhibitors
Novel compounds and pharmaceutical compositions useful as hypocholesterolemic and hypolipidemic agents are described. More specifically, potent inhibitors of the enzyme...
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7417151 |
Boron-based organic cations and related methods
Generally disclosed are boron-based organic cations, a method for their manufacture, a method for their use in ionic liquids, and a method for their use as phase-transfer catalysts. More...
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7396850 |
Pyrazole derivative as PPAR modulator
The present invention is directed to a compound, {2-Methyl-4-[3-methyl-1-(4-trifluoromethyl-phenyl)-1H-pyrazo
l-4-ylmethylsulfanyl]-phenoxy}-acetic acid and pharmaceutical uses thereof.
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