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7265112 |
Small molecule modulators of hepatocyte growth factor (scatter factor) activity
The present invention provides compounds having formula (I):
and pharmaceutically acceptable derivatives thereof, wherein R 1 , R 2 and B are as described generally and in classes and...
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7241793 |
Phenyloxyalkanonic acid derivatives as hPPAR activators
A compound of formula (I) or a pharmaceutically acceptable salt, solvate, or hydrolysable ester thereof, wherein:
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RE39681 |
1-(4-sulfamyaryl)-3-substituted-5-aryl-2-pyrazolines and inhibitors of cyclooxygenase-2
Compounds of the formula
wherein:
X is selected from the group consisting of trihalomethyl, C 1 -C 6 alkyl, and a group of formula II:
wherein:
R 3 and R 4 are...
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7195649 |
N-aryl-4,5-diaminopyrazoles and dyes containing said compounds
N-Aryl-4,5-diaminopyrazole of formula (I) or a physiologically compatible salt thereof of an organic or inorganic acid
wherein
R1 and R2 independently of each other denote a hydrogen atom, a...
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7173129 |
Sulfonamide-substituted chalcone derivatives and their use to treat diseases
The invention relates to compounds, pharmaceutical compositions and methods of using compounds of the general formula
or its pharmaceutically acceptable salt or ester, wherein the substituents...
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7138361 |
Herbicidal heterocycles
Compounds of Formula (1), their N-oxides and agriculturally suitable salts, are disclosed which are useful for controlling undesired vegetation
wherein
A, R 1 , R 2a , R 2b , W, Y, and Z...
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7105564 |
Pharmaceutical composition comprising a dual antagonist against PGD2/TXA2 receptors having a [2.2.1] or [3.1.1] bicyclic skeleton
The present invention provides novel compounds having a dual antagonistic activity against thromboxane A2 receptor and prostaglandin D 2 receptor and pharmaceutical compositions comprising them. ...
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7091350 |
Diaminopyrazole derivatives and their use for oxidation dyeing of keratinous fibres
The invention relates to diaminopyrazole derivatives having the following structure (I), wherein R 1 represents an alkyl or alkenyl radical bearing at least one substituent selected from among OR,...
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7078531 |
Process for obtaining enantiomers of thienylazolylalcoxyethanamines
A process is described for the preparation of a precursor alcohol of (±)-2-[thienyl(1-methyl-1H-pyrazol-5-yl)methoxy]-N,N-dimeth
yletanamine and in general for thienylazolylalcoxyethanamines and...
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7034154 |
Synthesis of substituted pyrazolopyrimidines
Methods of making substituted pyrazolopyrimidines generally and, more particularly, N-methyl-N-(3-{3-[2-thienylcarbonyl]-pyrazol-[1,5-α]-pyrimi
din-7-yl}phenyl)acetamide. Such compounds have...
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7034049 |
3(5)-amino-pyrazole derivatives, process for their preparation and their use as antitumor agents
Compounds which are 3-amino-pyrazole derivatives represented by formula (I) wherein R is C 3 –C 6 cycloalkyl group optionally substituted by a straight or branched C 1 –C 6 alkyl or arylalkyl...
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6965036 |
Intermediates for guanidine mimics as factor Xa inhibitors
The present application describes intermediates for nitrogen containing heteroaromatics and derivatives thereof of formula I:
or pharmaceutically acceptable salt forms thereof, wherein rings...
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6706711 |
Pyrazole derived kinase inhibitor
Described herein are compounds that are useful as protein kinase inhibitors having the formula: wherein R 1 , R 2 , T, n and Q are as described in the specification. The compounds are useful for...
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6660732 |
Compounds useful as anti-inflammatory agents
Disclosed are novel aromatic compounds which are useful for treating diseases or pathological conditions involving inflammation such as chronic inflammatory diseases. Also disclosed are...
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6656933 |
Compounds useful as anti-inflammatory agents
Disclosed are novel aromatic compounds which are useful for treating diseases or pathological conditions involving inflammation such as chronic inflammatory diseases. Also disclosed are...
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6610726 |
Compositions and agents for modulating cellular proliferation and angiogenesis
The invention is directed to pharmaceutical compositions containing small organic molecules having the ability to mimic or agonize hepatocyte growth factor/scatter factor (HGF/SF) activity, useful...
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6605637 |
Lipoic acid derivatives, their preparation, and pharmaceutical compositions containing them
The invention concerns novel lipoic acid derivatives, which have an inhibiting action with respect to NO-synthase enzymes producing nitrogen monoxide NO and/or are agents enabling the regeneration...
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6593358 |
Thienyl-pyrazoles and their use for controlling pests
The present invention relates to compounds of the formulae (Ia) and (Ib) wherein R 1 represents C 1-10 alkyl which may be unsubstituted or substituted with halogen, or represents C 2-4 ...
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6593357 |
Pyrazole compositions useful as inhibitors of ERK
Described herein are compounds that are useful as protein kinase inhibitors having the formula: where R 1-4 , Q, and T are described in the specification. The compounds are useful for treating...
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6569860 |
Alkoxycarbonylamino heteroaryl carboxylic acid derivatives as IP antagonists
This invention relates to compounds which are IP receptor antagonists and which are represented by Formula (I): wherein G 2 is a heteroaryl group containing one or two nitrogen atoms...
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6518295 |
Utilization of aryl(or heteroaryl)azolylcarbinol derivatives in the preparation of a medicament for the treatment of troubles mediated by an excess of substance P
The present invention relates to the use of derivatives of aryl (or heteroaryl) azolylcarbinols of general formula (1) of the specification, as well as their physiologically acceptable salts, in...
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6492416 |
4,5-diaryl-3(2H)-furanone derivatives as cyclooxygenase-2 inhibitors
The present invention provides a novel class of 4,5-diaryl-3(2H)-furanone derivatives, which inhibit strongly and selectively COX-2 over COX-1. They are useful to treat inflammation,...
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6476060 |
4,5-dihydro-1H-pyrazole derivatives having CB1-antagonistic activity
The present invention relates, among many things, to novel 4,5-dihydro-1H-pyrazole compounds which can be potent antagonists of the cannabis CB 1 -receptor. The compounds have the formula (I) ...
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6462069 |
Compounds, pharmaceutical compositions, and methods for inhibiting protein kinases
Amino-pyrazole compounds that modulate and/or inhibit the activity of protein kinases. These compounds and pharmaceutical compositions containing them are capable of mediating and/or inhibiting the...
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6448201 |
Benzoylcyclohexanediones and benzoylpyrazoles, their preparation, and their use as herbicides and plant growth regulators
Benzoylcyclohexanediones and benzoylpyrazoles, their preparation and their use as herbicides and plant growth regulators. There are described benzoyl compounds of the formula (I), their...
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6444696 |
Pyrazole derivatives P38 MAP kinase inhibitors
The present invention relates to certain pyrazole derivatives of Formula (I): that are p-38 MAP kinase inhibitors, pharmaceutical compositions containing them, methods for their use, and methods...
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6376519 |
1-(4-sulfamylaryl)-3-substituted-5-aryl-2-pyrazolines and inhibitors of cyclooxygenase-2
Compounds of the formula wherein: X is selected from the group consisting of trihalomethyl, C 1 -C 6 alkyl, and a group of formula II: wherein: R 3 and R 4 are independently selected from...
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6342510 |
Treatment of inflammation and inflammation-related disorders with a combination of a cyclooxygenase-2 inhibitors and a leukotriene B4 receptor antagonist
Combinations of a cyclooxygenase-2 inhibitor and a leukotriene B 4 receptor antagonist are described for treatment of inflammation and inflammation-related disorders.
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6335357 |
Pyrazole derivatives, process for preparing the same, intermediates, and pest control agent containing the same as active ingredient
A 1-aryl-3-cyano-5-(het)arylalkylaminopyrazole derivative represented by the general formula (1): process of making, intermediate thereof and pesticide therewith.
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6331639 |
Process for preparing 2-alkyl-3-aminothiophene derivative and 3-aminothiophene derivative
A compound represented by the formula (1) which is useful as an agricultural fungicide or an intermediate thereof can be obtained by reacting a compound of the general formula (2) with a compound...
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6316466 |
Pyrazole derivatives P-38 MAP kinase inhibitors
The present invention relates to certain pyrazole derivatives of Formula (I): ##STR1## that are p-38 MAP kinase inhibitors, pharmaceutical compositions containing them, methods for their use, and...
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6310049 |
Nematicidal pyrazoles
##STR1## Novel pyrazoles of formula (1) wherein R 1 represents halogen, C 1 -6 alkyl, C 1 -5 haloalkyl, C 2 -6 alkoxy, C 1 -4 alkylthio, C 2 -5 alkenyloxy, C 3 -5 alkynyloxy, C 2 -6 (total carbon...
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6271179 |
Benzylidene pyrazolones, production and use thereof
Benzylidenepyrazolones of the formula I, ##STR1## Useful as herbicides.
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6265351 |
Phenylpyrazoles with a herbicidal activity
The invention relates to phenylpyrazoles having general formula (I): ##STR1## The compounds having formula (I) have a high herbicidal activity and are used for controlling weeds in the agronomic...
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6255333 |
Parasiticidal compounds
Parasiticidal pyrazole derivatives of formula (I) wherein: R 1 represents CN, C 1 -6 alkoxycarbonyl, NO 2 , CHO, C 1 -6 alkanoyl, phenyl optionally substituted by one or more halogen, or C 1 -6...
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6207618 |
Heterocyclic substituted 4-benzoyl-pyrazole as herbicides
Substituted 4-benzoylpyrazole of the formula I ##STR1## where: Q is a pyrazole of the formula II ##STR2## X 1 is a straight-chain or branched C 1 -C 6 -alkylene, a C 2 -C 6 -alkenylene...
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6187799 |
Inhibition of raf kinase activity using aryl ureas
Methods of treating tumors mediated by raf kinase, with substituted urea compounds, and such compounds per se.
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6169181 |
Compounds useful to treat retroviral infections
The present invention relates to compounds of formula I and II which are pyran-2-ones, 5,6-dihydro-pyran-2-ones, 4-hydroxy-benzopyran-2-ones, 4-hydroxy-cycloalkyl[b]pyran-2-ones, and derivatives...
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6165944 |
4-(3-heterocyclyl-1-benzoyl) pyrazoles and their use as herbicides
4-(3-Heterocyclyl-1-benzoyl)pyrazoles of the formula I ##STR1## where: R 1 and R 3 are each hydrogen, nitro, halogen, cyano, alkyl, haloalkyl, alkoxy, haloalkoxy, alkylthio, haloalkylthio,...
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6143696 |
Substituted 4-(3-alkenylbenzoyl)pyrazoles
4-(3-Alkenylbenzoyl)pyrazoles of the formula I ##STR1## and agriculturally useful salts thereof; processes for preparing the compounds of the formula I; compositions comprising them; and the use of...
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6140272 |
Substituted 4-benzoyl-pyrazoles
4-Benzoylpyrazoles of the formula I where: A is a group of the formula IIIa, IIIb or IV ##STR1## Q is a pyrazole of the formula II, ##STR2## useful as herbicides.
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6054413 |
1-sulfonyl-3-phenylpyrazoles and their use as herbicides and for desiccating or defoliating plants
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6030926 |
Pyrazole derivative and herbicidal composition
A pyrazole derivative represented by the general formula (1a) or (1b): ##STR1## wherein R 1 represents a hydrogen atom or a pesticidally acceptable protecting group; R 2 and R 3 represent a...
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6028035 |
Substituted 4-benzoylpyrazoles
The invention relates to 4-benzoylpyrazoles of the formula I and their agriculturally useful salts thereof, processes and intermediates; compositions thereof; and use thereof for controlling...
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6015911 |
Process for preparing 1-alkyl-4-(2-chloro-3-alkoxy-4-alkylsulfonylbenzoyl)-5-hydroxypyrazole and related compounds
Herbicidal 1-alkyl-4-(2-chloro-3-alkoxy-4-alkylsulfonylbenzoyl)-5-hydro
xypyrazole compounds, as well as 1-halo-2-chloro-3-alkoxy-4-alkylsulfonylbenzene compounds and...
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6013666 |
Oxirane carboxylic acid derivative and its manufacturing method
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5958382 |
4,4-dihydroxy-5-pyrazolinones and cosmetic/dermatological compositions comprised thereof
Novel 4,4-dihydroxy-5-pyrazolinones having the structural formula (I): ##STR1## and cosmetic/dermatological formulations comprised thereof are useful for artificially coloring, e.g.,...
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5931973 |
4,5-dIiminopyrazolines, processes for their preparation, and their application in keratin fiber dyeing compositions and processes
Dyes selected from 4,5-diiminopyrazolines or their 4-ylideneamino-5-aminopyrazole tautomeric forms, a process for their preparation, and their use as direct dyes in dye compositions for keratin...
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5925769 |
Acetylenic 1,5-diarylpyrazoles as antiinflammatory agents
Compounds of Formula I ##STR1## wherein, R 1 through R 7 are described herein. These compounds inhibit the production of arachidonic acid products associated with 5-lipoxygenase and...
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5922741 |
5-aminopyrazoles useful as tyrosine kinase inhibitors
Compounds of general formula (1) are described: ##STR1## wherein Ar is an optionally substituted aromatic or heteroaromatic group; X 1 is an oxygen or sulphur atom; R 1 is a hydrogen atom...
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