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9012478 Pyrazolyl substituted carbonic acid derivatives as modulators of the prostacyclin (PGI2) receptor useful for the treatment of disorders related thereto  
Pyrazole derivatives of Formula Ia and pharmaceutical compositions thereof that modulate the activity of the PGI2 receptor. Compounds of the present invention and pharmaceutical compositions...
9006429 Herbicidal pyrandione, thiopyrandione, and cyclohexanetrione derivatives  
Pyrandione, thiopyrandione and cyclohexanetrione compounds, which are suitable for use as herbicides.
8999956 N-[(het)arylalkyl)] pyrazole(thio)carboxamides and their heterosubstituted analogues  
The present invention relates to fungicidal N-[(het)arylalkyl)]pyrazolecarboxamide or thiocarboxamide and their heterosubstituted analogs, their process of preparation and intermediate compounds...
8993752 Neprilysin inhibitors  
In one aspect, the invention relates to compounds having the formula: where R1, R2, R3, R4, and R5 are as defined in the specification, or a pharmaceutically acceptable salt thereof. These...
8987318 Liver X receptor (LXR) modulators for the treatment of dermal diseases, disorders and conditions  
Described herein are liver X receptor (LXR) modulators and methods of utilizing LXR modulators in the treatment of dermal diseases, disorders or conditions. Also described herein are...
8952026 PRMT1 inhibitors and uses thereof  
Described herein are compounds of Formula (I), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds described herein are useful for inhibiting PRMT1...
8946278 Inhibitors of AkT activity  
Invented are novel heterocyclic carboxamide compounds, the use of such compounds as inhibitors of protein kinase B activity and in the treatment of cancer and arthritis.
8946204 Substituted phenylureas and phenylamides as vanilloid receptor ligands  
Substituted phenylureas and phenylamides, processes for their preparation, pharmaceutical compositions containing these compounds, and the use of these compounds for preparing pharmaceutical...
8916555 3,5-diaminopyrazole kinase inhibitors  
Provided herein are 3,5-diaminopyrazoles, for example, compounds of Formula IA, that are useful for modulating regulated-in-COPD kinase activity, and pharmaceutical compositions thereof. Also...
8912342 Pyrazole synthesis by coupling of carboxylic acid derivatives and enamines  
A method of synthesizing Pyrazoles by means of the oxidative conversion of Enamines with suitable N-containing carboxylic acid derivatives in the presence of copper ions and 2-picolinic acid...
8901314 Substituted pyrazoles as N-type calcium channel blockers  
The present invention relates to compounds of Formula (I), wherein X1, X2, X3, X4, R1, R2, R3, and Q are as defined herein, useful as N-type calcium channel blockers.
8884028 Process for preparing alkyl 2-alkoxymethylene-4,4-difluoro-3-oxobutyrates  
The present invention relates to a process for preparing a compound of formula (II) wherein R1 is CF3, CF2H or CFH2, and R2 and R3 are both independently C1-C6 alkyl, comprising a) reacting...
8853205 Heteropyrrole analogs acting on cannabinoid receptors  
Disclosed are biologically active hetero pyrrole analogs such as imidazoles, thiazoles, oxazoles and pyrazoles capable of interacting with the CB1 and/or CB2 cannabinoid receptors. Aspects...
8853281 Cysteine protease inhibitors  
Compounds of the formula I whereinR1a is H; and R1b is C1-C6 alkyl, Carbocyclyl or Het; orR1a and R1b together define a saturated cyclic amine with 3-6 ring atoms;R2a and R2b are H, halo,...
8791143 Anthranilic diamide derivatives having cyclic side-chains  
The present invention relates to novel anthranilic diamide derivatives of the general formula (I) in which R1, R2, R3, R4, R5, R6, A, Q and n have the meanings given in the description, to their...
8772326 Methods and compositions of small molecule modulators of hepatocyte growth factor (scatter factor) activity  
The present invention provides compositions and formulations of compounds having formula (I) and pharmaceutically acceptable derivatives thereof, wherein p, R1, R2 and B are as described generally...
8735600 Process for purification of 1-methylpyrazole-4-carboxylic acid esters  
The present invention relates to improvements in processes towards the production 3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid, which is a useful intermediate in fungicide production....
8716485 Pyrazole synthesis by coupling of carboxylic acid derivatives and enamines  
The invention describes a novel process for synthesizing pyrazoles by means of oxidative conversion of enamines with suitable N-containing carboxylic acid derivatives.
8703805 Modulators of LXR  
Compounds of the invention, such as compounds of Formulae Ia, Ib, Ic, or Id and pharmaceutically acceptable salts, isomers, and prodrugs thereof, which are useful as modulators of the activity of...
8685975 PDE10 inhibitors and related compositions and methods  
Compounds that inhibit PDE10 are disclosed that have utility in the treatment of a variety of conditions, including (but not limited to) psychotic, anxiety, movement disorders and/or neurological...
8680292 Bis(thienyl)isopyrazoles and process for preparing and method for using bis(thienyl)isopyrazoles  
The invention demonstrates the synthesis of a new pyrazole-containing monomer by means of an easily implemented two-step process. This monomer can be electropolymerized to yield a stable n-doping...
8680119 Ethers, secondary amines and derivatives thereof as modulators of the 5-HT2A serotonin receptor useful for the treatment of disorders related thereto  
The present invention pertains to certain compounds of Formula (Ia) and pharmaceutical compositions thereof that modulate the activity of the 5-HT2A serotonin receptor. Compounds and...
8664258 Primary amines and derivatives thereof as modulators of the 5-HT2A serotonin receptor useful for the treatment of disorders related thereto  
The present invention pertains to certain compounds of Formula (Ia) and pharmaceutical compositions thereof that modulate the activity of the 5-HT2A serotonin receptor. Compounds and...
8664257 Oxygen-substituted 3-heteroaroylamino-propionic acid derivatives and their use as pharmaceuticals  
The present invention relates to compounds of the formula I, wherein A, D, E, G, R10, R30, R40, R50 and R60 have the meanings indicated in the claims, which are valuable pharmaceutical active...
8653112 Substituted pyrazoles as estrogen receptor ligands  
The invention provides a compound of formula (I) wherein G is a pyrazole ring as defined in the specification and R4, R5, R6 and R7 are as defined in the specification; or a pharmaceutically...
8642637 Salts of bicyclo-substituted pyrazolon azo derivatives, preparation method and use thereof  
The pharmaceutically acceptable salts of bicyclo-substituted pyrazolon azo derivatives represented by the general formula (I), their preparation methods, pharmaceutical compositions containing the...
8629286 Pyrazole derivatives  
The present invention relates to heterocycles which have microbiocidal activity, in particular, fungicidal activity. The invention also relates to preparation of these heterocycles, to...
8614243 Small-molecule modulators of Trp-p8 activity  
Provided are small-molecule Trp-p8 modulators, including Trp-p8 agonists and Trp-p8 antagonists, and compositions comprising small-molecule Trp-p8 agonists as well as methods for identifying and...
8609711 Crystalline N-{(1S)-2-amino-1-[(3-fluorophenyl)methyl]ethyl}-5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)-2-thiophenecarboxamic hydrochloride  
An improved AKT inhibiting compound, crystalline N-{(1S)-2-amino-1-[(3-fluorophenyl)methyl]ethyl}-5-chloro-4- (4-chloro-1-methyl-1H-pyrazol-5-yl)-2-thiophenecarboxamide hydrochloride.
8598078 Condensed anthran I lami de derivatives as insecticides  
Compounds of Formula I wherein the substituents are as defined in Claim 1, and the agrochemically acceptable salts and all stereoisomers and tautomeric forms of the compounds of formula I can be...
8592475 Inhibitors of Akt activity  
Invented are novel heterocyclic carboxamide compounds, the use of such compounds as inhibitors of protein kinase B activity and in the treatment of cancer and arthritis.
8580834 Small molecule modulators of hepatocyte growth factor (scatter factor) activity  
The present invention provides compounds having formula (I): and pharmaceutically acceptable derivatives thereof, wherein R1, R2 and B are as described generally and in classes and subclasses...
8563747 Processes for the alkylation of pyrazoles  
The invention provides a process for the preparation of a compound of formula (I) in particular, wherein a compound of formula (II) is reacted with a dialkylsulphate. R1 is C1-C4haloalkyl; R2 is...
8551426 Compound for inhibiting activity of ribonuclease, and container for storing nucleic acid containing the same  
Provided are an RNase activity inhibitory compound to effectively control the activity of the RNase promoting degradation of extracted RNAs and, in addition, a sample storage container including...
8519188 Compounds which can be used for the treatment of cancers  
The present invention relates to a compound of general formula (I): and also to the pharmaceutically acceptable salts thereof, to the isomers or isomer mixtures thereof in all proportions, in...
8513244 Neprilysin inhibitors  
In one aspect, the invention relates to compounds having the formula: where R1, R2, R3, R4, and R5 are as defined in the specification, or a pharmaceutically acceptable salt thereof. These...
8486986 Microbiocides  
Compounds of the formula (I), in which the substituents are as defined in claim 1 are suitable for use as microbiocides.
8476458 Methods and compositions for modulating P300/CBP activity  
The present invention relates to a method for identifying compounds that modulate the activity of p300/CBP. Compounds of the invention are identified by designing or screening for a compound which...
8420690 Inhibitors of Akt activity  
Invented are novel heterocyclic carboxamide compounds, the use of such compounds as inhibitors of protein kinase B activity and in the treatment of cancer and arthritis.
8410158 Inhibitors of Akt activity  
Invented are novel heterocyclic carboxamide compounds, the use of such compounds as inhibitors of protein kinase B activity and in the treatment of cancer and arthritis.
8410097 Heteropyrrole analogs acting on cannabinoid receptors  
Disclosed are biologically active hetero pyrrole analogs such as imidazoles, thiazoles, oxazoles and pyrazoles capable of interacting with the CB1 and/or the CB2 cannabinoid receptors. One aspect...
8367846 Method of producing 2-alkyl-3-aminothiophene derivative  
The present invention provides a method of producing 2-alkyl-3-aminothiophene derivative represented by Formula (4), the method comprising oxidizing a compound represented by the following Formula...
8367710 Bicyclo-substituted pyrazolon azo derivatives, preparation process and pharmaceutical use thereof  
The bicyclo-substituted pyrazolon-azo derivatives of formula (I) or pharmaceutical acceptable salts, hydrates or solvates thereof, methods for their preparation, pharmaceutical compositions...
8343970 PDE10 inhibitors and related compositions and methods  
Compounds that inhibit PDE10 are disclosed that have utility in the treatment of a variety of conditions, including (but not limited to) psychotic, anxiety, movement disorders and/or neurological...
8318951 Stem cell differentiating agents and uses therefor  
The present invention relates to screens for compounds that can induce stem cell differentiation. In addition, isoxazoles and sulfonyl hydrazones are identified as general classes of compounds...
8299063 Amido-thiophene compounds and their use  
The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain amido-thiophene compounds that, inter alia, inhibit...
8288419 Aminopyrazole derivatives  
The invention relates to aminopyrazole derivatives of formula (I), wherein A, E, R1 and R2 are as defined in the description, their preparation and their use as pharmaceutically active compounds.
8288319 4-(3-alkylthiobenzoyl)pyrazoles and their use as herbicides  
4-(3-Alkylthiobenzoyl)pyrazoles of the formula (I) are described as herbicides. In this formula (I), X, Y, R1, R2, R3 and R4 represent radicals such as hydrogen, organic radicals such as alkyl,...
8273783 Microbiocides  
Compounds of formula (I), in which the substituents are as defined in claim 1, are suitable for use as microbiocides.
8273782 Inhibitors of Akt activity  
Invented are novel heterocyclic carboxamide compounds, the use of such compounds as inhibitors of protein kinase B activity and in the treatment of cancer and arthritis.

Matches 1 - 50 out of 400 1 2 3 4 5 6 7 8 >