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7632852 |
(1,5-diphenyl-1H-pyrazol-3-yl)oxadiazole derivatives, preparation method thereof and use of same in therapeutics
The invention relates to compounds having formula (I):
Wherein R1, R2, R3 and R4 are as defined herein. The invention also relates to a method of preparing said compounds and to the application...
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7625932 |
Pyrrole and pyrazole derivatives as potentiators of glutamate receptors
The present invention relates to pyrrole and pyrazole compounds of formula (I) and their pharmaceutically acceptable salts, and further relates to their use in treating schizophrenia, cognitive...
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7582589 |
3-carbonylaminothiophenes and their use as fungicides
The invention also relates to novel compounds of formula (1) where Het is a 5- or 6-membered heterocyclic ring containing one to three heteroatoms, each independently selected from oxygen, nitrogen...
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7576112 |
Therapeutic N-aryl or N-heteroaryl pyrazolidine and pyrazolidinone derivatives
A compound having a structure
and therapeutic methods, compositions, and medicaments related thereto are disclosed herein.
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7572816 |
Therapeutic agents for the treatment of cancer, metabolic diseases and skin disorders
The present invention is directed to compounds having the structure wherein R 1 , R 2 , R 3 , R 4 , R 5 and m are as defined herein. The compounds of this invention are novel therapeutic agents...
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7569592 |
Heteroaryl substituted pyrazole modulators of metabotropic glutamate receptor-5
Pyrazole compounds substituted directly, or by a bridge, with a heteroaryl moiety containing N adjacent to the point of connection of the heteroaryl, are mGluR5 modulators useful in the treatment...
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7553798 |
Heterocyclic carboxamides with microbiocidal activity
Compounds of the formula (I), in which the substituents are as defined in claim 1 are suitable for use as microbiocides.
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7528260 |
Method for preparing N-phenylpyrazole-1-carboxamides
A method is disclosed for preparing compounds of Formula 1 by combining compounds of Formulae 2 and 3 and a sulfonyl chloride.
Also disclosed are compounds of Formula 3, which are useful as...
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7528156 |
Compounds
The invention provides compounds of general formula (D wherein m, n, Q, Z1, Z2, R1, R2, R3, R4, R5, R6, R7, and R8 are as defined in the specification, processes for their preparation,...
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7524957 |
Compounds effecting glucokinase
The invention relates to the use of a compound of Formula (I) or a salt, solvate or prodrug thereof, wherein R 1 , R 2 , R 3 , n and m are as described in the specification, in the preparation of a...
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7507833 |
Therapeutic N-aryl or N-heteroaryl pyrazolidine and pyrazolidinone derivatives
A compound having a structure
and therapeutic methods, compositions, and medicaments related thereto are disclosed herein.
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7491829 |
RAF inhibitor compounds and methods
Pyrazolyl compounds of Formulas Ia and Ib are useful for inhibiting Raf kinase and for treating disorders mediated thereby. Methods of using pyrazolyl compounds for in vitro, in situ, and in vivo...
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7473701 |
Substituted indazoles, compositions containing them, method of production and use
Substituted indazoles, compositions containing them, method of production and use. The present invention relates in particular to novel specific substituted indazoles exhibiting kinase-inhibiting...
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7465808 |
CCK-1 receptor modulators
There are provided by the present invention certain pyrazole based CCK-1 receptor modulators.
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7452874 |
Thrombopoietin mimetics
Invented are non-peptide TPO mimetics. Also invented are novel processes and intermediates used in the preparation of the presently invented compounds. Also invented is a method of treating...
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7435829 |
Pyrazolyl-substituted heterocycles and their use as phytosanitary products
The present invention relates to novel pyrazolyl-substituted heterocycles of the formula (I)
in which X, Y, Z and Het are as defined in the disclosure, to processes for their preparation,...
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7432271 |
Pyrazolyl inhibitors of 15-lipoxygenase
The present invention provides pyrazolyl inhibitors of 15-LO, pharmaceutical compositions containing such inhibitors and methods for treating diseases related to the 15-LO cascade using such...
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7429581 |
Pyrazole-derivatives as factor Xa inhibitors
The present invention is directed to a compound of formula I,
in which R 0 ; R 1 ; R 2 ; R 3 ; R 4 ; Q; V, G and M have the meanings indicated below. The compound of formula I is a...
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7414056 |
Pyrazole-amide compounds useful as kinase inhibitors
The present invention provides pyrazole derived compounds of formula (I)
useful for treating p38 kinase-associated conditions, where G, X, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 and m are as...
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7407977 |
Substituted N-acyl-2-aminothiazoles
There are presented compounds of the formula
or a pharmaceutically acceptable salt thereof, which are useful in the treatment of diabetes, diabetic retinopathy, asthma and diarrhea.
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7407974 |
Inhibitors of factor Xa and other serine proteases involved in the coagulation cascade
The present invention provides compounds of Formula (I):
wherein A, B, C, G, and W 1 have any of the values defined in the specification, and pharmaceutically acceptable salt thereof, that are...
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7402683 |
Cinnamic acid amides
The present invention relates to compounds, to processes for preparing them, to pharmaceutical compositions comprising them, and to their use in the therapy and/or prophylaxis in illnesses in...
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7393842 |
Pyrazole analogs acting on cannabinoid receptors
One aspect of the invention is concerned with cannabimimetic pyrazole analogs. Another aspect of the invention is concerned with new and improved pyrazole analogs having high affinities and/or...
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7361672 |
Heteroarylacetamide inhibitors of factor Xa
The invention is concerned with novel heteroarylacetamides of formula (I)
R d —C(O)—N(R e )—R c —CH 2 —C(O)—N(R a )(R b ) ...
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7354944 |
Thiadiazole compounds and methods of use
The invention relates to thiadiazole compounds useful for treating diseases mediated by protein kinase B (PKB). The invention also relates to the therapeutic use of such thiadiazole compounds and...
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7348440 |
Mitotic kinesin inhibitors
The present invention relates to dihydropyrrole compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for...
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7332518 |
Carboxamides as fungicides in agriculture
The invention concerns novel carboxamides of formula (I) wherein A is (A1), (A2), (A3), (A4), (A5); Q is (Q1), (Q2), (Q3), (Q4), (Q5), (Q6); R 1 is CH 2 R 2 , CH 2 CH═CHR 2 , CH═C═CHR 2 or...
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7300950 |
Pyrazole derivatives, their preparation and their use in pharmaceuticals
The present invention relates to pyrazole derivatives of the formula I, their preparation and their use in pharmaceuticals:
in which X, R 1 , R 1a , R 2 , R 3 , R 4 and n are as defined in the...
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7279476 |
Pyrazole-derived kinase inhibitors and uses thereof
Described herein are compounds that are useful as protein kinase inhibitors having the formula:
where B, R 1 , n, R 3 , Q, and R 4 are described in the specification. The compounds are useful...
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7253290 |
Pyrazole derivatives as GnRH inhibitors
The invention relates to a group of novel thieno-pyrrole compounds of Formula (I):
wherein: R 1 , R 2 , R 5 , R 6 , R 6a , R 7 , R 8 , A, B and M are as defined in the specification, which are...
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7247734 |
3,4-diarylpyrazoles and their use in the therapy of cancer
The present invention pertains to the use of certain 3,4-diarylpyazoles of formula (I), both in vitro and in vivo, to inhibit heat shock protein 90 (HSP90), and in the treatment of conditions...
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7244739 |
Compounds and uses thereof in modulating amyloid beta
Novel compounds, compositions, and kits are provided. Methods of modulating Aβ levels, and methods of treating a disease associated with aberrant Aβ levels are also provided.
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7238722 |
Pyrazolylalkines
The present invention relates to pyrazolyalkines and to their use, to a process for preparing them and also to intermediates.
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7230025 |
Pyrazole derivatives
This invention relates to pyrazole derivatives of formula (I)
or pharmaceutically acceptable salts, solvates or derivative thereof, wherein R 1 to R 4 are defined in the description, and to...
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7208169 |
Biphenyl carboxamides
The invention relates to novel biphenylcarboxamides of the formula (I)
in which R 1 , R 2 , m, n, R 3 , Y and A are as defined in the disclosure, to a plurality of processes for preparing...
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7205323 |
Dipeptidyl peptidase IV inhibitors pharmaceutical compositions containing them, and process for their preparation
The present invention relates to novel compounds useful as dipeptidyl peptidase IV (DPP-IV) inhibitors of the formula:
wherein X, Y, a, R 1 , and R 2 are as defined herein.
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7189755 |
Pyrrolidine melanocortin-specific compounds
Melanocortin receptor-specific pyrrolidine compounds having the structure:
and stereoisomer and pharmaceutically acceptable salts thereof, where R 1 , R 2 , and R 3 are as described in the...
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7186741 |
Neurotensin active 2,3,diaryl-pyrazolidine derivatives
The invention relates to a group of novel 2,3 diaryl-pyparazolidine derivatives having formula (1). The symbols used in formula (1) have the meanings given in the specification. The compounds have...
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7186738 |
Antibacterial oxalidinones
Compounds of the formula (I), or a pharmaceutically-acceptable salts, or in-vivo-hydrolysable esters thereo Formula (I): wherein N-HeT is for example triazolyl; Q is for example phenyl or pyridyl,...
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7186843 |
Aminomethylpyrrolidine derivatives having aromatic substituents
This invention provides a quinolone derivative having potent antibacterial activity against various bacteria including drug-resistant strains which is a compound of the following formula wherein R...
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7183307 |
Pyrazole-derived kinase inhibitors and uses thereof
Described herein are compounds that are useful as protein kinase inhibitors having the formula:
wherein B, R 1 , n, R 3 , Q and R 4 are described in the specification. The compounds are useful...
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7179835 |
2-(3-sulfonylamino-2-oxopyrrolidin-1-yl)propanamides as factor xa inhibitors
The invention relates to compounds of formula (I) pharmaceutical compositions containing the same as well as methods of treating patients suffering from a condition susceptible to amelioration by a...
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7157482 |
Antibacterial 1,3-oxazolidin-2-one derivatives
Compounds of the formula (I), or a pharmaceutically-acceptable salts, or in-vivo-hydrolysable esters thereof, wherein: N—HET is for example triazolyl substituted with R 1 ; R 1 is for example...
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7151113 |
Pyrazole-amine compounds useful as kinase inhibitors
The present invention provides pyrazole derived compounds of formula (I)
useful for treating p38 kinase-associated conditions, where W, X, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 and m are as...
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7148069 |
Method for analysis of compounds with amino group and analytical reagent therefor
The present invention provides a method for the analysis of a compound with amino group (e.g., an amino acid or peptide) contained in a sample and convenient manner with a high sensitivity. The...
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7144910 |
Sulfonamides, sulfamates and sulfamides as gamma-secretase inhibitors
Compounds of formula I:
inhibit the processing of APP by gamma-secretase, and hence are useful in treating or preventing Alzheimer's disease.
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7138361 |
Herbicidal heterocycles
Compounds of Formula (1), their N-oxides and agriculturally suitable salts, are disclosed which are useful for controlling undesired vegetation
wherein
A, R 1 , R 2a , R 2b , W, Y, and Z...
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7132534 |
Para-phenylenediamine derivatives containing a pyrrolidyl group, and use of these derivatives for coloring keratin fibers
The invention relates to novel pyrrolidyl-substituted para-phenylenediamine derivatives, to dye compositions containing them and to the process for dyeing keratin fibers using these compositions. ...
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7125863 |
Inhibitors of dipeptidyl peptidase IV
Compounds according to formula (1), wherein R 1 is H or CN, X 1 is S, O, SO 2 or CH 2 , X 2 is CO, CH 2 or a covalent bond, Het is a nitrogen-containing heterocycle and n is 1–5 are new. The...
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7109228 |
Pyrazole derivatives
This invention relates to pyrazole derivatives of formula (I)
or pharmaceutically acceptable salts, solvates or derivatives thereof, and to processes for the preparation thereof, intermediates...
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