Patents in Class 548/356.1

Matches 1 - 47 out of 47

Match	Document	Document Title
1	7625938	Substituted pyrazoles, compositions containing such compounds and methods of use The present invention relates to substituted pyrazoles, compositions containing such compounds and methods of treatment. The compounds are glucagon receptor antagonists and thus are useful for...
2	7622491	Modulators of PPAR and methods of their preparation The present invention is directed to certain novel compounds represented by Formula (I) and pharmaceutically acceptable salts, solvates, hydrates and prodrugs thereof. The present invention is also...
3	7605266	Azaindole inhibitors of Aurora kinases The present invention relates to a compound represented by Formula (I): and pharmaceutically acceptable salts. Compounds of the present invention inhibit Aurora kinase, making them especially...
4	7598395	Heterocyclocarboxamide derivatives The invention relates to a fungicidally active compound of formula (I): where Het is a 5- or 6-membered heterocyclic ring containing one to three heteroatoms, each independently selected from...
5	7598389	Silylated carboxamides Novel silylated carboxamides of the formula (I) in which R, L, R 1 , R 3 , R 3 , R 4 and A are as defined in the description, a plurality of processes for preparing these compounds and their...
6	7595320	Hydrazinocarbonyl-thieno[2,3-C]pyrazoles, process for preparing them, compositions containing them and use thereof The present invention concerns hydrazinocarbonyl-thieno[2,3- c ]pyrazoles of formula (I): wherein R1, R3, R4, are R5 are as defined in the disclosure; their preparation method, compositions...
7	7592337	Di-aryl substituted tetrazole modulators of metabotropic glutamate receptor-5 Tetrazole compounds substituted directly, or by a bridge, with i) a heteroaryl moiety containing N adjacent to the point of connection of the heteroaryl and ii) another heteroaryl or aryl ring,...
8	7589116	Biaryl substituted pyrazoles as sodium channel blockers Biaryl substituted pyrazole compounds are sodium channel blockers useful for the treatment of pain and other conditions. Pharmaceutical compositions comprise an effective amount of the instant...
9	7582589	3-carbonylaminothiophenes and their use as fungicides The invention also relates to novel compounds of formula (1) where Het is a 5- or 6-membered heterocyclic ring containing one to three heteroatoms, each independently selected from oxygen, nitrogen...
10	7576087	Heterocyclyl-3-sulfonylazaindole or -azaindazole derivatives as 5-hydroxytryptamine-6 ligands The present invention provides a compound of formula I and the use thereof for the treatment of a central nervous system disorder related to or affected by the 5-HT6 receptor.
11	7572816	Therapeutic agents for the treatment of cancer, metabolic diseases and skin disorders The present invention is directed to compounds having the structure wherein R 1 , R 2 , R 3 , R 4 , R 5 and m are as defined herein. The compounds of this invention are novel therapeutic agents...
12	7557102	Pyrazolidine-1,2-dicarboxyldiphenylamide derivatives as coagulation factor Xa inhibitors for the treatment of thromboses Novel compounds of the formula (I), in which R, R 1 , R 2 and R 3 have the meanings indicated in Patent Claim 1 , are inhibitors of coagulation factor Xa and can be employed for the prophylaxis...
13	7553863	Ultrapure 4-methylpyrazole Disclosed is an ultrapure 4-methylpyrazole containing less than 0.1% pyrazole and containing less than 10 ppm each of hydrazine and nitrobenzaldehyde. The ultrapure 4-methylpyrazole is prepared by...
14	7538134	Substituted arylpyrazoles This invention relates to a range of 1-aryl-4-cyclopropylpyrazoles in which the cyclopropyl ring is substituted at the angular position, and pharmaceutically acceptable salts and solvates thereof,...
15	7534273	Cationic pyrazolone dyes, method for production thereof and coloring agents for keratin fibers containing said compounds The present application relates to cationic pyrazolone dyes of the general formula (I), and to coloring agents for keratin fibers comprising these dyes.
16	7531560	Anti-cytokine heterocyclic compounds Disclosed are compounds of formula (I) which inhibit production of cytokines involved in inflammatory processes and are thus useful for treating diseases and pathological conditions involving...
17	7528260	Method for preparing N-phenylpyrazole-1-carboxamides A method is disclosed for preparing compounds of Formula 1 by combining compounds of Formulae 2 and 3 and a sulfonyl chloride. Also disclosed are compounds of Formula 3, which are useful as...
18	7521554	A_2Badenosine receptor antagonists Disclosed are processes for the synthesis of novel compounds that are A 2B adenosine receptor antagonists, useful for treating various disease states, including asthma and diarrhea.
19	7521471	4-cyanopyrazole-3-carboxamide derivatives, preparation and application thereof The invention relates to 4-cyanopyrazole-3-carboxamide derivatives of formula (I): in which R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 are as described herein. Also disclosed and claimed...
20	7517900	Pyrazole derivatives as cannabinoid receptor modulators The present application describes compounds according to Formula I, wherein A, B, E, R 1 , R 2 , R 3 , R 4 , Y and Z are described herein. Additionally, the present application describes...
21	7514428	Pesticidal 1-aryl-3-amidoxime-pyrazole derivatives 1-Arylpyrazole-3-substituted-amidoxime derivatives of formula (Ia) or (Ib): or salts thereof, wherein the various symbols are as defined in the description, and pesticidal compositions thereof,...
22	7511069	Indazole compounds as β3 andrenoceptor agonist Compounds of the general formula (I): or a salt thereof, wherein R 1 is a hydrogen atom or the like; R 2 is NHSO 2 R 3 or the like; R 3 is a (C 1 -C 6 )alkyl group or the like; R 5 is a...
23	7507833	Therapeutic N-aryl or N-heteroaryl pyrazolidine and pyrazolidinone derivatives A compound having a structure and therapeutic methods, compositions, and medicaments related thereto are disclosed herein.
24	7507755	Inhibitors of cathepsin s The present invention provides compounds, compositions and methods for the selective inhibition of cathepsin S. In a preferred aspect, cathepsin S is selectively inhibited in the presence of at...
25	7504519	Derivatives of pyrazoline, procedure for obtaining them and use thereof as therapeutic agents The invention relates to derivatives of general formula (I), and to their pharmaceutically acceptable salts, their stereoisomeric forms, preferably their pure enantiomeric or diastereomeric forms...
26	7504518	Process for producing blocked isocyanate compound Disclosed is a process for producing a blocked isocyanate compound represented by general formula (III): wherein R 1 , R 2 , Q 1 , and Q 2 are as defined in the specification, characterized by...
27	7501449	2H -or 3H-benzo[e]indazol-1-yl carbamate derivatives, the preparation and therapeutic use thereof Compounds corresponding to the formula (I) as defined in the disclosure as well as methods for making such compounds, intermediates employed in such methods, pharmaceutical compositions...
28	7485660	Non-steroidal ligands for the glucocorticoid receptor, compositions and uses thereof The invention provides non-steroidal ligands for the glucocorticoid receptor, methods for making non-steroidal ligands of the glucocorticoid receptor, compositions of non-steroidal ligands of the...
29	7482375	Compounds useful in therapy Compounds of formula (I), or pharmaceutically acceptable derivatives thereof, wherein: R 1 represents H, C 1-6 -alkyl, C 1-6 alkyloxy, C 3-8 cycloalkyl, or halo; R 2 represents H, C...
30	7470717	Indazole derivatives The present invention provides a compound represented by Formula (I): [wherein R 1 represents CONR 1a R 1b (wherein R 1a and R 1b may be the same or different and each represents a hydrogen...
31	7468437	Phenyl pyrrolidine ether tachykinin receptor antagonists The present invention is directed to certain phenyl pyrrolidine ether compounds which are useful as neurokinin-1 (NK-1) receptor antagonists, and inhibitors of tachykinin and in particular...
32	7468371	Tricyclic pyrazole kinase inhibitors Compounds of the present invention are useful for inhibiting protein tyrosine kinases. Also disclosed are methods of making the compounds, compositions containing the compounds, and methods of...
33	7465805	Isoxazoline derivatives and their use as herbicides Compounds of formula: (I) wherein the substituents are as defined in claim 1 , are suitable for use as herbicides. Also claimed are processes for the preparation of the claimed compounds, a...
34	7449586	Processes for the preparation of CGRP-receptor antagonists and intermediates thereof The invention relates to novel processes for the preparation of small molecule antagonists of calcitonin gene-related peptide receptors (“CGRP-receptor”) and intermediates thereof.
35	7449488	Pyrazolopyrimidines as protein kinase inhibitors In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]pyrimidine compounds as inhibitors of protein and/or checkpoint kinases, methods of preparing such compounds,...
36	7446210	Factor Xa compounds The present invention is directed to novel compounds of Formula I: and forms and pharmaceutical compositions thereof, and the use thereof as inhibitors of Factor Xa.
37	7446121	Pyrazole-based HMG CoA reductase inhibitors Novel compounds and pharmaceutical compositions useful as hypocholesterolemic and hypolipidemic agents are described. More specifically, potent inhibitors of the enzyme...
38	7442799	Preparation and use of 2-substituted-5-oxo-3-pyrazolidinecarboxylates A method is disclosed for preparing a 2-substituted-5-oxo-3-pyrazolidinecarboxylate compound of Formula I. The method comprises contacting a succinic acid derivative of the formula R 1...
39	7439366	Phenacylamine derivatives, process for their production and pesticides containing them The present invention relates to a phenacylamine derivative of the formula (I) or a salt thereof: wherein A is alkyl, cycloalkyl, phenyl which may be substituted by Y, pyridyl which may be...
40	7432271	Pyrazolyl inhibitors of 15-lipoxygenase The present invention provides pyrazolyl inhibitors of 15-LO, pharmaceutical compositions containing such inhibitors and methods for treating diseases related to the 15-LO cascade using such...
41	7425572	Use of dioxindoindazoles and dioxoloindazoles for treating glaucoma Novel dioxinoindazole compounds and dioxoloindazole compounds are disclosed. Also disclosed are methods for the lowering and controlling of normal or elevated intraocular pressure as well as a...
42	7423159	Agent for preventing or treating neuropathy The present invention provides an agent for preventing or treating neuropathy having superior action and low toxicity. This agent comprises a compound represented by the formula: wherein ring A is...
43	7410995	N-linked sulfonamide of heterocyclic thioesters for vision and memory disorders This invention relates to pharmaceutical compositions and methods for treating a vision disorder, improving vision, treating memory impairment, or enhancing memory performance using N-linked...
44	7407981	Aminoindazole derivatives as medicaments and pharmaceutical compositions including them The present invention relates to the use of novel derivatives of general formula (I) in which R3 is a (1-6C)alkyl, aryl, aryl(1-6C)alkyl, heteroaryl, heteroaryl(1-6C)alkyl, aryl or heteroaryl...
45	7407977	Substituted N-acyl-2-aminothiazoles There are presented compounds of the formula or a pharmaceutically acceptable salt thereof, which are useful in the treatment of diabetes, diabetic retinopathy, asthma and diarrhea.
46	7396939	3-cyclopropyl-4-(3-amino-2-methylbenzoyl)pyrazoles and their use as herbicides What is described are 3-cyclopropyl-4-(3-amino-2-methylbenzoyl)pyrazoles of the formula (I) and their use as herbicides. In this formula (I), R 1 , R 2 , R 3 , R 4 and R 5 are various radicals.
47	7396850	Pyrazole derivative as PPAR modulator The present invention is directed to a compound, {2-Methyl-4-[3-methyl-1-(4-trifluoromethyl-phenyl)-1H-pyrazo l-4-ylmethylsulfanyl]-phenoxy}-acetic acid and pharmaceutical uses thereof.

Matches 1 - 47 out of 47