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8623942 Epoxy resin composition, curing agent, and curing accelerator  
The present invention provides a liquid curable epoxy resin composition that has excellent storage stability and curing properties and provides a cured product having excellent properties,...
8383829 Electrochromic compound, electrode, and display element  
An electrochromic compound represented by Formula (1), wherein R1 is an alkyl group, an alkenyl group, an aryl group, or a heterocyclic group; R2 and R3 are each a hydrogen atom or a substituent; X...
7915426 Imidazolium salts and their use of these ionic liquids as a solvent  
New 1,2,3- or 1,2,3,4- or 1,2,3,4,5- substituted imidazolium salts and their uses as solvent in catalyzed organic reactions, as well as compositions containing them and a transition metal compound....
7750032 Compounds and compositions as PPAR modulators  
The invention provides trisubstituted pyrazoles and imidazoles of Formula I: wherein L2, q, R13, R14, R15, R16, Z1 and Z2 are as described in the Summary of the Invention; and methods of using such...
7026357 Diphenylurea compounds  
Compound of formula (I): and medicinal products containing the same are useful as dual α2/5-HT2c antagonist receptors.
6528535 Bicyclic inhibitors of protein farnesyl transferase  
The present invention provide compounds of Formula I The present invention also provides a method of treating cancer and treating or preventing restenosis or atherosclerosis. Also provided by the...
6524770 Hexaaryl biimidazole compounds as photoinitiators, photosensitive composition and method of manufacturing patterns using the compounds  
A hexaaryl biimidazole compound useful as a photoinitiator, represented by Formula (I): wherein each R group represents an alkyl group which may be the same or different, and each X group is...
6426360 4,5-substituted imidazolyl compounds for the treatment of inflammation  
A class of compounds is described for treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula wherein R1 is selected from lower alkyl,...
6407258 Method for producing S-alkyl(aryl)-substituted imidazol derivatives  
The invention relates to a process for the preparation of compounds of the formula (I) in which R(2) and R(3) independently of one another are —SR(4) or —COOR(5) and R(1), R(4) and R(5) have the...
6395724 Multibinding inhibitors of cyclooxygenase-2  
Disclosed are multibinding compounds which inhibit cyclooxygenase-2 (COX-2), an enzyme which catalyzes the first committed step in the biosynthesis of prostaglandins. The multibinding compounds of...
6201001 Imidazole antiproliferative agents  
Compounds of formula I ##STR1##inhibit celluar proliferation. Processes for the preparation of the compounds, pharmaceutical compositions containing the compounds, and methods of treatment using...
6153757 Metalloproteinase inhibitors and intermediates useful for their preparation  
The invention relates to compounds of formula (1) ##STR1## wherein: Z is O or S; V is a divalent radical which together with C* and N forms a ring having six ring atoms, where each of said ring...
6103749 Aryl imidazole compounds having phosphodiesterase IV inhibitory activity  
Novel compounds which are effective PDE IV inhibitors are disclosed. These compounds have the general structure of: ##STR1## where R1, R2, R3, R4, X1, X2 and Z are described herein. The compounds...
6060603 Synthetic antagonists based on angiotensin  
Disclosed are methods for modelling the three-dimensional structure (tertiary structure) of a ligand having one or more active sites employing a charge-transfer interaction. Also disclosed is a...
5977377 Process for producing N-alkylimidazole  
Disclosed is a process for producing an N-alkylimidazole which comprises reacting an imidazole with an N-alkylating agent in an organic solvent in the presence of alkali particles having a specific...
5929249 Substituted imidazolyl-alkyethio-aldanoic acids  
Angiotensin II receptor antagonists having the formula: ##STR1## which are useful in regulating hypertension and in the treatment of congestive heart failure, renal failure, and glaucoma,...
5922751 Aryl pyrazole compound for inhibiting phosphodiesterase IV and methods of using same  
Novel compounds which are effective PDE IV inhibitors are disclosed The compounds possess similar or improved PDE IV inhibition as compared to rolipram, with improved selectivity with regard to,...
5905152 Preparation of aminomethyl-phenylimidazoles  
Aminomethyl-phenylimidazoles are produced by reaction of an ester of a hydroxymethyl-phenylimidazole with an amine. A particularly preferred ester is the acetate ester. The...
5877196 N- 4-(imidazolyl or pyrazolyl)phenyl(oxy, sulfinyl, sulfenyl or sulfonyl)alkyl!carboxamides, sulfonamides or phosphoramides having antiarrhythmic properties  
The present invention relates to substituted ω- phenoxy, phenylthio, phenylsulfinyl, phenylsulfonyl! alkyl, alkenyl or alkynyl!amine carboxamides, sulfonamides and phosphonylamides which are ...
5807878 Tetrasubstituted imidazoles  
A compound of the formula ##STR1## wherein the substituents are defined in the specification useful for the treatment of cardiovascular disorders.
5741794 Heterocyclic sulfonamide derivatives as antagonists of PAF and angiotensin II  
Compounds of formula (I), wherein: A represents: a) a --VR6 group wherein v is --C(O), --C(O)O--, --CH2 O--, --CH2 OC(O)--, --C(S)--, --CH2 OC(O)NH--, --C(S)O--, --CH2 S--, --C(O)NHSO...
5728842 Substituted imidazolyl-alkylthio-alkanoic acids  
Angiotensin II receptor antagonists having the formula: ##STR1## which are useful in regulating hypertension and in the treatment of congestive heart failure, renal failure, and glaucoma,...
5721265 Fluorinated 2-nitroimidazole analogs for detecting hypoxic tumor cells  
Agents useful for detecting hypoxic tumor cells are provided. The compounds have the structural formula (I) ##STR1## Methods of using the compounds to detect hypoxic tumor cells are also provided,...
5646293 Preparation of N-alkenylazoles  
A process for preparing N-alkenylazoles of the general formula I ##STR1## where X is CH--R6 or nitrogen, R1 and R2 are hydrogen or C1 - to C8 -alkyl, R3,R4,R5 and R6 are hydrogen, C1 - to C40...
5620944 Phenylimidazole derivatives, herbicides comprising said derivatives, and usages of said herbicides  
The present invention discloses phenylimidazole derivatives having herbicidal activities, represented by general formula (I) ##STR1## (R1 and R2 each represent an alkyl group or the like; R3...
5620999 Benzenesulfonamide subtituted imidazolyl compounds for the treatment of inflammation  
A class of imidazolyl compounds is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula II ##STR1## wherein R1 is...
5616601 1,2-aryl and heteroaryl substituted imidazolyl compounds for the treatment of inflammation  
A class of imidazolyl compounds is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula I: ##STR1## wherein R1 -R6...
5514811 Process for synthesizing 4-halo-5-(hydroxymethyl) imidazole compounds  
A process for preparing, on an industrial scale, 4-halo-5-(hydroxymethyl) imidazole compounds that are useful as intermediates for medicines. A 4-chloro-5-(hydroxymethyl) imidazole compound, a...
5482957 Azole derivatives, process for their preparation and their use  
Azole derivatives, process for their preparation, and their useAzole derivatives of the formula (I) ##STR1## in which A, L, O, R1, X, Y, Z and q have the meanings given, process for their...
5462958 Benzene derivatives and method of treating arteriosclerosis with benzene derivatives  
The present invention provides a novel benzene derivative useful as a preventive and medically treating medicine for arteriosclerosis, and a cholesterol O-acyl transferase inhibitor comprising the...
5395932 2,3-,4-,5-,6-,7-,8-,9- and/or 10-substituted dibenzoxazepine compounds, pharmaceutical compositions and methods of use  
The present invention provides substituted dibenzoxazepine compounds of Formula I: ##STR1## wherein X is oxygen, sulfur ##STR2## A is --CH2 -- or ##STR3## E and F may be --CH, oxygen, nitrogen or...
5364944 Substituted benzoylbenzene-, biphenyl- and 2-oxazole- alkanoic acid compounds  
There are disclosed substituted benzoylbenzene-, biphenyl- and 2-oxazole- alkanoic acid derivatives and the pharmacologically acceptable salts thereof as inhibitors of PLA2 and lipoxygenase, and...
5338749 Diaryl-substituted heterocyclic compounds, their preparation and drigs and cosmetics obtained therefrom  
Compounds of formula I ##STR1## and compounds of formula Ia ##STR2## where the substituents are as defined in the specification.
5312828 Substituted imidazoles having angiotensin II receptor blocking activity  
Angiotensin II receptor antagonists having the formula: ##STR1## which are useful in regulating hypertension and in the treatment of congestive heart failure, renal failure, and glaucoma,...
5312927 Preparation of imidazoles  
The present invention relates to preparation of imidazoles which are useful as pharmaceutical and agricultural chemicals. Specifically, the present invention relates to a process for preparing...
5260278 Diol-containing renin inhibitors  
The invention concerns novel renin-inhibitory peptides which are useful for treating renin-associated hypertension, congestive heart failure, hyperaldosteronism, and diseases caused by retroviruses...
5254546 Fused aryl substituted imidazole angiotensin II receptor inhibitors  
Substituted imidazoles such as ##STR1## which are useful as angiotensin II receptor inhibitors. These compounds have activity in treating hypertension and congestive heart failure.
5204352 Compounds exhibiting anti-parasitic activity and a method for their use  
Novel compounds are provided which exhibit high levels of anti-parasitic activity, specifically against parasites of the genus Trypanosoma. The compounds are comprised of aryl-substituted...
5190942 Benzoxazole and related heterocyclic substituted imidazole and benzimidazole derivatives  
Novel compounds are disclosed having the formula ##STR1## wherein X, Y, R1, R2, R3, R4, and R5 are as defined herein. These compounds inhibit the action of angiotensin II and are useful, therefore,...
5191086 Imidazole and benzimidazole derivatives  
Novel angiotensin-II receptor antagonists are disclosed having the general formula ##STR1## wherein R1, R2, R3, R4, R5, W and X are as defined herein.
5180732 4-tert.-butyl imidazole derivative and use  
A novel 4-tert.-butylimidazole derivative having the formula: ##STR1## wherein R1 is a hydrogen atom, a C1 -C3 alkyl group, a C1 -C3 alkylthio group or a C2 -C3 alkoxyalkyl group; R2 is a halogen...
5179210 Preparation of N-substituted imidazoles  
A process for preparing N-substituted imidazoles of the formula I ##STR1## where R1 is C1 -C20 -alkyl, C2 -C20 -alkenyl, C2 -C20 -alkynyl, C2 -C20 -alkoxyalkyl, C3 -C20 -alkenyloxyalkyl, C3 -C12...
5179117 Antihypercholesterolemic 2-substituted imidazoles  
The compounds of the described invention are potent ACAT inhibitors and are useful in pharmaceutical compositions for the treatment of atherosclerosis and have the formulas: ##STR1## when Q is a...
5159085 2-anilino phenylacetic acid derivatives as inhibitors of PLA2 and lipoxygenase  
There are disclosed compounds of the formula ##STR1## wherein R is hydroxy, lower alkoxy or lower alkoxyamino; R1 is hydrogen or A(CH2)n O--; R2 is hydrogen or A(CH2)n O--, with the proviso that...
5116860 N-substituted azoles for combating insects, arachnids and nematodes  
N-substituted azoles of the formula I ##STR1## where R1, R2, R3 are each hydrogen, halogen, C1 -C8 -alkyl, C1 -C8 -alkoxy, C1 -C4 -haloalkyl, C1 -C4 -haloalkoxy, C3 -C10 -cycloalkyl, nitro or...
5089514 3-coxazolyl [phenyl, chromanyl or benzofuranyl]-2-hydroxypropionic acid derivatives and analogs as hypoglycemic agents  
Certain 3-(phenyl, chroman-2-yl, benzofuran-5-yl, or benzoxazol-5-yl)-2-(hydroxy or mercapto)propionic acid derivatives and analogs are useful as hypoglycemic and hypocholesterolemic agents.
5084465 Antifungal carbinols  
Antifungal carbinols, particularly α-styryl carbinols, and the corresponding epoxy carbinols are provided. These carbinol compounds have the formula: ##STR1## or a pharmaceutically or ...
5011851 Imidazole carboxylic acids and esters and inhibition of blood platelet aggregation therewith  
Heterocyclic acids and esters useful as inhibitors of mammalian blood platelet aggregation characterized by Formula I or II are disclosed. HET1 --(CH2)n CO2 R (I) ##STR1## Formula I compounds are...
4987133 Salicylic acid derivatives  
New salicylic acid derivatives of the general formula I ##STR1## in which R1 is H or CH3, R2 is 4-(4-methyl-2-thiazolyl)-piperazino, 4-(tetrahydro-2-furoyl)-piperazino,...
4943585 N-substituted azoles and insecticide, arachnicide, and nematocide compositions thereof  
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