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7625935 |
High purity butoconazole nitrate with specified particle size and a process for the preparation thereof
One object of the invention is high purity butoconazole nitrate of the formula (I) (I) containing maximum 0.1 wt % of chemical impurities, wherein at least 95% of the particles of the substance are...
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7560475 |
Phenylacetic acid derivative, process for producing the same, and use
The present invention relates to the compound represented by formula (I)
(wherein R 1 and R 2 is hydrogen atom, C1-8 alkyl etc.; R 3 is C1-8 alkyl which may be substituted with 1 to 3...
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7550497 |
Phosphoramide derivatives
New phosphoramide derivatives of formula (I) and the salts and solvates thereof, wherein the meanings of the various substituents are as disclosed in the description. Said compounds are useful as...
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7521461 |
Benzoic acid derivatives as modulators of PPAR alpha and gamma
A compound of formula (I) wherein R 1 represents aryl optionally substituted by a heterocyclic group or a heterocyclic group optionally substituted by aryl wherein each aryl or heterocyclic group...
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7517999 |
Imidazolium compound
A novel imidazolium compound represented by the following general formula (I),
which has an allyl group incorporated in the 3-position of the imidazolium ring. It needs no complicated...
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7511149 |
Process for the oxidation of certain substituted sulfilimines to insecticidal sulfoximines
Insecticidal sulfoximines are produced efficiently and in high yield by the oxidation of the corresponding sulfilimine with ruthenium tetraoxide or an alkali metal permanganate.
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RE40558 |
Therapeutic uses of di-aryl acid derivatives
The use of diaryl acid derivatives of formula (I)
or pharmaceutically acceptable salts, N-oxides, hydrates or solvates thereof, wherein the variables shown are defined in the disclosure, and...
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7300639 |
Process for removing metals from liquids
A process is provided for removing one or more metals from liquids. Also provided is a process for the synthesis of aP2 inhibiting compounds having the formula (I)
wherein R 1 , R 2 , R 3 , R 4...
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7297794 |
Phenoxy amine compounds and compositions for delivering active agents
Phenoxy amine compounds and compositions for the delivery of active agents are provided. Methods of administration and preparation are provided as well.
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7238212 |
Imidazole compounds and use of these compounds for dyeing keratinous fibers
The disclosure relates to novel imidazole compounds which can be useful as couplers for the oxidation dyeing of keratinous fibers. The present disclosure also relates to a dyeing composition for...
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7179925 |
Method for reducing organic compounds in microreactor by means of hydrides and/or the derivatives thereof
The present invention relates to a process for the reduction of aliphatic, aromatic or heterocyclic organic compounds by means of hydrides and/or derivatives thereof.
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7164029 |
Process for the preparation of benzylimidazole derivatives
A process for the preparation of benzylimidazole derivatives useful as intermediates for preparation of losartan, novel intermediates for their preparation and a process for the preparation of...
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7074867 |
Ion conducting polymers
A compound having the general formula (I):
− O 3 S—R 1 —V 1 —R 2 —V 2
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6979696 |
Method for detecting a gram-negative bacterial autoinducer molecule
This invention relates to compounds which are alpha-1 receptor agonists, preferably alpha-1A/L receptor agonists, and which are represented by Formula I:
wherein m, A, X, Y, R 1 , R 2 , R 3 ,...
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6951948 |
Method for synthesis of substituted azole libraries
The invention relates to methods of synthesizing libraries of diverse and complex 2-substituted azole compounds of the general formula (I) or (II)
wherein X, R 2 and the ring components
...
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6949578 |
Cycloalkyl alkanoic acids as integrin receptor antagonists
The present invention relates to a class of compounds represented by the Formula I
or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the...
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6943183 |
5-substituted tetralones as inhibitors of ras farnesyl transferase
The present invention provides novel 5-substituted tetralones of Formulas I, II, III, and IV and pharmaceutically acceptable salts, esters, amides, and prodrugs thereof, which are useful for...
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6933391 |
Methods of synthesizing heteroatom-bearing ligands and intermediate used therefor
The invention provides improved and simplified methods of synthesizing ligands containing a heteroatom-bearing bridge using a novel intermediate compound. The ligands may be used to form metal...
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6927227 |
Heterocyclic containing biphenyl aP2 inhibitors and method
aP2 inhibiting compounds are provided having the formula
wherein R 1 , R 2 , R 3 , R 4 , X—Z and
are as described herein.
A method is also provided for treating diabetes and related...
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6887871 |
Use of phenylheteroakylamine derivatives
There is disclosed the use of a compound of formula (I) wherein R 1 , R 2 , X, Y, V, W and Z are as defined in the specification, and pharmaceutically acceptable salts, enantiomers or racemates...
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6884821 |
Carboxylic acid derivatives and drugs containing the same
Novel carboxylic acid derivatives of general formula (I), salts of the same, esters thereof, or hydrates of them, which are useful as insulin resistance improvers; and drugs containing the...
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6737434 |
Imidazole derivatives or their salts
Imidazole derivatives of the formula (1) or salts thereof, pharmaceuticals containing the derivatives or the salts, and intermediates for the synthesis of the derivatives or the salts (wherein R 1 ...
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6706888 |
Processes for preparing imidazole derivatives and salts thereof
The present invention provides a process for preparing an imidazole derivative or its salt which comprises reacting a tetrahydrofuran or tetrahydropyran derivative with formamidine or its salt in...
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6649643 |
Imidazol-4-ylmehanols and their use as inhibitors of steroid C17-20 lyase
Imidazol-4-ylmethanols and their uses for preventing and treating primary tumors, metastasis and recurrence of tumors, various symptoms accompanying tumors, prostatic hypertrophy, virilism,...
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6630593 |
Process for preparing a 1-substituted 5-hydroxymethyl imidazole
A process for preparing a 1-substituted 5-hydroxymethylimidazole of the formula: , wherein R represents alkyl, hydroxyalkyl, allyl, or substituted or unsubstituted arylmethyl or diarylmethyl,...
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6545163 |
Process to prepare 1-aryl-2-(1-imidazolyl) alkyl ethers and thioethers
A process is disclosed for the preparation of imidazole derivatives, in particular, 1-aryl-2-(1-imidazolyl) alkyl ethers and thioethers, and more particular for the preparation of tioconazole. The...
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6518257 |
1-substituted phenyl-1-(1h-imidazol-4-yl) alcohols, process for producing the same and use thereof
To provide a composition having a steroid C 17,20 -lyase inhibitory activity and useful as an agent for the prophylaxis or treatment of prostatism and tumors such as breast cancer. A compound...
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6515133 |
Pharmaceutical compositions containing certain diarylimidazole derivatives
Certain diaryl imidazoles act as partial agonists or antagonists for NPY receptors, in particular NPY 5 receptors. They are of use, for example in treating loss of appetite. Such compounds bear...
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6486156 |
Chemical compounds
This invention relates to compounds of formula (1), wherein substituents are defined in the description, that inhibit farnesylation of mutant ras gene products tough inhibition of the enzyme...
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6479530 |
Imidazole derivatives having affinity for α2 receptors
Imidazole derivatives of formula I wherein n is 0 or 1, R 1 is hydrogen or C 1 -C 4 -alkyl, R 2 is hydrogen or R 2 and R 3 together form a double bond, R 3 is hydrogen or C 1 -C 4 -alkyl or...
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6426360 |
4,5-substituted imidazolyl compounds for the treatment of inflammation
A class of compounds is described for treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula wherein R 1 is selected from lower alkyl,...
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6362373 |
Chiral amino alcohols and process for preparation of same
The disclosed invention comprises a compound having the formula: in which R 1 and R 2 independently represent a hydrogen or an alkyl group of 4 carbon atoms or greater. Further disclosed is a...
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6362211 |
Polycyclic indanylimidazoles with alpha2 adrenergic activity
A compound of formula I wherein R 1 to R 3 , —A—, m and t are as defined in claim 1 , or a pharmaceutically acceptable salt or ester thereof, useful as an alpha2 adrenergic agent.
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6348482 |
Catechols as antimicrobial agents
Compounds, pharmaceutically acceptable salts, and compositions thereof of the general formula: wherein Ar is aryl and heteroaryl; R 1 , R 2 , R 3 , and R 4 are hydrido, alkyl, cyano,...
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6329371 |
α-substrates benzyl heterocyclic derivatives, intermediates for producing the same and agrochemical composition containing the same as active ingredient
A compound represented by the formula (I): ##STR1## wherein R 1 is an optionally substituted heterocyclic group; R 2 is optionally substituted aryl or heterocyclic group; R 3 is hydrogen, alkyl,...
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6288071 |
1-ethylene-2-alkylene-1,4-cyclohexadiene pesticides
Pesticidally active cyclohexadienyl derivative compounds of the formula I that are esters, oximes or amides are claimed. These compounds may be used as fungicides, acaricides and insecticides in...
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6265428 |
Substituted phenyl compounds and derivatives thereof that modulate the activity of endothelin
Methods, compositions, and compounds for modulating the activity of an endothelin peptide are provided. The methods use compositions that contain compounds of formula (1): ##STR1## where X and Y...
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6201001 |
Imidazole antiproliferative agents
Compounds of formula I ##STR1## inhibit celluar proliferation. Processes for the preparation of the compounds, pharmaceutical compositions containing the compounds, and methods of treatment using...
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6201123 |
Catalyst composition, catalyst solution and process for preparing optically active epoxide
A catalyst composition for organic a symmetric synthesis is provided, which comprises: (A) a lanthanoid element ion; (B) a binaphthol, and (C) a nitrogen and/or phosphorus compound such as...
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6177575 |
Process for manufacture of imidazoles
Imidazoles may be manufactured by reacting a glyoxal, ammonia, an aldehyde, and optionally a primary amine, in the presence of a Bronsted acid whose pKa is approximately equal to the pKa of the...
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6140508 |
Process for making 1,5-disubstituted imidazoles
The present invention is directed to a process for synthesizing 1,5-disubstituted imidazoles, which are useful in the preparation of farnesyl-protein transferase inhibitors.
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6136837 |
α-substituted benzyl heterocyclic derivatives, intermediates for producing the same and agrochemical composition containing the same as active ingredient
A compound represented by the formula (I): wherein R 1 is an optionally substituted heterocyclic group; R 2 is optionally substituted aryl or heterocyclic group; R 3 is hydrogen, alkyl, alkenyl,...
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6107490 |
Process for the manufacture of 4-methyl-5-hydroxymethyl-imidazole
A process is provided for the manufacture of 4-lower-alkyl-5-hydroxymethyl-imidazole comprising reacting (4)-lower-alkyl imidazole with formaldehyde in an alkanol solvent having from 2 to 5 carbon...
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6103909 |
Azole compounds endowed with antimycotic activity for human and veterinary use
Compounds of formula ##STR1## wherein R 1 is chloro, fluoro, bromo or trifluoromethyl; R 2 is hydrogen, chloro , fluoro, bromo or trifluoromethyl; Z is CH or N; R 3 , R 4 and R 5 ,...
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6054591 |
Lymph-absorbable aryl substituted imidazole derivatives
A compound of the formula (I): ##STR1## salt thereof, or hydrate thereof which can effectively be absorbed from the lymph vessel in the intestinal tract and transferred to the lymph node in a high...
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6048984 |
Intermediates to herbicidal 2-benzoylcyclohexane-1,3-diones and related compounds
The invention relates to compounds of formula (I): and to their use as herbicides, and to intermediates useful in their preparation.
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6034251 |
Phenyl-alkyl-imidazoles
Disclosed are novel phenyl-alkyl-imidazoles of the formula ##STR1## wherein R 1 , R 7 , m, n, p, q, X, Y, Z, R and R 15 are as defined in the specification. Also disclosed are pharmaceutical...
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6008240 |
2-(1H-4(5)-imidazoyl) cyclopropyl derivatives
The present invention provides compounds having H 3 histamine receptor antagonist activity of the general formula: ##STR1## R 2 is a hydrogen or a methyl or ethyl group; R 3 is a hydrogen or a...
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6004903 |
2-Anylocyclohexanediones having improved herbicidal properties
Benzoyl derivatives of the formula I ##STR1## where Z is a 5-membered or 6-membered heterocyclic, saturated or unsaturated radical containing one to three hetero atoms selected from the group...
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5977376 |
Herbicidal 2-benzoylcyclohexane-1,3-diones and related compounds
The invention relates to compounds of formula (I): ##STR1## and to their use as herbicides.
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