Matches 1 - 50 out of 138 1 2 3 >
Match Document Document Title
7259263 Method of synthesis of azole-containing amino acids  
The invention relates to methods of synthesizing 2-substituted azole compunds of formula (I): The invention is also relates to compounds of formula (I) and to intermediate compounds in the...
7045532 ACE-2 modulating compounds and methods of use thereof  
ACE-2 inhibitors for the treatment of body weight and related disorders are disclosed. ACE-2 inhibitors include peptides and small molecules. Examples of small molecule ACE-2 inhibitors include...
6949658 Process for producing optically active α-amino acid and optically active α-amino acid amide  
The present invention provides a process for efficiently producing an optically active α-amino acid and an optically active α-amino acid amide. After contacting with cells or processed cells...
6878829 Method for producing β-alaninamides  
β-alaninamides of the general formula Wherein R 1 is hydrogen or C 1-6 alkyl which is unsubstituted or substituted with hyroxy, amino, carboxy, carbamoyl, methylmercapto, guanidino,...
6730693 Double salts of fumaric acid with a carnitine and an amino acid and food supplements, dietary supplements and drugs containing same  
Double fumarates of L-carnitine or isovaleryl L-carnitine and an amino acid having formula (I) are disclosed which are useful as active ingredients of food supplements, dietary supplements or...
6673942 Resolution of DL-racemic mixtures  
The present invention relates to a process for the resolution of DL-racemic mixtures of compounds which crystalize in the form of a conglumerate. Both, the D and L-enantiomers are obtained...
6632830 ACE-2 inhibiting compounds and methods of use thereof  
ACE-2 inhibiting compounds are disclosed. These compounds include compounds of formula (IV): wherein the variables are as described in the specification. Pharmaceutical compositions containing...
6350907 Matrix metalloprotease inhibitors  
Compounds of formula (I): or pharmaceutically acceptable salts thereof, or solvates of either entity, wherein the substituents have the values described herein, are useful as matrix...
6316656 Process for making optically active alpha-amino ketones and selected novel optically active alpha-amino ketones  
The invention includes selected novel optically active α-ketones which either are themselves useful or are intermediates for the preparation of known ketomethylene pseudopeptides useful as...
RE37303 Imidazole compounds and their therapeutic applications  
A compound selected from the group consisting of a compound of the formula ##STR1## wherein the substituents are defined as in the specification having antagonist properties to histamine H 3 ...
6265382 Dipeptide inhibitors of protein farnesyltransferase  
6194184 Compounds labeled with cyanate or thiocyanate metal complexes for detection by infrared spectroscopy  
A labeled compound detectable by IR spectroscopy contains at least one histidine residue bound to a cyanate or thiocyanate metal complex that has an IR absorption band within the spectral region of...
6180116 Histidine derivatives, preparation process and uses  
Histidine derivatives and processes of preparing the histidine derivatives. The histidine derivatives can be used to combat free radicals. The histidine derivatives may be used in cosmetic and/or...
5981564 Water-soluble derivatives of paclitaxel, method for producing same and uses thereof  
The invention relates to new paclitaxel derivatives showing an increased solubility in water. More particularly, the invention relates to glutarylpaclitaxel, glutarylpaclitaxel 6-aminohexanol...
5981761 Crosslinked polyaspartate salts a process for their production  
A first embodiment comprises reacting PSI with polyhydrazide selected from the group consisting of dihydrazides and trihydrazides and mixtures thereof, subsequently hydrolyzing the crosslinked PSI...
5962722 α-hydrazino acid derivatives and method for making same  
An α-hydrazino acid derivative of general formula (I) is described, wherein R 1 , R 2 , R 3 are hydrogen or a carbon radical, such that when R 2 and R 3 are different, C* is an asymmetric...
5916915 Water-in-stable L-ascorbic acid derivative and a method for preparation thereof, and a skin-whitening cosmetic composition containing the same  
Disclosed herein are a L-ascorbic acid derivative having an improved water-in-stability, represented by a following general formula (I): ##STR1## and a method for preparation thereof, and to a...
5811446 Prophylactic and therapeutic methods for ocular degenerative diseases and inflammations and histidine compositions therefor  
The present invention relates to methods for protecting the eye from degenerative eye conditions by administering prophylactic histidine compositions. The invention also relates to methods for...
5770739 Non-aqueous hydrogen peroxide complex  
An apparatus and process for hydrogen peroxide vapor sterilization of medical instruments and similar devices make use of hydrogen peroxide vapor released from a substantially non-aqueous organic...
5763657 Phosphoric acid-amino acid-polyvalent metal composite salt and ruminant feed additive composition  
The present specification discloses a ruminant feed additive composition which contains as an active ingredient a phosphoric acid-amino acid-polyvalent metal composite salt (final composite salt)...
5741807 Histidine compositions and methods for treating or preventing infectious and non-infectious diarrheas  
A method of preventing or reducing fluid and electrolyte losses in mammalian subjects under the effect of a stimulus that directly or indirectly causes such losses, by administering a...
5741794 Heterocyclic sulfonamide derivatives as antagonists of PAF and angiotensin II  
Compounds of formula (I), wherein: A represents: a) a --VR 6 group wherein v is --C(O), --C(O)O--, --CH 2 O--, --CH 2 OC(O)--, --C(S)--, --CH 2 OC(O)NH--, --C(S)O--, --CH 2 ...
5708171 Imidazole derivatives for pharmaceutical use  
A compound selected from the group consisting of a compound of the formula ##STR1## having antagonist properties to histamine H 3 -receptors.
5688946 Amino acid derivatives having renin inhibiting activity  
The compounds of the formula ##STR1## in the form of optically pure diastereomers, mixtures of diastereomers, diastereomeric racemates or mixtures of diastereomeric racemates as well as...
5679852 Process for the production of DTPA-monoamides of the central carboxylic acid and their use as pharmaceutical agents  
A process for the production of of general formula I diethylenetriaminepentacarboxylic acid monoamide derivatives ##STR1## in which E 1 , E 2 and Z have varying meanings.
5659065 Alpha-aminoalkanoic acids and reduction products  
Compounds of formula I ##STR1## wherein R 1 is an aliphatic, cycloaliphatic, cycloaliphatic-aliphatic, aromatic or heteroaromatic radical, a hydroxy group that is aliphatically, araliphatically or...
5631031 Water-insoluble amino acid salt  
Disclosed are water-insoluble, calcium or magnesium salts of alpha amino acids and a process for their preparation. The process comprises the steps of reacting an alpha-amino-protected alkyl ester...
5585498 Imidazole derivatives useful as synthetic intermediates  
Compounds of formula (I) ##STR1## wherein R 1 represents either a hydrogen atom, or a (C 1 -C 4 )alkyl group, X represents either a sulphur atom, an oxygen atom or a methylene group, Z 1 ...
5536815 Cyclopropyl based O- and N- and S-protecting groups  
The present invention is directed to the use of a cyclopropylmethyl derivative as a protecting group for compounds containing an amino group, carboxy group, amido group, mercapto group or hydroxy...
5514781 Use of azoles as virucidal agents in solutions of biologically active proteins  
Soluble azoles in aqueous solutions can be used as virucidal agents for biologically active protein preparations.
5506362 Process for the preparation of an α-amino acid amide  
An α-amino acid amide is prepared by reaction of an N α -aryloxycarbonylamino acid with a compound containing a free amino group. This process makes it possible readily to prepare peptides, by...
5496955 Preparation of D-histidine and derivatives thereof from L-histidine  
D-histidine and its derivatives are manufactured from L-histidine, by mixing L-histidine and tartaric acid with an aldehyde in acetic acid medium and thereafter precipitating D-histidine tartrate...
5399707 Selective precipitation of α-aryl carboxylic acid salts  
A process is provided whereby S(+)-ibuprofen or R(-)-ibuprofen L-lysinate salt is produced by selective precipitation from a mixture containing enantiomers of ibuprofen and L-lysine. The quantity...
5371234 Ion specific chelating agents derived from β-hydroxyhistidine, 4-(1-hydroxy-1-alkyl)imidazole and derivatives thereof  
β-hydroxyhistidine, 4-(1-hydroxy-1-alkyl)imidazole or derivatives thereof can be used as a bidentate ligand in the chelation of iron(III), Al(III), Cr(III), Ga(III) and the actinides(IV), such as...
5359128 Malic acid derivatives and compositions for the treatment of psoriasis  
The invention comprises compositions and methods for the treatment of psoriasis. The compositions comprise compounds of the formula: ##STR1##
5332834 Racemization of an enantomerically enriched α-aryl carboxylic acid  
There is disclosed and claimed a process whereby S(+)-ibuprofen L-lysinate salt is produced by selective precipitation from a mixture containing enantiomers of ibuprofen and L-lysine. The quantity...
5276147 Compounds and complexes useful in medical imaging  
The subject of the present invention is compounds which correspond to the following general formula: ##STR1## in which R 1 and R 3 independently of one another represent H, an alkyl, alkenyl,...
5179117 Antihypercholesterolemic 2-substituted imidazoles  
The compounds of the described invention are potent ACAT inhibitors and are useful in pharmaceutical compositions for the treatment of atherosclerosis and have the formulas: ##STR1## when Q is a...
5153358 Process for the preparation of alpha-alkylated alpha-amino acids and alpha-halogenated alpha-amino acids  
A novel process for the preparation of α-alkylated α-amino acids and α-halogenated α-amino acids is disclosed. These α-alkylated α-amino acids and α-halogenated α-amino acids are useful as...
5149692 Bisalkoxyphosphinyl compounds as renin inhibitors  
The invention concerns novel renin-inhibitory peptides which are useful for treating renin-associated hypertension, congestive heart failure, hyperaldosteronism, glaucoma, and diseases caused by...
5110799 Antiherpetic agents  
A series of carboxyl-containing N-alkyldipeptides have been found to posess antiviral potency--specifically against herpes simplex virus--by selectively inhibiting the viral ribonucleotide...
5110797 Peptide compound and a pharmaceutically acceptable salt thereof  
Peptide compounds of formula (I): ##STR1## wherein A is hydrogen or an amino-protecting group; X is a member selected from the group consisting of Gly, Glu, Tyr, Asp, Phe, Ile, Ala, Pro, Leu, Hyp,...
5072041 Optically active N-hydroxy-alpha-amino acids, amides and their derivatives  
The invention relates to new pure D- or L-N-hydroxy-alpha-amino acids and the derivatives thereof, including optically active N-hydroxy-phenylglycine amide, which has antibiotic and antitumor...
5063208 Peptidyl aminodiol renin inhibitors  
A renin inhibiting compound having an aminodiol functional group is useful for treating hypertension, congestive heart failure and glaucoma and inhibits retroviral protease.
5055588 Process for preparing N-substituted amino acid esters  
A process for preparing N-substituted amino acid esters having the formula (I): ##STR1## wherein R 1 and R 4 , the same or different, are an alkyl, aralkyl, cycloalkyl or aryl group; and R 2 and...
5041644 Peptide derivatives of β-chloro-L(Z)-dehydro-glutamic acid  
New peptide derivatives β-chloro-L-(Z)-dehydroglutamic acid are described which display antibacterial activity.
5039664 Renin inhibitors containing phenylalanyl-histidine replacements  
Peptides of the formula: ##STR1## which comprise novel elements replacing the Phe(8)-His(9) sequence in renin-inhibitory peptides based on substrate analogy, which inhibit the substrate-cleaving...
5034539 Histamine derivative, process for preparing it and its therapeutic use  
The present invention relates to α,β-dimethylhistamine, of the rmula: ##STR1## in racemic form, or an optical isomer form or mixture of diastereoisomers and its acid addition salts. It may be...
5026909 Method for preparing biologically active organic compound labelled with hydrogen isotope  
A method according to the invention comprises mixing the starting biologically active organic compound, an inorganic vehicle and a catalyst in the form of a platinum-group metal, followed by...
5025027 Cyclic carbamate analogues of (+)-pilocarpine  
Pilocarpine analogues are provided having the structure ##STR1## where one of R 1 or R 2 is an alkyl, such as methyl, ethyl, propyl, butyl, and so forth, and the corresponding secondary alkyl...
Matches 1 - 50 out of 138 1 2 3 >