Patents in Class 548/338.500

Matches 1 - 50 out of 98

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Match	Document	Document Title
1	7179825	Retinoic acid mimetic anilides The present invention is concerned with compounds of formula the N-oxides, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein X represents...
2	7060721	Imidazole compounds and medicinal use thereof Imidazole compounds represented by general formula (I): wherein each symbol is as defined in the specification, and salts thereof, and a pharmaceutical composition containing same are provided....
3	6875765	Arylsulfonamide ethers, and methods of use thereof The novel arylsulfonamide ether compounds, pharmaceutical compositions and uses thereof as inhibitors of interleukin-1β converting enzyme and other cysteine proteases in the ICE family are...
4	6743929	Sulfonylalkanoylamino hydroxyethylamino sulfonamides useful as retroviral protease inhibitors Sulfonamide-containing hydroxyethylamine compounds are effecive as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
5	6620826	Endothelin receptor antagonists Novel N-phenyl imidazole derivatives, pharmaceutical compositions containing these compounds and their use as endothelin receptor antagonists are described.
6	6515133	Pharmaceutical compositions containing certain diarylimidazole derivatives Certain diaryl imidazoles act as partial agonists or antagonists for NPY receptors, in particular NPY 5 receptors. They are of use, for example in treating loss of appetite. Such compounds bear...
7	6384220	Para-aryl or heterocyclic substituted phenyl glucokinase activators Para-aryl or heteroaryl substituted phenyl amides which are active as glucokinase activators to increase insulin secretion which makes them useful for treating type II diabetes.
8	6359061	Amide compound libraries Amide compounds of formula (I), combinatorial libraries of amide compounds and methods of preparing the same are provided. Libraries of the invention are useful for screening in biological assays...
9	6319939	Retinoic acid mimetic anlides The present invention is concerned with compounds of formula ##STR1## the N-oxides, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein X...
10	6265590	Nα-2-(4-nitrophenylsulfonyl)ethoxycarbonyl-amino acids Protected amino acid derivatives of general formula (I) ##STR1## and methods for the prepatation of the derivatives are provided.
11	6242474	Aromatic ring derivatives Novel aromatic ring derivatives represented by formula (I) or their pharmaceutical acceptable salts are provided. ##STR1## wherein Nu represents a 5- or 6-membered aromatic ring; ch 1 and ch 2 ...
12	6008372	Substituted dinaphthylmethyl and diheteroarylmethylacetyl histidine inhibitors of protein farnesyltransferase Substituted histidine compounds of formula (I) are described as well as methods for the preparation and pharamaceutical compositions of same, which are useful as inhibitors of protein...
13	5965588	Sulfonylalkanoylamino hydroxyethylamimo sulfonamides useful as retroviral protease inhibitors Sulfonamide-containing hydroxyethylamine compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
14	5959120	Acetate ester compounds The present invention provides an acetate ester compound of formula (III), ##STR1## a process for synthesizing compound (III), and a process for using that compound to prepare a pyrazolone...
15	5792784	Coupling product obtained from histamine and an amino acid The invention relates to a pseudo-dipeptide product obtained by coupling between histamine or methyl-substituted histamine and an amino-acid having formula ##STR1## wherein A is a radical selected...
16	5733882	Retroviral protease inhibitors The present invention provides compounds, more particularly dipeptide analogs, which bind to retroviral proteases. These compounds are inhibitors of retroviral proteases and are useful for treating...
17	5616788	N.sub.α -2-(4-Nitrophenylsulfonyl) ethoxycarbonyl-amino acids Protected amino acid derivatives of the general formula ##STR1## wherein R 1 represents hydrogen atom, and R 2 represents hydrogen, methyl, isopropyl, 1-methylpropyl, 2-methylpropyl,...
18	5545838	Diol sulfonamide and sulfinyl renin inhibitors Compounds of the formula ##STR1## wherein Z is SO or SO 2 possess renin inhibition activity and are useful in treating hypertension and other diseases where the reduction of the levels of...
19	5541213	Propenoic acid derivatives diazole propenoic acid compounds which have useful pharmaceutical utility A novel propenoic acid derivative which exhibits adenosine A1 antagonism is defined by the general formula (I): ##STR1## (wherein A represents an aromatic ring; R 1 represents aryl or the like; R...
20	5504212	Inhibitors of farnesyl-protein transferase The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to...
21	5439927	Imidazoyl-β-oxo-β-benzenepropanethiomide derivative, compositions and method of use thereof The β-oxo-β-benzenepropanethioamide derivative of the present invention has potassium channel opening action and is useful for treatment of hypertension, asthma, hypersensitive colon syndrome,...
22	5373017	Imidazolyl/benzimidazolyl-terminated alkylamino ethynyl alanine amino diol compounds for treatment of hypertension Compounds characterized generally as imidazolyl/benzimidazolyl-terminated alkylamino ethynyl alanine amino diol derivatives are useful as renin inhibitors for the treatment of hypertension....
23	5356921	Imidazolylphenol compounds, pharmaceutical compositions containing them, and processes for preparing such compounds and compositions 3- and 4-(1H-imidazol-1-yl)phenol compounds corresponding to the formula I ##STR1## in which R 1 represents NH 2 or CH 3 , R 2 represents H or CH 3 , X represents O or S, Y represents H, OH or...
24	5346907	Amino acid analog CCK antagonists Analogs of CCK-tetrapeptides, which analogs have the formula ##STR1## wherein A, B, D, R 1 , R 2 , R 3 , and R 4 are specifically defined, having activity as CCK antagonists, useful in the...
25	5332833	β-oxo-β-benzenepropanethioamide compounds The β-oxo-β-benzenepropanethioamide derivative of the present invention has potassium channel opening action and is useful for treatment of hypertension, asthma, hypersensitive colon syndrome,...
26	5302610	Renal-selective biphenylmethyl imidazole angiotensin II antagonists for treatment of hypertension Renal-selective compounds are described which, in one embodiment, are prodrugs preferentially converted in the kidney to compounds capable of blocking angiotensin II (AII) receptors. These prodrugs...
27	5298647	Aromatic compounds of amide structure derived from aminobenzoic acids, hydroxy-benzoic acids, cinnamic acids, urocanic acids and benzimidazoles, absorbing UVB and/or UVA Aromatic compounds absorbing UVB and/or UVA, substituted with an amide function, selected from the group consisting of ##STR1## whose variable substituents are as defined in the specification, e.g....
28	5250517	Renin inhibiting compounds Compounds which are amino acid derivatives and have the formula ##STR1## in which R 1 is hydrogen or methyl, R 2 is ethyl, propyl or imidazol-4-yl, R 3 is isobutyl, cyclohexylmethyl or benzyl,...
29	5246958	Antihypertensive thiocarbamoylascetonitrile compounds Disclosed are antihypertensive pharmaceutical compositions and compounds which include the thiocarbamoylacetonitrile having the formula: ##STR1## wherein: R 1 is selected from the group consisting...
30	5236928	Imidazole derivatives bearing acidic functional groups at the 5-position, their compositions and methods of use as angiotensin II antagonists There are disclosed substituted imidazole derivatives of Formula I bearing acidic functional groups which are useful as angiotensin II antagonists. ##STR1##
31	5223489	Amino acid derivatives, processes for the preparation thereof and pharmaceutical composition comprising the same A compound of the formula: ##STR1## wherein R 1 is lower alkyl optionally substituted aryl; or amino optionally substituted; and R 2 is hydrogen or lower alkyl; or R 1 and R 2 are taken...
32	5214206	Aminosulfonyl urea ACAT inhibitors The present invention provides pharmaceutically useful compounds which are aminosulfonyl urea compounds which are ACAT inhibitors rendering them useful in controlling blood cholesterol levels,...
33	5198426	Renin inhibitors containing C-terminal dihydroxy amides The invention concerns novel renin-inhibitory peptides which are useful for treating renin-associated hypertension, congestive heart failure, hyperaldosteronism, glaucoma and diseases caused by...
34	5179117	Antihypercholesterolemic 2-substituted imidazoles The compounds of the described invention are potent ACAT inhibitors and are useful in pharmaceutical compositions for the treatment of atherosclerosis and have the formulas: ##STR1## when Q is a...
35	5175181	Imidazolyl/imidazolylalkyl-N-terminal amino hydroxy Non-peptidyl compounds characterized generally as imidazolyl/imidazolylalkyl-N-terminal amino hydroxy β-amino acid derivatives are useful as renin inhibitors for treatment of hypertension....
36	5138067	Lipid derivatives Lipid derivatives represented by the formula: ##STR1## wherein R 1 is alkyl or alkylcarbamoyl; R 2 is lower alkyloxy, lower alkylcarbamoyloxy, lower alkylcarbonylamino, lower...
37	5135914	Substituted derivatives of 3-amino-2-hydroxypropionic acid as inhibitors of renin Novel substituted derivatives of 3-amino-2-hydroxypropionic acid are described, as well as methods for the preparation and pharmaceutical compositions of same, which are useful as renin inhibitors...
38	5096700	Halogenated aminohexanoates and aminobutyrates antimicrobial agents The subject invention involves halogenated amino acid derivatives useful as antimicrobial agents having the structure: ##STR1## wherein --R is hydrogen or 2-aminoethyl; --R' is hydroxy, alkoxy,...
39	5032577	Peptidylaminodiols A renin inhibiting compound of the formula: ##STR1## wherein A is a substituent; W is CO or CHOH; U is CH 2 or NR 2 , provided that when W is CHOH then U is CH 2 ; R 1 is loweralkyl,...
40	5030738	Synthesis of antiulcer compounds To synthesize molecules with antiulcer action, specifically ranitidine, niperotidine and cimetidine, having the formula: ##STR1## wherein R 1 is hydrogen or together with R 2 represents the rest...
41	5013861	Ester substituted aminoalkanoylureido amino and imino acid and ester compounds Compounds of the formula ##STR1## are disclosed. These compounds are useful as intermediates in the preparation of pharmaceutically active products.
42	4980366	Amide, sulfonamide, urea, carbamate, thiocarbamate, and thiourea derivatives of 4'hydroxybenzylamine having anti-inflammatory and analgesic activity Novel 4'-hydroxybenzylamine derivatives of the formula ##STR1## pharmaceutical compositions and methods of use thereof are the present invention. Utility is for the treatment of arthritis, asthma,...
43	4945098	Novel propane-1,3-diol derivatives and use A derivative of 2-methylenepropane-1,3-diol of the general formula I ##STR1## where O--A 1 and O--A 2 , which can be the same or different, each represents O, O--C(O), O--C(O)NH, O--C(S)NH or...
44	4925856	Aldoxime-substituted imidazolium derivatives useful in the treatment of poisoning by phosphorus-containing chemicals A therapeutically effective class of low toxicity aldoxime-substituted functionalized imidazolium compounds and compositions is disclosed which is effective in the treatment of living species...
45	4895834	Renin inhibitors III The invention concerns novel renin-inhibitory peptides which are useful for treating renin associated hypertension, hyperaldosternoism, and congestive heart failure. Processes for preparing the...
46	4892952	Substituted heteroaralkyl, heteroaralkenyl or halomethyl fungicides Compounds of the formula: ##STR1## wherein R is phenyl or phenyl substituted with 1 to 4 of the same or different substituents selected from fluoro, chloro, bromo, iodo, lower alkyl and...
47	4880781	Renin inhibitory peptides containing an N-alkyl-histidine moiety The present invention provides novel renin-inhibiting peptides and novel processes and intermediates for the preparation of both novel and known renin-inhibiting peptide analogs. Such inhibitors...
48	4855439	Process for the preparation of cimetidine A new and simple process for the preparation of crystalline cimetidine (N-cyano-N'-methyl-N"-{2/(5-methyl-1H-imidazole-4-yl)methylt hio/ethyl}guan idine) is described, wherein cimetidine is...
49	4826815	Renin inhibiting compounds The invention relates to renin inhibiting compounds of the formula ##STR1## wherein A is hydrogen; loweralkyl; arylalkyl; Or 10 wherein R 10 is hydrogen or loweralkyl; NR 11 R 12 wherein R 11 ...
50	4812463	Alkanesulfonamides as antiglaucoma agents Alkane sulfonamides with an electron withdrawing function β to the sulfonamide group are topically effective carbonic anhydrase inhibitors useful in the treatment of elevated intraocular pressure...

Matches 1 - 50 out of 98

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