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7569595 |
2-((2-thioxo-2,3-dihydro-1H-imidazol-4-yl)methyl)-3,4-dihydronaphthalen-1(2H)-one
A compound of the formula
or a pharmaceutically acceptable salt thereof, is disclosed herein. Methods and compositions related thereto are also disclosed.
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7544812 |
Peroxisome proliferator activated receptor agonists
The present invention is directed to compounds represented by the following structural Formula (I), (a) R1 is selected from the group consisting of hydrogen, substituted or unsubstituted group...
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7511068 |
Mercaptoimidazoles as CCR2 receptor antagonists
The present invention relates to a compound of formula (I) having CCR2 receptor antagonistic properties, particularly anti-inflammatory properties.
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7511149 |
Process for the oxidation of certain substituted sulfilimines to insecticidal sulfoximines
Insecticidal sulfoximines are produced efficiently and in high yield by the oxidation of the corresponding sulfilimine with ruthenium tetraoxide or an alkali metal permanganate.
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7390829 |
Alpha-2 adrenergic agonists
A compound is disclosed herein comprising
or a pharmaceutically acceptable salt or a prodrug thereof;
wherein R is OH or NH 2 .
Methods, compositions, and medicaments related thereto are...
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7365196 |
Sulphonamido-substituted bridged bicycloalkyl derivatives
A class of compounds is disclosed, comprising sulphonamido-substituted bridged bicycloalkyl structures. The compounds are inhibitors of gamma-secretase, and hence are useful in the treatment of...
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7358269 |
2-((2-Thioxo-2,3-dihydro-1H-imidazol-4-yl)methyl)-3,4-dihydronapthalen-1(2H)-one
A compound of the formula
or a pharmaceutically acceptable salt thereof, is disclosed herein. Methods and compositions related thereto are also disclosed.
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7335778 |
Intermediate for biotin and process for producing the same
The present invention is to provide a process for preparing a synthetic intermediate of biotin which is industrially advantageous, and discloses a process for preparing a compound represented by...
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7265135 |
2-oxy, 2-amino, and 2-thio-imidazole compounds
The invention relates to novel 2-Oxy, 2-Amino, and 2-Thio-imidazole compounds of formula (I):
wherein all variables are as herein defined, pharmaceutical compositions containing the...
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7220770 |
Heterocyclo-substituted imidazoles for the treatment of inflammation
A class of imidazolyl compounds is described for use in treating inflammation. Compounds of particular interest are defined by formula (V), wherein R 3 is a radical selected from hydrido, alkyl,...
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6960688 |
Use of compounds for the elevation of pyruvate dehydrogenase activity
The use of compounds of formula (I), and salts thereof; and pharmaceutically acceptable in vivo cleavable prodrugs of said compound of formula (I); and pharmaceutically acceptable salts of said...
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6916837 |
Amidino derivatives and anticoagulants and thrombosis therapeutic agents containing them
Amidino derivatives represented by the following general formula (I):
{where X is a group represented by R 1 SO 2 NR 2 — (wherein R 1 represents optionally substituted C 6-14 aryl, etc....
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6787552 |
PPAR delta activators
Compounds of the general formula (I) or salts thereof and activators of PPARδ (peroxisome proliferator activated receptor δ) containing the compounds or the salts as the active ingredient:...
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6706739 |
Imidazolidinone compounds
A compound having the formula: in which R 1 , R 2 , R 3 , T, W, m, x, and y are defined as in the specification. Also disclosed is a method of treating enterovirus infection by using a compound...
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6646009 |
N-(aryl)-2-arylethenesulfonamides and therapeutic uses thereof
N-(Aryl)-2-arylethenesulfonamides and pharmaceutically acceptable salts and compositions thereof are useful as antiproliferative agents, including, for example, anticancer agents. They are also...
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6635630 |
Selective neurokinin antagonists
Compound represented by the structural formula or a pharmaceutically acceptable salt thereof, wherein Ar 1 and Ar 2 are optionally substituted heteroaryl or optionally substituted phenyl; X 1 ...
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6528535 |
Bicyclic inhibitors of protein farnesyl transferase
The present invention provide compounds of Formula I The present invention also provides a method of treating cancer and treating or preventing restenosis or atherosclerosis. Also provided by...
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6403805 |
1,3-dihydro-1-(phenylalkyl)-2H-imidazol-2-one derivatves
The present invention describes compounds useful for treating warm-blooded animals suffering from disease states related to an abnormal enzymatic or catalytic activity of phosphodiesterase IV (PDE...
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6395724 |
Multibinding inhibitors of cyclooxygenase-2
Disclosed are multibinding compounds which inhibit cyclooxygenase-2 (COX-2), an enzyme which catalyzes the first committed step in the biosynthesis of prostaglandins. The multibinding compounds of...
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6369273 |
Chemical compounds and their use to elevate pyruvate dehydrogenase activity
The use of a compound of the formula (I): wherein: ring C is phenyl or carbon-linked heteroaryl selected from pyridyl, pyrazinyl, pyrimidinyl and pyridazinyl; and wherein said phenyl or...
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6312538 |
Chemical compound suitable for use as an explosive, intermediate and method for preparing the compound
A new compound, 1,1-diamino-2,2-dinitroethylene suitable for use as an explosive, as well as an intermediate for preparing the compound consisting of a heterocyclic 5- or 6-ring of the general...
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6229011 |
N-aroylphenylalanine derivative VCAM-1 inhibitors
Compounds of the formula: ##STR1## are disclosed which have activity as inhibitors of binding between VCAM-1 and cells expressing VLA-4. Such compounds are useful for treating diseases whose...
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6147097 |
Imidazole derivatives as anti-HIV agents
An imidazole derivative represented by general formula (I) or a salt thereof, having the effect of specifically inhibiting the growth of HIV as a pathogenic virus and being reduced in toxicity. In...
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6136983 |
Pesticidal sulfur compounds
Pyrazole, pyrrole and imidazole derivatives having formula (I) or (II): ##STR1## wherein X is NR 3 , O or an electron pair and Q comprises certain pyrazole, pyrrole and imidazole...
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6114539 |
Mercapto-imidazolyl derivatives
The present invention provides mercapto-imidazolyl compounds, and the acid addition salts and metal salt complexes thereof; a process for their preparation; and a method for their use as microbicides.
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6107322 |
Pesticidal 1-polyarylimidazoles
A compound of formula (I): ##STR1## compositions containing them and methods of use to control pests.
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6090944 |
Alkanoic acid derivatives as αv integrin receptor antagonists
The present invention relates to compounds and derivatives thereof, their synthesis, and their use as integrin receptor antagonists. More particularly, the compounds of the present invention are...
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6066662 |
Hydroxylamine derivatives and their use as metalloproteinase inhibiting agents
The invention provides hydroxylamine derivatives of formula (I) wherein A, R 1 , R 2 and R 3 have the significance given in the description, which are matrix metalloproteinase inhibitors and...
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6063934 |
Imidazolone anorectic agents: 1. 2-substituted-3,5-dihydro-5,5-diphenyl-4H-imidazol-4-ones
A series of non-peptidergic antagonists of NPY have been synthesized and are comprised of acyclic derivatives of imidazolone compounds of Formula I. ##STR1## As antagonists of NPY-induced feeding...
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6057448 |
Process for producing imidazole derivatives
The present invention provides a process for producing a compound of the formula (III): ##STR1## wherein R 1 and R 3 are independently hydrogen or an organic group; R 2 is an organic group; and...
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6054591 |
Lymph-absorbable aryl substituted imidazole derivatives
A compound of the formula (I): ##STR1## salt thereof, or hydrate thereof which can effectively be absorbed from the lymph vessel in the intestinal tract and transferred to the lymph node in a high...
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6054590 |
Imidazolone anorectic agents: II. phenyl derivatives
A series of non-peptidergic antagonists of NPY have been synthesized and are comprised of phenyl derivatives of imidazolone compounds of Formula I. ##STR1## As antagonists of NPY-induced feeding...
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6046355 |
Dihydropyrones with improved antiviral activity
This invention pertains to improved antiviral activity of 6,6-disubstituted-5,6-dihydropyran-2-ones caused by judicious placement of certain polar substituents at the 3 and/or 6 positions. The same...
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5994376 |
1,3-dihydro-1-(phenylalkyl)-2H-imidazol-2-one compounds and their use for treating allergic, atopic or inflammatory diseases
The present invention describes 1,3-dihydro-1-(phenylalkyl)-2H-imidazol-2-one compounds and their use for treating warm-blooded animals suffering from disease states related to an abnormal...
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5977377 |
Process for producing N-alkylimidazole
Disclosed is a process for producing an N-alkylimidazole which comprises reacting an imidazole with an N-alkylating agent in an organic solvent in the presence of alkali particles having a specific...
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5952510 |
1,3-dihydro-1-(phenylalkenyl)-2H-imidazol-2-one derivatives having PDE IV and cytokine inhibiting activity
The present invention concerns the compounds of formula ##STR1## the N-oxide forms, the pharmaceutically acceptable acid or base addition salts and the stereochemically isomeric forms thereof,...
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5945413 |
Aspartyl protease inhibitors
This invention relates to a novel class of compounds that are aspartyl protease inhibitors. In one embodiment, this invention relates to a novel class of aspartyl protease inhibitors characterized...
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5869515 |
1,3-dihydro-2H-imidazol-2-one compounds
The present invention concerns the compounds of formula ##STR1## the N-oxide forms, the pharmaceutically acceptable acid or base addition salts and the stereochemically isomeric forms thereof,...
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5691366 |
Nitro compounds, process for preparation thereof and use thereof
A new nitro compound of the formula: ##STR1## wherein R 1 and R 2 are each lower alkyl or lower alkoxy(lower)-alkyl, or ##STR2## is cyclized to form ##STR3## X is --O--, --S-- or --NH--, m is an...
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5677464 |
Production of optically active triazole compounds and their intermediates
A compound of the formula (V): ##STR1## wherein Ar' is a halogenated phenyl group, R is a hydrocarbon residue having a functional group at the α-carbon, R 3 ' is an optionally substituted...
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5663053 |
Inhibition of inflammatory lipid mediators
Coenzyme A-independent transacylase is required for the release of free arachidonic acid, and the production of arachidonic acid metabolites and platelet activation factor. Blocking of this enzyme...
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5643855 |
Herbicidal imidazolones
Compounds such as Formula I having herbicidal utility are disclosed: ##STR1## wherein Q is ##STR2## R 1 is H; alkyl, haloalkyl or halogen R 2 is C 1 -C 2 alkyl optionally substituted with one...
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5618945 |
Process for the sulfinylation of heterocyclic compounds
The invention relates to a novel process for the sulfinylation of heterocyclic compounds, which comprises reacting: a compound of the formula RS(O)X, in which R is a linear or branched alkyl...
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5616601 |
1,2-aryl and heteroaryl substituted imidazolyl compounds for the treatment of inflammation
A class of imidazolyl compounds is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula I: ##STR1## wherein R 1 -R...
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5604251 |
Imidazole derivatives with a biphenylsulfonylurea or biphenylsulfonylurethane side chain and their use as angitensin II receptors
Imidazole derivatives with a biphenylsulfonylurea or biphenylsulfonylurethane side chain, process for their preparation and their use Compounds of the formula (I) ##STR1## in which R 1 is, for...
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5559233 |
Methods for preparing n-substituted heterocyclic derivatives
The invention relates to processes for preparing N-substituted heterocyclic compounds of formula (I) ##STR1##
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5536841 |
Process for the preparation of 2-substituted 5-chloroimidazole-4-carbaldehydes
A process for preparing 2-substituted 5-chloroimidazole-4-carbaldehydes of the general formula: ##STR1## In the process, a glycine ester hydrohalide is ring-closed with an imidate ester to obtain...
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5494927 |
3,5-di-tertiarybutyl-4-hydroxyphenylmethylene derivatives of 2-substituted thiazolidinones, oxazolidinones, and imidazolidinones as antiinflammatory agents
The novel 3,5-ditertiarybutyl-4-hydroxy-phenylmethylene derivative of 2-substituted thiazolidinones, oxazolidinones, and imidazolidinones as antiinflammatory agents having inhibiting activity for...
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5457211 |
Hydroxyalkyl-substituted cyclic urea-substituted amines
A fuel composition comprising a major amount of hydrocarbons boiling in the gasoline or diesel range and an effective detergent amount of a hydroxyalkyl-substituted, five- or six-membered cyclic...
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5455243 |
Fibrinogen receptor antagonists for inhibiting aggregation of blood platelets
Fibrinogen receptor antagonists of the formula: ##STR1## such as ##STR2## are disclosed for use in inhibiting the binding of fibrinogen to blood platelets and for inhibiting the aggregation of...
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