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9035054 Dinitroxide-type biradical compounds optimized for dynamic nuclear polarization (DNP)  
The present invention relates to the field of organic chemistry and in particular to organic free radicals used as polarizing agents in the technique of Dynamic Nuclear Polarization (DNP), which...
8969588 Solid forms of an antiviral compound  
Amorphous and crystalline solid forms of the anti-HCV compound (1-{3-[6-(9,9-difluoro-7-{2 -[5-(2-methoxycarbonylamino-3-methyl-butyryl)-5-aza-spiro[2. 4]hept-6-yl]-3H-imidazol-4-yl}-9H-fluoren-2-y...
8921573 Processes for the preparation of novel benzimidazole derivatives  
The present invention relates to processes and intermediates for the preparation of novel benzimidazole derivatives, especially in the synthesis of hepatitis C virus NS5A inhibitors. In...
8853416 Chemical compounds  
Disclosed are compounds of Formula III. Also disclosed are salts of the compounds, pharmaceutical composition comprising the compounds or salts, and methods for treating HCV infection by...
8846023 Hepatitis C virus inhibitors  
The present disclosure relates to compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such...
8834749 Photosensitive resin composition and light blocking layer using the same  
Disclosed are a photosensitive resin composition including (A) a binder resin including a cardo-based resin including a repeating unit represented by the following Chemical Formula 1, (B) a...
8778938 Hepatitis C virus inhibitors  
The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit RNA-containing virus, particularly the Hepatitis C Virus...
8765731 Benzimidazole analogues for the treatment or prevention of flavivirus infections  
Compounds represented by formula I: or pharmaceutically acceptable salts and solvates thereof, wherein A, B, B′, X, Y, R1, R1′, R2, R2′, R3, R3′, R5, R5′, R6, m, n, or p are as defined herein, are...
8722695 Imidazolidinedione derivatives  
The invention provides a compound of formula (Ia), and pharmaceutically acceptable salts thereof. The invention also provides use of the compounds or salts as modulators of Kv3.1 and/or Kv3.2, and...
8674113 Compounds  
This invention relates to compounds of formula I their use as inhibitors of the microsomal prostaglandin E2 synthase-1 (mPGES-1), pharmaceutical compositions containing them, and their use as...
8648193 Dinitroxide-type biradical compounds optimized for dynamic nuclear polarization (DNP)  
The present invention relates to the field of organic chemistry and in particular to organic free radicals used as polarizing agents in the technique of Dynamic Nuclear Polarization (DNP), which...
8609859 One pot process for preparing 2-butyl-3-[[2′-(1H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-1,3-diazaspiro [4, 4] non-1-en-4-one (irbesartan)  
A one pot process for the synthesis of Irbesartan comprising reacting 2-n-Butyl-1,3-Diazaspiro[4,4]Non-1-en-4-one (Formula III) and Bromomethyl Cyanobiphenyl (Formula IV) in the presence of base...
8574563 Hepatitis C virus inhibitors  
The present disclosure relates to compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such...
8569312 Biaryl-spiroaminooxzaoline analogues as alpha 2C adrenergic receptor modulators  
In its many embodiments, the present invention provides a novel class of biaryl spiroaminooxazoline analogues as modulators of α2C adrenergic receptor agonists, methods of preparing such...
8563714 Bridged spiro [2.4] heptane derivatives as ALX receptor and/or FPRL2 agonists  
The present invention relates to bridged spiro[2.4]heptane derivatives of formula (I), wherein W, Y, Z, R1 and R2 are as defined in the description, their preparation and their use as...
8541595 Imidazoisoindole neuropeptide S receptor antagonists  
The present invention is directed to imidazoisoindole compounds which are antagonists of neuropeptide S receptors, and which are useful in the treatment or prevention of neurological and...
8492554 Chemical compounds  
Disclosed are compounds of Formula III. Also disclosed are salts of the compounds, pharmaceutical composition comprising the compounds or salts, and methods for treating HCV infection by...
8361959 Spiro-imidazolone derivatives as glucagon receptor antagonists  
The present invention relates to compounds of the general formula: (I) wherein ring A, ring B, R1, R3, Z, L1, and L2 are selected independently of each other and are as defined herein, to...
8344155 Chemical compounds  
Disclosed are compounds of Formula III. Also disclosed are salts of the compounds, pharmaceutical composition comprising the compounds or salts, and methods for treating HCV infection by...
8263624 Aryl-substituted heterocycles, and use thereof  
The invention relates to aryl-substituted heterocycles, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments...
8236963 Tricyclic spiro derivatives as CRTH2 modulators  
The present invention is related to the use of spiro derivatives of Formula (I) for the treatment and/or prevention of allergic diseases, inflammatory dermatoses and other diseases with an...
8232409 Heterocyclic benzimidazoles as TRPM8 modulators  
Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows:...
8211932 Organic compounds and their uses  
The present application describes organic compounds of the Formula I that are useful for the treatment, prevention and/or amelioration of human diseases.
8129423 Imidazolone and imidazoloidinone derivatives as 11b-HSD1 inhibitors  
Compounds of formula as well as pharmaceutically acceptable salts and esters thereof, wherein R1 to R6 have the significance given in claim 1 can be used in the form of pharmaceutical compositions.
8106216 Process for the preparation of Irbesartan  
The present invention relates to an improved process for the preparation of 2-n-butyl-3-[[2′-(1H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]-1,3 -diazaspiro[4.4]non-1-en-4-one (Irbesartan).
8003653 Imidazolidinone compounds useful as β-secretase inhibitors for the treatment of Alzheimer's disease  
The present invention is directed to imidazolidinone compounds which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme...
7825152 Organic compounds and their uses  
The present application describes organic compounds that are useful for the treatment, prevention and/or amelioration of human diseases.
7687514 Benzimidazole derivatives  
The present invention relates to a compound of the formula (I): (wherein A, B, C and D are independently nitrogen or optionally substituted methine; E is nitrogen, methine or hydroxy substituted...
7511153 4-alkoxy cyclohexane-1 amino carboxylic acid esters and method for the production thereof  
The invention relates to novel 4-alkoxy-cyclohexane-1-amino-carboxylic esters of the formula (IV) in which R1 and R2 are as defined in the description, to intermediates and processes for their...
7482372 Hydantoins and related heterocycles as inhibitors of matrix metalloproteinases and/or TNF-α converting enzyme (TACE)  
The present application describes novel hydantoin derivatives of formula (I): or pharmaceutically acceptable salt or prodrug forms thereof, wherein A, B, R1, R2, R3, R4, R5, R6, R7, R11, and n are...
7365208 Method for preparing irbesartan and intermediates thereof  
A method for preparing irbesartan and intermediates thereof. Irbesartan has the structure of formula I,
7301035 Intermediates for the synthesis of irbesartan  
Provided are a method of making irbesartan via a Suzuki coupling reaction and a novel intermediate, 2-butyl-3-(4′-bromobenzyl)-1,3-diazaspiro[4.4]non-1-ene-4-on e, for such process. The novel...
7153973 Imidazolidinone derivatives  
A compound of the formula (IA) or (IB) wherein G1, G2, G3 and G4 are independently of one another C1–C18alkyl or C5–C12cycloalkyl or the radicals G1 and G2 and the radicals G3 and G4 form...
7074937 Method for production of additives for lubricating oils  
A method for making a compound of formula (I) wherein bonds a and b are single or double bonds, provided that one of a and b is a single bond and the other is a double bond; one of B1 and B2 is...
7019148 Synthesis of irbesartan  
Provided are a method of making irbesartan via a Suzuki coupling reaction and a novel intermediate, 2-butyl-3-(4′-bromobenzyl)-1,3-diazaspiro[4.4]non-1-ene-4-on e, for such process. The novel...
6924330 Thioimidazolidine derivatives as light stabilizers for polymers  
A compound of the formula (I) wherein G1, G2, G3 and G4 are independently of one another C1-C18alkyl or C5-C12cycloalkyl or the radicals G1 and G2 and the radicals G3 and G4 form independently of...
6897208 Benzimidazoles  
The invention is directed to physiologically active compounds of the general formula (Ix) and compositions containing such compounds, and their prodrugs, and pharmaceutically acceptable salts and...
6803368 Antipsychotic aminomethyl derivatives of 7,8-dihydro-3H-6,9-dioxa-1,3-diaza-cyclopenta&lsqb a&rsqb naphthalene  
Compounds of the formula useful for treatment of disorders of the dopaminergic system, such as schizophrenia, schizoaffective disorder, bipolar disorder, Parkinson's disease, L-DOPA induced...
6683709 Photochromic pyran compounds  
Photochromic pyran compounds and their use in synthetic resin objects of all types, especially for ophthalmic applications, particularly spiro compounds having a fluorene structure derived from...
6316437 Spirohydantoin compounds and uses thereof  
Spirohydantoin compounds and their pharmaceutically acceptable salts are disclosed. The synthesis of these compounds and their use as alpha 1a adrenergic receptor antagonists is also described....
6162922 Method for preparing N-substituted heterocyclic derivatives using a phase-transfer catalyst  
Disclosed is a process for preparing N-substituted heterocyclic derivatives and its salts using phase transfer catalysis.
6162923 Process for the preparation of imidazolones  
The present invention relates to a process for the preparation of a compound of general formula (I), ##STR1## wherein R1 represents a hydrogen atom or an alkyl group of 1-6 carbon atoms, and their...
5910595 Process for preparing oximidazoles  
A process is disclosed for the preparation of an imidazolone and the pharmaceutically acceptable salts thereof having the formula ##STR1## wherein R1 and R2 are the same or different and are C1 to...
5869698 1,2-dioxetane compounds as chemiluminescent labels for organic and biological molecules  
Dioxetanes which couple with organic and biological molecules of the formula: ##STR1## wherein X is a leaving group which is removed by an `activating agent to produce light, wherein A is a...
5840217 Spiro compounds and their use as electroluminescence materials  
Use of spiro compounds of the formula (I) ##STR1## where K1 and K2 are, independently of one another, conjugated systems, in electroluminescence devices.Preferred compounds of the formula (I) are...
5830825 3-aryl-tetronic acid derivatives, the production thereof and the use thereof as antiparasitic agents  
The present invention relates to new 3-aryl-4-hydroxy-Δ3 -dihydrofuranone derivatives of the formula (I) ##STR1## in which A and B together with the carbon atom to which they are bonded form an...
5760029 Spirocycle integrin inhibitors  
This invention relates to novel heterocycles, including (S)-2-phenylsulfonylamino-3- 8-(2-pyridinylaminomethyl)-!-1-oxa-2-azaspi ro- 4,5!-dec-2-en-3-yl!carbonylamino! propionic acid, which are...
5714599 Process for the preparation of ste specific 1'-spiro-nucleosides  
The invention relates to a novel process for stereocontrolled preparation of 1',1'-disubstituted and 1'-spiro-nucleosides of the formula I ##STR1## in which the substituents A, R8 and R9 are as...
5698704 Process for the preparation of 4-oxoimidazolinium salts  
4-Oxoimidazolinium salts of the general formula: ##STR1## wherein R1 and R2 independently of one another are C1-10 -alkyl, C2-10 -alkenyl, C3-7 -cycloalkyl or optionally substituted aryl,...
5696137 Azaheterocyclymethyl-chromans  
Azaheterocyclylmethyl-chromans of the formula: ##STR1## in which E represents an azaheterocyclyl group selected from the group consisting of: ##STR2## wherein R6 represents hydrogen, hydroxyl,...

Matches 1 - 50 out of 145 1 2 3 >