Matches 1 - 50 out of 258 1 2 3 4 5 6 >


Match Document Document Title
8987473 Ring-fused compound  
The present invention relates to a compound that has URAT1 inhibitory action, and a URAT1 inhibitor, a blood uric acid level-reducing agent and a pharmaceutical composition comprising the...
8962580 Chemical modifications of monomers and oligonucleotides with cycloaddition  
The invention features compounds of formula I or II: In one embodiment, the invention relates compounds and processes for conjugating ligand to oligonucleotide. The invention further relates to...
8691856 Glucagon receptor antagonists, preparation and therapeutic uses  
The present invention discloses novel compounds of Formula (I), or pharmaceutically acceptable salts thereof, which have glucagon receptor antagonist or inverse agonist activity, as well as...
8680270 Metallo-oxidoreductase inhibitors using metal binding moieties in combination with targeting moieties  
The presently disclosed subject matter is directed to metallo-oxidoreductase inhibitors having metal binding moities linked to a targeting moiety through a linking group or a direct bond, methods...
8563586 1,(3,)5-substituted imidazoles, their use in the treatment of hypertension and methods for their preparation  
The present invention provides novel 1,5 and 1,3,5-substituted imidazole compounds in hydrophilic or lipophilic form, which are useful as angiotensin II ATI receptor antagonists suitable for...
8546374 Amino-tetrazoles analogues and methods of use  
A compound having Formula (I) or Formula (II) is disclosed as an P2X7 antagonist, wherein A, B, C, Y, Y, Z, m, v, R1, R2, R3, R4, and R5, are as defined in the description. Methods and...
8404730 3-substituted propanamine compounds  
Racemic or enantiomerically enriched 3-substituted propanamine compounds represented by the following structural formula (I): or a pharmaceutically acceptable salt thereof are disclosed....
8404728 Small-molecule botulinum toxin inhibitors  
This disclosure relates to materials and methods for inhibiting Botulinum neurotoxin, and more particularly to materials and methods for inhibiting the zinc endopeptidase of Botulinum neurotoxin...
8362054 Therapeutic substituted lactams  
Therapeutic compounds, compositions, methods, and medicaments related thereto are disclosed herein.
8207183 Inhibitors of IAP  
Novel compounds that inhibit the binding of the Smac protein to Inhibitor of Apoptosis Proteins (IAPs) of the formula (I).
8207373 Benzoic acid derivatives as human papilloma virus inhibitors  
HPV inhibitors with formula (I) where G1 represents a hydrocarbonated bond or chain possibly substituted by one or two alkyl groups, G2 represents a group (see formula Ia+Ib) or R represents a...
8193368 Tetrazole-substituted arylamides as P2X3 and P2X2/3 antagonists  
Compounds of the formula I: or a pharmaceutically acceptable salt thereof, wherein, R1 is optionally substituted tetrazolyl, R2 is optionally substituted phenyl, optionally substituted pyridinyl...
8168799 Process for the preparation of tetrazolytetrahydrocyclopentapyrazoles  
A process for the preparation of a compound of formula (I), or a salt, hydrate or solvate thereof; wherein R1 and R2 are each independently hydrogen, or C1-6 alkyl groups or R1 and R2 are linked...
8101642 3-substituted propanamine compounds  
Racemic or enantiomerically enriched 3-substituted propanamine compounds represented by the following structural formula (I): or a pharmaceutically acceptable salt thereof are disclosed....
8048886 Substituted pyrazine-3-one-derivatives as IAP inhibitors  
The present invention relates to novel IAP inhibitor compounds of formula I:
8048904 Process for the preparation of olmesartan medoxomil  
The present invention provides a process for the preparation of Olmesartan medoxomil by condensing the ethyl 4-(1-hydroxy-1-methylethyl)-2-propylimidazole-5-carboxylate with 4-[2-(trityl...
8026255 Substituted piperidines as somatostatin receptor subtype 5 (SSTR5) antagonists  
This invention is concerned with compounds of the formula and pharmaceutically acceptable salts thereof. The invention further relates to pharmaceutical compositions containing such compounds, to...
7855308 Inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme  
The present invention relates to compounds which are inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme. The present invention further relates to the use of inhibitors of...
7834023 Substituted dihydroquinazolines as platelet ADP receptor inhibitors  
Compounds of formula I are provided: wherein Ar1 and Ar2 are substituted aromatic rings and L1 and L2 are independent divalent linking groups. The compounds are useful as platelet ADP receptor...
7799820 2-Heterocycle-substituted indole derivatives for treating diabetes and associated conditions  
Disclosed is a compound represented by the formula (I) below, which has a glucokinase-activating effect and is thus useful for treatment of diabetes or obesity, or a pharmaceutically acceptable...
7795287 Therapeutic substituted hydantoins and related compounds  
A compound having a structure is disclosed herein. Therapeutic methods, compositions, and medicaments related thereto are also disclosed.
7728023 Indole compound and use thereof  
The present invention relates to a compound represented by the formula (I), wherein all symbols are as defined in the description, a salt thereof, a solvate thereof, or a prodrug thereof, which...
7714143 Method of making monoammonium salt of 5,5′-bis-1H-tetrazole  
A method of forming monoammonium salt of 5,5′-bis-1H-tetrazole (BTA-1NH3) is presented comprising the steps of charging a mixing vessel with a solution of free BTA acid and distilled water, adding...
RE41226 Compounds having reversible inhibiting activity of carnitine palmitoyl-transferase  
Compounds of formula (I) wherein the groups are as defined in the description are disclosed. The compounds of formula (I) are endowed with reversible inhibiting activity of carnitine...
7678796 MGluR5 modulators I  
The present invention is directed to novel compounds, to a process for their preparation, their use in therapy and pharmaceutical compositions comprising the novel compounds.
7649009 Pyrazole amide derivatives, compositions containing such compounds and methods of use  
Pyrazole amides are disclosed. The compounds are useful for treating type 2 diabetes and related conditions. Pharmaceutical compositions and methods of treatment are also included.
7595405 Tetrazole-substituted arylamides as P2X3 and P2X2/3 antagonists  
Compounds of the formula I: or a pharmaceutically acceptable salt thereof, wherein, R1 is optionally substituted tetrazolyl, R2 is optionally substituted phenyl, optionally substituted pyridinyl...
7576098 Heterocyclic compounds as inhibitors of factor VIIa  
The present invention relates generally to compounds that inhibit serine proteases. In particular it is directed to novel heterocyclic compounds, or a stereoisomer or pharmaceutically acceptable...
7572753 Tetrazole fungicides  
The use of certain tetrazole compounds as fungicides is disclosed wherein said compounds are of the structural formula: wherein: R is selected from the group consisting of phenyl groups of the...
7557220 Tetrazole based linear polymers  
A linear isocyanate polymer produced by utilizing an effective amount of tetrazole diol or tetrazole polyol, reacting with an effective amount isocyanate resin, and cooling to room temperature...
7414068 Benzopyran derivatives substituted with secondary amines including tetrazole, method for the preparation thereof and pharmaceutical compositions containing them  
The present invention relates to benzopyran derivatives substituted with secondary amines including tetrazole, method for preparing thereof and pharmaceutical compositions containing them. The...
7407974 Inhibitors of factor Xa and other serine proteases involved in the coagulation cascade  
The present invention provides compounds of Formula (I): wherein A, B, C, G, and W1 have any of the values defined in the specification, and pharmaceutically acceptable salt thereof, that are...
7378433 N-[4-(heteroarylmethyl)phenyl]-heteroarylamines  
The present invention is concerned with compounds of formula the N-oxides, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein R1 is hydrogen,...
7323480 Substituted triazoles as modulators of PPAR and methods of their preparation  
The present invention is directed to certain novel triazole compounds represented by Formula I and pharmaceutically acceptable salts, solvates, hydrates, and prodrugs thereof. The present...
7323483 Processes and compounds for the preparation of substituted naphthylindole derivatives  
The present invention provides processes for the preparation of substituted naphthylindole derivatives that can be used as inhibitors of plasminogen activator inhibitor-1(PAI-1). In certain...
7217706 Propanolamine derivatives  
This invention relates to new propanolamine derivatives or salts thereof represented by the following formula [I]: Wherein each symbol is as defined in the specification or salts thereof which...
7138415 Indolamid derivatives which possess glycogenphosphorylase inhibitory activity  
Heterocyclic amides of formula (1) wherein: is a single or double bond;A is phenylene or heteroarylene;m is 0, 1 or 2;n is 0, 1 or 2;R1 is selected from for example halo, nitro, cyano, hydroxy,...
7109223 Oxazolidin-2-one and thiazolidin-2-one derivatives for use as EP4 receptor agonists in the treatment of glaucoma  
This invention relates to potent selective agonists of the EP4 subtype of prostaglandin E2 receptors, their use or a formulation thereof in the treatment of glaucoma and other conditions which are...
7041832 Processes for preparing losartan and losartan potassium  
Losartan is prepared by acid catalyzed cleavage of a triarylmethyl group from a triarylmethyl-substituted losartan derivative in a diluent comprising liquid ketone. The reaction mixture is...
7019033 2-(4-bromo or 4-iodo phenylamino) benzoic acid derivatives  
Phenylamino benzoic acid, benzamides, and benzyl alcohol derivatives of the formula where R1, R2, R3, R4, R5, and R6 are hydrogen or substituent groups such as alkyl, and where R7 is hydrogen or...
6972287 Method of inhibiting amyloid protein aggregation and imaging amyloid deposits  
The present invention provides a method of treating Alzheimer's disease using a compound of Formula (I). Also provided is a method of inhibiting the aggregation of amyloid proteins using a...
6949575 Method of inhibiting amyloid protein aggregation and imaging amyloid deposits using aminoindane derivatives  
The present invention provides compounds of Formula (I) and a method of treating Alzheimer's disease using a compound of Formula (I), wherein: R1 and R2 include alkyl and phenylalkyl; R3 is...
6927217 HIV protease inhibitors  
The present invention relates to novel dihydropyrones of Formula I wherein X is NH or NR8, which inhibit the HIV aspartyl protease blocking HIV infectivity. The dihydropyrones are useful in the...
6835513 Carbazole based charge transport compounds  
Improved organophotoreceptors have: (a) a charge transport compound having the formula: where R1 is hydrogen, a branched or linear alkyl group, a branched or linear unsaturated hydrocarbon group,...
6833375 N-&lsqb 4-(heteroarylmethyl)phenyl&rsqb -heteroarylamines  
The present invention is concerned with compounds of formula the N-oxides, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein R1 is hydrogen,...
6797708 Inhibitors of cytosolic phospholipase A2  
This invention provides substituted indole compounds of the general formula: and pharmaceutically acceptable salt forms thereof, and methods for using the compounds as inhibitors of the activity...
6699904 PPAR agonists  
PPAR alpha activators, pharmaceutical compositions containing such compounds and the use of such compounds to elevate certain plasma lipid levels, including high density lipoprotein-cholesterol...
6642379 Benzamide derivatives, insecticides for agricultural and horticultural use and usage thereof  
Benzamide derivatives represented by the general formula (I): and insecticides for agricultural and horticultural use and usage thereof, wherein Z1 is O or S; R is H, (substituted) alkyl, or...
6593355 Benzimidazoles with antithrombotic activity  
Novel benzimidazoles having antithrombotic activity. Exemplary are: (a) 2-(4-amidinophenylaminomethyl)-1-methyl-5-[1-(ethoxycarbonyl methylamino)-1-(2,5-dihydropyrrolocarbonyl)-ethyl]-benzimida zol...
6589914 Dihalopropene compounds, insecticidal/acaridcidal agents containing same, and intermediates for their production  
The dihalopropene compounds of the general formula (I) have excellent insecticidal/acaricidal activity, so that they are satisfactorily effective for the control of noxious insects, mites and ticks.

Matches 1 - 50 out of 258 1 2 3 4 5 6 >