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7612210 |
Process for selective synthesis of enantiomers of substituted 1-(2-amino-1-phenyl-ethyl)-cyclohexanols
A process for the enantioselective synthesis of an (S)- or (R)-1-[2-dimethylamino)-1-(methoxyphenyl)ethyl]cyclohexanol and analogues or salt thereof are described. The method involves the steps of...
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7582659 |
Cyclopropyl group substituted oxazolidinone antibiotics and derivatives thereof
This invention relates to new oxazolidinones having a cyclopropyl moiety, which are effective against aerobic and anerobic pathogens such as multi-resistant staphylococci, streptococci and...
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7582666 |
Substituted 2-oxo-3-phenyl-5-carbonylaminomethyl-1,3-oxazolines and their use as anticoagulant and antithrombotics
The invention relates to the field of blood coagulation, more particularly, to novel compounds of general formula (I),
to a method for producing the compounds and to their use as active...
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7563904 |
Synthesis intermediates useful for preparing zolmitriptan
In particular, this invention relates to the synthesis intermediates (IV), (V), (VI) and (VIII) useful for preparing zolmitriptanzohnitriptan or a pharmaceutically acceptable salt thereof, which...
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7557214 |
Intermediate products for producing oxazolidinone-quinolone hybrids
The present invention describes intermediates (ZP) for a novel and efficient synthesis of compounds in which the pharmacophores of quinolone and oxazolidinone are linked to one another by way of a...
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7550448 |
Therapeutic compounds
Disclosed herein is a compound having a structure
or a pharmaceutically acceptable salt, or a prodrug thereof. Therapeutic methods, compositions, and medicaments related thereto are also...
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7488818 |
Method for producing 1,4-diphenyl azetidinone derivatives
The present invention is directed to the preparation of novel compounds useful in the treatment of hyperlipidemia, arteriosclerosis, hypercholesterolemia, and other related metabolic disorders....
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7488829 |
Diphenylazetidinones, process for their preparation, medicaments comprising these compounds and their use
Compounds of the formula I,
in which R1, R2, R3, R4, R5, and R6 have the meanings given in the description, and their physiologically acceptable salts. The compounds are suitable for use, for...
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7482467 |
N-thiolated 2-oxazolidinone-derived antibiotics
This invention describes the discovery and synthesis of N-thiolated 2-oxazolidinones as a new class of anti bacterial agents. These compounds can be synthesized from 2-oxazolidinones by...
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7473699 |
3-cyclyl-5-(nitrogen-containing 5-membered ring)methyl-oxazolidinone derivatives and their use as antibacterial agents
Compounds of the formula (I), or a pharmaceutically-acceptable salt, or an in-vivo-hydrolysable ester thereof,
wherein —N-HET is, for example, (Ic) or (If)
wherein R1 is (1-4C)alkyl;
Q...
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7462633 |
Cyclopropyl group substituted oxazolidinone antibiotics and derivatives thereof
This invention relates to new oxazolidinones having a cyclopropyl moiety, which are effective against aerobic and anerobic pathogens such as multi-resistant staphylococci, streptococci and ...
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7435751 |
7-Fluoro-1,3-dihydro-indol-2-one oxazolidinones as antibacterial agents
The present invention provides a compound of formula I
or a pharmaceutically acceptable salt thereof wherein R 1 is C 1-4 alkyl, optionally substituted with a fluoro atom, or R 1 is a...
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7432383 |
Intermediates for the hemisynthesis of taxanes and preparation processes therefor
The present invention generally relates to at least one precursor compound and derivatives thereof, a process for preparing a taxane, and a baccatin derivative.
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7390826 |
Inhibitors of animal cell motility and growth
Cell motility and growth inhibitors, including compounds of the general structural formula
and use of the cell motility and cell growth inhibitors, and pharmaceutically acceptable salts,...
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7342035 |
Process for preparing zolmitriptan compounds
In particular, zolmitriptan or a pharmaceutically acceptable salt thereof, which includes a) Preparation of the diazonium salt of the aniline hydrochloride (II); followed by reduction and...
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7342039 |
Substituted indole oximes
The present invention relates to substituted indole oximes and methods of using them.
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7332611 |
N-thiolated 2 oxazolidone antibiotics
This invention describes the discovery and synthesis of N-thiolated 2-oxazolidinones as a new class of anti bacterial agents. These compounds can be synthesized from 2-oxazolidinones by...
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7294719 |
Synthesis of amino acid, N-carboxyanhydrides
A process for producing N-carboxyanhydrides is disclosed. The process produces N-carboxyanhydrides as a product and HCl as a by-product. The HCl by-product is purged from the reaction mixture by...
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7285565 |
Benzamides and related inhibitors of factor Xa
Novel benzamide compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or...
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7279494 |
Antimicrobial [3.1.0] bicyclohexylphenyl-oxazolidinone derivatives and analogues
The present invention provides certain [3.1.0] bicyclic oxazolidinone derivatives of formula I
or pharmaceutically acceptable salts or prodrugs thereof that are antibacterial agents,...
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7279582 |
Retroviral protease inhibiting compounds
A compound of the formula:
is disclosed as an HIV protease inhibitor. Methods and compositions for inhibiting an HIV infection are also disclosed.
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7273867 |
Phenyl derivatives
Novel compounds of the formula I in which W, X, Y, T, R 1 and R 2 are as defined in Patent claim 1 , are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or...
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7265140 |
Acyloxymethylcarbamate prodrugs of oxazolidinones
The present invention relates to acyloxymethylcarbamate oxazolidinones. The compounds of the present invention have potent activity with excellent oral bioavailability against Gram-positive and...
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7262299 |
Catalysts
A process for performing a catalytic Diels-Alder reaction by reacting a diene with a dienophile in the presence of a heterogeneous catalyst comprising a zeolitic material exchanged or impregnated...
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7259263 |
Method of synthesis of azole-containing amino acids
The invention relates to methods of synthesizing 2-substituted azole compunds of formula (I):
The invention is also relates to compounds of formula (I) and to intermediate compounds in the...
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7238814 |
Compositions of S-nitrosothiols and methods of use
The invention describes compositions and kits comprising 4-aza-4-(2-methyl-2-sulfanylpropyl) tricyclo(5.2.1.0<2,6>)dec-8-ene-3,5-dione; 4-aza-4-(2-methyl-2-(nitrosothio)propyl)...
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7223870 |
Methods for preparing N-arylated oxazolidinones via a copper catalyzed cross coupling reaction
Methods for the preparation of N-arylated oxazolidinone compounds via a copper catalyzed cross coupling reaction are disclosed.
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7199143 |
Chemical compounds
Compounds of the formula (I), or a pharmaceutically-acceptable salt, or an in-vivo-hydrolysable ester thereof,
wherein —N-HET is, for example, (Ic) or (If)
wherein R1 is, for example,...
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7192954 |
Monocyclic anilide spirohydantoin CGRP receptor antagonists
The present invention is directed to compounds that are antagonists of CGRP receptors and that are useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache,...
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7186738 |
Antibacterial oxalidinones
Compounds of the formula (I), or a pharmaceutically-acceptable salts, or in-vivo-hydrolysable esters thereo Formula (I): wherein N-HeT is for example triazolyl; Q is for example phenyl or pyridyl,...
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7186844 |
Method for producing cyclic carbamate ester
A method for producing a cyclic carbamate ester produces the cyclic carbamate ester by reacting an organic compound having at least two halogen atoms per molecule, an amine having at least two...
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7166607 |
Substituted indoles
The present invention relates to substituted indoles of formula (I) useful as pharmaceutical compounds for treating respiratory disorders
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7160912 |
Heterocyclic compounds having antibacterial activity: process for their preparation and pharmaceutical compositions containing them
The present invention relates to novel oxazolidinone compounds of formula (I), their stereoisomers, their salts and pharmaceutical compositions containing them.
The present invention also...
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7157482 |
Antibacterial 1,3-oxazolidin-2-one derivatives
Compounds of the formula (I), or a pharmaceutically-acceptable salts, or in-vivo-hydrolysable esters thereof, wherein: N—HET is for example triazolyl substituted with R 1 ; R 1 is for example...
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7125863 |
Inhibitors of dipeptidyl peptidase IV
Compounds according to formula (1), wherein R 1 is H or CN, X 1 is S, O, SO 2 or CH 2 , X 2 is CO, CH 2 or a covalent bond, Het is a nitrogen-containing heterocycle and n is 1–5 are new. The...
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7115777 |
Amide derivatives as inhibitors of the enzymatic activity of renin
The present inventions relates to a novel compound of formula (I)
or a pharmaceutically acceptable salt thereof, the use and manufacture of a compound of formula (I) or a pharmaceutical...
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7087629 |
Heterocyclylaminomethyloxazolidinones as antibacterials
Compounds of formula (I)
or a pharmaceutically-acceptable salt, or an in-vivo-hydrolysable ester thereof, wherein, for example, HET is an optionally substituted C-linked 5-membered...
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7074785 |
Δ1-pyrrolines used as pesticides
Novel Δ 1 -pyrrolines of the formula (I)
in which
R 1 , R 2 , R 3 , A, R 4 and m have the meanings given in the description,
a number of processes for preparing these substances, and their...
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7049443 |
Amide-containing compound having improved solubility and method of improving the solubility of an amide-containing compound
The present invention is directed to novel amide-containing compounds which have an improved solubility and a method of improving the solubility of amide-containing compounds. The amide-containing...
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7034017 |
Substituted oxazolidinones and their use in the field of blood coagulation
This invention relates to compounds of formula (I)
wherein R 1 represents optionally substituted phenyl, R 2 represents optionally substituted
and the remaining “R” groups are as...
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7002020 |
Oxazolidinone combinatorial libraries, compositions and methods of preparation
Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods...
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6992103 |
Benzamide derivatives, processes for their preparation, and their pharmaceutical use
The present invention relates to novel hydroxyethylene compounds having Asp2 (β-secretase, BACE1 or Memapsin) inhibitory activity, processes for their preparation, to compositions containing them...
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6979741 |
Acetyl-CoA carboxylase inhibitors
Acetyl Coenzyme A Carboxylase inhibitors, pharmaceutical compositions containing such compounds and the use of such compounds to treat for example, Metabolic Syndrome including atherosclerosis,...
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6967196 |
Sulfonamide compounds and uses thereof
In accordance with the present invention, there is provided a novel class of sulfonamide compounds. Compounds of the invention contain a core sulfonamide group. Variable moieties connected to the...
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6943179 |
Biurethane derivatives
Novel compounds of the formula I in which X, Y, Z, R, R 1 , R 2 and R 3 are as defined in Patent Claim 1 , are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or...
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6939867 |
β3 agonists and uses thereof
Sulfamide compounds having formula (I) are described as well as their use in the treatment of diseases dependent on the signaling pathways associated with β-adrenergic receptors, such as obesity,...
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6909005 |
One post synthesis of 2-oxazolidinone derivatives
The present invention provides an improved (S)-4-{[3-[2-(dimethylamino)ethyl]-1H-indol-5-yl]methyl}-2-o
xazolidinone product which is prepared by a method which comprises: a) forming a carbamate of...
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6897230 |
Bicyclo[3/1/0] hexane containing oxazolidinone antibiotics and derivatives thereof
Oxazolidinones having a bicyclic[3.1.0]hexane containing moiety, which are effective against aerobic and anerobic pathogens such as multi-resistant staphylococci, streptococci and enterococci,...
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6884813 |
Antimicrobial dihydrothiazine and dihydrothiopyran oxazolidinones
The present invention provides a compound of formula I
or a pharmaceutically acceptable salt thereof wherein A is a structure i, ii, iii, or iv
X is CR 7 ; Y is —S(═O) n —,...
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6875784 |
Antimibicrobial [3.1.0.] bicyclic oxazolidinone derivatives
The present invention provides certain [3.1.0] bicyclic oxazolidinone derivatives of Formulea I and II, described herein, or pharmaceutically acceptable salts or prodrugs thereof that are...
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