Patents in Class 548/215

Matches 1 - 50 out of 661

Match	Document	Document Title
1	7622491	Modulators of PPAR and methods of their preparation The present invention is directed to certain novel compounds represented by Formula (I) and pharmaceutically acceptable salts, solvates, hydrates and prodrugs thereof. The present invention is also...
2	7612210	Process for selective synthesis of enantiomers of substituted 1-(2-amino-1-phenyl-ethyl)-cyclohexanols A process for the enantioselective synthesis of an (S)- or (R)-1-[2-dimethylamino)-1-(methoxyphenyl)ethyl]cyclohexanol and analogues or salt thereof are described. The method involves the steps of...
3	7612209	Pseudo proline dipeptides Disclosed is a process for the manufacture of pseudo proline dipeptides of the formula wherein R 1 is a side chain of an alpha amino acid, R 2 is an amino protecting group and R 3 and R 4 ...
4	7608564	3-heterocyclyl-substituted benzoyl derivatives Benzoyl derivatives of the formula I where the variables have the following meanings: R 1 , R 2 are hydrogen, nitro, halogen, cyano, alkyl, haloalkyl, alkoxy, haloalkoxy, alkylthio,...
5	7608244	Hydrophilic light absorbing compositions for determination of physiological function in critically ill patients Highly hydrophilic indole and benzoindole derivatives that absorb and fluoresce in the visible region of light are disclosed. These compounds are useful for physiological and organ function...
6	7595334	Broadspectrum 2-(substituted-amino)-benzoxazole sulfonamide HIV protease inhibitors The present invention concerns the compounds having the formula N-oxides, salts, stereoisomeric forms, racemic mixtures, prodrugs, esters and metabolites thereof, wherein R 1 and R 8 each are...
7	7589196	Amine-substituted biphenyldiphosphines 1,1′-Biphenyl-2,2′-diphosphines having at least one amine substituent in the para position relative to the phosphine group and having the formulae are ligands for metal complexes which...
8	7585880	Phenylpropanoic acid derivatives The present invention provides a novel compound having a GPR40 receptor function modulating action, which is useful as an insulin secretagogue, a drug for the prophylaxis or treatment of diabetes...
9	7579478	Process for the purification of substituted benzoxazole compounds The present invention provides processes for the purification of substituted benzoxazole compounds, and in particular 2-(3-fluoro-4-hydroxy-phenyl)-7-vinyl-benzooxazol-5-ol. The processes include...
10	7563904	Synthesis intermediates useful for preparing zolmitriptan In particular, this invention relates to the synthesis intermediates (IV), (V), (VI) and (VIII) useful for preparing zolmitriptanzohnitriptan or a pharmaceutically acceptable salt thereof, which...
11	7560569	Bicycloamide derivative Novel bicycloamide derivatives (general formula (1)) and pharmaceutically acceptable salts thereof effectively inhibit DPP-IV. The bicycloamide derivatives are represented by the general formula...
12	7556797	Minimally invasive physiological function monitoring agents Highly hydrophilic indole and benzoindole derivatives that absorb and fluoresce in the visible region of light are disclosed. These compounds are useful for physiological and organ function...
13	7553964	Cyclobutyl amine derivatives Compounds of formula (I) are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions comprising...
14	RE40795	Process for producing 5-substituted oxazole compounds and 5-substituted imidazole compounds A process for producing heterocyclic compounds which are useful as pesticides, drugs, fungicidal materials or intermediates thereof. TosMIC is reacted with an aldehyde or an imino compound: 1) in a...
15	7547790	Optically active 4,4-di-substituted oxazolidine derivative and method for producing same An optically active 4,4-di-substituted oxazolidine compound having the formula (I) wherein R 1 represents a substituted C 1 -C 3 alkyl group, a substituted C 2 -C 3 alkenyl group, a...
16	7538130	Hindered amine light stabilizer, methods of making, and compositions A compound in which n is 0, 1, 2, or 3; R 1 , R 2 , R 7 , and R 8 are each independently alkyl group, including cycloalkyl, an alkylaryl group, or an aryl group, optionally with one or more...
17	7534804	Benzoxazole inhibitors of 15-lipoxygenase The present application provides benzoxazole inhibitors of 15-LO, pharmaceutical compositions containing such inhibitors and methods for treating diseases related to the 15-LO cascade using such...
18	7534751	Photo-labile pro-fragrance conjugates The present invention relates to photo-labile pro-fragrance conjugates comprising: a) a photo-labile unit which upon exposure to electromagnetic radiation is capable of releasing a pro-fragrance...
19	7524869	Taxanes having a C10 ester substituent Taxanes having an ester substituent at C(10), a hydroxy substituent at C(7), and a range of C(2), C(9), C(14), and side chain substituents.
20	7521563	Hydroxamic acid derivative and medicine containing the same as active ingredient A compound which inhibits the production of IL-6 and/or TNFα by inflammatory cytokines and is useful in the prevention of or treatments for diseases such as various inflammatory diseases in which...
21	7517902	Substituted indazoles, compositions containing the same, and the preparation and use thereof Disclosed are novel substituted indazole compounds, pharmaceutical compositions comprising such compounds, and methods of treatment comprising such compounds.
22	7511034	Dialkylhydroxybenzoic acid derivatives containing metal chelating groups and their therapeutic uses Novel dialkylhydroxybenzoic acid derivatives containing metal chelating groups are disclosed. The novel compounds are used as therapeutics for treating and/or preventing various medical...
23	7504520	Antagonists of the vanilloid receptor subtype 1 (VR1) and use thereof The present invention is directed to compounds of formula (I) wherein variables W, X, Y, D, A, n, R 1 , R 2 and R 9 are as defined in the description.
24	7491733	Bicyclic guanidine derivatives and therapeutic uses thereof The invention relates to compounds of general formula (I), in which A, X, Y and R1 are defined in Claim 1 . These compounds may be used in the treatment of pathologies associated with insulin...
25	7476686	Substituted aryl thioureas and related compounds; inhibitors of viral replication The invention provides compounds and pharmaceutically acceptable salts of Formula I wherein the variables A 1 , A 2 , R 1 , R 2 , V, W, X, Y, and Z are defined herein. Certain compounds of...
26	7470794	Preparation and use of ortho-sulfonamido aryl hydroxamic acids as matrix metalloproteinase inhibitors Ortho-sulfonamido aryl hydroxamic acids are provided which are useful, inter alia, for the inhibition of matrix metalloproteinases and the treatment of conditions associated with overexpression of...
27	7468437	Phenyl pyrrolidine ether tachykinin receptor antagonists The present invention is directed to certain phenyl pyrrolidine ether compounds which are useful as neurokinin-1 (NK-1) receptor antagonists, and inhibitors of tachykinin and in particular...
28	7465748	Amide derivative There is provided a pharmaceutical drug, particularly a novel compound useful for prophylaxis or a therapeutic treatment of various diseases involving infections with viruses of the herpesvirus...
29	7452899	Gamma-secretase inhibitors Compounds of Formula (I): inhibit the processing of APP by gamma-secretase, and hence are useful for treatment or prevention of Alzheimer's disease.
30	7442486	Radiation-sensitive compositions comprising oxazole derivatives and imageable elements based thereon Radiation-sensitive element comprising: (a) one or more types of monomers each comprising at least one ethylenically unsaturated group accessible to a free-radical polymerization, (b) at least one...
31	RE40558	Therapeutic uses of di-aryl acid derivatives The use of diaryl acid derivatives of formula (I) or pharmaceutically acceptable salts, N-oxides, hydrates or solvates thereof, wherein the variables shown are defined in the disclosure, and...
32	7435751	7-Fluoro-1,3-dihydro-indol-2-one oxazolidinones as antibacterial agents The present invention provides a compound of formula I or a pharmaceutically acceptable salt thereof wherein R 1 is C 1-4 alkyl, optionally substituted with a fluoro atom, or R 1 is a...
33	7432293	Heterocyclic compounds useful as Nurr-1 activators The present invention relates to compounds of formula (I): wherein R 1 is hydroxy, C 1-4 alkoxy, amino, C 1-4 alkyl-amino, di C 1-4 alkylamino, benzyloxy or C 2 -C 7 alkanoyl, R 2 is C 1-4 ...
34	7432290	Inhibitors of IMPDH enzyme The present invention relates to compounds which inhibit IMPDH. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions...
35	7429581	Pyrazole-derivatives as factor Xa inhibitors The present invention is directed to a compound of formula I, in which R 0 ; R 1 ; R 2 ; R 3 ; R 4 ; Q; V, G and M have the meanings indicated below. The compound of formula I is a...
36	7425633	Pyrrolidine compounds A compound of the following formula: wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , T, X, Y, and Z are as defined herein. Also disclosed is a method for inhibiting dipeptidyl peptidase...
37	7425221	Composition comprising at least one substituted derivative of carbocyanine, method for treating keratin fibers using it, device and use The invention relates to a composition comprising, in a cosmetically acceptable medium, at least one particular direct dye. The invention further relates to a method for treating keratin fibers,...
38	7417030	Indazole peptidomimetics as thrombin receptor antagonists The invention is directed to novel indazole peptidomimetic compounds which are useful as thrombin receptor antagonists for the treatment of diseases associated with thrombosis, restenosis,...
39	7396847	Oxazolidinone and/or isoxazoline as antibacterial agents Compounds of the formula (I), or a pharmaceutically-acceptable salt, or an in-vivo-hydrolysable ester thereof, and compounds as shown in (I) wherein C is for example wherein A and B are...
40	7378421	Chromenone derivatives Novel compounds of the formula I in which R 1 , R 2 , R 3 and Het are as defined herein, which are inhibitors of tyrosine kinases and/or Raf kinases and can be employed for the treatment of...
41	7378397	TRH-degrading ectoenzyme inhibitors Peptide derivatives useful as inhibitors of activity of thyrotropin-releasing hormone-degrading ectoenzyme (TRH-DE) are of formula I a : wherein: R 1 is an optionally substituted 4-, 5-...
42	7371777	Cyclic compound and PPAR agonist The present invention provides a novel compound having an excellent PPAR agonist action. More specifically, it provides a compound represented by the following formula, a salt thereof, an ester...
43	7368578	Five-membered heterocyclic compounds The present invention provides a compound represented by the formula: wherein R 1 is an optionally substituted 5-membered heterocyclic group; X, Y and V are the same or different and each is a...
44	7361755	Transition-metal-catalyzed process for the conversion of alkenes to sterically hindered substituted n-alkoxyamines This invention pertains to a novel process for preparing sterically hindered N-substituted alkyloxyamines from alkenes by the transition-metal-catalyzed reaction of a intermediate alkylborane with...
45	7351728	Oxazolyl-aryloxyacetic acid derivatives and their use as PPAR agonists Compounds represented by the following structural formula (I), and pharmaceutically acceptable salts, solvates and hydrates thereof, wherein R1 is an unsubstituted or substituted aryl, heteroaryl,...
46	7342039	Substituted indole oximes The present invention relates to substituted indole oximes and methods of using them.
47	7342035	Process for preparing zolmitriptan compounds In particular, zolmitriptan or a pharmaceutically acceptable salt thereof, which includes a) Preparation of the diazonium salt of the aniline hydrochloride (II); followed by reduction and...
48	7342030	Indole derivatives The present invention relates to the compounds of formula I: their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned...
49	7335775	Effector conjugates, process for their production and their pharmaceutical use Conjugates of epothilones and epothilone derivatives (as effectors) with suitable biomolecules (as recognition units) are described. Their production is carried out by the effectors being reacted...
50	7335671	Arylcycloalkyl-substituted alkanoic acid derivatives, processes for their preparation and their use as pharmaceuticals Arylcycloalkyl-substituted alkanoic acid derivatives, processes for their preparation and their use as pharmaceuticals The invention relates to arylcycloalkyl-substituted alkanoic acid derivatives...

Matches 1 - 50 out of 661

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