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9018206 Carboxamide compounds and their use as calpain inhibitors  
The present invention relates to novel carboxamide compounds and their use for the manufacture of a medicament. The carboxamide compounds are inhibitors of calpain (calcium dependant cysteine...
8927735 Preparation of N-substituted isothiazolinone derivatives  
Provided is a process for the preparation of an N-substituted isothiazolinone derivative having the general formula (I), comprising reacting N-substituted 3-mercaptopropionamides of formula (II)...
8884025 Processes for the preparation of isothiazole derivatives  
Processes and intermediates for the preparation of compounds of the Formula (1) and the pharmaceutically acceptable salts, prodrugs, solvates and hydrates thereof, wherein R1, R2, and R3 have the...
8765752 3-hydroxyisothiazole 1-oxide derivatives  
[Object] To provide a GPR40 activating agent containing, as an active ingredient, a novel compound having a GPR40 agonist action, a salt of the compound, a solvate of the compound or the salt, or...
8629102 3-hydroxyisothiazole 1-oxide derivatives  
[Object] To provide a GPR40 activating agent containing, as an active ingredient, a novel compound having a GPR40 agonist action, a salt of the compound, a solvate of the compound or the salt, or...
8524745 Benzisothiazol-3(1H)-one-5-sulfonyl derivatives as chemokine receptor modulators  
The present invention relates to novel benzisothiazol-3(1H)-one-5-sulfonyl derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals...
8507691 Process for continuously producing 3-isothiazolinone derivatives and intermediate products thereof  
The present application provides a process for continuously producing 3-isothiazolinone derivatives and intermediate products thereof, comprising continuously carrying out four steps, i.e.,...
8487098 Synergistic combination of flumetsulam or diclosulam with isothiazolones  
A synergistic antimicrobial composition containing flumetsulam and an isothiazolone biocide chosen from among 4,5-dichloro-2-n-octyl-4-isothiazolin-3-one, 2-n-octyl-4-isothiazolin-3-one and...
8476287 3-hydroxy-5-arylisothiazole derivative  
[Problem] To provide a GPR40 activating agent having, as an active ingredient, a novel compound having a GPR40 agonist action, a salt of the compound, a solvate of the salt or the compound, or the...
8470739 Isothiazolyloxyphenylamidines and their use as fungicides  
The present invention relates to isothiazolyloxyphenylamidines of the general formula (I), to a process for their preparation, to the use of the amidines according to the invention for controlling...
8283363 Carboxamide compounds and their use as calpain inhibitors  
The present invention relates to novel carboxamide compounds and their use for the manufacture of a medicament. The carboxamide compounds are inhibitors of calpain (calcium dependant cysteine...
8138211 Isothiazolyloxyphenylamidines and their use as fungicides  
The present invention relates to isothiazolyloxyphenylamidines of the general formula (I), to a process for their preparation, to the use of the amidines according to the invention for controlling...
8067452 3-hydroxyisothiazole-4-carboxamidine derivatives as CHK2 inhibitors  
This invention provides compounds of Formula I which are inhibitors of Chk2 and are useful as a radiation protection agents in anticancer radiotherapy. A method of modulating Chk2 in vitro...
7897629 Therapeutic compounds  
Disclosed herein is a compound having a structure or a pharmaceutically acceptable salt thereof, or a prodrug thereof. Therapeutic methods, compositions, and medicaments related thereto are also...
7893273 Preparation of N-substituted isothiazolinone derivatives  
Provided is a process for the preparation of an N-substituted isothiazolinone derivative having the general formula (I), comprising reacting N-substituted 3-mercaptopropionamides of formula (II)...
7790902 Isothiazole derivatives useful as anticancer agents  
The present invention relates to compounds of the formula 1 and to pharmaceutically acceptable salts, prodrugs and solvates thereof, wherein X1, R1, R2 and R3 are as defined herein. The invention...
7723333 Non-anilinic derivatives of isothiazol-3(2H)-one 1,1-dioxides as liver X receptor modulators  
The present invention relates to certain novel compounds of the formula (I) to processes for preparing such compounds, to their the utility in modulation of nuclear hormone receptors Liver X...
7659300 Monocyclic anilide spirolactam CGRP receptor antagonists  
The present invention is directed to compounds of Formula I: I (where A1, A2, B, J, K, m, n, R4, R5a, R5b and R5c are as defined herein) useful as antagonists of CGRP receptors and useful in the...
7598236 Diazabicyclic central nervous system active agents  
Compounds of formula I pharmaceutical compositions of these compounds, and use of said compositions to control synaptic transmission in mammals.
7582629 Derivatives of isothiazol-3(2H)-one 1,1-dioxides as liver X receptor modulators  
The present invention relates to certain novel compounds of the formula (I) to processes for preparing such compounds, to their the utility in modulation of nuclear hormone receptors Liver X...
7557095 Therapeutic compounds  
Disclosed herein is a compound having a structure or a pharmaceutically acceptable salt thereof, or a prodrug thereof. Therapeutic methods, compositions, and medicaments related thereto are also...
7511149 Process for the oxidation of certain substituted sulfilimines to insecticidal sulfoximines  
Insecticidal sulfoximines are produced efficiently and in high yield by the oxidation of the corresponding sulfilimine with ruthenium tetraoxide or an alkali metal permanganate.
7442240 Alkoxylpropylisothiazolinone and preparation method and use thereof  
An alkoxylpropyl isothiazolinone of formula: C6H6Cl2NO2SR, in which R is CH3, CH2CH3, CH(CH3)2, CH2CH2CH2CH3, CH2CH2OCH3 or CH2CH2OC6H5Cl. A method for preparing the isothiazolinone by reacting...
7405218 Isothiazole derivatives useful as anticancer agents  
The present invention relates to compounds of the formula 1 and to pharmaceutically acceptable salts, prodrugs and solvates thereof, wherein X1, R1, R2 and R3 are as defined herein. The invention...
7402678 Multifunctional amine capture agents  
Multifunctional compounds having acylsulfonamide amine-reactive groups are described that can be used for the capture of amine containing materials.
7365196 Sulphonamido-substituted bridged bicycloalkyl derivatives  
A class of compounds is disclosed, comprising sulphonamido-substituted bridged bicycloalkyl structures. The compounds are inhibitors of gamma-secretase, and hence are useful in the treatment of...
7276602 Isothiazole derivatives useful as anticancer agents  
The invention relates to compounds of the formula 1 or pharmaceutically acceptable salts, prodrugs, solvates or hydrates thereof, wherein wherein X, R1, and R2 are as defined herein. The invention...
7253198 Hydroxyethylamine derivatives for the treatment of Alzheimer's disease  
The present invention relates to novel hydroxyethylamine compounds having Asp2 (β-secretase, BACE1 or Memapsin) inhibitory activity, processes for their preparation, to compositions containing...
6989451 Heterocyclic compounds and uses thereof  
Substituted isothiazole compounds and compositions are provided, wherein particularly preferred compositions and methods are directed towards inhibition of various protein kinases (especially MEK...
6927216 Cyclic sulfonyl compounds as inhibitors of metalloproteases  
The present application describes novel cyclic sulfonyl derivatives of formula I: or pharmaceutically acceptable salt forms thereof, wherein ring B is a 5-7 membered cyclic system containing from...
6852716 Substituted-aryl compounds for treatment of disease  
The invention provides compounds of Formula I: These compounds may be in the form of pharmaceutical salts or compositions, racemic mixtures, or pure enantiomers thereof. The compounds of Formula I...
6833370 Heterocycle substituted aminoazacycles useful as central nervous system agents  
Heterocyclic substituted aminoazacyclic compounds of formula I Z—R3 I, wherein Z is a defined aminoazacycle and R3 is a defined heterocycle moiety, pharmaceutical compositions of these compounds,...
6831091 Salt forms of 3-(4-bromo-2,6-difluoro-benzyloxy)-5-&lsqb 3-(4-pyrrolidin-1-yl-butyl)-ureido&rsqb -isothiazole-4-carboxylic acid amide and method of production  
The invention relates to hydrochloride, hydrobromide, hemi-citrate, acetate, p-tosylate, L-tartrate, hemi-succinate, and mesylate salt forms of...
6828276 Herbicidally active benzoylcyclohexanediones  
There are described benzoylcyclohexanediones of the formula I, their preparation, and their use as herbicides and plant growth regulators. In this formula (I), C1, C2, C3 are cyclic radicals, X1...
6809107 Neurotrophic pyrrolidines and piperidines, and related compositions and methods  
This invention provides compounds having the following general structures: This invention also provides pharmaceutical compositions comprising same and methods of using these compositions to treat...
6759423 4-Hydroxyisothiazole compounds  
The present invention relates to the use of 4-hydroxyisothiazole compounds as antimicrobially active substances, certain new 4-hydroxyisothiazole compounds and a process for their preparation.
6750346 Stable near-infrared (NIR) marker dyes based on benzopyrylium-polymethines  
The disclosure is directed to so-called laser-compatible NIR marker dyes based on polymethines for use in optical, in particular, fluorescence optical determination and detection methods, for...
6746989 Substituted benzoylpyrazoles as herbicides  
The invention relates to novel substituted benzoylpyrazoles of the general formula (I), in whichn represents the numbers 0, 1, 2 or 3,A represents a single bond or represents...
6740759 Method for producing 2-alkyl-4-isothiazoline-3-one  
Chlorinating agent is reacted with a compound represented by formula (I) (wherein R represents C1 to C8 alkyl groups or aralkyl groups) or a compound represented by formula (II) in a solvent in...
6670385 α-phenyl-βketosulfone  
The present invention relates to novel aryl-substituted S(O)m cycles of the formula (I) in which F1, F2, G, V, W, X, Y, Z and m are each as defined in the description, to processes for their...
6593349 Bisarylamines as potassium channel openers  
Compounds, compositions and methods are provided which are useful in the treatment of diseases through the modulation of potassium ion flux through voltage-dependent potassium channels. More...
6583291 Process for obtaining compounds usable in the production of Cefotetan, and new compounds obtained thereby  
A safe and economical process for obtaining salts of 4-carboxy-3-hydroxy-5-mercapto-isothiazole. This process comprises refluxing a disodium or dipotassium salt of...
6566382 Stabilized isothiazolone-containing compositions  
The present invention relates to isothiazolone-containing compositions comprising a) 3-isothiazolone compounds; b) a metal nitrate; c) magnesium chloride; d) at least one compound selected from...
6534076 Stabilized isothiazolone compositions and methods of stabilization of isothiazolone  
The present invention relates to stabilized isothiazolone compositions and methods of stabilization of isothiazolone, more particularly, to stabilized isothiazolone solutions comprising (a) an...
6531604 Benzothiepine derivatives, their production and use  
The invention provides compounds of the formula: wherein the ring A is an optionally substituted benzene ring; R1 is an optionally substituted non-aromatic heterocyclic group; R2 and R3 are...
6511673 Microbicidal composition  
Microbicidal compositions containing selected ratios of a non-halogenated 2-alkyl-3-isothiazolone and one or more (C1-C7) esters of para-hydroxybenzoic acid are disclosed as improved formulations...
6506904 Method of preparing N,N′-disubstituted-3,3′-dithiodipropionamide and method of preparing substituted 3-isothiazolone by using the same  
A method of preparing N,N-disubstituted 3,3′-dithiodipropionamide of formula (2) is provided. In the method, 3-mercaptopropi-onamide of formula (4) reacts with an aqueous solution of amine to...
6380214 Heterocyclic derivatives useful as anticancer agents  
The present invention relates to compounds of the formula 1 and to pharmaceutically acceptable salts, prodrugs and solvates thereof, wherein Z, X, X1, R1, R2 and R3 are as defined herein as it...
6376680 Process for the preparation of 3-isothiazolone mixture and composition comprising the mixture  
An impurity-free biologically active mixture of 2-methyl-4-isothiazolin-3-one and 5-chloro-2-methyl-4-isothiazolin-3-one, which is useful as a biocide in various products, can be prepared by...
6358983 Heterocyclically substituted α-hydroxycarboxylic acid derivatives, method for producing the same and their use as endothelin receptor antagonists  
The present invention relates to carboxylic acid derivatives of the formula I the substituents having the meanings explained in the description, preparation and use as endothelin receptor antagonists.

Matches 1 - 50 out of 310 1 2 3 4 5 6 7 >