Matches 301 - 350 out of 575 < 1 2 3 4 5 6 7 8 9 10 11 12 >
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5234917 Substituted 5-(alkyl)carboxamide imidazoles  
Angiotensin II receptor antagonists having the formula: ##STR1## which are useful in regulating hypertension and in the treatment of congestive heart failure, renal failure, and glaucoma...
5231182 Method of making certain aryl containing amides  
Methods of preparing bis-aryl amide and urea compounds of the general formula: ##STR1## wherein x is a divalent amide or urea substituent and Y is a nitrogen containing heterocycle, which compounds...
5229386 Thiazole compounds, processes for the preparation thereof and pharmaceutical composition comprising the same  
The invention relates to new thiazole compounds, of antithrombotic, vasodilating, antiallergic, antiinflammatory and 5-lipoxygenase inhibitory activity, of the formula: ##STR1##
5225570 5-heterocyclic-substituted oxazolidine dihaloacetamides  
The disclosure herein relates to a new family of haloalkyl oxazolidinyl derivatives as antidotal compounds to reduce injury to crop plants by a variety of herbicides. The antidotal compounds are...
5214206 Aminosulfonyl urea ACAT inhibitors  
The present invention provides pharmaceutically useful compounds which are aminosulfonyl urea compounds which are ACAT inhibitors rendering them useful in controlling blood cholesterol levels,...
5210239 Ouinone derivatives and pharmacological use  
A quinone derivative useful in the treatment of hepatic diseases defined by the general formula: ##STR1## where R1 is selected from the group consisting of alkyl, alkenly, alkynyl or heterocycle,...
5194622 Process for preparation of thiazolylalkoxy acrylates  
A process for the preparation of a compound of the formula ##STR1## wherein R 1 and R 2 are individually selected from the group consisting of hydrogen, halogen, --CF 3 , alkyl, alkoxy and...
5192781 Thiazole derivatives which are angiotensin II receptor antagonists, their methods of preparation and pharmaceutical compositions in which they are present  
The present invention relates to the derivatives of formula (I): ##STR1## and their addition salts, and to their use in therapeutics, especially for the treatment of cardiovascular diseases and in...
5189180 Seco-mevinic acid derivatives useful as antihypercholesterolemic agents and new intermediates  
Seco-mevinic acid derivatives are provided which have the structure ##STR1## including all stereoisomers thereof, wherein Z is ##STR2## R is H, alkali metal or lower alkyl, R 1 is H, lower alkyl,...
5189165 Process for the preparation of 1,1-disubstituted cyclopropane derivatives  
A process for preparing a compound I ##STR1## with A=t-butyl, aryl and R=alkyl, alkenyl, alkynyl, alkenynyl, cycloalkyl(alkyl), aryl, arylalkyl, alkyl-S-(-O)-aryl by reacting a compound III...
5185354 Pyrazolecarboxamide, insecticidal and miticidal composition, and fungicidal composition for use in agriculture and horticulture  
A pyrazolecarboxamide derivative represented by the following formula (I): ##STR1## wherein R 1 represents a C 1 .about.C 3 alkyl group, R 2 represents a C 1 .about.C 3 alkyl group, R 3 ...
5182295 Insecticidal benzofuran derivatives  
A compound of the formula ##STR1## wherein R is selected from the group consisting of hydrogen, optionally substituted alkyl, alkenyl and alkynyl of up to 8 carbon atoms, optionally substituted...
5182402 Herbicidal compositions  
A method of killing or controlling unwanted plants by applying to the plant on to a locus thereof an effective amount of a compound of formula (I) ##STR1## or a salt thereof: wherein R 1 , R 2 , R...
5177095 Triazole angiotensin II antagonists incorporating a substituted benzyl element  
Substituted triazoles attached through a methylene bridge to novel substituted phenyl derivatives of the Formula I, are useful as angiotensin II antagonists. ##STR1##
5166167 α-Methylene-4-(phenoxymethyl)-5-thiazolacetate  
A compound of the formula ##STR1## wherein Ar is phenyl optionally substituted with at least one member of the group consisting of halogen, methylenedioxy, phenoxy, phenyl, --CF 3 and alkyl,...
5162362 Octahydroindole-2-carboxylic acids  
What are disclosed are aminoacid compounds of the formula ##STR1## wherein n is 0 or 1, and salts thereof, said compounds and salts having hypotensive properties; methods for making the compounds;...
5142056 Retroviral protease inhibiting compounds  
A retroviral protease inhibiting compound of the formula A--X--B or a pharmaceutically acceptable salt, prodrug or ester thereof, wherein X is a linking group; A is (1) substituted amino, ...
5137897 2-substituted 4-(3-alkyl-5-tert.-butyl-4-hydroxyphenyl) thiazoles, processes for their preparation, pharmaceuticals containing them and their use  
Novel substituted thiazoles of the formula I ##STR1## in which R 1 is a saturated or unsaturated, straight-chain or branched C 1 -C 5 -alkyl group, R 2 is a hydrogen atom or an alkyl radical...
5138067 Lipid derivatives  
Lipid derivatives represented by the formula: ##STR1## wherein R 1 is alkyl or alkylcarbamoyl; R 2 is lower alkyloxy, lower alkylcarbamoyloxy, lower alkylcarbonylamino, lower...
5128481 Pyrazolyl derivatives  
A pyrazolyl acrylic acid derivative having plant fungicidal activity of formula (I): ##STR1## wherein: R 1 and R 2 are independently hydrogen or C 1 -C 5 alkyl; A is a group of the formula:...
5116954 Pharmaceutically useful flavonoic compounds containing at least one substituent on the benzopyranone ring moiety  
Substituted six-membered benzo-fused heterocycles of the formula (I) ##STR1## in which: X=0, NH, S➝(O) n (n=0 or 2); R 1 is phenyl, phenyl substituted by methoxy, hydroxy, chlorine,...
5116850 Heterocyclic pyrazoline carboxanilides  
Heterocyclic pyrazoline carboxanilide insecticides including all geometric and stereoisomers thereof, as well as agricultural compositions containing them.
5110956 Benzodioxale derivatives  
A new benzodioxole derivative has a substituent in the phenyl ring which is a carboxyalkylthioalkyl or the like and is effective to treat a liver disease.
5103007 Lipids  
Lipid derivatives represented by the formula: ##STR1## wherein R 1 stands for an optionally substituted higher alkyl group, R 2 stands for an optionally substituted lower alkyl group or an...
5103014 Certain 3,3'-[[[(2-phenyl-4-thiazolyl)methoxy]phenyl]methylene]dithiobis-propano ic acid derivatives  
There are disclosed compounds of the formula ##STR1## wherein X is ##STR2## Y is ##STR3## Z is --(CH 2 ) n O--, --(CH 2 ) n S--, ##STR4## R 1 is ##STR5## n is 0-5; R 2 is hydrogen, loweralkyl,...
5089512 Thiazole derivatives  
The invention provides thiazole derivatives of the general formula I: ##STR1## or acid-addition salts or metal salt complexes thereof, in which R represents an optionally substituted phenyl group;...
5084575 Quinoline substituted naphthalenepropionic acid derivatives as anti-inflammatory/antiallergic agents  
There are disclosed compounds of the formula ##STR1## wherein a is alkyl 3-19 carbon atoms, diloweralkyl allyl, diahaloallyl, diphenylallyl, lower alkynyl, ##STR2## W is --CR 2 O--, --CHCH-- or...
5081245 Carboxylic acid derivatives  
A compound represented by the formula: ##STR1## wherein R represents a hydrogen atom or a lower alkyl group; R 1 represents a higher alkyl group which may be substituted; R 2 represents a...
5077409 Method of preparing bis-aryl amide and urea antagonists of platelet activating factor  
Methods of preparing bis-aryl amide and urea compounds of the general formula: ##STR1## wherein x is a divalent amide or urea substituent and Y is a nitrogen containing heterocycle, which compounds...
5077305 Thiazole carboxylic acids and esters  
Heterocyclic acids and esters useful as inhibitors of mammalian blood platelet aggregation characterized by Formula I or II are disclosed. HET 1 -(CH 2 ) n CO 2 R (I)...
5068343 4-substituted 5-chloro-2-hydrazinothiazoles  
4-Substituted 5-chloro-2-hydrazinothiazoles of the formula ##STR1## in which R represents CHF 2 , CF 3 , CN or COOR 1 , where R 1 represents C 1 -C 4 -alkyl. They are useful as pesticides and...
5066663 Substituted-hetero-cyclopentanones and cyclopentenones and derivatives thereof acting at muscarinic receptors  
Substituted-hetero-cyclopentanones and cyclopentenones and derivatives thereof are described, as well as methods for the preparation and pharmaceutical compositions of same, which are useful as...
5066662 Substituted oxazolidin-2-ones and 1,2,4-oxadiazolin-5-ones and derivatives thereof acting at muscarinic receptors  
Oxazolidin-2-ones and 1,2,4-oxadiazolin-5-ones substituted in the 4-position of the oxazolidin-2-one ring and the 3-position of the 1,2,4-oxadiazolin-5-one ring with a 5- or 6-member...
5066665 Substituted isoxazolidin-3-ones and derivatives thereof acting at muscarinic receptors  
Substituted isoxazolidin-3-ones and derivatives thereof are described, as well as methods for the preparation and pharmaceutical compositions of same, which are useful as centrally acting...
5051437 Thiazolylphenoxyalkylisoxazoles, related compounds, and their use as antiviral agents  
Compounds of the formula ##STR1## wherein: Y is an alkylene bridge of 3-9 carbon atoms; Z is N or HC; R is hydrogen or lower-alkyl of 1-5 carbon atoms, with the proviso that when Z is N, R is...
5047549 Derivatives of pravastatin for inhibiting cholesterol biosynthesis  
Derivatives of pravastatin are provided which are useful in inhibiting cholesterol biosynthesis and in preparing radiolabeled compounds useful in the radioimmunoassay (RIA) of pravastatin and...
5047417 Butenoic or propenoic acid derivatives  
A butenoic or propenoic acid derivative having the following formula in which G is an aryl or a heterocyclic ring, R11 and R12 are hydrogen or an alkyl, X is sulfur or oxygen, R2 and R3 are...
5032590 Substituted hydroxylamines  
Substituted hydroxylamines of the formula ##STR1## in which R 1 stands for an aromatic or heterocyclic radical, are especially useful in the treatment of hyperlipoproteinaemia, lipoproteinaemia...
5006555 Esters of 2-arylmethyl-1-naphthol derivatives as 5-lipoxygenase inhibitors  
There are provided novel esters of 2-arylmethyl-1-naphthol derivatives useful as anti-inflammatory agents. Also provided are pharmaceutical compositions containing these compounds and methods of...
5006548 Acrylamidobenzoic acid derivatives and their use  
Compounds of the general formula: ##STR1## wherein R 1 is heterocyclic group other than pyridyl and which is unsubstituted or substituted with lower alkyl or lower alkoxycarbonyl, R 2 is...
5001140 Cycloalkylthiazoles  
The invention relates to compounds of the formula: ##STR1## wherein R is hydrogen or lower alkyl, R 1 , R 2 , R 3 and R 4 , independently, are hydrogen, lower alkyl, lower alkenyl, cycloalkyl or...
4999042 Phenyl oximino-acetate fungicides  
Compounds of the fomrula (I): ##STR1## and sterioisomers thereof, wherein X is halogen, alkyl, cycloalkyl, aralkyl, aryloxyalkyl, alkenyl, alkynyl, aryl, amino, arylazo, heteroarylalkyl,...
4997843 2,4-disubstituted derivatives of tetrahydrofuran useful for the treatment of PAF mediated illnesses  
The present invention describes novel 2,4-disubstituted derivatives of tetrahydrofuran, having the formula I ##STR1## wherein: -X- is either an oxygen atom or a covalent single bond; --CH 2 XR 1 ...
4992421 Luteinizing hormone releasing hormone antagonist  
The present invention relates to novel luteinizing hormone releasing hormone antagonists ##STR1## The invention also relates to pharmaceutical compositions containing such compounds and to the use...
4987130 Substituted amine derivatives, their production and use  
Substituted amino derivatives represented by the formula: ##STR1## wherein R 1 and R 2 each stand for an acyclic hydrocarbon residue or an alicyclic hydrocarbon residue; R 3 and R 4 each stand...
4962117 Heterazole dialkanoic acids  
Compounds having the formula: ##STR1## are leukotriene antagonists and inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, antiallergic, anti-inflammatory, and...
4960900 Oxyimino derivatives of thiazole, method of preparation and use in therapy  
The present invention relates, by way of novel industrial products, to the ollowing oxyimino derivatives of thiazole: (a) the E and Z diastereoisomers of the formula ##STR1## in which R 1 ...
4948415 Agents for regulating plant growth  
Agents for regulating plant growth containing an effective amount of at least one cyclohexenone derivative of the formula ##STR1## where R 1 , R 2 and R 3 have the meanings given in the...
4945098 Novel propane-1,3-diol derivatives and use  
A derivative of 2-methylenepropane-1,3-diol of the general formula I ##STR1## where O--A 1 and O--A 2 , which can be the same or different, each represents O, O--C(O), O--C(O)NH, O--C(S)NH or...
4945178 Preparation of 4-carboalkoxy-1,3-cyclohexanedione type compounds  
Acetoacetic esters of the formula R--OOCCH 2 COCH 3 are reacted with an unsaturated ester of the formula R 1 R 2 CCHCOOR 3 in the presence of basic catalyst such as ethanolic sodium...
Matches 301 - 350 out of 575 < 1 2 3 4 5 6 7 8 9 10 11 12 >