Matches 151 - 200 out of 575 < 1 2 3 4 5 6 7 8 9 10 11 12 >
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6342633 O-benzyl oxime ether derivatives and their use as pesticides  
Compounds of the formula I in which Y is hydrogen, C 1 -C 4 alkyl, C 1 -C 4 alkoxy, OH, CN, NO 2 , Si(CH 3 ) 3 , CF 3 or halogen, Z is a group a) R 1 is hydrogen, C 1 -C 4 alkyl, C 2 -C 4...
6323227 Substituted N-[(aminoiminomethyl or aminomethyl)phenyl]propyl amides  
This invention relates to compounds of formula ##STR1## which inhibit Factor Xa, to pharmaceutical compositions containing the compounds, and to the use of the compounds for the treatment of...
6320045 Process for the reduction of oxiranyl epothilones to olefinic epothilones  
The invention as claimed is directed to a process for making an epothilone having the following structures ##STR1## from ones having an oxiranyl moiety, by reacting a compound having the latter...
6300353 Azoles for treatment of fungal infections  
Azole derivatives of the formula I ##STR1## wherein R 14 , R 15 are each independently hydrogen or fluorine, T is a group of the formula: ##STR2## wherein R 9 is pyrrolidinyl or a group...
6277849 N-sulphonyl and N-sulphinyl amino acid amides as microbiocides  
The invention relates to novel pesticidally active compounds of the general formula I ##STR1## as well as possible isomers and isomeric mixtures thereof, wherein n is a number zero or one; and ...
6271179 Benzylidene pyrazolones, production and use thereof  
Benzylidenepyrazolones of the formula I, ##STR1## Useful as herbicides.
6262094 C-21 modified epothilones  
The invention is concerned with epothilones in which the thiazole substituent has been modified, with methods for their preparation and with antifungal or therapeutic agents which contain these...
6251926 Oxyiminoalkanoic acid derivatives with hypoglycemic and hypolipidemic activity  
This invention provides a novel oxyiminoalkanoic acid derivative which has excellent hypoglycemic and hypolipidemic actions and which is used for the treatment of diabetes mellitus, hyperlipemia,...
6245790 Oxazole compounds useful as PGE2 agonists and antagonists  
Azole compounds of the formula: ##STR1## wherein R 1 is lower alkyl substituted with carboxy, etc., R 2 is hydrogen or lower alkyl, R 3 is aryl, etc. R 4 is aryl, etc. Q is ##STR2##...
6239104 Isolation and structural elucidation of the cytostatic linear and cyclo-depsipeptides dolastatin 16, dolastatin 17, and dolastatin 18  
Cytostatic linear and cyclo-depsipeptides, "Dolastatin 16", "Dolastatin 18", and "Dolastatin 17", are disclosed which are obtained from Indian Ocean shelless mollusk Dolabella auricularia. Methods...
6211240 O-benzyl oxime ether derivatives and their use as pesticides  
Compounds of the formula I ##STR1## in which Y is hydrogen, C 1 -C 4 alkyl, C 1 -C 4 alkoxy, OH, CN, NO 2 , Si(CH 3 ) 3 , CF 3 or halogen, Z is a group a) ##STR2## R 1 is hydrogen, C...
6197802 Fungicidal melithiazole derivatives  
Compounds of formula (I), wherein R 1 represents a hydrogen atom or an optionally substituted alkyl, alkenyl, alkyloxiranyl, alkanoyl, alkoxycarbonyl, formyl, hydroxyalkyl, alkoxyalkyl,...
6194448 N, N-disubstituted amides that inhibit the binding of integrins to their receptors  
A method for the inhibition of the binding of α 4 β 1 integrin to its receptors, for example VCAM-1 (vascular cell adhesion molecule-1) and fibronectin; compounds that inhibit this binding;...
6166051 Thiol derivatives with metallopeptidase (ACE/NEP) inhibitory activity  
Compounds of formula (I) wherein R, R 1 , R 2 , R 3 have the meanings reported in the description, processes for their preparation and pharmaceutical compositions which contain them as active...
6166023 1,5- and 3-O-substituted 1H-indazoles having anti-asthmatic, anti-allergic, anti-inflammatory, immunomodulating and neuroprotective action, process for their preparation and their use as medicaments  
The invention relates to 1,5- and 3-O-substituted 1H-indazoles of formula (I) ##STR1##
6166004 Combinations of HIV protease inhibitors with reverse transcriptase inhibitors  
There are described compounds of formula I*, ##STR1## wherein R 1 is lower alkoxycarbonyl, R 2 is secondary or tertiary lower alkyl or lower alkylthio-lower alkyl, R 3 is phenyl that is...
6165944 4-(3-heterocyclyl-1-benzoyl) pyrazoles and their use as herbicides  
4-(3-Heterocyclyl-1-benzoyl)pyrazoles of the formula I ##STR1## where: R 1 and R 3 are each hydrogen, nitro, halogen, cyano, alkyl, haloalkyl, alkoxy, haloalkoxy, alkylthio, haloalkylthio,...
6162823 LTA.sub.4 hydrolase inhibitors  
The present invention provides compounds having the of the formula I: ##STR1## and pharmaceutically acceptable salts and stereoisomers thereof that are useful in the treatment of inflammatory...
6160122 Process for the preparation of a disubstituted thiazole  
A process is disclosed for the preparation of N-((N-Methyl-N-((2-isopropyl-4-thiazolyl)methyl)amino)carbon yl)-amino acid derivatives.
6156776 Diaryl substituted thiazoles useful in the treatment of fungal infections  
Disclosed is a novel class of thiazole, thiadiazole, and oxadiazole compounds which are substituted at their nuclear carbons by aromatic moieties. These compounds exhibit antifungal activity...
6156905 Deoxy epothilones and intermediates utilized in the process for preparing epothilones  
The invention relates to a process for the production of epothilones and intermediate products within the process. Epothilones A and B are natural substances, which can be produced by...
6143696 Substituted 4-(3-alkenylbenzoyl)pyrazoles  
4-(3-Alkenylbenzoyl)pyrazoles of the formula I ##STR1## and agriculturally useful salts thereof; processes for preparing the compounds of the formula I; compositions comprising them; and the use of...
6140330 Thiazole derivative  
A thiazole compound of the formula: ##STR1## wherein T is lower alkylene; u is 0 or 1; R 1 and R 2 are the same or different and are each H, or lower alkyl, etc.; R 3 is ##STR2## R 4 is H or...
6140272 Substituted 4-benzoyl-pyrazoles  
4-Benzoylpyrazoles of the formula I where: A is a group of the formula IIIa, IIIb or IV ##STR1## Q is a pyrazole of the formula II, ##STR2## useful as herbicides.
6096898 One pot synthesis of 1,2,4-triazoles  
One pot synthesis of 1,2,4-triazoles uses thioimidate intermediate and 1,2-dichloroethane solvent.
6077864 Cyclic sulfone derivatives  
A compound of the formula ##STR1## wherein n, X, Y and Ar are as defined herein, useful in the treatment of a condition selected from the group consisting of arthritis, cancer, tissue ulceration,...
6069162 Indolyl and benzofuranyl carboxamides as inhibitors of nitric oxide production  
6048883 Heterocyclic compounds as pharmaceutical  
This invention provides compounds of formula (I): A 1 --X--(CH 2 ) n --O--A 2 --A 3 --Y.R 2 (I) or a tautomeric form thereof or a pharmaceutically acceptable salt thereof, or a...
6046137 Herbicidal heterocyclically substituted benzoylisothiazoles  
4-Benzoylisothiazoles of the general formula 1 ##STR1## where the substituents have the following meanings: X is oxygen or sulfur; R 3 is a radical of the general formula 2 ##STR2## where Z and...
6043282 Azinooximethers, processes and intermediate products for manufacturing same, and the uses thereof in combating harmful fungi and pests  
Azinooxime ethers of the formula I ##STR1## (X=NOCH 3 , CHOCH 3 , CHCH 3 ; Y=O, NZ, where Z=H, alkyl; R 1 =H, alkyl; R 2 =cyano, nitro, trifluoromethyl, halogen, alkyl, alkoxy; m=0, 1, 2, it...
6043263 (2,3-dihydrobenzofuranyl)-thiazoles as phosphodiesterase inhibitors  
The invention relates to compounds of the formula (I), wherein R1, R2, R3, R4, R5 and n have the meanings cited in the description said compounds being new effective bronchial therapeutic agents.
6037365 Aminobenzamidinosuccinyl lactone derivatives useful as inhibitors of platelet aggregation  
This invention provides a compound of the formula ##STR1## or a pharmaceutically acceptable salt thereof. The invention also provides pharmaceutical compositions of such compounds and a method of...
6037367 Substituted-pent-4-ynoic acids  
Compounds of formula (I) wherein: R 1 is --(CR 4 R 5 ) n C(O)O(CR 4 R 5 ) m R 6 , --(CR 4 R 5 ) n C(O)NR 4 (CR 4 R 5 ) m R 6 , (CR 4 R 5 ) n O(CR 4 R 5 ) m R 6 , or --(CR 4 R 5 ) r ...
6020495 Stereoselective method for synthesizing dolaphenine  
The present invention relates to a method for the stereospecific synthesis of an enantiomer of a chiral amine, wherein the chiral amine has the formula R 1 CH(NH 2 )R 2 . R 1 and R 2 are each...
6013811 Preparation process of benzodifuranone dyes  
A process for the preparation of a polycyclic dye of Formula (1) which comprises steps: i) reaction of a compound of formula (2) with a compound of formula (3) or a derivative thereof to form an...
6007865 Reversing the formation of advanced glycosylation endproducts  
The present invention relates to compositions and methods for inhibiting and reversing nonenzymatic cross-linking (protein aging). Accordingly, compositions are disclosed which comprise an agent...
6004988 Carboxylic acid derivatives, their preparation and their use  
Carboxylic acid derivatives of the formula I ##STR1## here R 1 is a tetrazole [sic], nitrile [sic], a group COOH or a radical which can be hydrolyzed to COOH, and the other substituents have the...
5994539 Mercapto acyl aminoacid derivatives endowed with dual ACE-NEP inhibitory activity, useful in the treatment of cardiovascular diseases  
Compounds of formula ##STR1## wherein R, R 1 , R 2 , R 3 , R 4 , m and n have the meanings reported in the description, processes for their preparation and pharmaceutical compositions which contain...
5981559 Azole derivative with leukotriene (LTs) antagonizing activity and thromboxane (TX) A.sub.2 antagonizing activity  
An azole derivative represented by general formula (I) or a pharmaceutically acceptable salt thereof, having both of a leukotriene antagonistic effect and a thromboxane A2 antagonistic effect and...
5977149 Dihydrotriazole compounds and their use for controlling fungal plant diseases  
Cyclic amides of Formula (I) which are useful as fungicides wherein: A is O; S; N; NR 5 ;or CR 14 --, G is C or N; W is O or S; X is OR 1 , S(O) m R 1 or halogen; R 1 , R 2 , and R 5 are...
5969145 Process for the production of epothilones and intermediate products within the process  
The invention relates to a process for the production of epothilones and intermediate products within the process. Epothilones A and B are natural substances, which can be produced by...
5965741 Ortho-substituted aromatic ether compounds and their use in pharmaceutical compositions for pain relief  
The invention provides compounds of formula I: ##STR1## wherein A, B, D, X, R 1 , and R 3 have any of the values defined in the specification, as well as N-oxides thereof, S-oxides thereof,...
5962686 N-benzylazolium derivatives  
N-Benzylazolium derivatives of the general formula (I), ##STR1## wherein Q is the remainder of an azole compound of the formula II ##STR2## possessing antifungal activity; Z is nitrogen or methine;...
5948779 Substituted condensation products of n-benzyl-3-indenyl acetamides with heterocyclic aldehydes  
Substituted condensation products of N-benzyl-3-indenylacetamides with heterocyclic aldehydes are useful for inducing or promoting apotosis and for arresting uncontrolled neoplastic cell...
5942535 a!-Annelated pyrrole derivatives and pharmaceutical use thereof  
The present invention relates to heterocyclic compounds of the formula ##STR1## in which R 1 -R 7 , B, a and X have the meanings recited in the specification. These compounds are usable in the...
5932606 Pyrazinone, pyridinone, piperidine and pyrrolidine thrombin inhibitors  
A compound which inhibits human thrombin and where has the structure and pharmaceutically acceptable salts thereof, wherein such as ##STR1## which are useful for inhibiting formation of blood...
5929248 Substituted heteroarylphenyloxazolidinones  
The present invention discloses novel substituted aryl- and heteroarylphenyloxazolidinones which are useful as anti-bacterial agents. More specifically, the substituted aryl- and...
5925631 Alkylated styrenes as prodrugs to COX-2 inhibitors  
The invention encompasses the novel compound of Formula I useful in the treatment of cyclooxygenase-2 mediated diseases. ##STR1## The invention also encompasses certain pharmaceutical compositions...
5914351 Anti-viral aromatic hydrazones  
Compounds of the formula ##STR1## wherein Q is a hydrazone derivative; R 1 is hydrogen, halogen, alkyl or alkoxy; R 2 is hydrogen, halogen, alkyl, alkoxy, alkenoxy, alkynyloxy, halomethyl,...
5892033 Metallic chelating dye  
Disclosed is a metal chelate dye which is composed of a metal ion and a ligand that is a methine dye having 2 or more bonding positions capable of coordinate bond to the metal ion at the bonding...
Matches 151 - 200 out of 575 < 1 2 3 4 5 6 7 8 9 10 11 12 >