|
Match
|
Document |
Document Title |
|
|
6719540 |
C3-cyano epothilone derivatives
The present invention relates to compounds useful in the treatment of cancer or other proliferative diseases represented by formula I: wherein: Q is selected from the group consisting of M is...
|
|
|
6713498 |
Method for treating glaucoma VI
Provided, among things, is a method of decreasing intraocular pressure in an animal, including a human, comprising administering an intraocular pressure decreasing amount of a compound of the...
|
|
|
6710063 |
Activators of PPAR delta
Compounds of Formula (1) are disclosed. These compounds include selective activators of human PPAR delta.
|
|
|
6703403 |
Method for improving pharmacokinetics
A method is disclosed for improving the pharmacokinetics of a drug which is metabolized by cytochrome P450 monooxygenase.
|
|
|
6689794 |
Aromatic sulfone hydroxamates and their use as protease inhibitors
This invention is directed to aromatic sulfone hydroxamates (also known as “aromatic sulfone hydroxamic acids”) and salts thereof that, inter alia, inhibit matrix metalloproteinase (also known...
|
|
|
6667404 |
Retroviral protease inhibiting compounds
A retroviral protease inhibiting compound of the formula: is disclosed.
|
|
|
6664277 |
Prenylation inhibitors containing dimethylcyclobutane and methods of their synthesis and use
The present invention is directed to compounds useful in the treatment of diseases associated with prenylation of proteins and pharmaceutically acceptable salts thereof, to pharmaceutical...
|
|
|
6656711 |
Fermentative preparation process for and crystal forms of cytostatics
The invention relates to a new process for concentrating epothilones in culture media, a new process for the production of epothilones, a new process for separating epothilones A and B and a new...
|
|
|
6653472 |
Preparing amidines derived from 6-hydroxy-2,5,7,8-tetramethylchromane-2-carboxylic acid
New intermediates of the formula (II)B described below for the synthesis of amidine derivatives of (−)-6-hydroxy-2,5,7,8-tetramethylchromane-2-carboxylic acid, such as for example...
|
|
|
6642234 |
Acrylonitrile compounds
The present invention relates to acrylonitrile compounds of formula (1): [wherein, R is a C 1 -C 6 alkyl, a C 3 -C 7 cycloalkyl optionally substituted by a C 1 -C 4 alkyl, a naphthyl, etc., R...
|
|
|
6632830 |
ACE-2 inhibiting compounds and methods of use thereof
ACE-2 inhibiting compounds are disclosed. These compounds include compounds of formula (IV): wherein the variables are as described in the specification. Pharmaceutical compositions containing...
|
|
|
6624310 |
Epothilone minor constituents
The invention relates to compounds which are obtained by fermenting DSM 6773, especially epothilones A1, A2, A8, A9, B10, C1, C2, C3, C4, C5, C6, C7, C8, C9, D1, D2, D5, G1, G2, H1, H2, I1, I2, I3,...
|
|
|
6603012 |
RAR selective retinoid agonists
New compounds containing bicyclic fused rings, one of which being a phenyl moiety connected by an aliphatic chain to a cycloalkyl or aryl moiety, and pharmaceutically active salts thereof are...
|
|
|
6589968 |
Epothilone compounds and methods for making and using the same
This present invention relates to compounds of formula (I) and to pharmaceutically acceptable salts and solvates thereof, wherein R 1 , R 2 , R 3 , R 4 , R 5 , W, X, Y, and Ar are as defined...
|
|
|
6583163 |
Agent for inhibition of cytokine production and agent for inhibition of cell adhesion
The present invention provides an agent for inhibiting cytokine production or cell adhesion, comprising at least one compound selected from the group consisting of thiazole derivatives represented...
|
|
|
6576643 |
Vitronectin receptor antagonists
Compounds of the formula (I) are disclosed which are vitronectin receptor antagonists and are useful in the treatment of osteoporosis: or a pharmaceutically acceptable salt thereof.
|
|
|
6559100 |
2-benzoyl-cyclohexane-1,3-diones
Substituted 2-benzoylcyclohexane-1,3-diones of the formula I where: R 1 and R 2 are each hydrogen, mercapto, nitro, halogen, cyano, thiocyanato, C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl, C 1 -C 6...
|
|
|
6545009 |
Retinoid-related receptor function regulating agent
1,3-Azole derivatives, pharmaceutical compositions thereof and methods for regulating the function of retinoid-related receptors with 1,3-azole derivatives are disclosed. Such regulation may be...
|
|
|
6521653 |
Microbicidal benzotriazoles
Novel benzotriazoles of the formula in which R, X 1 , X 2 , X 3 , X 4 and Y have the meanings given in the description, and their acid addition salts and metal salt complexes, a process for the...
|
|
|
6515002 |
Compounds and compositions for treating C1s-mediated diseases and conditions
Disclosed is a method for treating the symptoms of an acute or chronic disorder mediated by the classical pathway of the complement cascade, comprising administering to a mammal in need of such...
|
|
|
6515001 |
IL-8 receptor ligands-drugs for inflammatory and autoimmune diseases
The invention provides therapeutic and biological uses of chemokine-receptor-binding compounds (including chemokine receptor ligands such as chemokine receptor agonists or antagonists), such as...
|
|
|
6506903 |
Process for producing 4-thiazolylmethyl derivative
A process for the production of 4-thiazolylmethyl derivatives are provided. A process for the production of the compound represented by the formula (I): wherein R 1 is hydrogen or halogen and...
|
|
|
6506902 |
Synthesis of thiazolium compounds
Provided is a method of synthesizing a compound of formula I, comprising: (a) reacting a compound of formula II wherein R 1 and R 2 are independently hydrogen, hydroxy(C 1 -C 2 )alkyl, or (C...
|
|
|
6503935 |
Imidazoles and related compounds as α1A agonists
Compounds having formula I: are useful in treating diseases prevented by or ameliorated with α 1A agonists. Also disclosed are α 1A agonist compositions and a method of activating α 1 ...
|
|
|
6500950 |
Benzylidenepyrazolones, their preparation and use
Benzylidenepyrazolones of the formula I, where the substituents and the index n have the following meanings: R 1 is unsubstituted or substituted C 1 -C 6 -alkyl; R 2 is unsubstituted or...
|
|
|
6498172 |
Prostaglandin agonists and their use to treat bone disorders
This invention relates to prostaglandin agonists, methods of using such prostaglandin agonists, pharmaceutical compositions containing such prostaglandin agonists and kits containing such...
|
|
|
6498174 |
Substituted oxazoles and thiazoles derivatives as hPPAR&ggr and hPPARα activators
The present invention discloses compounds of formula (I), and tautomeric forms, pharmaceutically acceptable salts, or solvates thereof. Preferably, the compounds of the invention are dual...
|
|
|
6495551 |
Substituted phenyloxazolidinones and their use as antibiotics
The invention concerns compounds of formula (I), wherein, for example, R 1 is of the formula —NHC(═O)R a wherein R a is (1-4C)alkyl; R 2 and R 3 are independently hydrogen or fluoro; R...
|
|
|
6492404 |
Thiazolylcinnamonitriles and pest controlling agents
Compounds represented by the general formula (1); and pest controlling agents containing one or more of the compounds as the active ingredients, wherein A is substituted phenyl, C 1 -C 6 alkly or...
|
|
|
6492421 |
Substituted phenylalanine type compounds which inhibit leukocyte adhesion mediated by VLA-4
Disclosed are compounds which bind VLA-4. Certain of these compounds aslo inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the...
|
|
|
6492402 |
Thrombin inhibitors
The present invention relates to a compound having formula I: and pharmaceutically acceptable salts thereof. The compounds of formula I and pharmaceutical compositions containing them are of the...
|
|
|
6489364 |
Antiviral protease inhibitors
Compounds of formula (I), wherein A′ and A″ are independently the same or different group of formula (II) wherein: R′ is H, CH 3 , C(CH 3 ) 2 , —OR a , —N(R a ) 2 , —N(R a )OR a or...
|
|
|
6482859 |
Microbicidal N-sulfonylglycin alkynyloxyphenethyl amide derivatives
The invention relates to novel pesticidally active compounds of the general formula I as well as possible isomers and mixtures of isomers thereof, wherein n is a number zero or one; and R 1 is...
|
|
|
6465647 |
Oxygen, sulfur and nitrogen substituted cyclohexene and cyclohexane derivatives having retinoid-like biological activity
Compounds of the Formula 1, Formula 2, Formula 3 and Formula 4 wherein the symbols have the meaning assigned to them in the disclosure have retinoid-like biological activity.
|
|
|
6465646 |
1-alkoxy and 1-acyloxy substituted cyclohex-1-ene compounds and sulfur and 1-alkoxycarbonyl analogs having retinoid-like biological activity
Compounds of Formula 1 and of Formula 2 where the symbols have the meaning defined in the specification, have retinoid, retinoid antagonist or retinoid negative hormone like biological activity.
|
|
|
6458959 |
Anti-herpesvirus compounds and methods for identifying, making and using same
This invention relates to methods for inhibiting herpes replication and for treating herpes infection in a mammal by inhibiting the herpes helicase-primase enzyme complex. This invention also...
|
|
|
6451791 |
Amidoaromatic ring sulfonamide hydroxamic acid compounds
An amidoaromatic ring sulfonamide hydroxamic acid compound that inter alia inhibits matrix metalloprotease activity is disclosed, as are a treatment process that comprises administering a...
|
|
|
6448201 |
Benzoylcyclohexanediones and benzoylpyrazoles, their preparation, and their use as herbicides and plant growth regulators
Benzoylcyclohexanediones and benzoylpyrazoles, their preparation and their use as herbicides and plant growth regulators. There are described benzoyl compounds of the formula (I), their...
|
|
|
6436980 |
Peptidomimetic efflux pump inhibitors
Compounds are described which have efflux pump inhibitor activity. Also described are methods of using such efflux pump inhibitor compounds and pharmaceutical compositions which include such...
|
|
|
6436989 |
Prodrugs of aspartyl protease inhibitors
The present invention relates to prodrugs of a class of sulfonamides which are aspartyl protease inhibitors. In one embodiment, this invention relates to a novel class of prodrugs of HIV aspartyl...
|
|
|
6414145 |
Imidazolyl compounds as inhibitors of farnesyl-protein tranferase
The present invention relates to inhibitors of ras farnesylation of Formula (I), wherein T is of Formula (1) or (2) or (3); A is aryl or heteroaryl; B is aryl or heteroaryl; X and Y represent...
|
|
|
6407268 |
Substituted 4-benzoylpyrazoles
4-Benzoylpyrazoles of the formula I where: R 1 and R 2 are each hydrogen, mercapto, nitro, halogen, cyano, thiocyanato, C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl, C 1 -C 6 -alkoxy, C 2 -C 6...
|
|
|
6407100 |
Fungicidal aromatic oximes
The invention relates to novel compounds of the formula in which R 1 is C 1-4 alkyl and (Y—X) is CH 2 , C 1-2 alkylthio-CH═ or C 1-2 alkyl-ON═ and Z is an aldimino or ketimino group, and...
|
|
|
6395724 |
Multibinding inhibitors of cyclooxygenase-2
Disclosed are multibinding compounds which inhibit cyclooxygenase-2 (COX-2), an enzyme which catalyzes the first committed step in the biosynthesis of prostaglandins. The multibinding compounds of...
|
|
|
6384230 |
Thiazole derivatives, method for their production and use
Thiazole derivatives of formula II, in which R 1 means C 1 -C 4 alkyl, R 2 means any protective group that can be chelated, R 3 means hydrogen or C 1 -C 4 alkyl, Y means CO 2 R 4 , CHO,...
|
|
|
6380227 |
Fermentative preparation process for and crystal forms of cytostatics
The invention relates to a new process for concentrating epothilones in culture media, a new process for the production of epothilones, a new process for separating epothilones A and B and a new...
|
|
|
6365749 |
Process for the preparation of ring-opened epothilone intermediates which are useful for the preparation of epothilone analogs
The present invention relates to a process to produce ring opened epothilones and the novel ring opened epothilones produced thereform.
|
|
|
6359140 |
Epothilones with modified side chain
Epothilones with a modified side chain and process for the preparation thereof are disclosed.
|
|
|
6350878 |
Intermediates for the synthesis of epothilones and methods for their preparation
The invention relates to a method of synthesis for a compound of formula (I), wherein R is a heterocyclyl moiety and X 1 , X 2 , X 3 and X 4 are, independently of each other, protecting...
|
|
|
RE37556 |
Superoxide radical inhibitor
A superoxide radical inhibitor containing, as an effective ingredient, an azole derivative represented by the general formula (1), [wherein R 1 represents a phenyl group which may have 1-3...
|