Patents in Class 548/204

Matches 51 - 100 out of 575

Match	Document	Document Title
51	7141672	Oxazole-aryl-carboxylic acids useful in the treatment of insulin resistance and hyperglycemia This invention provides compounds of Formula I having the structure or a pharmaceutically acceptable salt thereof, which are useful in treating metabolic disorders related to insulin resistance...
52	7125863	Inhibitors of dipeptidyl peptidase IV Compounds according to formula (1), wherein R 1 is H or CN, X 1 is S, O, SO 2 or CH 2 , X 2 is CO, CH 2 or a covalent bond, Het is a nitrogen-containing heterocycle and n is 1–5 are new. The...
53	RE39356	Process for the preparation of epothilone analogs The present invention relates to a process for the preparation of epothilone analogs by initially forming novel ring-opened epothilones and carrying out a macrolactamization reaction thereon. The...
54	7105556	Conformationally constrained analogs useful as antidiabetic and antiobesity agents and method Compounds are provided which have the structure wherein Q is C or N, X 1 is C or N, and R 1 , R 2 , R 2a , R 2b , R 2c , R 3 , Y, A, m, n, X 2 , X 3 and X 4 are as defined herein, which...
55	7105564	Pharmaceutical composition comprising a dual antagonist against PGD2/TXA2 receptors having a [2.2.1] or [3.1.1] bicyclic skeleton The present invention provides novel compounds having a dual antagonistic activity against thromboxane A2 receptor and prostaglandin D 2 receptor and pharmaceutical compositions comprising them. ...
56	7105551	Thiazole derivatives for treating PPAR related disorders The present invention provides compounds of formula (I). These compounds are used for the treatment of PPAR related diseases
57	7101702	Fermentative preparation process for and crystal forms of cytostatics The invention relates to a new process for concentrating epothilones in culture media, a new process for the production of epothilones, a new process for separating epothilones A and B and a new...
58	7098228	Indolyl derivatives The present invention provides compounds of formula I as well as pharmaceutically acceptable salts and esters thereof, wherein R 1 to R 4 , A and n have the significance given in the...
59	7094792	Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1 The present invention relates to compounds with the formula (I) and also to pharmaceutical compositions comprising the compounds, as well as to the use of the compounds in medicine and for...
60	7091225	Substituted oxazoles and thiazoles as hPPAR alpha agonists Compounds of formula (I) and pharmaceutically acceptable salts, solvates and hydrolysable esters thereof wherein X is O or S X1 is O or S; X is S or O; R1 and R2 are independently H, methyl, or...
61	7053069	Pharmaceutical compositions and methods of using C-21 modified epothilone derivatives Pharmaceutical compositions containing C-21 modified epothilone derivatives, methods for their preparation and dosing regimen for administration of these epothilone compounds are provided. The...
62	7045532	ACE-2 modulating compounds and methods of use thereof ACE-2 inhibitors for the treatment of body weight and related disorders are disclosed. ACE-2 inhibitors include peptides and small molecules. Examples of small molecule ACE-2 inhibitors include...
63	7041690	Inhibitors of HCV NS5B polymerase The present invention provides compounds of Formula I, compositions and methods that are useful for treating viral infections and associated diseases, particularly HCV infections and associated...
64	7030139	Compounds Compounds of general formula (I), are disclosed and claimed in the present application, as well as salts and pharmaceutical compositions comprising the novel compounds and their use in therapy, in...
65	7030239	Compounds to treat Alzheimer's disease The present invention is directed toward substituted hydroxyethylene compounds of formula (XII) useful in treating Alzheimer's disease and other similar diseases.
66	7022719	Preventing and reversing the formation of advance glycosylation endproducts The present invention relates to compositions and methods for inhibiting and reversing nonenzymatic cross-linking (protein aging). Accordingly, compositions are disclosed which comprise an agent...
67	7001916	Epothilon derivatives, method for the production and the use thereof as pharmaceuticals Disclosed are epothilone compounds of formula I, which are useful as pharmaceutical compounds for treating, for example, malignant tumors and chronic inflammatory diseases and are useful in...
68	6998256	Methods of obtaining epothilone D using crystallization and /or by the culture of cells in the presence of methyl oleate Methods are provided for purification of epothilone D and epothilone D analogs from epothilone producing cells such as, for example, Sorangium cellulosum and Myxococcus xanthus (recombinant)....
69	6989450	Synthesis of epothilones and related analogs The present invention relates to methods for use in producing epothilones and analogs and derivatives thereof. A general method according to the present invention broadly comprises performing an...
70	6958401	Method for synthesizing epothilones and epothilone analogs A method for making epothilones and epothilone analogs is described, as are novel compounds made by the method. One embodiment of the method was used to synthesize epothilone B by a convergent...
71	6949566	Thiazole and oxazole derivatives A compound of the formula (I): wherein R 1 is hydroxy and the like; R 2 is optionally substituted lower alkyl and the like; R 3 is hydrogen atom and the like; R 4 is optionally...
72	6946561	Process for the isolation and purification of epothilones The invention relates to a desorption process for epothilones, especially epothilone A and/or epothilone B, from resins and new production, work-up or purification processes or manufacturing...
73	6936602	Benzazepine derivatives, process for the preparation of the same and uses thereof Compounds of the general formula (I): or salts thereof, which exhibit CCR5 antagonism and exert preventive and therapeutic effects against HIV infections: wherein R 1 is a 5- to 6-membered...
74	6936719	Biaryl compounds as serine protease inhibitors Compounds of formula (I) are useful as inhibitors of trypsin like serine protease enzymes such as thrombin, factor VIIa, factor Xa, TF/FVIIa, and trypsin. These compounds could be useful to treat...
75	6936628	Oral administration of epothilones The invention relates to methods of increasing the bioavailability of orally administered epothilones. Epothilones administered by the methods of the invention are sufficiently bioavailable to have...
76	6930187	Method of preparation of 21-amino epothilone derivatives An improved method of synthesis of 21-amino epothilone derivatives which provides a one-pot conversion of 21-hydroxy epothilones to highly desirable 21-amino epothilones in high yield.
77	6924300	Oxyiminoalkanoic acid derivatives To provide a novel oxyiminoalkanoic acid derivative which has excellent hypoglycemic and hypolipidemic actions and which is used for the prevention or treatment of diabetes mellitus, hyperlipemia,...
78	6916813	(1-phenyl-2-heteoaryl)ethyl-guanidine compounds as inhibitors of mitochondrial F1F0 ATP hydrolase Compounds having the formula (I), and pharmaceutically acceptable salts thereof, are useful for modulating mitochondrial F 1 F 0 ATPase activity and treating ischemic conditions including...
79	6903119	Amino acid derivatives and drugs containing the same as the active ingredient The present invention relates to the compounds of the formula (I) and salts thereof (all the symbols are the same meanings as described in the specification). The compounds of the formula (I)...
80	6903131	3,4-di-substituted maleimide compounds as CXC chemokine receptor antagonists Disclosed are compounds of the formula (I) or a pharmaceutically acceptable salt or solvate thereof. The compounds are useful for the treatment of chemokine-mediated diseases such as acute and...
81	6900331	Derivatives of epothilone B and D and synthesis thereof The present invention provides the following new compounds: (R)-C14-methyl-epothilone B, (S)-C14-methyl-epothilone B, (S)-C14-methyl-epothilone D, and (R)-C14-methyl-epothilone D and methods for...
82	6894171	Polymorph of a pharmaceutical A new crystalline polymorph of ritonavir and methods for its use and preparation are disclosed.
83	6884821	Carboxylic acid derivatives and drugs containing the same Novel carboxylic acid derivatives of general formula (I), salts of the same, esters thereof, or hydrates of them, which are useful as insulin resistance improvers; and drugs containing the...
84	6875765	Arylsulfonamide ethers, and methods of use thereof The novel arylsulfonamide ether compounds, pharmaceutical compositions and uses thereof as inhibitors of interleukin-1β converting enzyme and other cysteine proteases in the ICE family are...
85	6869967	Peroxisome proliferator-activated receptor (PPAR) active vinyl carboxylic acid derivatives Novel compounds of the general formula (I), the use of these compounds as pharmaceutical compositions, pharmaceutical compositions comprising the compounds and methods of treatment employing these...
86	6864270	Iron binding agents Composition, article of manufacture for and method of treating malaria in a human having an infestation of Plasmodium protozoans are described. The method comprises administering a...
87	6858611	Potassium channel inhibitors Compounds which are useful as potassium channel inhibitors and which because of their slow off-rates are especially useful for the treatment of cardiac arrhythmias are described.
88	6838474	Sulphonamide derivatives as prodrugs of aspartyl protease inhibitors The present invention relates to prodrugs of a class of sulfonamides which are aspartyl protease inhibitors. In one embodiment, this invention relates to a novel class of prodrugs of HIV aspartyl...
89	6831076	Epothilons C and D, preparation and compositions The present invention relates to epothilon derivatives and to their use.
90	6818635	7-substituted tetracycline compounds The present invention pertains, at least in part, to novel 7-substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states,...
91	6812229	Carbamate derivative and agricultural/horticultural fungicide It is to provide a novel fungicide having high controlling effects on plant diseases particularly on wheat powdery mildew and cucumber gray mold, without ill effects on crops. A carbamate...
92	6809110	Thiazole derivatives The present invention provides compounds of formula (I) wherein R 1 to R 10 , X, Y and n are indicated in the specification, and pharmaceutically acceptable salts and esters thereof. The...
93	6803466	HIV/FIV protease inhibitors having a small P3 residue With the help of X-ray structural analyses of drug-resistant HIV proteases and molecular modeling, a new type of inhibitor with a small P3 residue has been developed. These inhibitors are effective...
94	6800653	Epothilone derivatives The present invention relates to 12,13-position modified epothilone derivatives, methods of preparation of the derivatives, and intermediates therefor.
95	6787552	PPAR delta activators Compounds of the general formula (I) or salts thereof and activators of PPARδ (peroxisome proliferator activated receptor δ) containing the compounds or the salts as the active ingredient:...
96	6784167	17-beta-hydroxysteroid dehydrogenase-II inhibitors 17-beta-hydroxysteroid dehydrogenase-II inhibitors having the structural formula wherein the phenyl group labeled A and the group —C(R 4 )(R 6 )Y are oriented cis to each other; W represents O...
97	6780995	Activated iododerivatives for the treatment of cancer and aids A series of activated iodo-benzamide derivatives are described as antineoplastic and antiviral drug compounds. The compounds generally possess a chelating group, a thiol trapping group and an...
98	6777418	Retinoid compounds (I) The current invention provide novel retinoid compounds and methods for their synthesis, methods of treating or preventing emphysema, cancer and dermatological disorders and pharmaceutical...
99	6743810	Indol-3-yl derivatives Indol-3-yl derivatives of the general formula I in which A, B, X, R 1 , R 2 , R 3 , R 4 , R 5 , n and m are as defined in patent claim 1 , and their physiologically acceptable salts or solvates...
100	6737418	Aryl substituted pyrazoles, imidazoles, oxazoles, thiazoles and pyrroles, and the use thereof This invention relates to compounds having the Formula I: or a pharmaceutically acceptable salt, prodrug or solvate thereof, wherein Het and R 5 -R 13 are set in the specification. The...

Matches 51 - 100 out of 575

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