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7598423 |
Potentiators of glutamate receptors
This application relates to a substituted hydroxyphenyl ketone compound of formula I, or a pharmaceutically acceptable salt thereof, a pharmaceutical composition thereof and its use in treating...
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7579366 |
Epothilone derivatives and their synthesis and use
The invention relates to epothilone analog represented by the formula I
wherein
(i) R 2 is absent or oxygen; “a” can be either a single or double bond; “b” can be either absent or a...
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7579355 |
Inhibitors of Akt activity
The present invention is directed to compounds which contain a substituted pyridine moeity which inhibit the activity of Akt, a serine/threonine protein kinase. The invention is further directed to...
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7524957 |
Compounds effecting glucokinase
The invention relates to the use of a compound of Formula (I) or a salt, solvate or prodrug thereof, wherein R 1 , R 2 , R 3 , n and m are as described in the specification, in the preparation of a...
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7427635 |
Substituted hydantoins
The present invention relates to compounds of the formula
which are useful in treating diseases characterized by the hyperactivity of MEK.
Accordingly the compounds are useful in the treatment...
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7423156 |
Preparation and use of aryl alkyl acid derivatives for the treatment of obesity
This invention relates to certain aryl alkyl acid compounds, compositions, and methods for treating or preventing obesity and related diseases.
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7423055 |
2-(3-Aminoaryl)amino-4-aryl-thiazoles for the treatment of diseases
The present invention relates to novel compounds selected from 2-(3-aminoaryl)amino-4-aryl-thiazoles that selectively modulate, regulate, and/or inhibit signal transduction mediated by certain...
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7414067 |
Ophthalmic compositions for treating ocular hypertension
This invention relates to the use of potent potassium channel blockers or a formulation thereof in the treatment of glaucoma and other conditions which leads to elevated intraoccular pressure in...
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7408069 |
Preparation of 2-amino-thiazole-5-carboxylic-acid derivatives
A method for preparing a compound of the structure I,
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7384968 |
Thiazole-amine compounds for the treatment of neurodegenerative disorders
The present invention relates to compounds of the Formula I
wherein R 1 , R 3 , R 4 , R 5 , R 6 and R 7 are as defined. Compounds of the Formula I have activity inhibiting production of...
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7384928 |
Broad spectrum cephem compounds
A compound of the formula:
(wherein,
T is S, SO or O; X is halogen, CN, carbamoyl optionally substituted with lower alkyl, lower alkyl, lower alkoxy, or lower alkylthio; A is substituted lower...
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7358267 |
Bis-aryl thiazole derivatives
Compounds, compositions and methods are provided that are useful in the treatment or prevention of a condition or disorder mediated by an uncoupling protein. In particular, the compounds of the...
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7342117 |
α-form or β-form crystal of acetanilide derivative
To provide novel crystals useful as an ingredient for the production of a diabetes remedy. The invention is concerned with α-form crystal and β-form crystal of...
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7291744 |
N-ureidoalkyl-amino compounds as modulators of chemokine receptor activity
The present application describes modulators of chemokine receptors of formula (I):
or pharmaceutically acceptable salt forms thereof, useful for the prevention of asthma and other allergic...
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7253197 |
Aminothiazole derivatives
Compounds of formula I
as well as pharmaceutically acceptable salts and esters thereof, wherein R 1 to R 4 have the significance given in the specification, and the compounds, salts and...
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7250508 |
Cefdinir intermediate
7-[2-(2-aminothiazol-4-yl)-2-(methylcarbonyloxyimino)acetami
do]-3-vinyl-cephem-4-carboxylic acid of formula I
in the form of a crystalline salt and use thereof, e.g. in the preparation of pure...
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7250431 |
Thiazole derivatives
Thiazole derivatives of formula I are provided
as well as pharmaceutically acceptable salts and esters thereof, wherein R 1 to R 5 , a and b have the significance given in the specification....
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7244278 |
Agent and method for oxidative coloring of keratin fibers
The object of the present invention is a ready-to-use agent for coloring keratin fibers containing (i) at least one heterocyclic hydrazone derivative of formula (I), (ii) at least one aromatic...
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7179827 |
Thiazoles and methods of their use
This invention concerns novel thiazole compounds. Methods of using these compounds for the treatment, prevention and management of various diseases or disorders, as well as pharmaceutical...
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7173137 |
Epothilone analogs
Epothilone A, epothilone B, analogs of epothilone and libraries of epothilone analogs are synthesized. Epothilone A and B are known anticancers agents that derive their anticancer activity by the...
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7173129 |
Sulfonamide-substituted chalcone derivatives and their use to treat diseases
The invention relates to compounds, pharmaceutical compositions and methods of using compounds of the general formula
or its pharmaceutically acceptable salt or ester, wherein the substituents...
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7163952 |
Azole compound and medicinal use thereof
The present invention relates to an azole compound represented by the formula [I]
wherein W is S or O; R is —COOR 7 , —X 1 -A 1 -COOR 7 (R 7 is H, alkyl) or tetrazolyl; R 1 , R 2 , R 3 ...
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7145017 |
Preparation of Aztreonam
The invention relates to a process for the synthesis of Aztreonam. Specifically, the process entails hydrolyzing...
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7125900 |
Inhibitors of 11-β-hydroxy steroid dehydrogenase type 1
The present invention relates to compounds with the formula (I) and also to pharmaceutical compositions comprising the compounds, to processes for their preparation, as well as to the use of the...
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7105564 |
Pharmaceutical composition comprising a dual antagonist against PGD2/TXA2 receptors having a [2.2.1] or [3.1.1] bicyclic skeleton
The present invention provides novel compounds having a dual antagonistic activity against thromboxane A2 receptor and prostaglandin D 2 receptor and pharmaceutical compositions comprising them. ...
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7091228 |
Preparation and use of aryl alkyl acid derivatives for the treatment of obesity
This invention relates to certain aryl alkyl acid compounds, compositions, and methods for treating or preventing obesity and related diseases.
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7074794 |
Proline derivatives and the use thereof as drugs
The present invention aims at providing compounds having therapeutic effects due to a DPP-IV inhibitory action, and satisfactory as pharmaceutical products. The present inventors have found that...
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6984735 |
Process for making an aldehyde
A process for making an aromatic aldehyde in which a sulfoxide is reacted with a dihalogenated aromatic compound in the absence of an effective amount of an activating reagent. The aldehyde may...
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6972297 |
2-Hydroxy-mutilin carbamate derivatives for antibacterial use
2-(S)-hydroxymutilin carbamate derivatives of formula (I), in which R 1 is a 5- or 6-membered optionally substituted heteroaryl group; and R 2 is vinyl or ethyl, are useful in the treatment of...
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6967212 |
Substituted azole acid derivatives useful as antidiabetic and antiobesity agents and method
Compounds are provided which have the structure
wherein Q is C or N; R 2a , R 2b , R 2c , X 1 to X 7 , R 1 , R 2 , R 3 , R 3a , R 4 , A, Y, m, and n are as defined herein, which compounds are...
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6960664 |
Aza hydroxylated ethyl amine compounds
Disclosed are compounds of formula:
and pharmaceutically acceptable salts and esters thereof, useful in treating and/or preventing Alzheimer's disease and other similar diseases, wherein R N ,...
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6924300 |
Oxyiminoalkanoic acid derivatives
To provide a novel oxyiminoalkanoic acid derivative which has excellent hypoglycemic and hypolipidemic actions and which is used for the prevention or treatment of diabetes mellitus, hyperlipemia,...
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6921770 |
2-Phenyliminothiazolines, their preparation method and anti-rice blast agent containing the same
2-phenyliminothiazolines of the following formula I, their salts, their preparation method and their use for treating rice blast. The phenyliminothiazolines and their salts of the present invention...
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6878827 |
Process for producing anhydride of aminothiazole derivative
This invention provides a novel industrial process for preparation of an anhydride of 2-(2-aminothiazole-4-yl)-2-hydroxy compound.
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6872730 |
Substituted benzofurans and benzothiophenes, methods of making and methods of use as integrin antagonists
The present invention relates to novel substituted benzofurans and benzothiophenes compounds that are antagonists of alpha V (αv) integrins, for example α v β 3 and α v β 5 integrins, their...
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6818775 |
Alkyl or aryl substituted dihydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity
Compounds of the formula where the symbols have the meaning described in the application, have retinoid-like or retinoid antagonist-like biological activity.
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6818634 |
7-and 9-carbamate, urea, thiourea, thiocarbamate, and heteroaryl-amino substituted tetracycline compounds
Substituted tetracycline compounds, methods of synthesis, and methods of use are discussed. Tetracyclines useful for treating tetracycline related disorders are also discussed. Intermediates useful...
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6797723 |
Heterocycle substituted diphenyl leukotriene antagonists
The invention relates to novel heterocycle substituted diphenyl leukotriene B 4 (LTB 4 ) antagonists, to compositions containing such compounds, and to methods of using such compounds for...
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6720346 |
Thiazole benzamide derivatives and pharmaceutical compositions for inhibiting cell proliferation
Aminothiazole compounds with mono-/di-substituted benzamide are represented by the Formula (I), and their pharmaceutically acceptable salts, pharmaceutically acceptable prodrugs, pharmaceutically...
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6716881 |
Carbanilides used as pesticides
The present invention provides carbanilides of formula (I), wherein A, Q, R, X, Z and m are as defined herein. A plurality of processes for preparing these compounds is provided, along with...
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6686381 |
Thiazole derivatives
Compounds of formula I are provided as well as pharmaceutically acceptable salts and esters thereof, wherein R 1 to R 5 , n, m and A have the significance disclosed in the specification, and...
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RE38330 |
Preventing and reversing advanced glycosylation endproducts
The present invention relates to compositions and methods for inhibiting and reversing nonenzymatic cross-linking (protein aging). Accordingly, a composition is disclosed which comprises a...
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6642180 |
Biphenyl-substituted cyclic ketoenols as pesticides
The present invention relates to novel biphenyl-substituted cyclic ketoenols of the formula (I) in which W represents hydrogen, halogen, alkyl, alkoxy, alkenyloxy, halogenoalkyl, halogenoalkoxy,...
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6610714 |
Non-nucleoside reverse transcriptase inhibitors
Compounds of the formula I: where; R 1 is O, S; R 2 is an optionally substituted nitrogen-containing heterocycle, wherein the nitrogen is located at the 2 position relative to the (thio)urea...
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6593327 |
Compounds and compositions as protease inhibitors
The present invention relates to novel N-cyanomethyl amides which are cysteine protease inhibitors, the pharmaceutically acceptable salts and N-oxides thereof, their uses as therapeutic agents and...
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6569878 |
Substituted 4-amino-thiazol-2-yl compounds as cyclin-dependent kinase inhibitors
Pharmaceutical compositions containing effective amounts of CDK-inhibiting diaminothiazole compounds of the following formula (where R 1 and R 2 are as defined in the specification) or their...
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6569874 |
Thiazoles as factor Xa inhibitors
The present application describes oxygen and sulfur containing heteroaromatics and derivatives thereof of formula I: or pharmaceutically acceptable salt or prodrug forms thereof, wherein J is O...
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6515005 |
Substituted azole derivatives as inhibitors of corticotropin releasing factor
The present invention relates to thiazoles, oxazoles, imidazoles and pharmaceutical compositions comprising said compounds antagonizing the corticotropin releasing factor receptor (“CRF...
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6498174 |
Substituted oxazoles and thiazoles derivatives as hPPAR&ggr and hPPARα activators
The present invention discloses compounds of formula (I), and tautomeric forms, pharmaceutically acceptable salts, or solvates thereof. Preferably, the compounds of the invention are dual...
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6458959 |
Anti-herpesvirus compounds and methods for identifying, making and using same
This invention relates to methods for inhibiting herpes replication and for treating herpes infection in a mammal by inhibiting the herpes helicase-primase enzyme complex. This invention also...
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