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9000181 3-amino-pyrazole derivatives useful against tuberculosis  
A compound of Formula (I) or a pharmaceutically acceptable salt thereof: Wherein: Het is a 5 to 10-membered heteroaromatic ring; Either X is N and Y is CR5; or X is C and Y is S; Z is selected...
8993619 Cyclic bridgehead ether DGAT1 inhibitors  
The invention relates to compounds of formula (I): useful for treating disorders mediated by acyl coA-diacylglycerol acyl transferase 1 (DGAT1), e.g. metabolic disorders. The invention also...
8962663 Small molecule inhibitors of the pleckstrin homology domain and methods for using same  
Pleckstrin homology domain binding compounds, pharmaceutical compositions including such compounds, and methods for their use are described herein.
8877741 Pyrrolidine derivatives, pharmaceutical compositions and uses thereof  
The invention relates to new pyrrolidine derivatives of the formula to their use as medicaments, to methods for their therapeutic use and to pharmaceutical compositions containing them.
8846727 Haloalkyl heteroaryl benzamide compounds  
A new class of haloalkyl heteroaryl benzamides is described. These compounds show strong activity against hepatitis viruses.
8802861 Thiazole derivatives and use thereof  
The present invention is related to thiazole derivatives of Formula (I) in particular for the treatment and/or prophylaxis of autoimmune disorders and/or inflammatory diseases, cardiovascular...
8779153 3-amino-pyrazole derivatives useful against tuberculosis  
A compound of Formula (I) or a pharmaceutically acceptable salt thereof: Wherein: Het is a 5 to 10-membered heteroaromatic ring; Either X is N and Y is CR5; or X is C and Y is S; Z is selected...
8623860 Azetidine derivatives, pharmaceutical compositions and uses thereof  
The invention relates to new azetidine derivatives of the formula I to their use as medicaments, to methods for their therapeutic use and to pharmaceutical compositions containing them.
8524750 (Pyrazol-3-yl)-1,3,4-thiadiazol-2-amine and (pyrazol-3-yl)-1,3,4-thiazol-2-amine compounds  
A compound of Formula (I) wherein: either X is N and Y is CR5 or X is C and Y is S; Z is selected from N and CH; R1 is selected from H and Me; R2 is selected from H, OH, OMe and Me; each R3 is...
8492415 Azoles and related derivatives as non-nucleoside reverse transcriptase inhibitors (NNRTIs) in antiviral therapy (HIV)  
The present invention relates to novel heterocyclic compounds, including oxadiazole compounds, pharmaceutical compositions and their use in the inhibition of reverse transcriptase and the...
8420678 Small molecule inhibitors of the pleckstrin homology domain and methods for using same  
Pleckstrin homology domain binding compounds, pharmaceutical compositions including such compounds, and methods for their use are described herein.
8389554 Imidazothiadiazole derivatives  
Novel imidazo[2,1-b][1,3,4]thiadiazole derivatives of formula (I) wherein R1 and R2 have the meaning according to claim 1, are inhibitors of TGF-beta receptor I kinase, and can be employed, inter...
8338615 Human protein tyrosine phosphatase inhibitors and methods of use  
The present disclosure relates to compounds effective as human protein tyrosine phosphatase beta (HPTP-β) inhibitors thereby regulating angiogenesis. The present disclosure further relates to...
8288403 Heterocyclic gamma secretase modulators  
The invention relates to methods for the treatment of Alzheimer's disease, cerebral amyloid angiopathy, hereditary cerebral hemorrhage with amyloidosis, Dutch-type (HCHWA-D), multi-infarct...
8173687 Compounds as cannabinoid receptor ligands  
Disclosed herein are cannabinoid receptor ligands of formula (I) wherein Y, X1, X2, X3, R1, and R2 are as defined in the specification. Compositions comprising such compounds, and methods for...
8119667 Carbonates of fenicol antibiotics  
Novel fenicol compounds having useful properties as antibiotic prodrugs, are provided, together with methods of making and using these new compounds.
7919514 Thiadiazole compounds and methods of use  
The invention relates to thiadiazole compounds useful for treating diseases mediated by protein kinase B (PKB). The invention also relates to the therapeutic use of such thiadiazole compounds and...
7910612 4-oxy-N-[1,3,4]-thiadiazol-2-yl-benzene sulfonamides, pharmaceutical compositions and methods for their therapeutic use  
The present invention comprises 4-Oxy-N-[1,3,4]-thiadiazol-2-yl-benzene sulfonamides, the derivatives thereof and salts thereof as well as processes for their preparation and methods for their use...
7858647 N-[1,3,4]-thiadiazol-2-yl-benzene sulfonamides, pharmaceutical compositions thereof and methods for their therapeutic use  
The present invention comprises N-[1,3,4]-thiadiazol-2-yl-benzene sulfonamides, their physiologically acceptable salts and functional derivatives that exhibit peroxisome proliferator activated...
7772257 Bicyclic aryl-sulfonic acid [1,3,4]-thiadiazol-2-yl-amides, processes for their preparation, pharmaceutical compositions and methods for their use  
The present invention comprises bicyclic aryl-sulfonic acid [1,3,4]-thiadiazol-2-yl-amides, their functional derivatives thereof as well as their physiologically acceptable salts and...
7754745 Azacyclopentane derivatives as inhibitors of stearoyl-coenzyme a delta-9 desaturase  
Azacyclopentane derivatives of structural formula (I) are selective inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD1) relative to other known stearoyl-coenzyme A desaturases. The...
7700636 Thiadiazole compounds and methods of use  
The invention relates to thiadiazole compounds useful for treating diseases mediated by protein kinase B (PKB). The invention also relates to the therapeutic use of such thiadiazole compounds and...
7683181 Cyclic N-[1,3,4]-thiadiazol-2-yl-benzene sulfonamides, pharmaceutical compositions and methods for the therapeutic use thereof  
The present invention comprises cyclic N-[1,3,4]-thiadiazol-2-yl-benzene sulfonamides, their functional derivatives as well as their physiologically acceptable salts and pharmaceutical...
7612104 Bicyclic aryl-sulfonic acid [1,3,4]-thiadiazol-2-yl-amides, processes for their preparation, pharmaceutical compositions and methods for their use  
The present invention comprises bicyclic aryl-sulfonic acid [1,3,4]-thiadiazol-2-yl-amides, their functional derivatives thereof as well as their physiologically acceptable salts and...
7354944 Thiadiazole compounds and methods of use  
The invention relates to thiadiazole compounds useful for treating diseases mediated by protein kinase B (PKB). The invention also relates to the therapeutic use of such thiadiazole compounds and...
7338966 Substituted oxindole derivatives as tyrosine kinase inhibitors  
The present invention is related to oxindole derivatives of structure (I), compositions containing the same, and methods of use and manufacture of the same. Such compounds generally are useful...
7226931 (R/S) rifamycin derivatives, their preparations and pharmaceutical compositions  
Rifamycin derivatives having the following structure of general formula I (both hydroquinone and corresponding quinone (C1-C4) forms): or its salts, hydrates or prodrugs thereof; wherein a...
7183277 Carboxylic acid amides  
Novel compounds of the formula I in which D, W, X, Y, T and R1 are as defined in Patent Claim 1, are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or therapy of...
7122565 Thiadiazoles and oxadiazoles and their use as phosphodiesterase-7 inhibitors  
The invention provides 1,3,4-thiadiazoles and 1,3,4-oxadiazoles having the following Formula I: in which, Y is S or O,R1 is alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, cycloalkenyl,...
7074532 Linked dihydrazone-based charge transport compounds  
Improved organophotoreceptors comprise: (a) a charge transport compound having the formula where n is an integer from 0 to 1;X is an (N,N-disubstituted)arylamine group;Ar is an aryl group or a...
7071217 Substituted oxindole derivatives as tyrosine kinase inhibitors  
The present invention is related to oxindole derivatives of structure (I), compositions containing the same, and methods of use and manufacture of the same. Such compounds generally are useful...
7041670 Florfenicol-type antibiotics  
The present invention relates to novel florfenicol compounds having the chemical structure: wherein the compounds are useful for the treatment and/or prevention of bacterial infections in a broad...
6716841 Nitrogen containing heterobicycles as factor Xa inhibitors  
This invention relates generally to nitrogen containing heterobicycles of formulas A and B: which are inhibitors of trypsin-like serine protease enzymes, especially factor Xa, pharmaceutical...
6713498 Method for treating glaucoma VI  
Provided, among things, is a method of decreasing intraocular pressure in an animal, including a human, comprising administering an intraocular pressure decreasing amount of a compound of the...
6686363 Cyclopropyl containing oxazolidinone antibiotics and derivatives thereof  
This invention relates to new oxazolidinones having a cyclopropyl moiety, which are effective against aerobic and anerobic pathogens such as multi-resistant staphylococci, streptococci and...
6329373 Metalloproteinase inhibitors  
A compound of formula (I) ##STR1##wherein X is a --CONHOH group and the R groups are defined in the claims. The compounds are inhibitors of matrix metalloproteinases involved in tissue degradation...
6323315 Dolastatin peptides  
The present invention provides compounds of the formula ##STR1##where R1 -R5 are each, independently, a hydrogen atom or a normal or branched C1 -C6 -alkyl group; A is a methionyl, phenylalanyl or...
6258751 Substituted triazoles imidazoles and pyrazoles as herbicides  
The present invention relates to novel heterocyclic compounds and their agronomically suitable salts, methods for the use of these compounds in controlling unwanted plant species, and the use of...
6197968 Decolorizable dye  
Described is a decolorizable dye represented by the following formula (I): ##STR1##wherein R1 represents an alkyl, aryl or heterocyclic group; R2 and R3 independently each represents a hydrogen...
5977373 Thiadiazolyl and oxadiazolyl phenyl oxazolidinone antibacterial agents  
The present invention provides thiadiazolyl and oxadiazolyl phenyl oxzolidinone compounds of formula I ##STR1## wherein Q is thiadiazolyl or oxadiazolyl; wherein X1 and X2 are independently...
5965738 Process for producing N-biphenylmethylthiadiazoline derivative or salt thereof and intermediate for producing the same  
Described is a process for producing an N-biphenyl-methylthiadiazoline derivative (7) in accordance with the reaction formula described below. According to the process of the present invention, it...
5948916 Arylthiadiazole derivative and antiviral agent containing the same  
Novel arylthiadiazole derivatives and salts thereof useful for preventing and treating human viral infection and a novel virucide which contains the arylthiadiazole derivative or a salt thereof...
5840980 Diamine compounds and electrophotographic photoreceptor  
A diamine compound of the following formula (1): ##STR1## wherein R1 is a hydrogen atom, a lower alkyl group or a lower alkoxy group, each of A1, A2 and A3 which are independent of one another, is...
5674894 Amidine derivatives useful as platelet aggregation inhibitors and vasodilators  
The current invention discloses novel amidine derivatives with nitric oxide donating property that can inhibit platelet aggregation and promote vasodilation in a single compound.
5654322 Biphenylmethane derivatives and pharmaceuticals containing the same  
This invention relates to a biphenylmethane derivative represented by the formula (1): ##STR1## wherein A represents a group ##STR2## in which R1, X, Y, Z and B are as defined in the...
5591695 Herbicidal [1,3,4]oxadiazoles and thiadiazoles  
Novel herbicidal compounds of the general formula I ##STR1## wherein X represents an oxygen or sulphur atom; A represents an optionally substituted alkyl, alkenyl, cycloalkyl, cycloalkenyl,...
5563159 Dithiocarbonimide derivatives useful as acaricidal, fungicidal, and insecticidal agents  
There is disclosed a dithiocarbonimide derivative of the formula: ##STR1## wherein B is a C1 -C6 alkyl group; X is an NH group or an oxygen atom and Y is a nitrogen atom or a CH group, A is a...
5554633 Substituted amines as tachykinin receptor antagonists  
Compounds of formula (I), and salts and prodrugs thereof, wherein Q is optionally substituted phenyl or benzhydryl; X and Y are each H or together form a group=O; Z is O, S or NR9, where R9 is H...
5510359 Heteroaromatic 5-hydroxytryptamine receptor agonists  
A class of substituted five-membered heteroaromatic compounds possessing an imino spacer group are selective agonists of 5-HT1 -like receptors and are therefore useful in the treatment of clinical...
5510344 Acrylate fungicides  
Compounds of formula I ##STR1## wherein X is oxygen or sulphur, W is CH or N, m is 0 or 1, and either a) n is 1 and Q is a non-aromatic heterocyclic ring of 3 to 10 ring atoms, containing one to...

Matches 1 - 50 out of 231 1 2 3 4 5 >