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7626036 |
Bicyclic heterocycles useful as selective androgen receptor modulators
The present invention is directed to novel bicyclic heterocycles, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by the androgen...
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7608632 |
Sulfonamide inhibitors of aspartyl protease
The present invention relates to a novel class of sulfonamides which are aspartyl protease inhibitors. In one embodiment, this invention relates to a novel class of HIV aspartyl protease inhibitors...
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7550207 |
Blue-emitting polymer and organic electroluminescent device using the same
A blue-emitting polymer in which a bisindenospirofluorene unit is incorporated in a polyarylene polymer backbone, and an organic EL device using the blue-emitting polymer as a light-emitting...
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7482465 |
Indol derivatives and their use as 5-HT ligands
The invention relates to indol derivatives of Formula (I) in which R1, R2, R3, X, A, n, m and p have the meanings indicated above.
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7482490 |
Amine compound having fluorene group as framework, process for producing the amine compound, and use of the amine compound
Novel amine compounds that can be utilized as hole transport materials, hole injection materials or the like of organic electroluminescence devices, electrophotographic receptors or the like, and...
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7427621 |
Cyclic sulfamides for inhibition of gamma-secretase
Compounds of formula I:
inhibit the processing of AP by gamma-secretase, and hence are useful for treatment or prevention of Alzheimer's disease.
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7388006 |
Non-steroidal progesting
The present invention relates to non-steroidal progestins of the general formula (I)
wherein
R 1 and R 2 are independently of each other —H or —F, R 3 is —CH 3 or —CF 3 , and Ar is...
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7371771 |
Alkenyl-substituted spirocyclic sulfamides as inhibitors of gamma-secretase
Compounds of formula (I) are disclosed: wherein R 4 is an alkenyl group of defined structure. The compounds inhibit gamma-secretase, and hence are useful for treatment of Alzheimer's disease.
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7371875 |
Cytotoxic agents and methods of use
Disclosed are compounds that inhibit proteasomic activity in cells. Also disclosed are pharmaceutical compositions comprising such compounds as well as methods to treat conditions, particularly...
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7354941 |
Nicotinamide benzofused-heterocyclyl derivatives useful as selective inhibitors of PDE4 isozymes
Compounds useful as inhibitors of PDE4 in the treatment of diseases regulated by the activation and degranulation of eosinophils, especially asthma, chronic bronchitis, and chronic obstructive...
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7282513 |
Heteroaryl substituted spirocyclic sulfamides for inhibition of gamma secretase
Compounds of formula I are disclosed:
in which X is a 5-membered heteroaryl ring and R is as defined herein. The compounds are inhibitors of the processing of APP by gamma-secretase, and hence...
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7271267 |
Nitrobenzodifuroxan compounds, including their salts, and methods thereof
A nitrobenzodifuroxan compound having the chemical structure of:
wherein two of the R 1 , R 2 , R 3 and R 4 comprise oxygen or are absent, and only one of R 1 or R 2 is present, and...
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7241759 |
Benzo[1,2,5]thiadiazole compounds
Certain amidophenyl-sulfanylamino-benzo[1,2,5]thiadiazole compounds are CCK2 modulators useful in the treatment of CCK2 mediated diseases.
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7223484 |
2,1,3-benzothiadiazoles for use as electronic active components
The present invention describes novel 2,1,3-benzothiadiazole-containing compounds. Such compounds can be used as active components (=functional materials) in a variety of different applications...
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7220756 |
N-sulfonylheterocyclopyrrolyl-alkylamine compounds as 5-hydroxytryptamine-6 ligands
The present invention provides a compound of formula I and the use thereof for the therapeutic treatment of a CNS disorder relating to or affected by the 5-HT6 receptor
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7217824 |
Process for preparing a 4,7-bis(5-halothien-2-yl)-2,1,3-benzothiadiazole and a precursor therefor
The present invention is directed to a method for preparing a 4,7-bis(5-halothien-2-yl)-2,1,3-benzothiadiazole, more particularly, 4,7-bis(5-bromothien-2-yl)-2,1,3-benzothiadiazole, and a precursor...
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7211592 |
Substituted an unsubstituted benzooxathiazoles and compounds derived therefrom
The invention relates to substituted and unsubstituted 3H-benzo[1,2,3]oxathiazole 2,2-dioxides, 1,3-dihydrobenzo[1,2,5]thiadiazole 2,2-dioxides and 1,3-dihydro-benzo[c]isothiazole 2,2-dioxides, to...
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7153873 |
Salts of bicyclic, N-acylated imidazo-3-amines and imidazo-5-amines
Salts of a bicyclic, N-acylated imidazo-3-amine or an imidazo-5-amine of the formula:
addition products thereof with acids, and methods for preparing the salts and addition products. Also...
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7151104 |
Pyrazolopyridines as cyclin dependent kinase inhibitors
In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]pyridine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds,...
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7145016 |
Nitrobenzodifuroxan compounds, including their salts, and methods thereof
A nitrobenzodifuroxan compound having the chemical structure of:
wherein two of the R 1 , R 2 , R 3 and R 4 comprise oxygen or are absent, and only one of R 1 or R 2 is present, and...
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7138483 |
Monomers, conjugated polymers and electronic devices using such polymers
The energy levels (HOMO, LUMO) of the conjugated polymer are tuned independently, so that an energy match on both sides of the device can be accomplished while keeping the emission color in the...
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7064215 |
Indazole benzimidazole compounds
Organic compounds having the structure I are provided where the variables have the values described herein.
Pharmaceutical formulations and medicaments include the organic compound or a...
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7041689 |
Heteroaryl substituted spriocyclic sulfamides for inhibition of gamma secretase
Compounds of formula I are disclosed: in which X is a 5-membered heteroaryl ring and R is as defined herein. The compounds are inhibitors of the processing of APP by gamma-secretase, and hence are...
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7041688 |
Alkynly-substituted spirocyclic sulfamides for the treatment of alzheimer's disease
Compounds of formula (I) are disclosed. The compounds inhibit gamma-secretase and hence find use in treatment of Alzheimer's disease
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7012085 |
1,3 disubstituted pyrrolidines as α-2-adrenoceptor antagonists
The invention provides compounds of formula (I) wherein R 0 , R 1 , R 2 and A are as defined in the description, and the preparation thereof. The compounds of formula (I) have high affinity as α...
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6858607 |
7,8-fused 4H-chromene and analogs as activators of caspases and inducers of apoptosis and the use thereof
The present invention is directed to substituted 4H-chromene and analogs thereof, represented by the general Formula I:
or pharmaceutically acceptable salts or prodrugs thereof, wherein:
...
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6852739 |
Methods using proton pump inhibitors and nitric oxide donors
The present invention describes novel nitrosated and/or nitrosylated proton pump inhibitor compounds, and novel compositions comprising at least one proton pump inhibitor compound that is...
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6821964 |
Modulators of chemokine receptor activity
Chemokine receptor antagonists, in particular, bicyclic diamine compounds of Formula (I) that act as antagonists of chemokine CCR2 and CCR3 receptors including pharmaceutical compositions and uses...
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6797708 |
Inhibitors of cytosolic phospholipase A2
This invention provides substituted indole compounds of the general formula: and pharmaceutically acceptable salt forms thereof, and methods for using the compounds as inhibitors of the activity...
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6743817 |
Substituted fused pyrroleimines and pyrazoleimines
Disclosed are compounds of the formula and the pharmaceutically acceptable salts thereof wherein R, Ar, A, n, R 1 and R 2 are defined herein. These compounds are highly selective agonists,...
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6706757 |
Chroman derivatives as 5-hydroxytryptamine-6 ligands
The present invention provides a compound of formula I and the use thereof for the therapeutic treatment of disorders relating to or affected by the 5-HT6 receptor.
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6677360 |
Biphenyl and biphenyl-analogous compounds as integrin antagonists
The present invention relates to biphenyl and biphenyl-analogous compounds, their preparation and use as pharmaceutical compositions, as integrin antagonists and in particular for the production of...
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6624186 |
Ion channel modulating agents comprising novel benzimidazolone derivatives
The present invention relates to ion channel modulating agents. More particularly, the present invention relates to a particular class of chemical compounds that has proven useful as modulators of...
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6579718 |
Carbazolylvinyl dye protein stains
The present invention describes a variety of substituted and unsubstituted carbazolylvinyl dyes and their use for detecting and quantifying poly(amino acids), including peptides, polypeptides and...
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6552052 |
Pyrrolo&lsqb 2,1-c&rsqb &lsqb 1,2,4&rsqb thiadiazoles and Pyrollo&lsqb 2,1-c&rsqb &lsqb 1,12,4&rsqb oxadiazoles useful as nitric oxide synthase inhibitors
Pyrrolo[2,1-c][1,2,4]thiadiazole or pyrollo[2,1-c][1,2,4]oxadiazoles having the formula: or pharmaceutically acceptable salts thereof, useful as nitric oxide synthase inhibitors wherein each...
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6552187 |
Process for the preparation of herbicidal derivatives
A process for the preparation of compounds of formula (I), which process comprises reacting a compound of formula (II), in an inert organic solvent, optionally in the presence of a base, with a...
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6498172 |
Prostaglandin agonists and their use to treat bone disorders
This invention relates to prostaglandin agonists, methods of using such prostaglandin agonists, pharmaceutical compositions containing such prostaglandin agonists and kits containing such...
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6469004 |
Benzoheterocycles and their uses as MEK inhibitors
The invention provides compounds having formula (I), wherein W is OH, or derivatives of the carboxylic acid, and Q is a heterocyclo-condensed ortho-phenylene residue. These compounds are useful as...
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6387919 |
Substituted oxindole derivatives as protein tyrosine kinase and as protein serine/threonine kinase inhibitors
Compounds of formula (I): wherein X is N, CH, CCF 3 , or C(C 1-12 aliphatic); R 4 is sulfonic acid, C 1-12 aliphatic-sulfonyl, sulfonyl-C 1-12 aliphatic, C 1-12 aliphatic-sulfonyl-C 1-6 ...
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6362191 |
Aminometyl oxooxazolidinyl benzene derivatives
The invention concerns compounds of formula (I), wherein: A is a 5 membered heteroaryl ring, a bicyclic benzo system containing such a 5 membered heteroaryl ring or a bicyclic or tricyclic...
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6313312 |
3-Azabicyclo[3.1.0]hexane derivatives useful in therapy
Compounds of formula (I), their salts and prodrugs thereof, where the substituents are as defined herein are disclosed as opiate binding agents useful in the treatment of opiate-mediated...
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6288071 |
1-ethylene-2-alkylene-1,4-cyclohexadiene pesticides
Pesticidally active cyclohexadienyl derivative compounds of the formula I that are esters, oximes or amides are claimed. These compounds may be used as fungicides, acaricides and insecticides in...
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6288092 |
Triaryl compounds
(4-oxy-3-(aryl)phenyl)pyridine compounds, in free or acid addition salt form, are useful as pharmaceuticals for treatment and prophylaxis of inflammation, particularly inflammatory or obstructive...
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6248895 |
Benzofuroxan compound, method of preparation, pharmaceutical composition and method of treatment using the same
The invention discloses a novel compound of the benzofuroxan series used for cardiovascular disorders represented by the general formula (I) ##STR1## and pharmaceutically acceptable salts...
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6211211 |
Benzopyrans and their use as therapeutic agents
This invention relates to substituted benzopyran amides useful in treating certain medical conditions and to processes for preparing these compounds.
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6197800 |
Benzothia(oxa)diazol derivatives and their use as endothelin-receptor antagonists
Novel compounds of the formula I ##STR1## in which R is ##STR2## X is O or S, and R 1 , R 2 , R 3 , R 4 , R 5 and R 6 have the meaning indicated in patent claim 1, or a tautomeric...
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6143734 |
Nitroso esters of β-oxo-amides and aryl propionic acid derivatives of non-steroidal antiinflammatory drugs
A compound comprising a non-steroidal antiinflammatory agent to which is directly or indirectly linked an NO group, a compound comprising an enolic anilide non-steroidal antiinflammatory agent to...
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6093738 |
Proton pump inhibitors
Novel thiadiazole compounds are provided, which are effective as proton pumps inhibitors, useful in treating peptic ulcers by inhibition of the proton pump enzyme H + /K + -ATPase. The compounds...
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6083505 |
1H-imidazo[4,5-C]quinolin-4-amines as vaccine adjuvants
An immunogen/vaccine adjuvant composition containing an immunogen in an amount effective to stimulate an immune response and as a vaccine adjuvant a 1H-imidazo[4,5-c]quinolin-4-amine in an amount...
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6075040 |
Selective β.sub.3 adrenergic agonists
The present invention is in the field of medicine, particularly in the treatment of Type II diabetes and obesity. More specifically, the present invention relates to selective β3 adrenergic...
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