Patents in Class 548/112

Matches 1 - 50 out of 332

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Match	Document	Document Title
1	7601845	Optically detectable organophosphonates The invention relates to compounds having general formula I in which X represents an optically detectable moiety, n is an integer with 1≦n≦20, R 1 is an unbranched or branched alkyl group...
2	7589211	Zoledronic acid crystal forms, zoledronate sodium salt crystal forms, amorphous zoledronate sodium salt, and processes for their preparation The invention relates to polymorphs of zoledronic acid and zoledronate sodium salts, amorphous zoledronate sodium salt, processes for making the polymorphs and amorphous zoledronate sodium salt,...
3	7582768	Zoledronic acid crystal forms, zoledronate sodium salt crystal forms, amorphous zoledronate sodium salt, and processes for their preparation The invention relates to polymorphs of zoledronic acid and zoledronate sodium salts, amorphous zoledronate sodium salt, processes for making the polymorphs and amorphous zoledronate sodium salt,...
4	7557095	Therapeutic compounds Disclosed herein is a compound having a structure or a pharmaceutically acceptable salt thereof, or a prodrug thereof. Therapeutic methods, compositions, and medicaments related thereto are...
5	7550448	Therapeutic compounds Disclosed herein is a compound having a structure or a pharmaceutically acceptable salt, or a prodrug thereof. Therapeutic methods, compositions, and medicaments related thereto are also...
6	7521436	Modified phosphocalcic compound, injectable composition containing same The invention concerns a phosphocalcic compound modified by a gem-bisphosphonic acid or one of its salts, a method for preparing same, as well as its use for preparing an injectable composition....
7	7479502	2-(2-hydroxybiphenyl-3-yl)-1H-benzoimidazole-5-carboxamidine derivatives as factor VIIA inhibitors The present invention relates to novel inhibitors of Factors VIIa, IXa, Xa, XIa, in particular Factor VIIa, pharmaceutical compositions comprising these inhibitors, and methods for using these...
8	7435827	Zoledronic acid crystal forms, zoledronate sodium salt crystal forms, amorphous zoledronate sodium salt, and processes for their preparation The invention relates to polymorphs of zoledronic acid and zoledronate sodium salts, amorphous zoledronate sodium salt, processes for making the polymorphs and amorphous zoledronate sodium salt,...
9	7427636	Inosine monophosphate dehydrogenase inhibitory phosphonate compounds The invention is related to phosphorus substituted IMPDH inhibitory compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as...
10	7410956	Caspase inhibitor prodrugs The present invention relates to compounds of formula I which are prodrugs of caspase inhibitors and pharmaceutically acceptable salts thereof. This invention further relates to the release of...
11	7361786	Bisphosphines as bidentate ligands The present invention relates to ligands of the general formula (I). In addition, a process for the production thereof and the use thereof are demonstrated.
12	7361761	Process for the preparation of bisphosphonic acid The present invention is to relate an improved process using anisole as solvent for the preparation of compound of formula (I) and its pharmaceutically acceptable salts thereof. wherein R...
13	7332603	Preparation of biphosphonic acids and salts thereof A process for preparing alendronate sodium includes the reaction of gammabutyric acid with phosphorous acid and phosphorus trichioride and subsequent treatment with an aqueous solution of an alkali...
14	7329758	Imidazolidine-based metal carbene metathesis catalysts The present invention relates to novel metathesis catalysts with an imidazolidine-based ligand and to methods for making and using the same. The inventive catalysts are of the formula wherein: ...
15	7323572	Process for controlling the hydrate mix of a compound This invention relates to a process for controlling the hydrate mix of a compound, or a composition comprising the compound, the compound being capable of forming a plurality of hydration forms of...
16	7312219	Heteroaromatic inhibitors of fructose 1,6-bisphosphatase Novel FBPase inhibitors of the formula I and X are useful in the treatment of diabetes and other conditions associated with elevated blood glucose.
17	7304163	Benzotriazole-1-yl-N-oxy phosphonium coupling agent Novel phosphonium salts of benzotraizoles, which are highly reactive coupling agents, and are particularly useful in peptide synthesis, are disclosed. Further disclosed is a process of preparing...
18	7253154	Substituted thiazolopyrimidines as xanthine oxidase inhibitors The invention relates to compounds of the following formula (I) or their salts: in which R 1 represents OR 4 or others, in which R 4 is an alkyl group having 1-8 carbon atoms which may have...
19	7241790	Compounds active in spinigosine 1-phosphate signaling The present invention relates to S1P analogs that have activity as S1P receptor modulating agents and the use of such compounds to treat diseases associated with inappropriate S1P receptor...
20	7235666	Process for the preparation of sodium fosphenytoin Phosphoric acid diester 2,5-dioxo-4,4-diphenylimidazolidin-1-ylmethyl esters, both of whose ester groups can be selectively cleaved, are obtained by converting...
21	7205404	Phosphorus-containing prodrugs Novel cyclic phosphoramidate prodrugs of drugs of formula I in their use in delivery of drugs to the liver, their use in enhancing oral bioavailability, and their method of preparation are...
22	7141672	Oxazole-aryl-carboxylic acids useful in the treatment of insulin resistance and hyperglycemia This invention provides compounds of Formula I having the structure or a pharmaceutically acceptable salt thereof, which are useful in treating metabolic disorders related to insulin resistance...
23	7112684	Compounds and methods for fluorescent labeling Dye reagents useful in labeling biological materials are provided along with methods for their use.
24	7109186	HIV integrase inhibitors The present invention describes novel compounds of Formula I which inhibit HIV integrase. The invention also describes compositions and treatments of AIDS or ARC by using these compounds
25	7081536	Isoxazoline derivatives as P N ligands The invention relates to novel ligands of the phosphanylbenzothiophenyl-dihydroisoxazoline, phosphanyl-dihydrooxazolyl-indole and phosphanyl-dihydrooxazolyl-benzofuran type, especially compounds of...
26	7030103	Sulfonamidomethyl phosphonate inhibitors of β-lactamase The intention relates to bacterial antibiotic resistance and, in particular, to compositions and methods for overcoming bacterial antibiotic resistance. The invention provides novel β-lactamase...
27	6977302	Triazole derivatives useful in therapy The invention provides compounds of formula I, R 1 —OP(O)(OH) 2 I wherein...
28	6951944	Production of imidazole derivatives and novel intermediates of the derivatives An improvement in the production of imidazole derivatives including histamine H 3 agonist immepip and histamine H 3 antagonist VUF4929. Desired imidazole derivatives can be easily obtained in...
29	6906006	N-arly-substituted nitrogen-containing heterocycles, processes and novel intermediates for their preparation, and their use as herbicides and plant growth regulators Substituted triazolinone compounds of the formula: wherein the variables R 1 , R 2 , R 7 , R 8 , R 12 and X are as defined in the specification are useful as herbicides, plant growth...
30	6706698	α-Substituted β-aminoethyl phosphonate derivatives The present invention relates to novel α-substituted-β-aminoethylphosphonate and α-substituted-β-aminovinylphosphonate derivatives and their uses for lowering plasma levels of apo (a), Lp(a),...
31	6632954	Phosphinite-oxazolines and metal complexes Compounds of formulae I and Ia, wherein X 1 is secondary phosphino; R 3 is hydrogen, a hydrocarbon radical having from 1 to 20 carbon atoms, a heterohydrocarbon radical, bonded via a carbon...
32	6576760	Processes for synthesis of cyclic and linear polyamine chelators containing N-monosubstituted coordinating arms Polyamines containing at least two nitrogen atoms monosubstituted with pendant arms capable of coordinating metal cations, or with precursors of such pendant arms, all nitrogen atoms of the...
33	6531607	Immobilized palladium complexes The invention relates to immobilized palladium complexes, to a process for their preparation, to their use as catalysts and to a process for the preparation of arylamines using immobilized...
34	6528500	Azole derivatives or salts thereof Described is an azole derivative represented by the following formula (1): wherein, R 1 represents a substituted phenyl group, R 2 and R 3 each represents a fluorine atom, an alkyl group or...
35	6509364	Interphenylene 7-oxabicyclic &lsqb 2.2.1&rsqb heptane oxazoles as prostaglandin F2α antagonists The present invention provides novel compounds represented by the general formula I. and pharmaceutically acceptable salts thereof wherein m, n, X, R, R 1 and R 2 are as defined in the...
36	6500811	Sulfonylaminophosphinic and sulfonylaminophosphonic acid derivatives, methods for their preparation and use Compounds of the formula I are suitable for the production of pharmaceuticals for the prophylaxis and therapy of disorders in the course of which an increased activity of matrix-degrading...
37	6498256	Phosphinite-oxazolines and metal complexes thereof Compounds of formulae I and Ia, wherein X 1 is secondary phosphino; R 3 is hydrogen, a hydrocarbon radical having from 1 to 20 carbon atoms, a heterohydrocarbon radical, bonded via a carbon...
38	6498151	Aryldifluoromethylphosphonic acids with sulfur-containing substituents as PTP-1B inhibitors The invention encompasses the novel class of compounds represented by the formula below, which are inhibitors of the PTP-1B enzyme. The invention also encompasses pharmaceutical compositions and...
39	6489476	Heteroaromatic compounds containing a phosphonate group that are inhibitors of fructose-1,6-bisphosphatase FBPase inhibitors of the formula I and X are useful in the treatment of diabetes and other conditions associated with elevated blood glucose or excess glycogen storage.
40	6472406	Sulfonamidomethyl phosphonate inhibitors of beta-lactamase The intention relates to bacterial antibiotic resistance and, in particular, to compositions and methods for overcoming bacterial antibiotic resistance. The invention provides novel β-lactamase...
41	6448401	Process for water soluble azole compounds An improved process is provided for preparing water-soluble prodrugs of triazole antifungal compounds containing a secondary or tertiary hydroxyl group. More particularly, the improved process is...
42	6399782	Benzimidazole inhibitors of fructose 1,6-bisphosphatase Novel benzimidazole compounds of the following structure and their use as fructose-1,6-bisphosphatase inhibitors is described
43	6380393	Ligands, transition metal complexes and methods of using same Compositions including at least one organic ligand including a first hetero atom and a second hetero atom directly bonded to the first hetero atom or located one carbon atom away from the first...
44	6362172	Water soluble prodrugs of azole compounds Water-soluble prodrugs of triazole antifungal compounds having a secondary or tertiary hydroxy group are provided. More particularly, new water-soluble triazole antifungal compounds are provided...
45	6352985	Benzimidazole compounds A benzimidazole compound represented by the formula (I): wherein R 3 is a carboxyl group, a esterified carboxyl group, an amidated carboxyl group, an amino group, an amido group, or a sulfonyl...
46	6255492	Diesters of phosphoric acid 2,5-dioxo-4,4-diphenyl-imidazolidin-1-ylmethyl ester An improved process for the preparation of a diester of phosphoric acid 2,5-dioxo-4,4-diphenyl-imidazolidin-1-ylmethyl ester is described where an alkali metal phosphate is treated with a...
47	6235728	Water-soluble prodrugs of azole compounds Water soluble prodrugs of azole antifungal agents are provided by quaternizing a nitrogen atom of the azole ring with a phosphonooxymethyl group.
48	6194576	Process for preparing antiviral 2-phosponate nucleotide analogs Nucleotide analogues having the general formula (I) and pharmaceutically acceptable derivatives: ##STR1## wherein n is 0 or an integer; X is O or S, CH 2 , CH-halogen, CH--N 3 , or CCH 2 ; ...
49	6054464	Azabicyclic esters of carbamic acids useful in therapy A compound of formula ##STR1## X is O or S; Y is O or S; G and D are independently nitrogen or carbon with the proviso that no more than one of G, D, or E is nitrogen; E is N or C--R 4 ; R 1 is...
50	6030960	Method of treating hepatitis virus infections A method of treating hepatitis virus infection is disclosed. The method comprising administering to a human subject in need of such treatment an effective hepatitis virus-combatting amount of an...

Matches 1 - 50 out of 332

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