Patents in Class 546/97

Matches 1 - 50 out of 171

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Match	Document	Document Title
1	8163916	Azaadamantane ester and carbamate derivatives and methods of use thereof The invention relates to compounds that are substituted azaadamantane ester and carbamate derivatives, compositions comprising such compounds, and methods of using such compounds and compositions.
2	8097726	Huperzine a compound for treatment of alzheimer's disease A huperzine A compound is provided. The huperzine A compound has following formula: wherein X comprises O or S, Y comprises —O—, —S—, —CH(R4)—, —C(R4)(R5)—, —C(R4)═C(R5)—, —C≡C—, —NH— or —N(R4)...
3	8026252	Large substituent, non-phenolic opioids and methods of use thereof 8-Substituted-2,6-methano-3-benzazocines of general structure are useful as analgesics, anti-diarrheal agents, anticonvulsants, antitussives and anti-addiction medications.
4	7897766	Amino-aza-adamantane derivatives and methods of use The invention relates to amine-substituted aza-adamantane derivatives, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and...
5	7893256	Azabicycloalkane compounds This invention provides compounds of formula I: wherein R1, R2, R3, R4, R5, R6 and R7 are as defined in the specification, or a pharmaceutically acceptable salt or solvate or stereoisomer thereof....
6	7732441	Azabicycloalkane compounds This invention provides compounds of formula I: wherein R1, R2, R3, R4, R5, R6 and R7 are as defined in the specification, or a pharmaceutically acceptable salt or solvate or stereoisomer thereof....
7	7557119	Large substituent, non-phenolic opioids 8-Substituted-2,6-methano-3-benzazocines of general structure are useful as analgesics, anti-diarrheal agents, anticonvulsants, antitussives and anti-addiction medications. One embodiment is the...
8	7358244	Azabicycloalkane compounds This invention provides compounds of formula I: wherein R1, R2, R3, R4, R5, R6 and R7 are as defined in the specification, or a pharmaceutically acceptable salt or solvate or stereoisomer thereof....
9	7253283	Tricyclic modulators of the glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof Novel non-steroidal compounds are provided which are useful in treating diseases associated with modulation of the glucocorticoid receptor, AP-1, and/or NF-κB activity including obesity, diabetes, ...
10	7205300	Aryl fused azapolycyclic compounds This invention is directed to compounds of the formula (I): and their pharmaceutically acceptable salts, wherein R1, R2, and R3 are as defined herein; intermediates for the synthesis of such...
11	7186844	Method for producing cyclic carbamate ester A method for producing a cyclic carbamate ester produces the cyclic carbamate ester by reacting an organic compound having at least two halogen atoms per molecule, an amine having at least two...
12	7041674	Carbamic acid esters with anticholinergic activity A compound of formula 1 wherein X−, A, R1, R2, R3, and R4 may have the meanings given in the claims and in the specification, processes for preparing them, their use in pharmaceutical c...
13	6982271	Tropane analogs The present invention provides compounds, specifically novel tropane analogs, capable of acting as inhibitors of reuptake of monoamines. In preferred embodiments, these compositions are selective...
14	6939867	β3 agonists and uses thereof Sulfamide compounds having formula (I) are described as well as their use in the treatment of diseases dependent on the signaling pathways associated with β-adrenergic receptors, such as obesity, ...
15	6858624	Aryl fused azapolycyclic compounds This invention is directed to compounds of the formula (I): and their pharmaceutically acceptable salts, wherein R1, R2, and R3 are as defined herein; intermediates for the synthesis of such...
16	6784186	Therapeutic compounds This invention relates to novel structural analogues and derivatives of compounds with general analgesic or related pharmacological activity. In particular the invention relates to derivatives of...
17	RE38460	Huperzine A derivatives, their preparation and their use The present invention relates to novel huperzine A derivatives of formula (II), wherein Y is or R″ and Y together form ═CH; R is (C1-C5) alkyl, wherein n is 0 or 1, X is H, (C1-C5) alkyl; (C1...
18	6683089	N-allyoxyethyl-1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocine-10-ols The present invention relates to 1,2,3,4,5,6-hexahydro-2,6-methano-3 -benzazocin-10-ols of general formula 1 wherein the groups R1, R2, R3, R4, R5, R6, R7, R8 and R9 have the meanings as set forth...
19	6455538	1,2,3,4,5,6-Hexahydro-2,6-methano-3-benzazocin-10-ols Compounds of general formula I wherein X is a single bond, —O—, C-C4-alkylene, or an alkylene bridge having 1 to 8 carbon atoms which may be branched or unbranched and optionally have one or two...
20	6423842	Muscarinic agonists and antagonists The present invention provides novel compounds and pharmaceutical compositions thereof useful in the treatment of pain. The compounds of the present invention are azaadamantanes, azanoradamantanes...
21	6387921	Substituted 1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocines and their use as pharmaceutical compositions Substituted 1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocines of general formula 1: wherein:R1 and R2, which are identical or different, are each hydrogen, C1-C6-alkyl, C1--C6-alkyloxy, OH, F, Cl,...
22	6271379	Intermediates useful for the synthesis of huperzine A Intermediates useful for the synthesis of huperzine A represented by the structures below, ##STR1##and methods for their synthesis, wherein: R1 is lower alkyl, benzyl, or substituted benzyl; X is a...
23	6245777	N-(5-phenyl-tetrahydrofuranyl)methyl- and N-(6-phenyl-tetrahydropyranyl)methyl-substituted 1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocin-10-ols The present invention relates to N-(5-phenyl-tetrahydrofuranyl)methyl- and N-(6-phenyl-tetrahydropyranyl)methyl-substituted 1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocin-10-ols of general formula...
24	6159986	Compounds and therapy for resisting memory loss in humans Therapies and compounds for the inhibition of memory loss. In one embodiment, a combination of Huperzine A and hypericin is employed.
25	6140502	Heat-based process for the re-racemisation of a (-)-2-phenylmethyl-3,3-dimethyl-piperidin-4-on derivative A process for the re-racemisation of a (-)-2-phenylmethyl-3,3-dimethyl-piperidin-4-on derivative wherein a (-)-2-phenylmethyl-3,3-dimethyl-piperidin-4-on derivative of the formula 8Bwherein R2...
26	6136980	Method of preparing norbenzomorphane as an intermediate in the preparation of pharmaceutically useful benzomorphane derivatives, in particular (-)-(1R,5S,2"R)-3'-hydroxy-2-(2-methoxypropyl)-5,9,9-trimethyl-6,7-benzo morphane The present invention relates to new processes for preparing norbenzomorphan, the central intermediate step in the preparation of pharmaceutically useful benzomorphan derivatives of general formula...
27	6124312	Heterocyclic compounds The present invention provides heterocyclic 2-aza-bicyclo[2.2.1]heptane compounds which are useful for modulating a muscarinic ptor.
28	6124459	Process for preparing pharmaceutically useful norbenzomorphane derivative The present invention relates to a new process for preparing norbenzomorphane derivatives of general formula 1 ##STR1##
29	6057446	Certain 1-aza-tricyclo [3.3.1-13,7 ] decane compounds A compound having the formula: ##STR1## wherein X' is nitrogen or carbon bonded to a substituent species characterized as having a sigma m value greater than 0, less than 0 or 0; X is nitrogen or...
30	5990104	Polycyclic alcaloid-derivatives as NMDA-receptor antagonists Polycyclic alkaloids of formula (I), wherein R1 is H, C1-6 alkyl, or C6-12 aryl optionally substituted with polar groups; R2 and R3 are independently H, OH, C1-6 alkyl, --C(NH)--NH2, a positively...
31	5945535	Method of preparing norbenzomorphanes The present invention relates to a new process for preparing norbenzomorphan, the central intermediate step in the preparation of pharmaceutically useful benzomorphan derivatives of general formula...
32	5731318	Benzomorphan derivatives Novel benzomorphan derivatives of the formula ##STR1## wherein R1 -R8 are as defined herein. The benzomorphan derivatives are useful for treating cerebral ischaemia of various origins, epilepsy and...
33	5717098	Process for the preparation of azanoradamantane benzamides A process for the preparation of a γ-lactone of the formula ##STR1## which can be used to produce a single enantiomer of aminoazanoradamantane which is coupled to aromatic acid moieties to produce ...
34	5663344	Method for the synthesis of huperzine A and analogs thereof and compounds useful therein The present invention relates to a method for the synthesis of certain bridged fused ring pyridines. Such bridged fused ring pyridines can be converted to huperzine A and analogs of huperzine A....
35	5650406	Adamantane derivative, process for producing the same, and use thereof A compound represented by general formula (1) or an innocuous salt thereof, a process for producing the same, and a schizophrenia remedy containing the same as the active ingredient (wherein the...
36	5607941	Useful for treating neurodegenerative diseases Novel benzomorphan derivatives of the formula ##STR1## wherein R1 -R8 are as defined herein. The benzomorphan derivatives are useful for treating cerebral ischaemia of various origins, epilepsy and...
37	5594002	Benzazabicyclic carbamates as novel cholinesterase inhibitors
38	5587481	Preparation of (S)-decahydroisoquinoline-3-carboxylic acid t-butylamide Methods for preparing (S)-N-tert-butyl-1,2,3,4-tetrahydro-3-isoquinoline-carboxami de ("tic-c"), and converting tic-c to (S)-decahydroisoquinoline-3-carboxylic acid t-butylamide ("tic-d") are...
39	5567818	Processes for preparing 2-(1-azabicyclo[2.2.2]oct-3-yl)-1H-benz[de] isoquinolin-1-one derivatives and intermediates useful therein This invention relates to processes for preparing 2-(1-azabicyclo[2.2.2]oct-3-yl)-2,3,3a,4,5,6-tetrahydro-1H-b enz[de]isoquin olin-1-one, particularly 2-(1-azabicyclo[2.2.2]oct-3S-yl)-2,...
40	5462960	Pyrazole-3-carboxamide derivatives, process for their preparation and pharmaceutical compositions in which they are present The present invention relates to novel pyrazole-3-carboxamide derivatives of the formula ##STR1## in which the substituents are as defined in the specification. The present invention further...
41	5420136	Eradication of pathogenic biological contaminants using non-azo naphthalimide dyes A class of predominantly hydrophobic non-azo N-substituted 1,8-naphthalimide compounds, each bearing, at its 3-position, a nucleofuge and, at its 4-position, a heteroatomic electron-releasing...
42	5399562	Indolones useful as serotonergic agents This invention relates to compounds of the formula: ##STR1## which are useful as 5-HT4 agonists or antagonists and 5-HT3 antagonists.
43	5354758	Benzomorphans useful as NMDA receptor antagonists Compounds of the formula I ##STR1## are disclosed. In this formula, R is a member selected from the group consisting of --CR1 R2 R3, hydroxy, an alkoxy group having 1 to 4 carbon atoms and --NR4...
44	5240935	Substituted 2-azabicyclo[2.2.2]octane derivatives and compositions and method of use thereof Novel substituted 2-azabicyclo[2.2.2]octane derivatives, pharmaceutical compositions containing them, methods for treating central nervous system disorders utilizing them, and processes for...
45	5177082	Huperzines and analogs The invention relates to compounds of the formulas ##STR1## wherein R1, R2 and R3 independently are hydrogen or lower alkyl, and the dotted ( . . . ) line is an optional double bond, and their...
46	5145965	2,6-methanopyrrolo-3-benzazocines Novel 2,6-methanopyrrolo-3-benzazocines, intermediates, processes for the preparation thereof, and methods for alleviating pain utilizing compounds or compositions thereof are disclosed.
47	5104880	Huperzine a analogs as acetylcholinesterase inhibitors An acetylcholinesterase inhibitor is provided of the general formula (I): ##STR1## wherein R1 is H, (C1 -C8)alkyl or halo; R2 is H or (C1 -C8)alkyl; R3 and R4 are individually H, (C1 -C8)alkyl,...
48	4985430	9-acylamino-tetrahydroacridine derivatives and memory enhancing agent containing said derivative as active ingredient There are disclosed a 9-acylamino-tetrahydroacridine derivative represented by the following formula (I): ##STR1## wherein R ##STR2## are as defined in the specification, its optical antipode or...
49	4871842	Piperidine derivatives Novel compounds of the formula: ##STR1## [wherein A is an α-amino acid residue; B is a group represented by the formula: ##STR2## (wherein R4 is hydrogen, lower alkyl, aralkyl or amino-lower ...
50	4777254	Cyclic imides as H1 -antagonists Polycyclic 1,3-dione imides N-alkylated with variously N-substituted alkyl- or cycloalkyl amines afford histamine H1 -receptor antagonists of the formula ##STR1## wherein R is polycyclic alkyl...

Matches 1 - 50 out of 171

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