Patents in Class 546/85

Matches 1 - 50 out of 197

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Match	Document	Document Title
1	8143248	Tricyclic N-heteroaryl-carboxamide derivatives containing a benzimidazole unit, method for preparing same and their therapeutic use The invention concerns tricyclic N-heteroarylcarboxamide derivatives containing a benzimidazole unit of general formula (I): Wherein A, P, Y, R1, R2 and R3 are as defined herein. The invention also...
2	8084937	Binaphthyl compound and organic light emitting element using the same The present invention provides a novel binaphthyl compound and an organic light emitting element having a good light emitting efficiency and a high durability at a low driving voltage. An organic...
3	8080658	Material for organic electroluminescent element and organic electroluminescent element employing the same A material for organic electroluminescence devices for use as a host material in combination with at least one phosphorescent metal complex contains a compound represented by formula 1: wherein R1...
4	8071587	(Dihydro)imidazoiso[5,1-A]quinolines The invention relates to imidazoiso[5,1-a]quinoline and 5,6-dihydro-imidazoiso[5,1-a]quinoline derivatives according to general Formula I or a pharmaceutically acceptable salt thereof. The...
5	8013160	Fluorene-based derivative and organic electroluminescence device employing the same A fluorene-based derivative having a specific structure and an organic electroluminescence device in which an organic thin film layer comprising a single layer or plural layers including at least a...
6	7749619	Organic electroluminescent element and display An organic electroluminescent element and a display device exhibiting high emission efficiency and long life. The organic electroluminescent element contains a pair of electrodes having...
7	7358364	Substituted carboxylic acids The present invention relates to compounds and pharmaceutically acceptable salts of formula (I): which are useful in the treatment of metabolic disorders related to insulin resistance or...
8	7326475	Material for organic electroluminescent device, organic electroluminescent device, illuminating device and display The present invention provides: an organic EL element exhibiting high luminance, a high external quantum efficiency and a long high temperature driving life at 50° C.; an illuminator and a display ...
9	7273885	Inhibitors of serine proteases, particularly HCV NS3-NS4A protease The present invention relates to compounds that inhibit serine protease activity, particularly the activity of hepatitis C virus NS3-NS4A protease. As such, they act by interfering with the life...
10	7253292	Synthesis of cyclopentadiene derivatives A process for preparing cyclopentadiene derivatives comprising the steps of: a) coupling a five membered heterocycle ring with a five or six membered heterocycle ring; b) reacting the obtained...
11	7223863	Process for preparing Tadalafil and its intermediate The present invention relates an improved process for the preparation of tetrahydro-β-carboline derivative of formula (V) which is useful as an intermediate for the preparation of Tadalafil of ...
12	7129261	Cytotoxic agents The present invention provides analogues of duocarmycins that are potent cytotoxins. Also provided are peptidyl and disulfide linkers that are cleaved in vivo. The linkers are of use in forming...
13	7122554	Carboline derivatives Compounds of the general structural formula and use of the compounds and salts and solvates thereof, as therapeutic agents.
14	7053093	Bicyclic and tricyclic hetroaromatic compounds Disclosed are compounds of the formula: and the pharmaceutically acceptable salts thereof, wherein W, Q, X, X1, Y and Z are as defined herein. These compounds bind with high selectivity and/or high...
15	7022856	Carboline derivatives Compounds of the general structural formula and use of the compounds and salts and solvates thereof, as therapeutic agents.
16	6998409	Substituted 2-pyridine cyclohexane-1,4-diamine compounds Substituted 2-pyridine cyclohexane-1,4-diamine compounds, a method for their production, pharmaceutical compositions containing them, and the use of such substituted 2-pyridine...
17	6987115	Antibacterial compounds Compounds of the formula (I) are disclosed and are useful in the treatment bacterial infections: wherein: R1 is Ar or Het;R2 is C1-6alkyl, (R″)2N—(CH2)m— or Ar—C0-6alkyl;X is H, C1-4alkyl, OR′, SR...
18	6967215	Tetrahydrocarbazoles, a process for the preparation of those compounds, and the use thereof Tetrahydrocarbazoles of formula where Q is —SO2—; —O—; or —(CO)—; X is —(CH)—; or —N—; m is from 1 to 3; t is 0 or 1 and the remaining substituents are as defined herein, are useful as antimicro...
19	6964970	Antibacterial compounds Compounds of the formula (I) are disclosed which are Fab I inhibitors and are useful in the treatment bacterial infections: wherein: R1 is Ar or Het;R2 is H, C1-6alkyl or Ar-C0-6alkyl;X is H,...
20	6933303	Heteroaryl-fused nitrogen heterocycles as therapeutic agents This invention provides compounds which are useful as inhibitors of protein tyrosine phosphatases (PTPases). As inhibitors of PTPases, the compounds of the invention are useful for the management,...
21	6890933	Kinesin inhibitors The present invention provides for compounds, compositions, methods and systems for inhibiting cell growth. More specifically, the present invention provides for methods, compounds and compositions...
22	6861430	β-carboline derivatives and its pharmaceutical use against depression and anxiety The invention provides compounds of formula (I) wherein R1 to R5 are as defined in the description, and their preparation. The compounds of formula (I) are useful as pharmaceuticals.
23	6858622	Cycloalkano-indole and -azaindole derivatives Cycloalkano-indole and -azaindole derivatives are prepared by reaction of appropriately substituted carboxylic acids with amines. The cycloalkano-indole and -azaindole derivatives are suitable as...
24	6849640	Therapeutic 1H-pyrido [4,3-b] indoles The present invention provides 2,3,4,4a,5,9b-hexahydro-1H-pyrido[4,3-b]indoles and 2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indoles. These compounds are 5-HT ligands that are useful for treating diseases...
25	6841555	Lavendamycin analogs, quinoline-5,8-diones and methods of using them The invention provides novel lavendamycin analogs having the following general formula: and quinoline-5,8-diones having the following formula: Methods of making and using and compositions...
26	6809091	Substances capable of inducing apoptosis A method for the manufacture of a substance having an apoptosis-inducing ability characterized in including a step of subjecting at least one compound selected from the following (a), (b), (c) and...
27	6734189	Hydroxamic and carboxylic acid derivatives The invention relates to hydroxamic and carboxylic acid derivatives. Compounds of the formula: are disclosed. These compounds are useful for the treatment of diseases mediated by inhibitors of...
28	6720331	1-substituted 1,2,3,4-tetrahydro-β-carboline and 3,4-dihydro-β-carboline and analogs as antitumor agents A composition includes a substituted dihydro- or tetrahydro-β-carboline of formula (II) or (III), wherein the aromatic ring of the carboline may include one or more substituents selected from the ...
29	6686372	Selective β3 adrenergic agonists The present invention is in the field of medicine, particularly in the treatment of Type II diabetes and obesity. More specifically, the present invention relates to selective β3 receptor agonists ...
30	6586445	β-carboline compounds The present invention is directed to compounds of the formula wherein the variables are defined in the specification, which bind to somatostatin receptors and block Na channels.
31	6579326	Compositions for dyeing keratin fibers, containing cationic indolizine derivatives, and dyeing process Compositions for the oxidation dyeing of keratin fibers, containing at least one oxidation base and at least one coupler chosen from indolizine derivative comprising at least one cationic group Z,...
32	6576640	Benzisoxazoles and phenones as α2-antagonists The present invention concerns compounds of formula (I) the N-oxide forms, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein Alk is...
33	6521623	N,N'-disubstituted benzimidazolone derivatives with affinity at the serotonin and dopamine receptors A compound of formula (I) wherein:R1 is C1-C6-alkyl substituted by a group selected from OH, C1-C6-alkoxy, —OCONHC1-C6-alkyl, —OCONHC1-C6-alkyl, —NHSO2C1-C6-alkyl, and —NHCOC1-C6-alkyl, orR1 is...
34	6514981	Methods of modulating tyrosine protein kinase function with indolinone compounds The invention relates to certain indolinone compounds, their method of synthesis, and a combinatorial library consisting of the indolinone compounds. The invention also relates to methods of...
35	6506768	Tetrahydro &ggr -carbolines The present invention concerns the compounds of formula the N-oxide forms, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein R1 is hydrogen,...
36	6503922	Bridged nicotine compounds for use in the treatment of CNS pathologies Pharmaceutical compounds comprising bridged nicotine analogs of N-octylnicotinium iodide (NONI) having selective antagonist properties at α3β2-containing nicotinic receptor subtypes, and c...
37	6498251	Tetrahydrobenzindole derivatives Compounds containing tetrahydrobenzindole which bind to serotonin receptor and are useful in treatment or prevention of disease induced by abnormality of central peripheral serotonin controlling...
38	6492358	β-carboline derivatives useful as inhibitors of phosphodiesterase The present invention relates to novel β-carboline derivatives of the general formula wherein all the variables are as described within the specification, useful as phosphodiesterase inhibitors. ...
39	6492364	Triazolo and derivatives as chemokine inhibitors Novel triazolo derivatives represented by the following formula and pharmaceutically acceptable salts thereof, as well as chemokine inhibitors containing the same as an effective component. These...
40	6479503	Cycloalkano-indole and -azaindole derivatives Cycloalcanoindole and -azaindole derivatives are prepared by reaction of appropriately substituted carboxylic acids with anmines. The cycloahloanindole and -azaindole derivatives are suitable as...
41	6469021	Non-peptide antagonists of GLP-1 receptor and methods of use Non-peptide compounds that act as antagonists of the intestinal hormone glucagons-like peptide 1 (GLP-1) have a 9H-b-carboline central motif. The compounds exhibit advantageous physical, chemical...
42	6462047	Carboline derivatives as cGMP phosphodiesterase inhibitors Compounds of general structural formula (I) wherein A represents a 5- or 6-membered heteroaryl group containing at least one heteroatom selected from the group consisting of oxygen, nitrogen, and...
43	6407112	Optically active tetrahydrobenzindole derivative Optically active tetrahydrobenzindole type compounds having affinity for a 5-HT receptor, useful for prevention and treatment of mental diseases. A species compound is...
44	6350757	Beta-carboline compounds A compound selected from those of formula (I): wherein: represents single or double bond,R1 represents hydrogen, alkyl, —R6-aryl, —R6-cycloalkyl, —R6-heterocycle, —CO2R7—, —COR8, or —CONHR8, wh...
45	6310073	Methods and compositions to treat glycosaminoglycan-associated molecular interactions Therapeutic compounds and methods for inhibiting a glycosaminoglycan (GAG)-associated molecular interaction in a subject, whatever its clinical setting, are described.
46	6218400	Treatment method using a cGMP-Specific PDE inhibitor A compound of formula ##STR1##and salts and solvates thereof, wherein R0, R1, and R2 are defined in the specification. A compound of the present invention is a potent and selective inhibitor of...
47	6211369	Spiro compounds and the use thereof Spiro compounds of the formula (I), ##STR1##where X1, X2, X3, X4 are identical or different and are --S--, --O--, --NR5 --, --CR5N-- or --CR5CH--, with the proviso that at least one of the gro...
48	6194574	Pyrido[2,3-b]indolizine derivatives and aza analogues thereof: CRF1 specific ligands Disclosed are compounds of the formula: ##STR1##wherein Ar, R1, R2, R3, W, X, Y, and Z are substituents as defined herein, which compounds are highly selective partial agonists or antagonists at...
49	6184381	Process for preparing optically active compounds This document describes a novel and practically excellent process for the preparation of optically active compounds, such as optically active alcohols or amines which are useful for various...
50	6175014	Process for the preparation of lactam derivatives The invention provides a process for the preparation of a compound of general formula (I): ##STR1##wherein Im represents an imidazolyl group of the formula: ##STR2##and R1 represents a hydrogen...

Matches 1 - 50 out of 197

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