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7622589 |
Substituted sulfonylaminoarylmethyl cyclopropanecarboxamide as VR1 receptor antagonists
This invention provides a compound of the formula (I):
wherein, variables A, B, D, E, and R 1 to R 11 are as defined in the specification.
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7517892 |
Ligands for monoamine receptors and transporters, and methods of use thereof
One aspect of the present invention relates to heterocyclic compounds. A second aspect of the present invention relates to the use of the heterocyclic compounds as ligands for various mammalian...
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7482462 |
Acylsulfonamides as inhibitors of steroid sulfatase
A compound of formula
wherein R 1 is haloalkyl, alkenyl, phenyl, thienyl, pyridine, benzthiazolyl, chromanyl (1,2-dihydrobenzopyranyl) or (C 6-18 )aryl, and R 1 or R 2 independently of each...
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7465748 |
Amide derivative
There is provided a pharmaceutical drug, particularly a novel compound useful for prophylaxis or a therapeutic treatment of various diseases involving infections with viruses of the herpesvirus...
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7429604 |
Six-membered heterocycles useful as serine protease inhibitors
The present invention provides compounds of Formula (I):
or a stereoisomer or pharmaceutically acceptable salt or solvate form thereof, wherein the variables A, L, Z, X 1 , X 2 , X 3 , X 4 ,...
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7321063 |
Sulfonamide inhibitors of aspartyl protease
The present invention relates to a novel class of sulfonamides which are aspartyl protease inhibitors. In one embodiment, this invention relates to a novel class of HIV aspartyl protease inhibitors...
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RE39991 |
Fungicidal heterocyclic aromatic amides and their compositions, methods of use and preparation
A compound having the following formula:
wherein R 3 and M are defined herein, and processes therewith.
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7271266 |
Substituted 2,3-diphenyl pyridines
Novel compounds of the structural formula (I) are antagonists and/or inverse agonists of the Cannabinoid-1 (CB1) receptor and are useful in the treatment, prevention and suppression of diseases...
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7166746 |
N-bisaryl- and n-aryl-cycloakylidenyl-αhydroxy-and α-alkoxy acid amides
The invention relates to N-bisaryl- and N-aryl-cycloalkylidenyl-a-hydroxy- and a-alkoxy acetic acid amides of the general formula (I) including the optical isomers thereof and mixtures of such...
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7135472 |
3-Heterocyclic benzylamide derivatives as potassium channel openers
The present invention provides novel 3-heterocyclic benzylamides and related derivatives having the general Formula I
wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , A and Het are as defined in the...
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7115618 |
α- and β-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors
α- and β-amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
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7067543 |
Anthranilic acid amides and pharmaceutical use thereof
The invention relates to anthranilic acid amide derivatives of formula (I), wherein Ar is represented by the subformula (I a ), wherein R a represents H or lower alkyl, and R 1 represents H or...
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7049317 |
CCR-3 receptor antagonists
The invention provides compounds of Formula (I):
wherein R 1 –R 4 have any of the values defined in the specification that are CCR-3 receptor antagonists, pharmaceutical compositions...
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7037927 |
Amides that inhibit vanilloid receptor subtype 1 (VR1) receptor
The present invention relates to compounds of formula (I)
that are novel VR1 antagonists useful in treating pain, inflammatory thermal hyperalgesia, urinary incontinence, or bladder overactivity.
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7026357 |
Diphenylurea compounds
Compound of formula (I):
and medicinal products containing the same are useful as dual α 2 /5-HT 2c antagonist receptors.
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6939882 |
Fungicides
Use of compounds of general formula (I) or salts thereof as phytopathogenic fungicides wherein the various radicals and substituents are as defined in the description, pesticidal compositions...
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6916830 |
Substituted tetrahydroisoquinolines as C5a receptor modulators
Substituted tetrahydroisoquinolines and related compounds are provided. Such compounds are ligands that may be used to modulate C5a receptor activity in vivo or in vitro, and are particularly...
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6849649 |
N-phenpropylcyclopentyl-substituted glutaramide derivatives as inhibitors of neutral endopeptidase
The invention relates to compounds of formula (I) for treating for example sexual dysfunction, wherein R 1 is optionally substituted C 1-6 alkyl, optionally substituted carbocyclyl, optionally...
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6818661 |
Anthranylalkyl and cycloalkyl amides and use thereof as VEGF receptor inhibitors
The invention relates to substituted anthranylalkyl and cycloalkyl amides of general formula (I) and to their use as medicaments for treating diseases caused by persistent angiogenesis.
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6803378 |
HIV integrase inhibitors
Novel diketoacid compounds of Formula I are provided which are useful as HIV integrase inhibitors and for the treatment of AIDS or ARC.
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6720433 |
Ethylamine derivatives
Ethylamine derivatives that function as a motilin receptor antagonist and are useful as medicines are represented by the general formula (1): wherein R 1 represents a phenyl group or the like,...
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6642261 |
N-(aryl/heteroarylacety) amino acid esters, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed pharmaceutical compositions...
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6632823 |
Substituted pyridine compounds useful as modulators of acetylcholine receptors
In accordance with the present invention, a novel class of substituted pyridine compounds (optionally containing ether, ester, amide, ketone or thioether substitutions) that promote the release of...
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6548523 |
Process for the preparation of arylethanolamine derivatives having an anti-obesity and anti-diabetic properties
The present invention is a process for the preparation of a compound of Formula (IA) or a pharmaceutically acceptable salt thereof: that includes preparing a diamide of Formula (II) or a...
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6545018 |
Oxamic acids and derivatives as thyroid receptor ligands
The present invention provides novel compounds of the Formula and prodrugs thereof, geometric and optical isomers thereof, and pharmaceutically acceptable salts of such compounds, prodrugs and...
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6534499 |
N-substituted-N′-substituted urea derivatives and the use thereof as TNF-α production inhibitory agents
N-Substituted-N′-substituted urea derivatives represented by the following formula, analogs thereof or pharmaceutically acceptable salts thereof are herein provided. These compounds show a TNF-α...
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6525078 |
Compound for the treatment of atherosclerotic-thrombotic pathological conditions
4-Methoxy-N 1 -(4-trans-nitrooxycyclohexyl)-N 3 -(3-pyridinylmethyl)-1,3-benzenedicarboxamide and acid addition salts thereof with pharmaceutically acceptable organic and inorganic acids, and a...
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6476054 |
Cyclic amine modulators of chemokine receptor activity
The present invention is directed to cyclic amines of the formula I: (wherein R 1 , R 2 , R 3 , m and n are defined herein) which are useful as modulators of chemokine receptor activity. In...
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6472349 |
Pyridine-2,3-dicarboxylic acid diamides
Pyridine-2,3-dicarboxamides of the formula I in which the variables are as defined in the description, which are suitable for use as herbicides or for the desiccation or defoliation of plants...
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6441177 |
Tertiary amines
Tertiary amines of the formula wherein A 1 , A 2 , A 3 , A 4 , M, p, T and Q are as defined herein, and acid addition salts thereof, have antimycotic and cholesterol-lowering activity.
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6426348 |
Diphenyl heterocyclic thioamide derivatives
It has been discovered that compounds of the formula: and the pharmaceutically acceptable salts and esters thereof wherein X and Y are as defined below, inhibit the binding of VCAM-1 to VLA-4...
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6423728 |
Heterocyclic thioamide derivatives
It has been discovered that compounds of the formula: and the pharmaceutically acceptable salts and esters thereof wherein X and Y are as defined below, inhibit the binding of VCAM-1 to VLA-4...
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6420398 |
Urea derivatives having nitrogen aromatic heterocycle
An object of the present invention is to provide novel urea derivatives which have TNF-α production inhibitory effects and are useful as therapeutic agents for various diseases, particularly as...
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6413995 |
Cinnamamide derivatives and drug compositions containing the same
The invention relates to cinnamamide derivatives having the following formula wherein R 1 represents a hydroxyl group, a C 1-6 -alkoxy group, an arylalkoxy group or a substituted or...
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6358960 |
Amidino derivatives and drugs containing the same as the active ingredient
The novel amidino derivatives of the formula (I): wherein all the symbols are as in specification defined; have an inhibitory activity of a blood coagulation factor VIIa and are useful for...
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6353108 |
Method for preparing 4-(3-pyridinyl)-1h-imidazole and the intermediates used
The invention concerns a method for preparing compounds of formula (I) wherein R represents a hydrogen atom or an allyl radical containing up to 8 carbon atoms, characterised in that it consists in...
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6329523 |
Compounds having a plurality of nitrogenous substitutents
Novel compounds having the formula: ##STR1## wherein the constituent variables are defined herein. The compounds are constructed to include a central aromatic, aliphatic, or heterocyclic ring...
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6313153 |
Compositions and methods for treating nephritis and inhibiting TGF -β related conditions using pyridylacrylamide derivatives
The present invention relates to an agent for treating nephritis and a TGF-β inhibiting agent comprising as an effective ingredient a pyridylacrylamide derivative represented by the following...
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6300352 |
Pyridine derivatives and pharmaceutical compositions containing them
The invention relates to novel pyridyl derivatives, their use as medicaments, pharmaceutical formulations containing them and methods for their preparation.
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6291491 |
Amide derivatives as β 3 agonists
Amide derivatives are selective β 3 adrenergic receptor agonists with very little β 1 and β 2 adrenergic receptor activity and as such the compounds are capable of increasing lipolysis and...
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6258851 |
Metalloproteinase inhibitors
Compounds of formula (I), wherein A, B, X, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 are as defined in the specification, are matrix metalloproteinase inhibitors. ##STR1##
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6221888 |
Sulfonamides as cell adhesion inhibitors
Compounds of Formula I are antagonists of VLA-4 and/or α 4 β 7 , and as such are useful in the inhibition or prevention of cell adhesion and cell-adhesion mediated pathologies. These compounds...
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6194418 |
Substituted aminosalicyclic acid amides with fungicidal effect and intermediate products for production thereof
The invention relates to novel substituted aminosalicylamides, to a plurality of processes for their preparation and to their use as fungicides, and also to novel intermediates and to a plurality...
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6194437 |
Non-peptide bombesin receptor antagonists
The compounds of the instant invention are novel compounds of Formula I ##STR1## or a pharmaceutically acceptable salt thereof wherein Ar is phenyl or pyridyl unsubstituted or substituted. Ar 1 ...
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6153630 |
Phenylpyridyl compounds for inhibiting phosphodiesterase IV and methods of using same
Novel compounds which are effective PDE IV inhibitors are disclosed. The compounds possess improved PDE IV inhibition as compared to theophylline or rolipram as well as with improved selectivity...
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6080839 |
Labeling reactants and their use
The invention relates to a novel labeling reactant, suitable for labeling of a biospecific binding reactant using solid-phase synthesis. The invention further concerns new labeling methods. The...
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6028087 |
Platelet aggregation inhibiting compounds
Compounds of the formula (I): W--Z--(CR'R 10 ) r --U--(CR' 2 ) s --V--A (I) wherein: A is ##STR1## W is N ; Z is (CH 2 ) 1 -2 ; U and V independently are present as CO, CR' 2 ,...
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6011174 |
Cyclic amic acid derivatives
The present invention relates to a compound of the formula (I), or its pharmaceutically acceptable salt or ester: ##STR1## wherein Ar 1 is an aryl group or a heteroaromatic ring group; Ar is a...
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5994507 |
Method for binding albumin and means to be used in the method
A method for binding albumin by contacting an aqueous liquid containing an albumin with an albumin-binding compound is selected from albumin-binding compounds containing the scaffold...
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5990314 |
Pharmaceutical pyridine compounds
This invention relates to a compound of formula I ##STR1## These compounds are leukotriene antagonists and as such can be used in treating various diseases associated with leukotrienes.
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