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7414136 Method for producing 3-substituted 2-chloro-5-fluoro-pyridine or its salt  
To provide a method for producing a 3-substituted 2-chloro-5-fluoro-pyridine or its salt in high yield from a readily available material through a short process under mild reaction conditions using...
7320993 Aryl-substituted pyridylalkane, alkene, and alkine carboxamides useful as cytostatic useful as cytostatic and immuosuppressive agents  
The invention relates to new pyridylalkane, alkene, and alkine acid amides substituted with an aryl and/or heteroaryl residue according to the general formula (I), with a saturated or one or...
7247645 Dihydropyridine derivatives  
Compounds having a selective N-type calcium channel antagonistic activity are provided. Dihydropyridine derivatives represented by the following formula: analogs thereof and pharmaceutically...
7199140 Vinyl phenyl derivatives as GLK activators  
The invention relates to novel compounds of Formula (I) or a salt, solvate or prodrug thereof, wherein A, R 1 , R 2 , R 3 , n and m are described in the specification, useful in the treatment of ...
6995179 Dihydropyridine derivative  
Dihydropyridine derivatives of the following formula, analogs thereof and pharmaceutically acceptable salts thereof have an activity of selectively inhibiting the action of N-type calcium channel....
6992095 Stilbene compounds comprising an adamantyl group, compositions and methods thereof  
The invention relates to novel stilbene compounds having the general formula (I): as well as to pharmaceutical compositions for use in human or veterinary medicine, including dermatological,...
6951877 Materials and methods for treating hypercholesterolemia  
The subject invention provides novel HMG-CoA-reductase inhibitors. In a preferred embodiment, the HMG-CoA reductase inhibitors of the subject invention can be deactivated to a primary inactive...
6900232 Cycloalkyl alkanoic acids as integrin receptor antagonists  
The present invention relates to a class of compounds represented by the Formula I Wherein A 1 is a pyridinyl of the formula optionally substituted by one or more R k selected from the...
6727237 Inhibitors of bacterial NAD synthetase  
The present invention provides methods of synthesizing and screening inhibitors of bacterial NAD synthetase enzyme, compounds thereof, and methods of treating bacterial and microbial infections...
6713467 Acid derivatives useful as serine protease inhibitors  
Compounds of formula I and II, or pharmaceutically-acceptable salts thereof, are useful as inhibitors of Factor VIIa, Factor IXa, Factor Xa, Factor FXIa, tryptase, and urokinase, wherein ring B...
6703509 Method for producing 5-aryl nicotinaldehydes  
The invention relates to a process for the preparation of 5-arylnicotinaldehydes by reduction of the corresponding 5-arylnicotinic acids by catalytic hydrogenation in the presence of carboxylic...
6673938 Substituted pyridine herbicides  
Compounds of formula (I), in which the substituents are as defined in claim 1 and the agrochemically tolerated salts M+ and all stereoisomers and tautomers of the compounds of formula (I) are...
6649767 Process for preparing 1,4-dihydropyridine compounds  
A process for preparing a 1,4-dihydropyridine compound comprising contacting an enamine compound and a compound having a structure of in the presence of a base; and treating the reaction...
6541640 Process for the preparation of 4-haloalkylnicotinonitriles  
4-Haloalkylnicotinonitriles having the formula (I) which are suitable as intermediates in the preparation of pesticides, are obtained by: (a) reacting a 3-amino-1-haloalkyl-2-propen-1-one R F...
6515023 Thrombin receptor antagonists  
A thrombin receptor antagonist having the formula useful for inhibiting the aggregation of blood platelets. The compounds can be used in a method of acting upon a thrombin receptor which...
6500852 Inhibitors of bacterial NAD synthetase  
The present invention provides methods of synthesizing and screening inhibitors of bacterial NAD synthetase enzyme, compounds thereof, and methods of treating bacterial and microbial infections...
6489347 Process  
Compounds of structure (1) are obtained by reduction of compounds of the structures Compounds of structure (1), especially where Z is a hydrogen atom or a 3,4-methylenedioxyphenyl group, are...
6441182 Method for the production of 2,6-dichloro-5-fluoro-nicotinic acid and coarse and particularly pure 2,6-dichloro-5-fluoro-nicotinic acid  
The invention relates to a method for the production of 2,6-dichloro-5-fluoronicotinic acid by hydrolyzing 2,6-dichloro-5-fluoro-3-cyanopyridine by (a) dissolving...
6441010 Bi-aromatic compounds linked via a heteroethynylene radical, and pharmaceutical and cosmetic compositions containing them  
Bi-aromatic compounds linked via a heteroethynylene radical are provided along with pharmaceutical and cosmetic compositions containing these compounds and methods for their use.
6432960 Squarate derivatives of dihydropyridine NPY antagonists  
A series of antagonists of NPY have been synthesized and are comprised of squarate derivatives of 4-phenyl-1,4-dihydropyridines of Formula (I). As antagonists of NPY-induced behavior, these...
6392050 Process for preparing substituted pyridines  
The invention relates to a process for preparing substituted pyridines in a simple and cost-effective manner in good yields by reacting substituted 1,4-dihydropyridines with methyl nitrite in the...
6391881 Thiourea derivatives of dihydropyridine NPY antagonists  
A series of antagonists of NPY have been synthesized and are comprised of thiourea linked piperazine and piperidine derivatives of 4-phenyl-1,4-dihydropyridines of Formula 1. where Z is NR 7 R 8...
6376521 A3 adenosine receptor antagonists  
Disclosed are pyridine and dihydropyridine derivatives, pharmaceutical compositions comprising one or more of these derivatives, and a method of selectively blocking an A 3 adenosine receptor of a...
6344561 O- or S- substituted tetrahydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity  
Compounds of the formula where the symbols have the meaning described in the application, have retinoid-like or retinoid antagonist-like biological activity.
6310214 Process for the preparation of chloropyridine sulphonic acid chlorides  
A process is disclosed for preparing chlorinated pyridinesulphonic acid chlorides of the general formula I ##STR1## from hydroxypyridine-sulphonic acids of the general formula II ##STR2## The...
6214878 Stilbene compounds comprising an adamantyl group, compositions and methods thereof  
The invention relates to novel stilbene compounds having the general formula (I): ##STR1## as well as to pharmaceutical compositions for use in human or veterinary medicine, including...
6165236 Poly(oxyalkylene) pyridyl and piperidyl esters and fuel compositions containing the same  
A poly(oxyalkylene)pyridyl or piperidyl ester having the formula: ##STR1## or a fuel-soluble salt thereof; wherein A is a nitrogen-containing ring selected from the group consisting of 3-pyridyl,...
6110970 Nitrogen-containing oxyalkylene esters and uses thereof  
This invention relates to nitrogen-containing oxyalkylene diester compositions for treating disease conditions including cancer and other proliferative diseases. The nitrogen-containing oxyalkylene...
6090824 Therapeutic neurokinin receptor antagonist compounds  
Compounds of formula I ##STR1## wherein Q 1 , Q 2 , Q 3 , and Q 4 have any of the meanings given in the specification, their N-oxides, and their pharmaceutically acceptable salts are nonpeptide...
6045720 Pyridine compound and liquid crystalline composition  
A compound expressed by the following formula (1) and a liquid crystalline composition with using it are provided: ##STR1## wherein, either one of rings A, B and C denotes ##STR2## remaining two of...
6022974 Process for the production of 2-chloro-5-chloromethyl-pyridine  
A process for the production of 2-chloro-5-chloromethylpyridine of the formula: ##STR1## starting from 6-hydroxynicotinic acid of the formula: ##STR2## In this way 6-hydroxynicotinic acid is...
5919792 Integrin antagonists  
This invention relates to certain novel compounds and derivatives thereof, their synthesis, and their use as vitronectin receptor antagonists. The vitronectin receptor antagonist compounds of the...
5892050 Process for the preparation of pyridine dicarboxylate derivatives  
There is provided a single vessel process for the preparation of a pyridine dicarboxylate compound of formula I ##STR1## via the sequential condensation of an alkyl vinyl ether with Vilsmeier...
5869676 Process for the synthesis of ribonucleotide reductase inhibitors 3-AP and 3-AMP  
The present invention relates to improved, efficient chemical syntheses of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP) and 3-amino-4-methylpyridine-2-carboxaldehyde thiosemicarbazone...
5861419 Substituted pyridines as selective cyclooxygenase-2 inhibitors  
The invention encompasses the novel compound of Formula I as well as a method of treating COX-2 mediated diseases comprising administration to a patient in need of such treatment of a non-toxic...
5747422 Substituted 2-phenylpiridines  
Substituted 2-phenylpyridines I ##STR1## where substituents have the meaning described in the specification and their use as herbicides; for the desiccation/defoliation of plants.
5739342 Process for the preparation of nicotinic acids  
The present invention relates to an improved process for the preparation of nicotinic acids represented by the following structural formula (I): ##STR1## which are prepared by reacting a nicotinic...
5716971 Pyridine derivatives, their production and use  
Pyridine derivatives of the formula ##STR1## wherein the ring A stands for an optionally further substituted benzene ring; the ring B stands for an optionally substituted pyridine ring; Q stands...
5708175 Process for producing 4-trifluoromethylnicotinic acid  
A process for producing 4-trifluoromethylnicotinic acid of the formula (VIII) or its salt: ##STR1## which comprises (i) a first step of reacting a halide of the formula (I): CF 3 COHal ...
5691366 Nitro compounds, process for preparation thereof and use thereof  
A new nitro compound of the formula: ##STR1## wherein R 1 and R 2 are each lower alkyl or lower alkoxy(lower)-alkyl, or ##STR2## is cyclized to form ##STR3## X is --O--, --S-- or --NH--, m is an...
5659042 Method for preparing esters of halonicotinic acids  
The present invention provides a method of preparation of ethyl 6-halonicotinate, wherein said halo is chloro or iodo, which comprises reacting the 6-halonicotinic acid with triethyl orthoacetate,...
5605915 Acetylenes disubstituted with a 5 substituted tetrahydronaphthyl group and with an aryl or heteroaryl group having retinoid-like biological activity  
Compounds of the formula ##STR1## wherein the symbols have the meaning defined in the specification.
5604227 Pyridazinedione compounds useful in treating neurological disorders  
The present invention relates to pyridazino[4,5-b]quinolines, and pharmaceutically useful salts thereof, which are excitatory amino acid antagonists and which are useful when such antagonism is...
5599814 Pyridazinedione compounds useful in treating neurological disorders  
The present invention relates to pyridazino[4,5-b]quinolines, and pharmaceutically useful salts thereof, which are excitatory amino acid antagonists and which are useful when such antagonism is...
5591756 LTB4 synthesis inhibitors  
This invention relates to a compound of the formula: ##STR1## or a pharmaceutically acceptable salt thereof wherein X is oxygen, sulfur, --CHCH--, or --CHN--; wherein R 1 is --CO 2 R 2 ...
5559134 Leukotriene-B.sub.4 antagonists, process for their production and their use as pharmaceutical agents  
The invention relates to leukotriene-B 4 antagonists of formula I ##STR1## in which n represents a whole number from 2 to 5, X represents a direct bond, 1 to 6 methylene units, an ortho-, meta-...
5534635 Process for preparing pyridine-2-carboxamides  
It has been found that pyridine-2-carboxamides of the formula ##STR1## wherein R is amino or a residue convertible into amino, and pharmaceutically usable acid addition salts of that carboxamide in...
5527921 Peroxycarboxylic ester initiators derived from nitrogen heterocycles  
Peroxycarboxylic ester photoinitiators derived from aromatic nitrogen containing heterocyclic carboxylic acids are described. The heterocyclic aromatic ring may contain additional nitrogen atoms,...
5520828 Fabric conditioners derived from pyridine carboxylic acids  
Novel fabric conditioners based on pyridine carboxylic acid esters or amides are described. The compounds are effective fabric conditioners and are biodegradable. Compositions including the...
5508293 Pyridinecarboxyimidamide compounds and the use thereof  
Disclosed are pyridinecarboximidamides having a vasodilating effect (hypotensive activity or antianginal activity), and acid adduct salts thereof. ##STR1## wherein when R 1 represents an alkyl,...
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