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7342115 3-substituted-6-aryl pyridines  
3-substituted-6-aryl pyridines of Formula I are provided: wherein R 1 , R 2 , R 3 , R 8 , R 9 , A and Ar are defined herein. Such compounds are ligands of C5a receptor. Preferred compounds of...
7226936 Pyridinic sulfonamide derivatives method of production and use thereof  
New pyridinic sulfonamide derivatives represented by a general formula (I), wherein R1, represents a mono- or polyhalogenated C1–12-alkyl or a mono- or poly-halogenated C3–8-cycloalkyl group....
7223778 5-substituted-2-arylpyridines  
Novel 5-substituted-2-arylpyridine compounds are provided. Such compounds can act as selective modulators of CRF receptors. The 5-substituted-2-arylpyridine compounds provided herein are useful in...
7208507 Pyridines and uses thereof  
The invention relates to pyridines and uses thereof, including to inhibit lysophosphatidic acid acyltransferase β (LPAAT-β) activity and/or proliferation of cells such as tumor cells.
7176312 Kinase inhibitor scaffolds and methods for their preparation  
General methods for the solution phase as well as solid phase synthesis of various substituted heteroaryls has been demonstrated. These substituted heteroaryls can be further elaborated by aromatic...
7138418 Pentafluorobenzenesulfonamides and analogs  
The invention provides methods and compositions relating to novel pentafluorophenylsulfonamide derivatives and analogs and their use as pharmacologically active agents. The compositions find...
7132546 Aniline derivatives or salts thereof and cytokine production inhibitors containing the same  
The present invention provides a cytokine production inhibitor containing as an active ingredient an aniline derivative of the formula (I) or a salt thereof: [wherein A is CO or SO 2 ; Cy is an...
7132425 5-substituted-six-membered heteroaromatic glucokinase activators  
The present invention provides a compound according to formula I where the substituent designations are provided in the specification. Pharmaceutical compositions comprising a compound...
7109220 Amino substituted pyridinyl methanone compounds useful in treating kinase disorders  
The present invention provides amino substituted pyridinyl methanone compounds; pharmaceutical compositions comprising the compounds and methods of synthesis thereof. The compounds, which are...
7034044 Conjugated aromatic compounds with a pyridine substituent  
The present invention relates to compounds of formulae The compounds of the present invention are NMDA (N-methyl-D-aspartate)-receptor subtype blockers and are used in the treatment of diseases...
6989382 Carbocycle based inhibitors of glycogen synthase kinase 3  
New carbocyclic compounds, compositions and methods of inhibiting the activity of glycogen synthase kinase (GSK3) in vitro and of treatment of GSK3 mediated disorders in vivo are provided. The...
6962929 Pentafluorobenzenesulfonamides and analogs  
The invention provides methods and compositions relating to novel pentafluorophenylsulfonamide derivatives and analogs and their use as pharmacologically active agents. The compositions find...
6953805 Excitatory amino acid receptor antagonists  
The present invention provides novel compounds of Formula I or Formula II, or the pharmaceutically acceptable salts or prodrugs thereof, pharmaceutical compositions comprising an effective amount...
6911595 Charge transfer material, and photoelectric conversion device and photoelectric cell using same, and pyridine compound  
A charge transfer material comprising a basic compound having negative charge and represented by the following general formula (I): (A 1...
6903088 Compounds which inhibit leukocyte adhesion mediated by VLA-4  
Disclosed are compounds which bind VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the...
6833378 Corticotropin releasing factor antagonists  
Corticotropin-releasing factor (CRF) antagonists having the formulae wherein the dashed lines, A, B, Y, Z, G, R 3 , R 4 , R 5 , R 6 , R 16 and R 17 are as defined in the application, and...
6809109 2, 4-disubstituted-pyridine N-oxides useful as HIV reverse transcriptase inhibitors  
The present invention relates to 2,4-disubstituted pyridine-N-oxide compounds of formula (I): or stereoisomeric forms, stereoisomeric mixtures, or pharmaceutically acceptable salt forms thereof,...
6794377 Ortho, ortho-substituted nitrogen-containing bisaryl compounds, processes for their preparation, their use as medicaments, and pharmaceutical preparation comprising them  
Ortho, ortho-substituted nitrogen-containing bisaryl compounds, processes for their preparation, their use as medicaments, and pharmaceutical preparations including their use as antiarrhythmic...
6747048 Pyridine-based thyroid receptor ligands  
Novel pyridine-based thyroid receptor ligands are provided which have the general formula I wherein: X is oxygen (—O—), sulfur (—S—), sulfoxide (—S(O)—), sulfonyl (—SO 2 —), CR 8...
6699990 3-(2,5-diaminophenyl)-acrylamide derivatives and coloring agents containing said compounds  
The present patent application relates to 3-(2,5-diaminophenyl)acrylamide derivatives of general formula (I) or to physiologically tolerated, water-soluble-salts thereof and to agents containing...
6645991 αvβ3 integrin inhibitors  
The invention describes novel compounds of the formula I which are biologically active as ligands of integrin α v β 3 X—Y—Z—R 1 —CH 2 —R 2 (R 4 )—CH 2 —CO—R 5 in which X, Y, Z,...
6632823 Substituted pyridine compounds useful as modulators of acetylcholine receptors  
In accordance with the present invention, a novel class of substituted pyridine compounds (optionally containing ether, ester, amide, ketone or thioether substitutions) that promote the release of...
6630004 Oxidation dye composition for keratinous fibers  
An oxidation dyeing composition for keratinous fibers, in particular hair, comprising, as oxidation base, at least one compound of the formula: where n=0-11, R represents H, amino, a saturated...
6589967 Oxime O-ether compounds and fungicides for agricultural and horticultural use  
The present invention relates to novel oxime O-ether compounds represented by a general formula [I]; wherein R 1 represents C 1-6 alkyl, C 3-6 cycloalkyl, C 1-6 alkoxy, etc., m represents an...
6555561 Diaminopyridine-containing thiourea inhibitors of herpes viruses  
This invention provides compounds of formula I having the structure Wherein substitutions at X, G, R 1 , R 2 , R 3 , R 4 , R 5 are set forth in the specification.
6503933 2-pyridylmethylamine derivatives useful as fungicides  
Compounds of formula (I) and salts thereof as phytopathogenic fungicides wherein A 1 is substituted 2-pyridyl; A 2 is optionally substituted phenyl; L is —(C═O)—, —SO 2 — or...
6432990 2-methoxyimino-2-(pyridinyloxymethyl) phenyl acetamides with polyether derivatives on the pyridine ring  
The present invention provides novel 2-methoxyimino-2-(pyridinyloxymethyl)phenyl acetamide compounds with polyether substituents on the pyridine ring, their use as fungicidal compounds, and their...
6403617 Diaminopyridine-containing thiourea inhibitors of herpes viruses  
Compounds of the formula Useful in the treatment of diseases associated with herpes viruses including human cytomegalovirus, herpes simplex viruses, Epstein-Barr virus, varicella-zoster virus,...
6335354 Aminopyridines and methods of using thereof  
This invention relates to aminopyridines of Formula I: or a pharmaceutically acceptable salt, prodrug or solvate thereof, wherein R 1 -R 8 , X and m are set in the specification. The invention...
6262090 Aminopyridine-containing thiourea inhibitors of herpes viruses  
Compounds of the formula ##STR1## wherein A is heteroaryl; R 9 -R 12 are independently hydrogen, alkyl of 1 to 4 carbon atoms, perhaloalkyl of 1 to 4 carbon atoms, halogen, alkoxy of 1...
6221886 Thio acid derived monocyclic N-heterocyclics as anticoagulants  
This invention is directed to monocyclic N-heterocyclics which are substituted by acyclic or cyclic thio derivatives which are useful as anti-coagulants. This invention is also directed to...
RE37087 Insecticidal triffluormethyl alkane derivatives  
There are provided new alkane and alkoxyalkane derivatives of the general formula I ##STR1## in which R 1 , R 2 , R 3 , R 4 and A have the meanings given in the description, processes for their...
6184382 Process for preparing N6-substituted adenosine derivatives  
The invention is directed to improved methods for preparing N6-substituted adenosine derivatives, to intermediates useful therefor and to methods of preparing these intermediates.
6156903 Pyridonecarboxylic acid derivatives or their salts, and antibacterial agents containing the same as their effective components  
A pyridonecarboxylic acid derivative represented by the following general formula (1): ##STR1## [wherein R 1 represents hydrogen atom or a carboxyl protective group; R 2 represents hydroxyl...
6133449 Processes and intermediates for the preparation of piperazine derivatives  
Compounds having the formula R 5 O--A--NR 4 --R 2 (V) where R 2 is a heteroaryl group linked to the remainder of the molecule via a carbon atom adjacent a nitrogen...
6046221 Immunotherapeutic aryl amides  
Novel aryl amides are inhibitors of tumor necrosis factor α and can be used to combat cachexia, endotoxic shock, and retrovirus replication. A typical embodiment is...
6031105 Substituted pyridines  
The present invention relates to certain compounds of the formula (I), ##STR1## which are useful in the synthesis of certian β-adrenergic receptor agonists. The invention also relates to a process...
6008361 Substituted pyridines  
The present invention relates to certain compounds of the formula (I), ##STR1## which are useful in the synthesis of certain β-adrenergic receptor agonists. The invention also relates to a process...
6008234 Benzamidine derivatives substituted by cyclic amino acid and cyclic hydroxy acid derivatives and their use as anti-coagulants  
This invention is directed to benzamidine derivatives substituted by cyclic amino acid and cyclic hydroxy acid derivatives which are useful as anti-coagulants. This invention is also directed to...
5994377 Piperidine compounds  
Novel compounds are described. The compounds generally comprise an acidic group, a basic group, a substituted amino or N-acyl and a group having an optionally hydroxylated alkane moiety....
5981756 Deuterated 2-adamantylamino-5-nitropyridine, organic nonlinear optical material containing the compound, and production method of the compound  
Of hydrogen atoms constituting 2-adamantylamino-5-nitropyridine, at least hydrogen atom of N--H part is substituted with deuterium to obtain a deuterated AANP. An organic optical material is made...
5972975 Substituted 2-aminopyridines as inhibitors of nitric oxide synthase  
Substituted 2-aminopyridine compounds of Formula (I) and pharmaceutically acceptable salts which have been found useful in the treatment of nitric oxide synthase mediated diseases and disorders....
5962479 Corticotropin releasing factor antagonists  
Corticotropin-releasing factor (CRF) antagonists having formulae (I), (II) or (III) wherein the dashed lines, A, B, Y, Z, G, R 3 , R 4 , R 5 , R 6 , R 16 and R 17 are as defined in the...
5945537 Nitration of pyridine-2, 6-diamines  
It has been found that the nitration of pyridine-2,6-diamines, which is commonly performed in a mixture of nitric acid and concentrated sulfuric acid, will give a significantly higher yield (from...
5939553 Process for preparing pyridine-2,6-diamines  
A process has been found for preparing pyridine-2,6-diamines, i.e., 2,6-diaminopyridine (DAP) and derivative compounds in which one of the amino groups is a substituted amine (secondary or...
5932599 Use of sulfonamides  
The present invention is concerned with compounds of formula ##STR1## wherein Z is a substituted pyridyl group of formula ##STR2## R 1 is hydrogen, amino, lower alkylamino, lower dialkylamino,...
5919792 Integrin antagonists  
This invention relates to certain novel compounds and derivatives thereof, their synthesis, and their use as vitronectin receptor antagonists. The vitronectin receptor antagonist compounds of the...
5863913 Aromatic compound and pharmaceutical composition  
An aromatic compound of the formula (I): ##STR1## specifically, for example, 3- (4-carboxyphenyl)methyl!valeramido!-4-dimethylaminobenzoic acid 4'-methylpiperazide, or a salt thereof, and a...
5705513 Fungicides for the control of take-all disease of plants  
A compound, composition, and method for controlling Take-all disease of plants by applying to the seed prior to planting, a fungicide of the formula: ##STR1## wherein Z 1 and Z 2 are C and are...
5686460 Carbocyclic diarylmethylene derivatives, processes for their preparation and their uses in therapeutics  
The present invention relates to the carbocyclic diarylmethylene derivatives of formula (I): ##STR1## and to their use in therapeutics, especially as drugs with anti-inflammatory and analgesic...
Matches 1 - 50 out of 336 1 2 3 4 5 6 7 >