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7629365 |
Heterocyclic compounds
3-Chloro-6-(hydroxymethyl)-2-methyl-5-[4-({4-[(trifluorometh
yl)oxy]phenyl}oxy)phenyl]-4(1H)-pyridinone, having the following formula:
is described along with its pharmaceutically acceptable...
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7585883 |
Substituted pyridines and their uses
The present invention is directed to substituted pyridines, methods for their preparation and methods for their use in the treatment and/or prevention of mast cell related conditions.
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7514564 |
Substituted amine derivatives and methods of use
Selected amines are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically...
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7446117 |
Cox-2 inhibiting pyridine derivatives
Compounds of formula (I)
or pharmaceutically acceptable salts thereof are potent and selective inhibitors of COX-2 and are of use in the treatment of the pain, fever and inflammation of a...
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7342115 |
3-substituted-6-aryl pyridines
3-substituted-6-aryl pyridines of Formula I are provided:
wherein R 1 , R 2 , R 3 , R 8 , R 9 , A and Ar are defined herein. Such compounds are ligands of C5a receptor. Preferred compounds of...
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7314580 |
Compound, liquid-crystal composition and optical material
Disclosed is a liquid-crystal composition capable of providing a functional film that exhibits useful optical properties. The composition comprises a compound of the following formula (1) that...
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7166621 |
Pyridyloxyalkanoic acid amide derivatives useful as fungicides
Fungicidal compounds of the general formula (I): wherein X and Y are independently H, halo, C 1-8 alkyl, C 3-6 cycloalkyl, C 2-8 alkenyl, C 2-8 alkynyl, C 1-8 alkoxy, C 1-8 alkylthio, nitro,...
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7135569 |
Process for the preparation of pyridinyl and pyrimidinyl mono-fluorinated beta keto-esters
The present invention relates to a process for preparing pyridinyl and pyrimidinyl mono-fluorinated beta keto esters of formula (I):
wherein: R1 represents a pyridine ring or a pyrimidine...
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7087599 |
Estrogen receptor modulators
The present invention relates to compounds and derivatives thereof, their synthesis, and their use as estrogen receptor modulators. The compounds of the instant invention are ligands for estrogen...
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7030111 |
Compounds that abrogate DNA-damage-induced cell cycle G2 checkpoint and/or augment the anti-cancer activity of DNA damaging treatments
The invention provides compositions and methods to inhibit the cell cycle G2 checkpoint, in particular the DNA-damage-induced G2 checkpoint, in mammalian cells including human cells. Specifically,...
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6881845 |
Process for preparing (±)trans-4-p-fluorophenyl-3-hydroxymethyl-1-methylpiperidine
The present invention relates to a process for preparing (±)-trans-4-p-fluorophenyl-3-hyroxymethyl-1-methylpiperdine
of formula (I). The present invention also relates to novel intermediates of...
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6872690 |
Herbicidal 2-alkynyl-pyri (mi) dines
The invention relates method of combating undesired plant growth at a locus, comprising application to the locus of an effective amount of at least one compound of formula (I):
wherein R...
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6844032 |
Liquid crystal compounds having bis(trifluoromethyl) phenyl rings, liquid crystal compositions and liquid crystal display devices
The compound (1) having 2,3-bis(trifluoromethyl)-1,4-phenylene is stable chemically and has excellent miscibility with other liquid crystal compounds, large and negative dielectric anisotropy and...
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6765095 |
2,3-disubstituted pyridine derivative, process for the preparation thereof, pharmaceutical composition containing the same, and intermediate therefor
A compound of the formula (I) wherein A is O, S, CHR 1 or NR 2 , R 1 and R 2 are H, lower alkyl, X 1 and X 2 are H, halogen, nitro, cyano, etc., Y 1 is H, lower alkyl, Z 1 and Z 2 are H,...
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6670380 |
Pyridone inhibitors of fatty acid binding protein and method
Compounds are provided having the formula: wherein A, Q, and X are as described herein. A method is also provided for treating diabetes and related diseases, especially Type II diabetes,...
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6635766 |
Process for the preparation of arylamides of heteroaromatic carboxylic acids
A process for the preparation of arylamides of heteroaromatic carboxylic acids of the formula: in which each A n is nitrogen or CR n (n=1 to 5), with the proviso that at least one of the ring...
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6632823 |
Substituted pyridine compounds useful as modulators of acetylcholine receptors
In accordance with the present invention, a novel class of substituted pyridine compounds (optionally containing ether, ester, amide, ketone or thioether substitutions) that promote the release of...
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6620937 |
Intermediates in the synthesis of camptothecin and related compounds and synthesis thereof
The present invention provides a short, convergent total synthesis of camptothecin and related compounds which consists of a novel 4+1 radical annulation. The present invention also provides novel...
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6590104 |
Production method of an ether compound
A production method of an ether compound given by formula (3): which comprises making an alcohol compound given by formula (4): wherein R 1 represents a 3,3-dihalo-2-propenyl group or a benzyl...
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6489347 |
Process
Compounds of structure (1) are obtained by reduction of compounds of the structures Compounds of structure (1), especially where Z is a hydrogen atom or a 3,4-methylenedioxyphenyl group, are...
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6455551 |
Use of 1-hydroxy-2-pyridones for treating mucosa diseases which are difficult to treat
The compound of the formula I is suitable for the preparation of pharmaceuticals for the treatment of fungal disorders caused by azole-resistant fungi.
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6451817 |
Alpha-substituted-1-benzyl-napthyls
This invention relates to the fields of pharmaceutical and organic chemistry and provides novel 1-benzyl-naphthyls which are α-substituted with ether, thioether, amino, hydrazino, cyano or halo...
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6406912 |
Method for enzymatic enantiomer-separation of 3(r)- and 3(s)-hydroxy-1-methyl-4-(2,4,6-trimethoxyphenyl)-1,2,3,6-tetrahydro-pyridine or its carboxylic acid esters
The invention relates to a method for producing optically pure compounds of 3(R)- and 3(S)-hydroxy-1-methyl-4-(2,4,6-trimethoxyphenyl)-1,2,3,6-tet
rahydro-pyridine or its carboxylic acid esters by...
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6391892 |
Naphthyl pharmaceutical compounds
The present invention provides a compound of formula I wherein R 1 is H, OH, halo, OCO(C 1 -C 6 alkyl), OCO(aryl), OSO 2 (C 4 -C 6 alkyl), OCOO(C 1 -C 6 alkyl), OCOO(aryl), OCONH(C 1 -C 6 ...
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6384053 |
α-substituted-1-benzyl-napthyls
This invention relates to the fields of pharmaceutical and organic chemistry and provides novel 1-benzyl-naphthyls which are α-substituted with ether, thioether amino, cyano or halo that are...
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6372766 |
Substituted 2-(2′-pyridyloxy)phenylacetamides, as fungicides and pesticides
Substituted 2-(2′-pyridyloxy)phenylacetamides I, where R 1 is fluorine, chlorine, CH 3 or halomethyl; R 2 is fluorine, bromine, alkyl or halomethyl; R 3 is hydrogen or one of the radicals...
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6316631 |
Process for converting 2,4-dichloropyridines into 2-aryloxy-4-chloropyridines
This invention relates to a process for converting 2,4-dichloropyridines into 2-aryloxy-4-chloropyridines, comprising reacting a compound of formula (I), wherein R 1 is (C 1 -C 4 )alkyl; R 2 is...
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6235907 |
Intermediates useful in making mappicine and related compounds
This invention discloses and claims novel intermediates and procedures for the synthesis of camptothecin derivatives, such as irinotecan, and other compounds related to the synthesis of CPT-11....
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RE37087 |
Insecticidal triffluormethyl alkane derivatives
There are provided new alkane and alkoxyalkane derivatives of the general formula I ##STR1## in which R 1 , R 2 , R 3 , R 4 and A have the meanings given in the description, processes for their...
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6175018 |
Process for preparation of propionic acid derivatives
(R)(+)-2-[4-(5-chloro 3-fluoropyridin-2-yloxy)-phenoxy]-propionic acid propinyl ester is produced by converting a compound of formula II ##STR1## in an inert organic solvent, without isolation of...
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6175017 |
Process for the production of aryl carbonates
A process for the preparation of carbonates containing aromatic ester groups is disclosed. The process entails reacting aromatic monohydroxy componds with phosgene or with chlorocarbonic acid...
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6169101 |
Pyridine derivatives as fungicides
A fungicidal compound having general formula (I) ##STR1## or a stereoisomer thereof, wherein A is CH or N, B is OCH 3 or NHCH 3 , R 1 is H, chloro or methyl and R 2 is H, fluoro, chloro or methyl.
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6153757 |
Metalloproteinase inhibitors and intermediates useful for their preparation
The invention relates to compounds of formula (1) ##STR1## wherein: Z is O or S; V is a divalent radical which together with C* and N forms a ring having six ring atoms, where each of said ring...
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6121451 |
Intermediates and process for the manufacture of camptothecin derivatives (CPT-11) and related compounds
This invention relates to intermediates and processes for the synthesis of camtothecin derivatives, such as irinotecan. Related procedures and compounds are disclosed, such as a method of making...
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6103732 |
Carboxylic acid derivatives, their production and use
Carboxylic acid derivatives of the formula I ##STR1## where the radicals have the meanings stated in the description, and the preparation of these agreements [sic] and their use as drugs are...
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6054583 |
Preparation of 2-substituted pyridines
This invention relates to a process for preparing 2-substituted pyridines via metal halogen exchange with sec-butyllithium on optionally substituted 2-bromo or 2-iodopyridines. The resulting...
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6046217 |
2,3,5-trisubstituted pyridines as inhibitors of cyclooxygenase-2
The invention encompasses the novel compound of Formula I as well as a method of treating cyclooxygenase-2 mediated diseases comprising administration to a patient in need of such treatment of a...
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6015905 |
Process for the preparation of 2-(6-substituted pyrid-2-yloxymethyl) phenylacetate
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5994379 |
Bisaryl COX-2 inhibiting compounds, compositions and methods of use
The present invention relates to inhibitors of COX-2, compositions which contain such compounds and methods of use. The compounds are represented by formula I: ##STR1## and include pharmaceutically...
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5952326 |
Tetralin and chroman derivatives useful in the treatment of asthma, arthritis and related diseases
Compounds of the formula ##STR1## wherein R is an optionally substituted heteroaryl group such as 2-chromanyl, 2-pyridyl or 5-fluoro-2-benzothiazoyl; X is O, S or (CH 2 ) m ; R 1 is phenyl...
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5919930 |
Process for cross-coupling aromatic boron compounds with aromatic halogen compounds or perfluoroalkylsulfonates
Process for cross-coupling aromatic boron compounds with aromatic halogen compounds or perfluoroalkylsulfonates. In a process for preparing polycyclic aromatic compounds by cross-coupling aromatic...
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5869506 |
Fluoropropene compound, an insecticide containing the same and an intermediate for production thereof
The present invention provides a fluoropropene compound represented by Formula I: ##STR1## wherein R 1 represents a C 1 -C 10 alkyl group or other groups, Z represents an oxygen atom or other...
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5817825 |
Process for the preparation of 1-hydroxy-2-pyridones
A process for the preparation of 1-hydroxy-2-pyridones is described in which a pyrone is reacted with a hydroxyl-ammonium salt in the presence of basic compounds, solvents and organic acids or...
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5780478 |
Tetra-substituted phenyl derivatives
Compounds of general formula (1): ##STR1## are described wherein W-- is (1) C(Y)-- where Y is a halogen atom, or an alkyl, or --X a R 1 group where X a is --O--, --S(O) m -- where m is...
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5726315 |
Certain 3-hydroxy-6-hydroxymethyl-pyridine intermediates
The compounds of the invention are tri-substituted pyridine intermediates, useful in the preparation of final products, wherein said final products are involved in the preparation of medicaments....
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5712226 |
Optically active D-pyridyloxy phenoxy propionate herbicides
Opticalls active enantiomers of the formula I ##STR1## where R is a group of the formulae ##STR2## R 1 and R 2 , among others, are halogen or CF 3 and Z is a carboxyl, carboxylate, carboxylic...
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5700943 |
Process for making phenylthiomethylpyridinylalkenoates
This invention relates to a process of making a compound of formula I ##STR1## where R 1 contains an α,β-unsaturated carbonyl group & R n is hydrogen or nonhydrogen radicals which do not have a...
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5698702 |
Intermediate compound for use in production of dihalopropene compound
There is disclosed a dihalopropene compound of the formula I: ##STR1## wherein l is an integer of 1 to 5; m is an integer of 1 to 4; R 1 's and R 2 's are the same or different and are...
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5684022 |
Ether compounds, their use, and intermediates for use in their production
There are disclosed novel ether compounds of the general formula: ##STR1## wherein R 1 is halogen; A is a group of the general formula Q-1: --CH(R 2 )--(CH 2 ) m --CH (R 3 )--N(R 4...
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5670510 |
Pyridyl substituted spirodienes for the treatment of inflammation
A class of substituted spirodienes is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula I: ##STR1## wherein A is...
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