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7629363 |
Diaryl substituted pyridinones
Disclosed are compounds Formula I
and pharmaceutically acceptable salts thereof, wherein R 1 , R 2 , R 3 /R 4 , and R 5 are defined herein. These compounds are useful for treating...
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7629365 |
Heterocyclic compounds
3-Chloro-6-(hydroxymethyl)-2-methyl-5-[4-({4-[(trifluorometh
yl)oxy]phenyl}oxy)phenyl]-4(1H)-pyridinone, having the following formula:
is described along with its pharmaceutically acceptable...
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7598380 |
Method of preparation of azaindole derivatives
A method of preparing azaindole compounds for antiviral use having the formula
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7585883 |
Substituted pyridines and their uses
The present invention is directed to substituted pyridines, methods for their preparation and methods for their use in the treatment and/or prevention of mast cell related conditions.
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7576203 |
Method for producing cyclic diamine derivative
The present invention provides an industrially useful method for synthesizing a cyclic diamine derivative (4) or a salt thereof which serves as an ACAT inhibitor. A 2-hydroxyacetylaminopyridine...
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7563893 |
3-Phenyl-cinnoline analogue and antitumor agent using the same
The present invention relates to a 3-phenyl-cinnoline compound or a physiologically acceptable salt thereof, and a cell proliferation inhibitor and an antitumor agent comprising the same, as an...
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7547713 |
O-pyridinequinone derivatives, the composition containing the derivatives, the process for preparation of the derivatives and the use of the derivatives
The present invention relates to the o-pyridinequinone disubstituted derivatives, the composition containing the derivatives, the process for preparation of the derivatives and the use of the...
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7514564 |
Substituted amine derivatives and methods of use
Selected amines are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically...
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7514455 |
Inhibitors against complex II of electron transport system
An electron transport system complex II inhibitor comprising 2-pyridinol derivative represented by the general formula [I]
wherein R is alkyl or alkenyl optionally having substituent containing...
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7459414 |
Herbicides
Compounds of formula
wherein the substituents have the meanings given in claim 1 , and agronomically tolerable salts, isomers and enantiomers of those compounds, are suitable for use as...
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7446117 |
Cox-2 inhibiting pyridine derivatives
Compounds of formula (I)
or pharmaceutically acceptable salts thereof are potent and selective inhibitors of COX-2 and are of use in the treatment of the pain, fever and inflammation of a...
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7432227 |
6-alkyl or alkenyl-4-aminopicolinates and their use as herbicides
4-Aminopicolinic acids having alkyl or alkenyl substituents in the 6-position and their amine and acid derivatives are potent herbicides demonstrating a broad spectrum of weed control.
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7410985 |
Cycloalkyl derivatives of 3-hydroxy-4-pyridinones
The present invention provides an cycloalkyl derivative of 3-hydroxy-4-pyridinone which is useful for the chelation of metal ions such as iron. Its preparation and use is described. In particular,...
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7342115 |
3-substituted-6-aryl pyridines
3-substituted-6-aryl pyridines of Formula I are provided:
wherein R 1 , R 2 , R 3 , R 8 , R 9 , A and Ar are defined herein. Such compounds are ligands of C5a receptor. Preferred compounds of...
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7320993 |
Aryl-substituted pyridylalkane, alkene, and alkine carboxamides useful as cytostatic useful as cytostatic and immuosuppressive agents
The invention relates to new pyridylalkane, alkene, and alkine acid amides substituted with an aryl and/or heteroaryl residue according to the general formula (I), with a saturated or one or...
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7279574 |
Epoxy compound and cured epoxy resin product
The present invention provides a novel epoxy compound, which can be converted into a cured epoxy resin product having liquid crystal properties by curing with a curing agent. Since the cured epoxy...
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7230110 |
Pyrithione compound and microcapsule using the same
A compound represented by formula (I); a multifunctional isocyanate composition, containing an adduct formed by treating the compound represented by formula (I) with a compound represented by...
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7223764 |
2,4-bis (trifluoroethoxy)pyridine compound and drug containing the compound
The present invention is directed to a 2,4-bis(trifluoroethoxy)pyridine compound represented by formula (1):
(wherein X 1 represents a fluorine atom or a hydrogen atom) or a salt thereof, and...
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7189855 |
Process for production of phenoxy-substituted 2-pyridone compounds
3-Phenoxy-2-pyridone compound can be produced by making the amide compound of the formula (1):
wherein R is optionally substituted phenyl;
react with a malonoaldehyde derivative such as...
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7183278 |
Picolinamide derivative and harmful organism control agent comprising said picolinamide derivative as active component
Disclosed are novel compounds useful for the control of harmful organisms, harmful organism control agents using the same, and processes for producing the novel compounds. The useful novel...
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7151182 |
Intermediates for N-substituted carbamoyloxyalkyl-azolium derivatives
N-substituted carbamoyloxyalkyl-azolium derivatives which have antifungal activity and are useful for the treatment of fungal diseases.
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7132409 |
Adenosine derivatives and use thereof
2-(6-Cyano-1-hexyn-1-yl)adenosine, 2-(6-cyano-1-hexyn-1-yl)adenosine 5′-monophosphate, or salts thereof; and drugs containing the same as an active ingredient. The compounds have excellent...
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7129246 |
N-adamantlmethyl derivatives and intermediates as pharmaceutical compositions and processes for their preparation
The invention provides compounds of general formula (I) in which m, A, R 1 and Ar have the meanings defined in the specification; a process for, and intermediates used in, their preparation;...
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7122563 |
Derivatives of 4-demethylpenclomedine, use thereof and preparation thereof
Thiocarbonate and thiocarbamate derivatives of 4-demethylpenclomedine are provided along with pharmaceutical compositions containing them and use for treating cancer. A method for preparing the...
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RE39263 |
Substituted aromatic thiocarboxylic acid amides and their use as herbicides
There is disclosed substituted thiocarboxamides of the general formula (I)
useful as herbicides.
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7084090 |
Catalyst comprised of n-substituted cyclic imides and processes for preparing organic compounds with the catalyst
A catalyst of the invention includes an imide compound having a N-substituted cyclic imide skeleton represented by following Formula (I):
wherein R is a hydroxyl-protecting group. Preferred R...
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7074813 |
Substituted N′-(arylcarbonyl)-benzhydrazides, N′-(arylcarbonyl)-benzylidene-hydrazides and analogs as activators of caspases and inducers of apoptosis and the use thereof
The present invention is directed to substituted N′-(arylcarbonyl)-benzhydrazides, N′-(arylcarbonyl)-benzylidene-hydrazides and analogs thereof, represented by the Formulae I and II:
...
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7067540 |
Substituted pyridinones
Disclosed are compounds Formula I
and pharmaceutically acceptable salts thereof, wherein R 1 , R 2 , R 3 , R 4 , and R 5 are defined herein. These compounds are useful for treating diseases...
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7030201 |
Bottom antireflective coatings
The present invention relates to bottom antireflective coating compositions and polymers useful in making such compositions.
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7026338 |
Pharmaceutical nitrones
Pharmaceutical nitrone comprise condensates of an N-hydroxylamine and a physiological aldehyde, providing improved delivery and absorption, enhanced stability and reduced toxicity. Preferred...
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7022727 |
Crystalline drug form
The present invention relates to a crystalline form of...
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7015237 |
Pyridine matrix metalloproteinase inhibitors
Selective MMP-13 inhibitors are pyridine derivatives of the formula
or a pharmaceutically acceptable salt thereof,
wherein:
R 1 and R 2 independently are hydrogen, halo, hydroxy, C 1 –C...
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7009058 |
Method for preparing pyridine-2,3-dicarboxylic acid esters
A method for preparing pyridine-2,3-dicarboxylic acid esters of the general formula:
wherein R is C 1-6 -alkyl, C 3-6 -cycloalkyl, aryl or arylalkyl, and R 1 to R 3 , independently of one...
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6995148 |
Adenosine cyclic ketals: novel adenosine analogues for pharmacotherapy
The present invention relates to novel compounds that are novel adenosine receptor analogues. Specifically, the compounds of the present invention preferably function as both adenosine receptor...
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6974827 |
Phenyl substituted 4-hydroxy tetrahydroxypyridone
The present invention relates to novel compounds of the formula (I)
in which
W, X, Y, Z, G, A, B, Q 1 , Q 2 and D are each as defined in the description, to a plurality of processes for...
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6969768 |
Preparation of 4-haloalkylnicotinic esters
A process for preparing 4-haloalkylnicotinic esters of the formula (I),
where
R F is (C 1 -C 4 )-haloalkyl and R is (C 1 -C 6 )-alkyl;
which comprises
a) reacting an aminoketone of the...
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6946479 |
N-sulfonyl-4-methyleneamino-3-hydroxy-2-pyridones
Compounds of Formula (I)
are effective in the treatment of a microbial infection.
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6936596 |
Adenosine derivatives and use thereof
2-(6-Cyano-1-hexyn-1-yl)adenosine, 2-(6-cyano-1-hexyn-1-yl)adenosine 5′-monophosphate, or salts thereof; and drugs containing the same as an active ingredient. The compounds have excellent...
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6932960 |
N-substituted 3-hydroxy-4-pyridinones and pharmaceuticals containing thereof
N-substituted 3-hydroxy-4-pyridinones and metal chelates, methods of preparing N-substituted 3-hydroxy-4-pyridinones and metal chelates, and pharmaceutical compositions containing new N-substituted...
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6930117 |
N-alkyl-4-methyleneamino-3-hydroxy-2-pyridones
Compounds of Formula (I)
are effective in the treatment of a microbial infection.
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6867210 |
Aryl substituted pyrimidines
This invention relates aryl substituted pyridines, pyrimidines, pyrazines and triazines of Formula I:
or a pharmaceutically acceptable salt, prodrug or solvate thereof, wherein A 1 , A 2 , A 3...
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6852673 |
Herbicidal pyridine compounds
The novel compounds of formula I:
wherein R, A, X 1 , X 2 , X 3 , Z and m have the meaning given in claim 1, and the agronomically acceptable salts or N-oxides thereof, and herbicidal...
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6828276 |
Herbicidally active benzoylcyclohexanediones
There are described benzoylcyclohexanediones of the formula I, their preparation, and their use as herbicides and plant growth regulators. In this formula (I), C 1 , C 2 , C 3 are cyclic...
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6828441 |
2-pyridylmethylamine derivatives useful as fungicides
Compounds of formula (I) and salts thereof as phytopathogenic fungicides wherein A 1 is substituted 2-pyridyl; A 2 is optionally substituted phenyl; L is —(C═O)—, —SO 2 — or...
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6770662 |
Benzoylpyridine derivative or its salt, fungicide containing it as an active ingredient, its production process and intermediate for producing it
The present invention relates to a fungicide containing a novel benzoylpyridine derivative or its salt. The present invention provides a fungicide containing a benzoylpyridine derivative...
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6765095 |
2,3-disubstituted pyridine derivative, process for the preparation thereof, pharmaceutical composition containing the same, and intermediate therefor
A compound of the formula (I) wherein A is O, S, CHR 1 or NR 2 , R 1 and R 2 are H, lower alkyl, X 1 and X 2 are H, halogen, nitro, cyano, etc., Y 1 is H, lower alkyl, Z 1 and Z 2 are H,...
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6762178 |
Acetylenic aryl sulfonamide and phosphinic acid amide hydroxamic acid TACE inhibitors
Hydroxamic acids having the formula are useful in treating disease conditions mediated by TNF-α, such as rheumatoid arthritis, osteoarthritis, sepsis, AIDS, ulcerative colitis, multiple...
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6756392 |
Nicotinamide derivatives useful as PDE4 inhibitors
The invention relates to nicotinamide derivatives and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. The...
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6747048 |
Pyridine-based thyroid receptor ligands
Novel pyridine-based thyroid receptor ligands are provided which have the general formula I wherein: X is oxygen (—O—), sulfur (—S—), sulfoxide (—S(O)—), sulfonyl (—SO 2 —), CR 8...
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6730668 |
6,7-dihydro-5H-pyrazolo&lsqb 1,2-a&rsqb pyrazol-1-ones which control inflammatory cytokines
The present invention relates to compound which are capable of preventing the extracellular release of inflammatory cytokines, said compounds, including all enantiomeric and diasteriomeric forms...
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