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7547782 |
Met kinase inhibitors
The present invention is directed to compounds having the formula I or II:
including salts thereof, and methods for using them for the treatment of cancer.
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7517994 |
Heterocyclic inhibitors of MEK and methods of use thereof
Disclosed are compounds of the Formula I
and pharmaceutically acceptable salts and prodrugs thereof, wherein R 1 , R 2 , R 7 , R 8 and R 9 , W, X and Y are as defined in the specification....
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7511151 |
Substituted pyridyloxyalkylamides and their use as fungicides
Fungicidal compounds of the general formula (1), or the corresponding pyridine N-oxide, wherein X, Y, R 1 , R 2 , R 3 , R 4 and R 5 are as defined in the description.
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7476683 |
Glycinamide derivatives as raf-kinase inhibitors
The present invention relates to glycinamide derivatives of formula (I), the use of the compounds of formula (I) as inhibitors of raf-kinase, the use of the compounds of formula (I) for the...
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7427618 |
Ethynyl derivatives as factor Xa inhibitors
Novel compounds of the formula (I), in which R 1 , R 2 , R 3 , X and Y have the meaning indicated in Patent claim 1, are inhibitors of coagulation factor Xa and can be employed for the...
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7425570 |
Pyridoxine and pyridoxal analogues: new uses
The invention provides pyridoxal and pyridoxine analogues, pharmaceutical compositions containing pyridoxine and pyridoxal analogues, and methods of administering pharmaceutical compositions...
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7304161 |
Diaclhydrazine ligands for modulating the expression of exogenous genes in mammalian systems via an ecdysone receptor complex
The present invention relates to non-steroidal ligands for use in nuclear receptor-based inducible gene expression system, and a method to modulate exogenous gene expression in which an ecdysone...
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7265220 |
Amino acid derivatives, method for production thereof and pharmaceutical compositions comprising said derivative
Compound of formula (I):
wherein:
R 1 represents aryl, heteroaryl or alkyl which is optionally substituted, or a group of formula —(CO)—CR 6 R 7 NR 8 R 9 wherein R 6 , R 7 , R 8 and R 9...
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7250518 |
Nicotinamide acids, amides, and their mimetics active as inhibitors of PDE4 isozymes
Compounds of the formula:
useful as inhibitors of PDE4 in the treatment of diseases regulated by the activation and degranulation of eosinophils.
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7235566 |
Pyridinone derivatives for treatment of atherosclerosis
Compounds of formula (I):
are inhibitors of the enzyme Lp-PLA 2 and are of use in therapy, in particular for treating atherosclerosis.
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7153876 |
Malonamid and malonamic ester derivatives with antithrombotic activity, their preparation, and their use
Compounds of formula I,
in which R 1 , R 2 , A, and B having the definitions set forth in the claims, are valuable pharmacologically active compounds, which exhibit a strong antithrombotic...
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7026339 |
Inhibitors of HCV NS5B polymerase
The present invention relates to compounds, process for their synthesis, compositions and methods for the treatment and prevention of hepatitis C virus (HCV) infection. In particular, the present...
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7002018 |
Process for the preparation of amorphous form of torsemide
The present invention relates to a simple and efficient process for the preparation of amorphous form of torsemide. The process includes recovering amorphous torsemide from a solution thereof in a...
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6949574 |
(Oxime)carbamoyl fatty acid amide hydrolase inhibitors
The present invention relates to novel oxime carbamyl derivatives and pharmaceutical compositions comprising said derivatives which inhibit fatty acid amide hydrolase. These pharmaceutical...
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6949539 |
Admantane derivatives
The invention provides compounds of general formula (I) in which m, A, R 1 and Ar have the meanings defined in the specification; a process for their preparation; pharmaceutical compositions...
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6927225 |
Fungicidal 2-pyridyl alkyl amides and their compositions, methods of use and preparation
The present invention relates to compounds of Formula I:
wherein:
represents a 6-membered heterocyclic aromatic ring in which X 1 is N, and X 2 , X 3 and X 4 are CR″;
wherein...
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6916933 |
4-pyridinyl-n-acyl-l-phenylalanines
Compounds of Formula I have activity as inhibitors of binding between VCAM-1 and cells expressing VLA-4 and are useful for treating disease whose symptoms and or damage are related to the binding...
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6911451 |
Phenylalanine derivatives
Phenylalanine derivatives of formula (1) are described:
wherein
L 1 is a linker atom or group; X 1 is a group selected from —N(R 3 )CO—, —N(R 3 )SO 2 —, —N(R 3 )C(O)O— or —N(R...
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6890942 |
Acyl sulfonamides as inhibitors of HIV integrase
The present invention relates a series of compounds of Formula I
wherein R 1 , R 2 , R 3 , and B are as defined in the specification. The compounds are useful for the inhibition of HIV...
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6852717 |
Compounds useful as anti-inflammatory agents
Disclosed are compounds useful in pharmaceutic compositions for treating diseases or pathological conditions involving inflammation such as chronic inflammatory diseases. Also disclosed are...
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6815556 |
Compounds having fungicidal activity and processes to make and use same
A compound according to formula one that is useful as a fungicide is provided. Additionally, processes to make and use same are provided.
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6790866 |
Sulfonamide and carboxamide derivatives and drugs containing the same as the active ingredient
The sulfonamide or carboamide derivatives of the formula (I) and a pharmaceutical composition which comprise them as an active ingredient: (wherein A ring, B ring is carbocyclic ring,...
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6767917 |
Amorphous torasemide modification
The present invention relates to an amorphous torasemide modification, to a process for preparation thereof, to its use as a raw material for the preparation of pharmaceutically acceptable salts of...
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6756392 |
Nicotinamide derivatives useful as PDE4 inhibitors
The invention relates to nicotinamide derivatives and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. The...
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6720424 |
Aminobenzoic acid derivatives
Aminobenzoic acid derivatives represented by Formula (1) as follows: (wherein, R 1 represents a hydrogen atom, a C 1-6 alkyl group, or the like; R 2 represents a hydrogen atom, a C 1-6 alkyl...
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6693121 |
Polycyclic aryl and heteroaryl substituted 4-pyridones useful for selective inhibition of the coagulation cascade
The invention relates to polycyclic aryl and heteroaryl substituted 4-pyridone compounds useful as inhibitors of serine proteases of the coagulation cascade and compounds, compositions and methods...
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6667327 |
Pyridine amido derivatives
Disclosed are pyridine amido derivatives of the formula wherein X, Y, and R 1 to R 6 are as defined herein. These compounds are selective MAO-B inhibitors and are useful in treating diseases...
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6656958 |
Substituted pyridine compounds useful for controlling chemical synaptic transmission
The present invention is directed to a series of substituted pyridine compounds, a method for selectively controlling neurotransmitter release in mammals using these compounds, and pharmaceutical...
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6605670 |
Resorcinolic derivatives and methods of making and using the same
Methods of making low molecular weight methylene acceptors are provided. The methylene acceptors are prepared by reacting a polyhydric phenol with an aromatic olefinic compound in the presence of...
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6603044 |
Phthalamide derivatives, or salt thereof agrohorticultural insecticide, and method for using the same
The present invention provides a phthalamide derivative of the formula (I): wherein A 1 is (substituted) C 1 -C 8 alkylene, (substituted) C 3 -C 8 alkenylene, (substituted) C 3 -C 8 ...
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6465496 |
Torsemide polymorphs
The present invention is directed to the novel forms of torsemide, designated Form V, amorphous torsemide, Dupont Form 2 solvent adduct, Dupont Form 2 ethanol adduct and Dupont Form 2 isopropanol...
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6369083 |
2-methoxyimino-2 (pyrinyloxymethyl) phenyl acetamides with polyether derivatives on the pyridine ring
The present invention provides novel 2-methoxyimino-2-(pyridinyloxymethyl) phenyl acetamide compounds with polyether substituents on the pyridine ring, their use as fungicidal compounds, and their...
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6335352 |
IL-8 receptor antagonists
Novel compounds useful in the treatment of Interleukin-8 mediated diseases, and methods of using them are disclosed.
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6320053 |
Preparation of heteroarylcarboxamides
The invention relates to a process for the preparation of hetero)aryloxyheteroarylcarboxylic amide or ester of formula VI ##STR1## wherein A 1 , A 2 , A 3 , A 4 , A 5 Hal, X, R 1 , and R 4 are...
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6191280 |
Method for producing substituted thiopyridines
A process for preparing thiopyridines of the formula I ##STR1## where the substituents are as defined in the description.
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6156898 |
Substituted 1,4-dihydro-4-oxonicotinic carboxamides; GABA brain receptor ligands
Disclosed are compounds of the formula ##STR1## or the pharmaceutically acceptable non-toxic salts thereof wherein: R 1 is lower alkyl; R 2 is hydrogen or lower alkyl; or R 1 and R 2 ...
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6153630 |
Phenylpyridyl compounds for inhibiting phosphodiesterase IV and methods of using same
Novel compounds which are effective PDE IV inhibitors are disclosed. The compounds possess improved PDE IV inhibition as compared to theophylline or rolipram as well as with improved selectivity...
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6133442 |
Aryl- and hetaryl-sulfonamide derivatives, their preparation and their use as endothelin antagonists
Compounds of formula I ##STR1## wherein R 1 signifies phenyl, substituted phenyl or heterocyclyl; R 2 signifies phenyl or substituted phenyl; R 3 signifies hydrogen, lower-alkyl, cyano,...
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6017956 |
N,N-disubstituted amic acid derivatives
The present invention relates to a compound of the formula (I): ##STR1## wherein Ar 1 , Ar 2 , Ar 3 and Ar 4 represent an aryl group or a heteroaromatic ring group; A represents a hydrocarbon...
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6005010 |
Phenyl-substituted alkenylcarboxylic acid guanidides, process for their preparation, their use as a medicament or diagnostic, and medicament containing them
Compounds of the formula ##STR1## where T is ##STR2## and R(A), R(B), R(C), R(D), R(E), R(F), x and y have the meanings indicated in the claims, and their pharmaceutically acceptable salts are...
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6001860 |
N-aryl and N-heteroarylurea derivatives as inhibitors of acyl coenzyme A: Cholesterol acyl transferase (ACAT)
A compound of the formula ##STR1## and the pharmaceutically acceptable salts thereof, wherein R 17 , R 18 and R 1 are as defined below. The compounds of formula I are inhibitors of acyl coenzyme...
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5994540 |
Di-and trisubstituted pyridines and their preparation
Substituted pyridines of the general formula: ##STR1## wherein R 1 is hydroxyl or chlorine, and a) X is hydrogen or chlorine, R 2 and R 3 together are O, R 4 is a group of the formula --OR 5...
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5968875 |
2-methoxyimino-2-(pyridinyloxymethyl)phenyl acetamides with carboxylic acid derivatives on the pyridine ring
The present invention provides novel 2-methoximino-2-(pyridinyloxymethyl)phenyl acetamide compounds with carboxylic acid substituents on the pyridine ring, their use as fungicidal compounds, and...
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5935976 |
Antiviral ethers of aspartate protease substrate isosteres
Antiretroviral compounds (which are effective, for example, against HIV) of the formula I ##STR1## in which R 1 is an acyl radical lower-alkoxy-lower-alkanoyl whose lower alkoxy radical is...
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5916905 |
2,3-substituted pyridines for the treatment of inflammation
A class of substituted pyridyl compounds is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula II wherein R 1 is...
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5877297 |
Boronic compound complexing reagents and highly stable complexes
Boron compound completing reagents, intermediate reagents of those reagents and methods of synthesizing these reagents. These reagents, including those shown as General Formula CII may be used,...
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5874615 |
Method for the preparation of insecticidal benzoylurea compounds
The present invention provides an improved method for the preparation of an insecticidal benzoylurea having the structural formula I ##STR1##
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5872224 |
Boronic compound complexing reagents and highly stable complexes
Boron compound complexing reagents, boron compound complexes, and methods of synthesizing these reagents and complexes are disclosed. These reagents and complexes include those shown in General...
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5869623 |
Boronic compound complexing reagents and complexes
Boron compound complexing reagents, intermediate reagents of those reagents, and methods of synthesizing these reagents are disclosed. These reagents, including those shown as General Formula II...
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5859210 |
Boronic compound complexing reagents and complexes
Boron compound complexing reagents, boron compound complexes, and methods of synthesizing these reagents and complexes are disclosed. These reagents and complexes include those shown in General...
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