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9040567 BAX agonist, compositions, and methods related thereto  
The disclosure relates to BAX activators and therapeutic uses relates thereto. In certain embodiments, the disclosure relates to methods of treating or preventing cancer, such as lung cancer,...
9035055 Photoelectric conversion material, film containing the material, photoelectric conversion device, production method thereof, photosensor, imaging device and their use methods  
An organic compound and a photoelectric conversion device containing the organic compound are disclosed. The organic compound and device realize high photoelectric conversion efficiency, low dark...
9005778 Organic compound and organic light-emitting device including the same  
There is provided a novel organic compound suitably used for a blue light-emitting device and an organic light-emitting device including the novel organic compound. The organic compound is an...
8975244 Process and intermediates for the preparation of abiraterone acetate  
The present invention relates to a process for the synthesis of (3beta)17-(3-pyridinyl)androsta-5,16-dien-3-yl acetate (Abiraterone acetate) represented by the structure of formula (1), and salts...
8968889 Organic compound and organic light-emitting device  
A novel organic compound suitable for emitting green light and an organic light-emitting device including the organic compound are provided. The organic compound is represented by general formula...
8927549 Adamantyl benzamide derivatives  
Embodiments of the present invention provide adamantyl benzamide derivatives and pharmaceutical compositions comprising adamantyl benzamide derivatives. Methods of use of such compounds and...
8916275 Light emitting device material and light emitting device  
Disclosed is an organic electroluminescent element which has achieved both high luminous efficiency and low driving voltage by containing a light-emitting element material, which comprises a...
8901310 Tricyclic compounds, compositions, and methods  
The present invention is directed to compounds of Formula I: or salt thereof, which are modulators of the glucocorticoid receptor. The compounds and salts of the invention are useful in the...
8901155 Method for treating a TRPV1-mediated disease  
A method for treating a TRPV1-mediated disease by administering to a patient a therapeutically effective amount of a compound or a salt thereof having the following formula [I]: wherein A...
8822043 Organic compound and organic light-emitting device  
The present invention provides organic compounds which are indenobenzo[k]fluoranthene derivatives represented by the following general formula (1): In general formula (1), R1 to R14 are each...
8680339 Herbicides  
Compounds of Formula (I), wherein the substituents are as defined in claim 1, are suitable for use as herbicides.
8653275 Bis-quaternary ammonium cyclophane compounds that interact with neuronal nicotinic acetylcholine receptors  
Provided are bis-quaternary ammonium cyclophane compounds which are modulators of nicotinic acetylcholine receptors. Also provided are methods of using the compounds for modulating the function of...
8552035 Phenanthrenone compounds, compositions and methods  
The present invention is directed to compounds of Formula I: or salt thereof, which are modulators of the glucocorticoid receptor. The compounds and salts of the invention are useful in the...
8546578 Iodonium Cyclophanes for SECURE arene functionalization  
This disclosure relates to compounds, reagents, and methods useful in the synthesis of aryl fluorides, for example, in the preparation of 18F labeled radiotracers. For example, this disclosure...
8530465 1, 2-disubstituted amido-anthraquinone derivatives, preparation method and application thereof  
The invention provides a series of novel 1,2-disubstituted amido-anthraquinone derivatives. Further, the invention also provides the preparation method and application of said derivatives, said...
8492365 7-substituted tetracycline compounds  
The present invention pertains, at least in part, to novel 7-substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states,...
8455652 Inhibitors for the soluble epoxide hydrolase  
Inhibitors of the soluble epoxide hydrolase (sEH) are provided that incorporate multiple pharmacophores and are useful in the treatment of diseases.
8455653 Hydroxy-6-heteroarylphenanthridines and their use as PDE4 inhibitors  
Compounds of the formula Ia***** in which the substituents have the definitions provided in the specification, are novel, effective PDE4 inhibitors, useful in the treatment of psoriasis.
8440684 Polycyclic pyrrolidine-2,5-dione derivatives as -formyl peptide receptor like-1 (FPRL-1) receptor modulators  
The present invention relates to novel polycyclic pyrrolidine-2,5-dione derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as...
8383820 N-adamantyl benzamides as inhibitors of 11-β-hydroxysteroid dehydrogenase  
Novel substituted benzamide based inhibitors, their use in therapy, pharmaceutical compositions comprising the compounds, the use of said compounds in the manufacture of medicaments, and...
8378112 Glycyrrhetinic acid derivative and use thereof  
Disclosed is a gap junction inhibitor which is more practically useful compared with carbenoxolone. Also disclosed is a novel glycyrrhetinic acid derivative. The glycyrrhetinic acid derivative is...
8334305 N-adamantyl benzamides as inhibitors of 11-β-hydroxysteroid dehydrogenase  
Novel substituted amide inhibitors, their use in therapy, pharmaceutical compositions comprising the compounds, the use of said compounds in the manufacture of medicaments, and therapeutic methods...
8324391 Hydroxy-6-heteroarylphenanthridines and their use as PDE4 inhibitors  
Compounds of the formula Ia***** in which the substituents have the definitions provided in the specification, are novel, effective PDE4 inhibitors.
8318944 Hydroxy-6-heteroarylphenanthridines and their use as PDE4 inhibitors  
Compounds of the formula Ia***** in which the substituents have the definitions provided in the specification, are novel, effective PDE4 inhibitors.
8304415 1, 2-disubstituted amido-anthraquinone derivatives, preparation method and application thereof  
A series of novel 1,2-disubstituted amido-anthraquinone derivatives, and the preparation method and application of said derivatives. Said application includes said derivatives with therapeutically...
8288018 Amino compound for organic light-emitting device and organic light-emitting device including the same  
An amino compound for an organic light-emitting device of general formula [1]: wherein X1 is bonded to the pair of fluorenyl groups at meta-positions to each other and is substituted or...
8232300 Tricyclic amide compound  
A compound represented by the following general formula (I): [wherein R1 represents hydrogen atom or a C1-6 alkyl group, A and B represent —(CH2)2—, —(CH2)3—or —(CH2)4—, X represents —N(R2)—CO—(R2...
8222519 Merocyanine dye and photoelectric conversion device  
A merocyanine dye is provided. The merocyanine dye is represented by formula (1). In the formula (1), A1 represents a divalent atomic group, n represents an integer of 1 to 3, A2 and A3 each...
8148409 Phenathrenone compounds, compositons and methods  
The present invention is directed to compounds of Formula I: or salt thereof, which are modulators of the glucocorticoid receptor. The compounds and salts of the invention are useful in the...
8124596 Demethylpenclomedine analogs and their use as anti-cancer agents  
This disclosure concerns novel demethylpenclomedine analogs. Also disclosed are pharmaceutical compositions and methods for using such compositions to treat hyperproliferative disorders. In one...
8084610 Compositions and methods for detecting and treating tumors containing acidic areas  
Improved compositions have been developed which are selectively sequestered in acidic areas of tumors. When the compositions contain a radioisotope effective to report the presence of the...
8034827 Phenanthridine derivatives as bradykinin antagonists  
The present invention relates to new phenanthridine derivatives of formula (I), wherein the variables are as defined in the specification, to processes for producing the same, to pharmacological...
8003798 Hydroxy-6-heteroarylphenanthridines and their use as PDE4 inhibitors  
Compounds of the formula I in which the substituents have the definitions provided in the specification, are novel, effective PDE4 inhibitors.
7994333 Methods and compositions for selectin inhibition  
The present invention relates to the field of anti-inflammatory substances, and more particularly to novel compounds that act as antagonists of the mammalian adhesion proteins known as selectins....
7989467 Use of indole-derived compounds for the preparation of a medicament that can be used to treat diseases related to the splicing process  
The invention relates to indole-derived compounds and to the use of said compounds for the preparation of a medicament that can be used to treat diseases related to the process of splicing...
7960039 Amino compound for organic light-emitting device and organic light-emitting device including the same  
An amino compound for an organic light-emitting device of general formula [1]: wherein X1 is bonded to the pair of fluorenyl groups at meta-positions to each other and is substituted or...
7893282 7-substituted fused ring tetracycline compounds  
7-substituted fused ring tetracycline compounds, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 7-substituted fused ring tetracycline compounds...
7888355 Compositions and methods for inhibiting growth and metastasis of melanoma  
There are provided methods of inhibiting growth and metastasis of melanoma, methods of sensitizing melanoma cells to apoptosis, and methods of treating a subject having melanoma using acetyl...
7667043 Molecular structures with controllable electron conducting properties  
Aromatic and heteroaromatic molecular structures with controllable electron conducting properties are derived from the incorporation of electron active substituents in selective positions. Such...
7612103 Pleuromutilin derivatives as antimicrobials  
Compounds of formula wherein R1 and R1′ are hydrogen or deuterium,R2, R3 and R4 are hydrogen or deuterium,R5 is the residue of an amino acid,X is S or N-ALK, is piperidinyl or tetrahydropyridinyl,...
7585574 Pyrene derivative and organic electroluminescence device making use of the same  
Provided are a pyrene derivative of a specified structure and an organic electroluminescence device including an organic thin film layer formed of one or multiple layers including at least a light...
7547714 Tricyclic compounds, compositions, and methods  
The present invention is directed to compounds of Formula I: or salt thereof, which are modulators of the glucocorticoid receptor. The compounds and salts of the invention are useful in the...
7365196 Sulphonamido-substituted bridged bicycloalkyl derivatives  
A class of compounds is disclosed, comprising sulphonamido-substituted bridged bicycloalkyl structures. The compounds are inhibitors of gamma-secretase, and hence are useful in the treatment of...
7361674 7, 8 and 9-substituted tetracycline compounds  
7, 8 and 9-substituted tetracycline compounds, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 7, 8 and 9-substituted tetracycline compounds are...
7338961 Sphingosine kinase inhibitors  
The invention relates to substituted adamantane compounds, pharmaceutical compositions thereof, processes for their preparation, and methods for inhibiting sphingosine kinase and for treating or...
7335659 Substituted 10-aryl-11H-benzo[b]fluorenes and 7-aryl-5, 6-dihydro-benzo[a]anthracenes for selective effects on estrogen receptors  
This invention provides a compound, or its possible salt, having the formula, wherein: Re and ′Re are OH, optionally independently etherified or esterified; Z is —CH2CH2— or —C(R4,R5)—, wherein R4...
7326723 Aralkyl-tetrahydro-pyridines, their preparation and pharmaceutical compositions containing same  
The present invention relates to compounds of formula (I): in which X represents N or CH; R1 represents a hydrogen or halogen atom or a CF3 group; n is an integer from 1 to 5; A represents a...
7326696 Amino-methyl substituted tetracycline compounds  
Aminomethyl substituted tetracycline compounds, pharmaceutical compositions, and methods of use thereof are discussed.
7320993 Aryl-substituted pyridylalkane, alkene, and alkine carboxamides useful as cytostatic useful as cytostatic and immuosuppressive agents  
The invention relates to new pyridylalkane, alkene, and alkine acid amides substituted with an aryl and/or heteroaryl residue according to the general formula (I), with a saturated or one or...
7317024 Heterocyclic modulators of the glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof  
The invention relates to a class of novel non-steroidal compounds which are useful in treating diseases associated with modulation of the glucocorticoid receptor, AP-1, and/or NF-κB activity...

Matches 1 - 50 out of 291 1 2 3 4 5 6 >