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7371777 |
Cyclic compound and PPAR agonist
The present invention provides a novel compound having an excellent PPAR agonist action. More specifically, it provides a compound represented by the following formula, a salt thereof, an ester...
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7365095 |
Chromane and chromene derivatives and uses thereof
Compounds of formula I or pharmaceutically acceptable salts thereof are provided:
wherein each of R 1 , R 2 , R 3 , R 4 , y, m, n, and Ar are as defined, and described in classes and subclasses...
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7345059 |
Diphenylpyridine derivatives, preparation and therapeutic application thereof
The invention relates to 5,6-diphenylpyridine-3-carboxamide derivatives of general formula (I):
where:
R 1 represents hydrogen or a (C 1 -C 4 )alkyl; R 2 represents:
a monoazo...
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7279574 |
Epoxy compound and cured epoxy resin product
The present invention provides a novel epoxy compound, which can be converted into a cured epoxy resin product having liquid crystal properties by curing with a curing agent. Since the cured epoxy...
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7256213 |
Taxanes having a C10 carbonate substituent
Taxanes having a methylcarbonate or ethylcarbonate substituent at C(10), a hydroxy substituent at C(7), and a range of C(13) side chain substituents.
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7256203 |
Dicationic 2,5-diarylfuran aza-analogs as anti-protozoan agents
A compound of Formula (I):
wherein:
X is selected from the group consisting of O, S, and NR 17 , where R 17 is hydrogen or lower alkyl; A and Y are CH, N, NR 17 , O, or S; C 1 and C 2 ...
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7250389 |
Antifungal compound and process for producing the same
Disclosed are novel compounds useful for prevention or control of diseases derived from fungi, a process for producing the same, and novel antifungal agents using the novel compounds. The compounds...
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7247735 |
Octupolar molecules used as organic semiconductors
In the case of the materials according to the invention, the charge carrier mobility in the correspondingly prepared films is achieved if the molecules are composed in such a way that side...
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7230013 |
C10 carbamoyloxy substituted taxane compositions
Compositions comprising a taxane having a carbamoyloxy substituent at C(10), a hydroxy substituent at C(7), and a range of C(2), C(9), C(14), and side chain substituents.
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7226944 |
Taxanes having a C7 carbonate substituent
Taxanes having a carbonate substituent at C(7), a hydroxy substituent at C(10), and a range of C(2), C(9), C(14), and side chain substituents.
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7208169 |
Biphenyl carboxamides
The invention relates to novel biphenylcarboxamides of the formula (I)
in which R 1 , R 2 , m, n, R 3 , Y and A are as defined in the disclosure, to a plurality of processes for preparing...
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7132425 |
5-substituted-six-membered heteroaromatic glucokinase activators
The present invention provides a compound according to formula I
where the substituent designations are provided in the specification. Pharmaceutical compositions comprising a compound...
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7087768 |
Fumagillol derivatives and preparing method thereof
The disclosure relates to a fumagillol compound which can be usefully used not only as an angiogenesis inhibiting agent showing a superior angeogenesis inhibitory effect with less toxicity, but...
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7064124 |
NF-κB inhibitor containing substituted benzoic acid derivative as active ingredient
A NF-κB inhibitor represented by the following formula (I) is provided:
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7056946 |
C10 carbonate taxane compositions
Taxanes having a carbonate substituent at C(10), a hydroxy substituent at C(7), and a range of C(2), C(9), C(14), and side chain substituents.
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7034035 |
Fungicidal mono-, bi-, and tri-cycloheteroalkyl amides and their compositions, methods of use and preparation
The present invention relates to compounds of Formula I:
wherein:
a)
represents a 6-membered heterocyclic aromatic ring in which X 1 is N and X 2 , X 3 and X 4 are each...
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7026352 |
Physiologically active substances
The present invention provides a novel bioactive substance having an antitumor activity and a process for producing it, and a medical use thereof. Namely, it provides a 12-membered ring macrolide...
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7002017 |
Enantioselective hydrogenation of intermediates in the synthesis of tipranavir
The invention relates to a process for preparing the compounds of general formula I
by enantioselective hydrogenation of the compounds of formula II
in the presence of special hydrogenation...
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6992104 |
C7 carbonate taxane compositions
Taxanes having a carbonate substituent at C(7), a hydroxy substituent at C(10), and a range of C(2), C(9), C(14), and side chain substituents.
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6967205 |
Compounds with antibacterial and antiparasitic properties
There are provided novel compounds which have both antibacterial and antiparasitic properties, thereby reducing the need for using several compounds in combined antibacterial and antiparasitic...
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6927225 |
Fungicidal 2-pyridyl alkyl amides and their compositions, methods of use and preparation
The present invention relates to compounds of Formula I:
wherein:
represents a 6-membered heterocyclic aromatic ring in which X 1 is N, and X 2 , X 3 and X 4 are CR″;
wherein...
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6919359 |
Azabicyclic-substituted-heteroaryl compounds for the treatment of disease
The invention provides compounds of Formula I:
Azabicyclo-N(R 1 )—C(═X)—W Formula I
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6916932 |
Reductive cleavage of the exocyclic ester of UK-2A or its derivatives and products formed therefrom
A process comprising reacting compound GF-I with a reducing agent to form compound GF-II wherein Y is selected from the group consisting of H, benzyl, substituted benzyl, CH 2 OC 1-8 alkyl, CH 2...
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6906088 |
Taxanes having a C10 carbamoyloxy substituent
Taxanes having a carbamoyloxy substituent at C(10), a hydroxy substituent at C(7), and a range of C(2), C(9), C(14), and side chain substituents.
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6903219 |
Process to produce derivatives from UK-2A derivatives
A process to produce alkyl ethers from UK-2A derivatives is provided. Additionally, alkyl ether derivatives of UK-2A are provided.
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6890928 |
Aromatic sulfone hydroxamic acids and their use as protease inhibitors
This invention is directed to aromatic sulfone hydroxamic acids (including hydroxamates) and salts thereof that, inter alia, inhibit matrix metalloproteinase (also known as “matrix...
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6872837 |
Taxanes having a c10 Heterosubstituted acetate substituent
Taxanes having a heterosubstituted acetate substituent at C(10), a hydroxy substituent at C(7), and a range of C(2), C(9), C(14), and side chain substituents.
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6872747 |
Decalactones, method for making, and pharmaceuticals there from
A novel class of decalactones with the general formula (I) and their stereoisomers is disclosed. A method for the synthesis of the decalactones of general formula (I) and the use of the...
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6861446 |
C7 heterosubstituted acetate taxane compositions
Taxanes having a heterosubstituted acetate substituent at C(7), a hydroxy substituent at C(10), and a range of C(2), C(9), C(14), and side chain substituents.
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6861390 |
Derivatives of UK-2A
Derivatives of UK-2A are provided.
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6784137 |
6-aryl-4-aminopicolinates and their use as herbicides
4-Aminopicolinic acids having aryl or heteroaryl substituents in the 6-position and their amine and acid derivatives are potent herbicides demonstrating a broad spectrum of weed control.
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6780879 |
C7 carbonate substituted taxanes
Taxanes having a carbonate substituent at C(7), a hydroxy substituent at C(10), and a range of C(2), C(9), C(14), and side chain substituents.
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6750245 |
C7 carbamate substituted taxanes
Taxanes having a carbamoyloxy substituent at C(7), a hydroxy substituent at C(10, and a range of C(2), C(9), C(14), and side chain substituents.
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6727239 |
Derivatives of 2-aminopyridines, their use as medicaments and pharmaceutical compositions containing them
A compound of the formula wherein the substituents are defined as in the specification and their pharmaceutically acceptable salts having NOS and ROS activity.
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6716987 |
Derivatives of benzofuran or benzodioxazole compounds
An oxygen-containing heterocyclic compound represented by following Formula (I): wherein R 1 and R 2 independently represent hydrogen, lower alkyl, cyano, —(CH 2 ) n —E 1 —CO—G 1 ...
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6710189 |
Method to produce novel polyketides
A polyketide, or an antibiotic which is obtainable from the polyketide by a method comprising treating the polyketide with a culture medium conditioned by Saccharopolyspora erythraea , selected...
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6689794 |
Aromatic sulfone hydroxamates and their use as protease inhibitors
This invention is directed to aromatic sulfone hydroxamates (also known as “aromatic sulfone hydroxamic acids”) and salts thereof that, inter alia, inhibit matrix metalloproteinase (also known...
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6686503 |
Methods for the synthesis of highly substituted 2,4-dioxopiperidine libraries
The invention relates to methods of synthesizing libraries of diverse and complex highly substituted 2,4-dioxopiperidine compounds of the general formula: wherein R 1 , R 2 and R 3 are as...
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6677330 |
Fluorides of 4-substituted piperidine derivatives
The present invention provides a novel compound having an excellent acetylcholinesterase inhibitory effect. That is, it provides a 4-substituted piperidine compound fluoride represented by the...
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6664275 |
C10 heterosubstituted acetate taxanes
Taxanes having a heterosubstituted acetate substituent at C(10), a hydroxy substituent at C(7), and a range of C(2), C(9), C(14), and side chain substituents.
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6660866 |
C10 carbonate substituted taxanes
Taxanes having a carbonate substituent at C(10), a hydroxy substituent at C(7), and a range of C(2), C(9), C(14), and side chain substituents.
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6649632 |
C10 ester substituted taxanes
Taxanes having an ester substituent at C(10), a hydroxy substituent at C(7), and a range of C(2), C(9), C(14), and side chain substituents.
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6646129 |
Cyanoguanidines as cell proliferation inhibitors
The present invention relates to hitherto unknown compounds of formula (I) or their tautomeric forms, the attachment to the pyridine ring being in the 3- or 4-position, in which formula R stands...
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6638967 |
Thiophene of furan pyrrolidine compounds
Compounds of Formula I Wherein Z2 is an Oxygen or a Sulfur, Z1 is —CH═CH— and Y is a bond, W1 and W2 are hydrogens and X1 and X2 are various heterocyclic rings are disclosed.
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6635662 |
Radicicol derivatives
Radicicol derivatives represented by the following formula (I) having tyrosine kinase inhibition activity or pharmacologically acceptable salts thereof: wherein R 1 and R 2 are the same or...
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6596737 |
C10 carbamoyloxy substituted taxanes
Taxanes having a carbamoyloxy substituent at C(10), a hydroxy substituent at C(7), and a range of C(2), C(9), C(14), and side chain substituents.
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6576643 |
Vitronectin receptor antagonists
Compounds of the formula (I) are disclosed which are vitronectin receptor antagonists and are useful in the treatment of osteoporosis: or a pharmaceutically acceptable salt thereof.
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6566375 |
Elevation of HDL cholesterol by 4-&lsqb (aminothioxomethyl)-hydrazono&rsqb -N-(substituted)-4-arylbutanamides
Compounds of this invention increase plasma levels of high density lipoprotein or HDL, the “good” cholesterol and as such may be useful for treating diseases such as atherosclerosis. These...
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RE38117 |
Trioxane dimer compound having antiproliferative and antitumor activities
Described herein are novel trioxane dimers of structure which possess antiproliferative and antitumor activities.
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6521643 |
Pyridine compounds and their pharmaceutical use
A compound of formula (I) wherein each symbol is as defined in the specification, and pharmaceutically acceptable salts thereof. The compound (I) of the present invention and pharmaceutically...
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