Patents in Class 546/276.700

Matches 1 - 50 out of 329

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Match	Document	Document Title
1	7629356	Substituted pyrrolo[3,4-b]pyridinamines and pharmaceutical compositions This invention relates to substituted pyrrolo[3,4-b]pyridinamines having the structural formula IA below: and to their pharmaceutically acceptable salt, compositions and methods of use. These...
2	7625905	Octahydro-pyrrolo[3,4-c]pyrrole CCR5 receptor antagonists Chemokine receptor antagonists, in particular, 3,7-diazabicyclo[3.3.0]octane compounds according to formula (I) wherein R 1 -R 3 and Ar are as defined herein are antagonists of chemokine CCR5...
3	7615567	Compounds and methods for promoting smoking cessation Compounds and methods for promoting smoking cessation. The compounds may be used to treat a variety of other conditions and disease states.
4	7598236	Diazabicyclic central nervous system active agents Compounds of formula I pharmaceutical compositions of these compounds, and use of said compositions to control synaptic transmission in mammals.
5	7579362	Aza-bicycloalkyl ethers and their use as alpha7-nAChR agonists The present invention relates to 1-aza-bicycloalkyl derivatives of formula I, wherein X is CH 2 or a single bond; Y is a group of formula and wherein R has the meanings as defined in the...
6	7547722	Chemical compounds The invention relates to a group of novel thieno-pyrrole compounds of Formula (I): wherein: R 1 , R 2 , R 3 , R 4 and R 5 are as defined in the specification, which are useful as...
7	7538226	(1S,5S)-3-(5,6-dichloro-3-pyridinyl)-3,6-diazabicyclo[3.2.0]heptane The present invention discloses (1S,5S)-3-(5,6-dichloro-3-pyridinyl)-3,6-diazabicyclo[3.2.0] heptane, salts thereof, and its use to treat pain and other disorders associated with the nicotinic...
8	7511056	TGF-β inhibitors The present invention is directed to inhibitors of TGF-β of Formula I:
9	7501076	Fluorescent diketopyrrolopyrroles The present invention relates to fluorescent diketopyrrolopyrrole of the formula (I), a process for their preparation and their use for the preparation of inks, colorants, pigmented plastics for...
10	7498444	(1S,5S)-3-(5,6-dichloropyridin-3-yl)-3,6-diazabicyclo[3.2.0]heptane benzenesulfonate The present invention relates to the salt (1S,5S)-3-(5,6-dichloropyridin-3-yl)-3,6-diazabicyclo[3.2.0] heptane benzenesulfonate and to methods of preparing the salt.
11	7456289	Anti-tumor compounds Compounds of the following formula: wherein A, D, Q, T, U, V, W, X, Y, Z, R 1 , and are as defined herein. This invention also relates to a method of inhibiting tubulin polymerization, or...
12	7449447	Peptidomimetic NS3-serine protease inhibitors of hepatitis C virus The present application discloses a compound, or enantiomers, stereoisomers, rotamers, tautomers, racemates or prodrug of said compound, or pharmaceutically acceptable salts or solvates of said...
13	7446122	Substituted indole derivatives Provided herein are indole derivatives, pharmaceutical compositions containing them, methods for their use, and methods for preparing these compounds.
14	7399765	Substituted diazabicycloalkane derivatives Compounds of formula (I) Z-Ar 1 —Ar 2 (I) wherein Z is a diazabicyclic...
15	7393867	Substituted thienopyrrole carboxylic acid amides, pyrrolothiazole carboxylic acid amides, and related analogs as inhibitors of casein kinase I The present invention discloses and claims compounds of formula (I) and formula (II), as inhibitors of human casein kinase Iε and methods for using said compounds for treating central nervous...
16	7390798	Carboxamide spirolactam CGRP receptor antagonists The present invention is directed to compounds of Formula I: I (where variables A 1 , A 2 , B, J, K, m, n, R 4 , R 5a , R 5b and R 5c are as defined herein) useful as antagonists of CGRP...
17	7384946	M₃muscarinic acetylcholine receptor antagonists Novel dimeric benzoazabicyclohepatane compounds, pharmaceutical compositions, processes for their preparation and use thereof in treating M 3 muscarinic acetylcholine receptor mediated diseases...
18	7351733	Tetrahydrocarbazole derivatives and their pharmaceutical use The present invention relates to novel compounds that are useful in the treatment of human papillomaviruses, and also to the methods for the making and use of such compounds.
19	7326793	Process for the preparation of diketopyrrolopyrroles The present invention relates to a process for the preparation of diketopyrrolopyrroles of the formula (I), wherein A1, A2, A3 and A4 are as defined in the description of the present invention, to...
20	7319106	Diazabicyclic central nervous system active agents Compounds of formula I pharmaceutical compositions of these compounds, and use of said compositions to control synaptic transmission in mammals.
21	7268158	6H-THIENO [2,3-b]pyrrole derivatives as antagonists of gonadotropin releasing hormone (GnRH) The invention relates to a group of novel thieno-pyrrole compounds of Formula (I): wherein: R 1 , R 2 , R 3 , R 4 and R 5 are as defined in the specification, which are useful as...
22	7265115	Diazabicyclic CNS active agents Compounds of formula I: or pharmaceutically acceptable salts thereof, are useful for controlling synaptic transmission in mammals.
23	7253168	Substituted 1-benzyl-4-substituted piperazine analogues Compounds of Formula I are provided, in which variables are as described herein: Such compounds may be used to modulate MCH binding to MCH receptors in vivo or in vitro, and are particularly...
24	7235567	Crystalline polymorph of a bisulfate salt of a thrombin receptor antagonist A crystalline polymorph of a bisulfate salt of a thrombin receptor antagonist compound, which exhibits a powder x-ray diffraction profile substantially the same as that shown in FIG. 1 , or which...
25	7173047	Benzo (f) insoindol derivatives and their use as ep4 receptor ligands Compounds of formula (I) and pharmaceutically acceptable derivatives thereof bind with high affinity to the EP4 receptor and are of use in the treatment or prevention of conditions such as a...
26	7153848	Inhibitors of HCV replication Indole compounds of Formula I are described. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV. Different forms and compositions...
27	7135484	Azabicyclic compounds are central nervous system active agents Compounds of formula (I) are novel CNS active agents that are useful for treating pain and for treating other disorders associated with the cholinergic system.
28	7132442	6H-thieno[2, 3-b]pyrrole derivatives as antagonists of gonadotropin releasing hormone (GnRH) The invention relates to a group of novel thieno-pyrrole compounds of Formula (I): wherein: R 1 , R 2 , R 3 , R 4 and R 5 are as defined in the specification, which are useful as gonadotrophin...
29	7122570	Tetrahydrocarbazol derivatives as ligands for G-protein-coupled receptors (GPCR) This invention provides new tetrahydrocarbazole derivatives that act as ligands for G-protein-coupled receptors (GPCR), especially as antagonists of the gonadotropin-releasing hormone (GnRH). A...
30	7094800	Cyanopyrrolidides, process for their preparation and their use as medicaments The invention relates to compounds of the formula I in which the radicals have the meanings stated in the text, their stereoisomeric forms, and their physiologically tolerated salts,...
31	7081458	Melanin concentrating hormone receptor ligands: substituted 1-benzyl-4-aryl piperazine analogues Melanin concentrating hormone receptor ligands (especially 1-benzyl-4-aryl-piperazines, 1-benzyl-4-aryl-piperidines and related compounds), capable of modulating MCH receptor activity, are...
32	7071207	Preparation and use of 1,5,6,7-tetrahydropyrrolo[3,2-c]pyridine derivatives for treatment of obesity This invention relates to 1,5,6,7-tetrahydropyrrolo[3,2-c]pyridine derivatives which have been found to suppress appetite and induce weight loss. The invention also provides methods for synthesis...
33	7053108	Indoline compounds A compound of formula (I): wherein: R 1 and R 2 together form a benzo ring optionally substituted by halogen or by alkyl, alkoxy, cyano, nitro, hydroxy, amino, alkylamino, dialkylamino or...
34	7041235	Fluorescent diketopyrrolopyrrole analogues The present invention relates to fluorescent diketopyrrolopyrrole analogues of the general formula (I), wherein A 1 and A 2 are C 1 –C 18 alkyl, C 2 –C 18 alkenyl, C 2 –C 18 alkynyl, C 5...
35	7041684	Selective β3 adrenergic agonists The present invention is in the field of medicine, particularly in the treatment of Type II diabetes and obesity. More specifically, the present invention relates to selective β 3 receptor...
36	7022706	Pharmaceutical compositions and methods for use Pharmaceutical compositions incorporate compounds that are capable of affecting nicotinic cholinergic receptors. A wide variety of conditions and disorders, and particularly conditions and...
37	6949539	Admantane derivatives The invention provides compounds of general formula (I) in which m, A, R 1 and Ar have the meanings defined in the specification; a process for their preparation; pharmaceutical compositions...
38	6939867	β3 agonists and uses thereof Sulfamide compounds having formula (I) are described as well as their use in the treatment of diseases dependent on the signaling pathways associated with β-adrenergic receptors, such as obesity,...
39	6924297	Naphathalene derivatives which bind to the EP4 receptor Compounds of formula (I) and pharmaceutically acceptable derivatives thereof bind with high affinity to the EP4 receptor and are of use in the treatment or prevention of conditions such as a...
40	6852716	Substituted-aryl compounds for treatment of disease The invention provides compounds of Formula I: These compounds may be in the form of pharmaceutical salts or compositions, racemic mixtures, or pure enantiomers thereof. The compounds of...
41	6821964	Modulators of chemokine receptor activity Chemokine receptor antagonists, in particular, bicyclic diamine compounds of Formula (I) that act as antagonists of chemokine CCR2 and CCR3 receptors including pharmaceutical compositions and uses...
42	6759421	Indoline compounds, a process for their preparation and pharmaceutical compositions containing them A compound of formula (I): wherein: R 1 and R 2 together form a benzo ring optionally substituted by halogen or by alkyl, alkoxy, cyano, nitro, hydroxy, amino, alkylamino, dialkylamino or...
43	6723138	Preparation of diketopyrrolopyrrole pigments A process for preparing diketopyrrolopyrrole pigments comprises conducting the elementary steps of pigment synthesis (reaction and hydrolysis) in a miniaturized continuous reactor.
44	6716856	4,5,6,7-tetrahydroindazole derivatives as antitumor agents Compounds which are 4,5,6,7-tetrahydroindazole derivative formula (1), wherein the dotted line (x) represents a single or double bond; n is 0 or 1; R 1 , R 2 and R 3 have the meanings reported in...
45	6649613	Diacylhydrazine derivatives Diacylhydrazine derivatives of general formula (I) wherein X, Y, Z, R 1 , 2 and R 3 are as defined herein, and their physiologically acceptable salts or solvates thereof, are integrin...
46	6586452	C1 to C4 side chain modified nodulisporic acid analogs The present invention relates to novel nodulosporic acid derivatives, which are acaricidal, antiparasitic, insecticidal and anthelmintic agents.
47	6579878	Pharmaceutical compositions and methods for use Pharmaceutical compositions incorporate compounds that are capable of affecting nicotinic cholinergic receptors. A wide variety of conditions and disorders, and particularly conditions and...
48	6570019	Cationic pyrrolo-pyrrol-derivatives, method for producing them and colorants for keratin fibers, containing these compounds The object of the present invention are diketopyrrolopyrroles of the general formula (I) wherein, independently of one another, Q 1 and Q 2 represent an optionally substituted, aromatic,...
49	6562816	Substituted-heteroaryl-7-aza&lsqb 2.2.1&rsqb bicycloheptanes for the treatment of disease The invention provides compounds of Formula I: compounds of the Formula I: wherein R 1 , R 2 , R 4 , R 6 , X, and W are defined herein. These compounds may be in the form of pharmaceutical salts...
50	6538010	Compounds and methods for promoting smoking cessation Compounds and methods for promoting smoking cessation. The compounds may be used to treat a variety of other conditions and disease states.

Matches 1 - 50 out of 329

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