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7388018 |
4-Piridinylmethylsulphonamide derivatives as fungicidal plant protein agents
Sulfonamides of the formula I
where the substituents are as follows:
R 1 is hydrogen, alkyl, alkoxy, alkenyl or alkynyl; and R 2 , R 3 , R 4 , R 5 are hydrogen, halogen, alkyl, alkoxy or...
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7375232 |
Ortho-heterocyclic substituted aryl amides for controlling invertebrate pests
Compounds of Formula I, their N-oxides and salts are disclosed
wherein A is O or S; G is a 5- or 6-membered heteroaromatic ring or a 5- or 6-membered nonaromatic heterocyclic ring optionally...
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7354938 |
Pyrazole compounds and uses related thereto
Substituted pyrazoles are provided that are useful for the treatment of, for example, diabetes, obesity and metabolic syndrome.
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7329670 |
Inhibition of RAF kinase using aryl and heteroaryl substituted heterocyclic ureas
The compounds are aryl and heteroaryl substituted heterocyclic ureas of the formula A—NH—C(O)—NH—B where A is the aryl or hetaryl substituted heterocyclic group and B is an aryl or...
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7309710 |
Crystals
Obtaining the crystal of 4,6-dimethyl-4′-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]
nicotinanilide having excellent activity of inhibiting Ca 2+ release-activated Ca 2+ channel and suppressing...
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7297797 |
Pyrrolines
The invention relates to novel Δ 1 -pyrrolines of the formula (I)
in which R 1 , R 2 , R 3 , R 4 , A 1 , A 2 , R 5 , R 6 , R 7 , R 8 , R 9 and Q are as defined in the disclosure, to a process...
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7288554 |
Ortho-substituted aryl amides for controlling invertebrate pests
Disclosed are compounds of Formula I, their N-oxides and agriculturally suitable salts (I) wherein J is a phenyl ring, a 5- or 6-membered heteroaromatic ring or an aromatic 8-, 9- or 10-membered...
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7288541 |
Propylcarbamate derivatives as inhibitors of serine and cysteine proteases
The present invention includes ketone derivatives (I) and (II), which are useful as cathepsin K inhibitors. The described invention also includes methods of making such ketone derivatives as well...
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7285554 |
Pyrazole derivative
Drugs, in particular, pyrazole derivatives represented by the following general formula (I) which have a calcium release-activated calcium channel inhibitory effect and medicinal compositions, in...
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7279476 |
Pyrazole-derived kinase inhibitors and uses thereof
Described herein are compounds that are useful as protein kinase inhibitors having the formula:
where B, R 1 , n, R 3 , Q, and R 4 are described in the specification. The compounds are useful...
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7279470 |
Compounds and uses thereof for decreasing activity of hormone-sensitive lipase
Use of compounds to inhibit hormone-sensitive lipase, pharmaceutical compositions comprising the compounds, methods of treatment employing these compounds and compositions, and novel compounds. The...
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7253187 |
Heterocyclic inhibitors of ERK2 and uses thereof
Described herein are compounds that are useful as protein kinase inhibitors having the formula:
wherein Z 1 and Z 2 are each independently nitrogen or CH and Ring A, T m R 1 , QR 2 , U n R 3...
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7253170 |
Pyrazole-amine compounds useful as kinase inhibitors
The present invention provides pyrazole derived compounds of formula (I)
useful for treating p38 kinase-associated conditions, where W, X, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 and m are as...
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7241758 |
Compounds useful as anti-inflammatory agents
Disclosed are novel aromatic compounds of the formula (I) wherein G, X, Ar, L and Q are defined herein. The compounds are useful in pharmaceutic compositions for treating diseases or pathological...
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7232836 |
Arthropodicidal anthranilamides
This invention provides compounds of Formula 1, their N-oxides and agriculturally suitable salts
wherein
R 1 , R 2 , R 3 , R 4a , R 4b and R 5 are as defined in the disclosure.
...
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7227025 |
Substituted dihydro 3-halo-1H-pyrazole-T-carboxylates, their preparation and use
This invention relates to a compound of Formula I, a method for its preparation and its use in the preparation of a compound of Formula II
wherein R 1 , R 2 , R 3 , X and n are as defined in...
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RE39681 |
1-(4-sulfamyaryl)-3-substituted-5-aryl-2-pyrazolines and inhibitors of cyclooxygenase-2
Compounds of the formula
wherein:
X is selected from the group consisting of trihalomethyl, C 1 -C 6 alkyl, and a group of formula II:
wherein:
R 3 and R 4 are...
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7223777 |
Compounds for the management of aging-related and diabetic vascular complications, process for their preparation, therapeutic and cosmetic uses thereof
The invention discloses a new clause of a five membered heterocylic ring compounds of general formula I
and its pharmaceutically or cosmetically acceptable salts, wherein R1, R2, R3, R4, R5, A,...
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7214678 |
Arylsulfanyl and heteroarylsulfanyl derivatives for treating pain
According to the invention there is provided a compound the formula I;
wherein A, X, B, R 1 , R 2 , R 3 and R 4 are as defined in the specification.
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7199138 |
Substituted anthranilamides for controlling invertebrate pests
This invention provides compounds of Formula I, N-oxides and salts thereof
wherein A, B, R 1 through R 5 , R 7 through R 9 , X and Y are as defined in the disclosure.
Also disclosed are...
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7186741 |
Neurotensin active 2,3,diaryl-pyrazolidine derivatives
The invention relates to a group of novel 2,3 diaryl-pyparazolidine derivatives having formula (1). The symbols used in formula (1) have the meanings given in the specification. The compounds have...
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7179824 |
Arthropodicidal anthranilamides
This invention pertains to a compound of Formula I, its N-oxide or an agriculturally suitable salt of the compound (Formula I) wherein R 1 , R 2 , R 3 , R 4 , and R 5 are as defined in the...
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7176311 |
Process for preparing pharmaceutically active compounds
A process for the preparation of Compounds of the formula (1):
wherein R 1 , R 2 , R 4 and R 13 are as defined or a pharmaceutically or veterinarily acceptable salt or polymorph thereof, or a...
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7176198 |
1H-pyrazole and 1H-pyrrole-azabicyclic compounds for the treatment of disease
The invention provides compounds of Formula I:
wherein Azabicyclo is
where the variables have the definitions discussed herein. These compounds may be in the form of pharmaceutical salts or...
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7169798 |
Inhibitors of c-Jun N terminal kinases (JNK) and other protein kinases
The present invention provides compounds of formula I:
where R 1 is H, CONH 2 , T( n )-R, or T( n )-Ar 2 , n may be zero or one, and G, XYZ, and Q are as described below. These compounds are...
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7157475 |
Diamide invertebrate pest control agents
Compounds of Formula (I), and their N-oxides and suitable slats, are disclosed which are useful as invertebrate pest control agents, wherein A and B are independently O or S; E is C or N; J is a...
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7153959 |
Substituted pyrazoles as p38 kinase inhibitors
A class of pyrazole derivatives is described for use in treating p38 kinase mediated disorders. Compounds of particular interest are defined by Formula IA
wherein R 1 , R 2 , R 3 and R 4 ...
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7138361 |
Herbicidal heterocycles
Compounds of Formula (1), their N-oxides and agriculturally suitable salts, are disclosed which are useful for controlling undesired vegetation
wherein
A, R 1 , R 2a , R 2b , W, Y, and Z...
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7135573 |
Processes for the preparation of O-(6-Pyrazol-1-yl-pyridin-3-ylmethyl)-hydroxylamine
The present invention relates to processes and intermediates for the preparation of 6–11 bicyclic erythromycin derivatives. In particular, the present invention relates to processes and...
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7112596 |
Prenylation inhibitors and methods of their synthesis and use
The present invention is directed to compounds useful in the treatment of diseases associated with prenylation of proteins and pharmaceutically acceptable salts thereof, to pharmaceutical...
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7109336 |
Azo compound and process of producing the same, and novel compound and process of producing azo compounds using the same
A compound represented by the following formula (I) or formula (2-I)
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7105556 |
Conformationally constrained analogs useful as antidiabetic and antiobesity agents and method
Compounds are provided which have the structure
wherein Q is C or N, X 1 is C or N, and R 1 , R 2 , R 2a , R 2b , R 2c , R 3 , Y, A, m, n, X 2 , X 3 and X 4 are as defined herein, which...
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7105549 |
Aryl substituted pyridines and the use thereof
This invention relates aryl substituted pyridines of Formula I:
or a pharmaceutically acceptable salt, prodrug or solvate thereof, wherein Ar and R 1 –R 4 are set in the specification. The...
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7105471 |
Arylphenyl-substituted cyclic ketoenols
The present invention relates to novel arylphenyl-substituted cyclic ketoenols of the formula (I)
in which
X represents halogen, alkyl, alkoxy, alkenyloxy, alkylthio, alkylsulphinyl,...
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7091352 |
Compounds substituted with bicyclic amino groups
Compounds of the formula (I) below, or pharmacologically acceptable salts, esters or other derivatives thereof:
wherein A is furan, thiophene, pyrazole, imidazole, isoxazole or isothiazole; R 1...
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7087624 |
Substituted pyrazole compounds
Substituted pyrazole compounds represented by formula (I), or salts thereof are disclosed, wherein R 1 is —CH(OH)—CH(R 4 )-(A) n -Y, —CH 2 —CH(R 4 )-(A) n -Y, —CO-B 1 -A-Y or the like...
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7087603 |
Pyrazole compounds useful as protein kinase inhibitors
This invention describes novel pyrazole compounds of formula IV:
wherein Z 1 or Z 2 is nitrogen, Q is —S—, —O—, —N(R 4 )—, —C(R 6′ ) 2 —, 1,2-cyclopropanediyl,...
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7087598 |
Diamide invertebrate pest control agents containing a non-aromatic heterocyclic ring
This invention provides compounds of Formula I, their N-oxides and agriculturally suitable salts wherein A and B are independently O or S; J is an optionally substituted 5- or 6-memebered...
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7071198 |
Substituted pyrazoles as p38 kinase inhibitors
A class of pyrazole derivatives is described for use in treating p38 kinase mediated disorders. Compounds of particular interest are defined by Formula IA
wherein R 1 , R 2 , R 3 and R 4 are...
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7056934 |
Nicotinamide derivatives useful as PDE4 inhibitors
This invention relates to nicotinamide derivatives of general formula (I):
in which R 1 , R 2 and R 3 have the meanings defined herein, and to processes for the preparation of, intermediates...
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7056933 |
Heterocyclo-alkylsulfonyl pyrazoles
The present invention relates to heterocyclo alkylsulfonyl pyrazoles of the formula I:
wherein the ring of the formula (R 5 )—A—(SO m R 4 ), m, X, R 1 through R 5 are as defined in the...
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7056932 |
Heterocyclyl substituted 1-alkoxy acetic acid amides
The invention is concerned with novel heterocyclyl substituted 1-alkoxy acetic acid derivatives of formula (I)
wherein R 1 to R 6 and A are as defined in the description and in the claims, as...
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7041669 |
1,4-benzofused urea compounds useful in treating cytokine mediated diseases
Disclosed are 1,4-disubstituted benzo-fused urea compounds of formula (I):
wherein Ar, X, A, L, and Q of formula(I) are defined herein. The compounds inhibit production of cytokines involved in...
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7034049 |
3(5)-amino-pyrazole derivatives, process for their preparation and their use as antitumor agents
Compounds which are 3-amino-pyrazole derivatives represented by formula (I) wherein R is C 3 –C 6 cycloalkyl group optionally substituted by a straight or branched C 1 –C 6 alkyl or arylalkyl...
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7022650 |
4-trifluoromethylpyrazolyl-substituted pyridines and pyrimidines
A description is given of 4-trifluoromethylpyrazolyl-substituted pyridines and pyrimidines of formula (I) and of their use as herbicides.
In this formula (I) R 1 , R 2 , R 3 and R 4 are...
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7019005 |
3 (5)-heteroaryl substituted pyrazoles as p38 kinase inhibitors
A class of pyrazole derivatives is described for use in treating p38 kinase mediated disorders. Compounds of particular interest are defined by Formula I
wherein R 1 , R 2 , Ar 1 and HetAr 2 ...
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6992092 |
Anti-diabetic agents
The present invention provides compounds of formula (I)
the stereoisomers and prodrugs thereof, and the pharmaceutically acceptable salts of the compounds, stereoisomers, and prodrugs; wherein...
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6979693 |
Pyrazole derivatives-p38 MAP kinase inhibitors
The present invention relates to certain pyrazole derivatives of Formula (I):
that are p-38 MAP kinase inhibitors, pharmaceutical compositions containing them, methods for their use, and...
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6953798 |
β-alanine derivates
Alkanoic acid derivatives of formula (1) are described:
Ar 1 (Alk a ) r L 1 Ar 2 CH(R 1 )C(R a )(R a′ )R (1)
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6951876 |
Sulfamoylheteroaryl pyrazole compounds as anti-inflammatory/analgesic agents
This invention relates to a compound of the formula:
or a pharmaceutically acceptable salt thereof, wherein A and R 1 are each an optionally substituted 5 to 6-membered heteroaryl, wherein...
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