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7629361 |
Salt of (S)-pantoprazole and its hydrates
The invention relates to (−)-pantoprazole magnesium and its hydrates and to medicaments comprising these compounds.
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7622588 |
Method for the purification of lansoprazole
The present invention provides a method for preparing a substantially pure lansoprazole containing less than about 0.2% (wt/wt) impurities including sulfone/sulfide derivatives. The present...
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7612098 |
Amorphous hydrous esomeprazole magnesium
A hydrate of esomeprazole magnesium in the form of an amorphous solid is provided. Methods of preparation and use of, as well as formulation containing the hydrate of esomeprazole magnesium in the...
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7605268 |
Process for the preparation of pyridine compounds
A process for preparation of a compound of formula (I), both as the isomeric mixture and individual isomers,
wherein Q is ═CR 8 — or ═N—; each R 1 , R 2 , R 3 , R 4 is...
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7598273 |
Inhibitors of the gastric H+, K+-ATPase with enhanced therapeutic properties
Chemical syntheses and medical uses of novel inhibitors of the gastric H + , K + -ATPase for the treatment and/or management of duodenal ulcers, heartburn, acid reflux, other conditions mediated by...
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7579476 |
Transition metal mediated oxidation of hetero atoms in organic molecules coordinated to transition metals
The present invention is directed to a process for the catalytic oxidation of the thioether 5-methoxy-2-((4-methoxy-3,5-dimethyl-2-pyridinyl)methyl)meth
ylthio)-1H-benzimidazole to its sulfoxide:...
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7576219 |
Crystalline S-omeprazole strontium hydrate, method for preparing same, and pharmaceutical composition containing same
This invention provides a crystalline S-omeprazole strontium hydrate for the prevention or treatment of gastric acid-related diseases, which has high optical purity, theremostability, solubility...
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7563812 |
Amorphous esomeprazole hydrate
The present invention relates to a novel amorphous form of esomeprazole hydrate, to a process for its preparation and to a pharmaceutical composition containing it. Thus, tetrahydrofuran and water...
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7560472 |
Salts of omeprazole and esomeprazole II
The present invention relates to new salts of the single enantiomers of omeprazole, i.e. salts of (S)-5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)-methy
l]sulfinyl]-1H-benzimidazole...
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7557218 |
Hydrates of optionally substituted 2-(2-pyridinyl) methylthio-1H-benzimidazoles and process for the production thereof
The invention relates to crystals from optionally substituted 2-(2-pyridinyl)methylthio-1H-benzimidazole hydrates and to a method for the production thereof.
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7557217 |
Process for production of benzimidazole derivative salt precipitate
The present invention provides a process for the production of a 2-[{4-(3-methoxypropoxy)-3-methylpyridin-2-yl}methylsulfinyl
]-1 H-benzimidazole alkali metal salt (1), which is a drug or an...
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7553856 |
Crystalline form of omeprazole
A novel crystalline form of the substrate known under the chemical name 5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sul
finy]-1H-benzimidazole, and having the generic name omeprazole,...
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7553857 |
S-omeprazole magnesium
The present invention discloses a process for preparing a magnesium salt of S-omeprazole. The S-omeprazole salt preferably has a water content below about 4.8% by weight, a magnesium content of...
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7531666 |
Method for preparing 2-(2-pyridinylmethylsulfinyl) benzimidazoles
The present invention provides a method for preparing an antiulcer agent, 2-(2-pyridinylmethylsulfinyl)benzimidazoles, such as Omeprazole, Lansoprazole, Pantoprazole and Rabeprazole, which includes...
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7514560 |
Crystalline form of omeprazole
The present invention relates to a novel crystalline form of 5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sul
finyl]-1H-benzimidazole, known under the generic name omeprazole. Further,...
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7507829 |
Solid states of pantoprazole sodium, processes for preparing them and processes for preparing known pantoprazole sodium hydrates
Crystalline pantoprazole sodium Forms II, IV, V, VI, VIII, IX, X, XI, XII, XIII, XIV, XV, XVI, XVII, XVIII, XIX and XX; pantoprazole sodium solvates containing water, acetone, butanol,...
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7482344 |
Tricyclic steroid hormone nuclear receptor modulators
The present invention provides a compound of Formula (I) or a pharmaceutically acceptable salt thereof; pharmaceutical compositions comprising an effective amount of a compound of Formula I in...
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7482463 |
Amorphous form of esomeprazole salts
The invention relates to an amorphous form of the salts of the (-) enantiomer or (S)-enantiomer of omeprazole, i.e., esomeprazole. The invention also relates to processes for preparing amorphous...
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7470712 |
Amino-benzazoles as P2Y1 receptor inhibitors
The present invention provides novel amino-benzazoles and analogues thereof, which are selective inhibitors of the human P2Y 1 receptor. The invention also provides for various pharmaceutical...
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7452998 |
Process for preparing optically pure active compounds
The invention relates to a novel process for preparing an optically pure PPI having a sulfinyl structure using a chiral zirconium complex or a chiral hafnium complex.
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7439367 |
Pharmaceutical process and compounds prepared thereby
The present invention relates to an improved process for the preparation of a sulfinyl compound of formula (I), or a pharmaceutically acceptable salt, hydrate or solvate thereof, from a sulfide...
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7435826 |
Substituted sulfoxides
The present invention relates to a process for preparing substituted sulfoxides either as a single enantiomer or in an enantiomerically enriched form. Thus, racemic omeprazole is reacted with...
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7425634 |
Benzimidazole compound
An object of the present invention is to provide a novel chemical compound useful as a therapeutic or prophylactic agent for acid-related diseases, having an excellent inhibitory effect against...
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7414066 |
Amide compounds and medications containing the same technical field
The present invention provides to a novel compound having an ACAT inhibiting activity. The present invention relates to compounds represented by formula (I)
wherein
represents an...
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7411070 |
Form of S-omeprazole
The present invention relates to a novel form of the (−)-enantiomer of 5-methoxy-2[[(4-methoxy-3,5-dimethyl-2-pyridinyl)-methyl]sul
finyl]-1H-benzimidazole, i.e. S-omeprazole. More specifically,...
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7410981 |
Prodrugs of imidazole derivatives, for use as proton pump inhibitors in the treatment of e.g. peptic ulcers
An imidazole compound represented by the formula (I), a salt thereof and a compound of the formula (V), which is one of the intermediates thereof. wherein each symbol is as defined in the present...
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7399772 |
Substituted benzimidazole dosage forms and method of using same
The present invention relates to pharmaceutical preparations comprising substituted benzimidazole proton pump inhibitors. There is provided a liquid or solid pharmaceutical composition consisting...
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7396841 |
Injections
An injectable composition comprises a benzimidazole compound having an antiulcer action and a strong alkali (e.g., an alkali metal hydroxide such as sodium hydroxide) in a proportion of about 1...
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7365206 |
Stereoselective synthesis of benzimidazole sulfoxides
The present invention relates to a process for stereoselective synthesis of substituted sulfoxides either as a single enantiomer or in an enantiomerically enriched form. Thus,...
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7345061 |
Alkylammonium salts of omeprazole and esomeprazole
The present invention relates to new salts of omeprazole and esomeprazole respectively, i.e. salts of 5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)-methyl]su
lfinyl]-1H-benzirnidazole and the...
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7339064 |
Benzimidazole compound crystal
A novel crystal of (R)-2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]meth
yl]sulfinyl]-1H-benzimidazole or a salt thereof of the present invention is useful for an excellent antiulcer agent.
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7332505 |
Nitrosated and nitrosylated proton pump inhibitors, compositions and methods of use
The present invention describes novel nitrosated and/or nitrosylated proton pump inhibitor compounds, and novel compositions comprising at least one proton pump inhibitor compound that is...
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7326724 |
Salts of omeprazole and esomeprazole I
The present invention relates to new salts of omeprazole and esomeprazole respectively, i.e. salts of 5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)-methyl]su
lfinyl]-1H-benzimidazole and the...
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7301030 |
Process for preparing (S)-pantoprazole
The invention relates to a novel process for preparing (S)-pantoprazole using a chiral zirconium complex or a chiral hafnium complex.
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7294716 |
Process for preparing isomerically pure prodrugs of proton pump inhibitors
Synthetic methods for preparing isomerically pure N-arylsulfonyl derivatives of proton pump inhibitors which include a substituted benzimidazole nucleus are shown by the synthetic schemes and...
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7285668 |
Process for the crystallization of (R)- or (S)-lansoprazole
The present invention relates to a production method of a crystal of (R)-lansoprazole or (S)-lansoprazole, which includes crystallization at a temperature of about 0° C. to about 35° C. from a C...
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7271182 |
Salts of benzimidazole compound and use thereof
A sodium salt, magnesium salt, lithium salt, potassium salt, calcium salt or barium salt of (R)-2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]meth
yl]sulfinyl]-1H-benzimidazole, and a...
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7227024 |
Method for the synthesis of a benzimidazole compound
A process for the manufacture of omeprazole or esomeprazole from pyrmethyl alcohol via pyrmethyl chloride and pyrmetazole characterized in that the whole reaction sequence is carried out without...
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7211590 |
Nitrosated proton pump inhibitors, compositions and methods of use
The invention describes novel nitrosated proton pump inhibitor compounds and pharmaceutically acceptable salts thereof, and novel compositions comprising at least one nitrosated proton pump...
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7189744 |
Crystals of benzimidazole compounds
Crystals of (S)-2[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methy
l]sulfinyl]-1H-benzimidazole or salts thereof, useful as excellent antiulcer drugs.
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7176319 |
Process for substituted sulfoxides
The present invention relates to a process for preparing substituted sulfoxides either as a single enantiomer or in an enantiomerically enriched form. Thus, racemic omeprazole is reacted with...
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7169793 |
Process for preparation of optically pure or optically enriched sulfoxide compounds, including amorphous esomeprazole and salts thereof
A process of preparation of optically pure or optically enriched isomers of omeprazole and structurally related sulfoxides is provided. Also provided are an amorphous form of esomeprazole, as well...
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7169799 |
Process for producing crystal
The present invention relates to a production method of a crystal of (R)-2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methyl
]sulfinyl]benzimidazole·n′H 2 O (wherein n′ is about 0 to...
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7129358 |
Processes for the production of substituted 2-(2-pyridylmethyl) sulfinyl-1H-benzimidazoles
Improved processes for preparing substituted 2-(2-pyridylmethyl)sulfinyl-1H-benzimidazoles are disclosed.
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7115644 |
Heterocyclic compounds
Disclosed are benzimidazolone compounds of formulas (I) & (II): wherein R 1 , R 2 , R 3 , R 4 , R 5 , X, L, m, n and t are defined herein. The compounds inhibit production of cytokines...
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7105682 |
Substituted amine derivatives and methods of use
Selected amines are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically...
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7105681 |
Process for the preparation of sulphinyl derivatives by oxidation of the corresponding sulfides
Process for preparing sulfinyl derivatives of Formula 2, useful as inhibitors of gastric acid secretion, comprising the selective oxidation of the corresponding sulfides of formula 1, as...
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7102009 |
Substituted amine derivatives and methods of use
Selected amines are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically...
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7081534 |
Process for the preparation of pantoprazole and salts thereof
A process for the preparation of pantoprazole and the salts thereof, comprising the reaction of a mercaptoimidazole with a picoline, to give a 2-pyridinyl-methylsulfinyl-2-benzimidazole...
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7060837 |
Method for the purification of lansoprazole
The present invention provides a method for preparing a substantially pure lansoprazole containing less than about 0.2% (wt/wt) impurities including sulfone/sulfide derivatives. The present...
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