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7388018 |
4-Piridinylmethylsulphonamide derivatives as fungicidal plant protein agents
Sulfonamides of the formula I
where the substituents are as follows:
R 1 is hydrogen, alkyl, alkoxy, alkenyl or alkynyl; and R 2 , R 3 , R 4 , R 5 are hydrogen, halogen, alkyl, alkoxy or...
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7375122 |
Compounds useful as pesticides
Compounds useful to control pests are provided.
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7304066 |
Pyridyl cyanoguanidine compounds
Compounds according to formula (I)
wherein R1 represents hydrogen, halogen or one or more straight or branched, saturated or unsaturated C 1-6 hydrocarbon radical, optionally substituted with...
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7297797 |
Pyrrolines
The invention relates to novel Δ 1 -pyrrolines of the formula (I)
in which R 1 , R 2 , R 3 , R 4 , A 1 , A 2 , R 5 , R 6 , R 7 , R 8 , R 9 and Q are as defined in the disclosure, to a process...
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7297708 |
Heteroaromatic substituted cyclopropane as corticotropin releasing hormone ligands
Provided herein are novel heteroaromatic substituted cyclopropanes of the Formula (I):
as well as compositions, including pharmaceutical compositions, containing the same, and the use thereof...
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7291642 |
Bradykinin-B1 antagonists, process for their preparation and their use as medicaments
The present invention provides bradykinin-B1 antagonists of the formula
in which A, Ar, G, Q, R 1 and R 4 are as defined in claim 1, their enantiomers, their diastereomers, their mixtures and...
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7288541 |
Propylcarbamate derivatives as inhibitors of serine and cysteine proteases
The present invention includes ketone derivatives (I) and (II), which are useful as cathepsin K inhibitors. The described invention also includes methods of making such ketone derivatives as well...
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7279470 |
Compounds and uses thereof for decreasing activity of hormone-sensitive lipase
Use of compounds to inhibit hormone-sensitive lipase, pharmaceutical compositions comprising the compounds, methods of treatment employing these compounds and compositions, and novel compounds. The...
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7253191 |
2-thio-substituted imidazole derivatives and the use thereof in the pharmaceutical industry
The invention relates to 2-thio-substituted imidazole derivatives of the formula I
in which the radicals R 1 , R 2 , R 3 and R 4 are as defined in the description. The compounds according to...
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7241758 |
Compounds useful as anti-inflammatory agents
Disclosed are novel aromatic compounds of the formula (I) wherein G, X, Ar, L and Q are defined herein. The compounds are useful in pharmaceutic compositions for treating diseases or pathological...
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7214693 |
Heterocyclic selective androgen receptor modulators and methods of use thereof
This invention provides a class of androgen receptor targeting agents (ARTA). The agents define a new subclass of compounds, which are selective androgen receptor modulators (SARM). Several of the...
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7160912 |
Heterocyclic compounds having antibacterial activity: process for their preparation and pharmaceutical compositions containing them
The present invention relates to novel oxazolidinone compounds of formula (I), their stereoisomers, their salts and pharmaceutical compositions containing them.
The present invention also...
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7153874 |
Imidazole derivatives
The present invention provides 4-[1-Aryl-imidazol-4-ylethynyl]-2-alkyl-pyridine and 1-heteroaryl-imidazol-4-ylethynyl]-2-alkyl-pyridine derivatives and pharmaceutically acceptable salts thereof for...
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7153872 |
Imidazole compounds as transforming growth factor (TGF) inhibitors
Novel imidazole compounds, including derivatives thereof, to intermediates for their preparation, to pharmaceutical compositions containing them and to their medicinal use are described. The...
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7132425 |
5-substituted-six-membered heteroaromatic glucokinase activators
The present invention provides a compound according to formula I
where the substituent designations are provided in the specification. Pharmaceutical compositions comprising a compound...
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7129359 |
Imidazolidinone compounds
This invention relates to compounds of the following formula:
in which R 1 , R 2 , A 1 , A 2 , X, Y, m, n, p, x and y are as defined herein, pharmaceutical compositions comprising the compounds...
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7122666 |
Heteroaryl-substituted pyrrole derivatives, their preparation and their therapeutic uses
Compounds having activity against production of an inflammatory cytokine of formula (I)′:
A′ is pyrrole; R 1′ is phenyl or naphthyl; R 2′ is pyridyl or pyrimidinyl; R 3′ is...
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7119104 |
Activator of peroxisome proliferator-activated receptor delta
A compound represented by the formula (I) or a salt of the compound, and a PPAR-δ activator which contains the compound or salt as the active ingredient:
(wherein A represents O or S; B 1...
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7105556 |
Conformationally constrained analogs useful as antidiabetic and antiobesity agents and method
Compounds are provided which have the structure
wherein Q is C or N, X 1 is C or N, and R 1 , R 2 , R 2a , R 2b , R 2c , R 3 , Y, A, m, n, X 2 , X 3 and X 4 are as defined herein, which...
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7105549 |
Aryl substituted pyridines and the use thereof
This invention relates aryl substituted pyridines of Formula I:
or a pharmaceutically acceptable salt, prodrug or solvate thereof, wherein Ar and R 1 –R 4 are set in the specification. The...
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7091222 |
Imidazole derivatives
The present invention relates to imidazole derivatives of the general formula
wherein R 1 , R 2 , R 3 and R 4 are as defined hereinabove. This invention also relates to the compound's...
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7064213 |
Method for preparing 2- (2-pyridylmethylsulphinyl) benzimidazoles
The present invention provides a method for preparing an antiulcer agent, 2-(2-pyridylmethylsulphinyl)benzimidazoles, such as Omeprazole, Lansoprazole and Pantoprazole, which includes oxidizing an...
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7056934 |
Nicotinamide derivatives useful as PDE4 inhibitors
This invention relates to nicotinamide derivatives of general formula (I):
in which R 1 , R 2 and R 3 have the meanings defined herein, and to processes for the preparation of, intermediates...
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RE39113 |
Utilization of derivatives of tetrahydropyridines(or 4-hydroxypiperidines)-butylazols in the preparation of a medicament for the treatment of pain
Derivatives of tetrahydropyridines (or 4-hydroxypiperidines)-butylazols of formula (I), wherein R 1 , R 2 and R 3 , which are similar or different, represent each of them hydrogen, halogen, alkyl...
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7034034 |
Substituted 2-cyclohexyl-4-phenyl-1H-imidazole derivatives
Substituted 2-cyclohexyl-4-phenyl-1H-imidazole derivatives capable of modulating NPY5 receptor activity, are provided. Such compounds may be used to modulate NPY binding to NPY5 receptors in vivo...
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7022695 |
Thioether-substituted benzamides as inhibitors of Factor Xa
Thioether-substituted benzamide compounds having the formula:
are provided that exhibit exceptionally strong inhibition of Factor Xa in combination with weak hERG binding.
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6987189 |
Short synthesis of pyridine-based pharmaceutical intermediates
A method of making a compound of Formula VI:
wherein Tr is a triphenyl group; R 1 , R 2 and R 3 are each independently selected from the group consisting of H, C1–C4 alkyl, C1–C4 alkoxy,...
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6982268 |
Substituted imidazolylmethyl pyridine and pyrazine derivatives GABAA receptor ligands
Substituted imidazolylmethyl pyridine and pyrazine derivatives that bind to GABA A receptors are provided. Such compounds may be used to modulate ligand binding to GABA A receptors in vivo or in...
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6982264 |
Substituted alcohols useful in treatment of Alzheimer's disease
The invention relates to substituted alcohol compounds of the formula (I):
wherein X, R 1 , R 2 , R 3 , R N , R 20 and R C are defined herein. The compounds are useful in the treatment or...
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6958353 |
Imidazole derivatives or salts thereof and drugs containing the derivatives or the salts
The invention is directed to an imidazole derivative represented by formula (1):
wherein each of R 1 and R 2 represents an aryl group, a heteroaryl group, etc.; each of A, X 1 , and X 2 ...
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6953807 |
4-substituted-picolinic acid amide derivatives useful as fungicides
Compound of general formula (I) in which Y is chosen from the following groups Y 1 to Y 3 (I*), the other substituents being as defined in the description, process for preparing this compound,...
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6930208 |
3-Keto- or 3- oxime-ether-substituted benzoylcyclohexanediones
What is described are derivatives of benzoylcyclohexanediones of the formula (I) and their use as herbicides.
In this formula (I), R 1a , R 1b , R 1c , R 2 , R 3 , R 4 and R 5 denote various...
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6919457 |
3-(imidazolyl)-2-aminopropanoic acids
Compounds according to formula (I) wherein n is 1-4, R 1 is optionally substituted C 1-6 alkyl, C 2-6 alkenyl, or C 2-6 alkynyl, Heterocycle, Aromatic heterocycle, Aryl or hydrogen and R 2 , R...
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6916933 |
4-pyridinyl-n-acyl-l-phenylalanines
Compounds of Formula I have activity as inhibitors of binding between VCAM-1 and cells expressing VLA-4 and are useful for treating disease whose symptoms and or damage are related to the binding...
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6906089 |
Triarylimidazole derivatives as cytokine inhibitors
Compounds of formula (I) or a pharmaceutically acceptable salt thereof:
wherein R 1 , R 2 and R 3 are various substituent groups; and one of X 1 and X 2 is N or CR″, and the other...
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6893650 |
N2-phenylamidine derivatives
The invention provides fungicidal compounds of formula (I) and salts thereof wherein: R 1 is alkyl, alkenyl, alkynyl, carbocyclyl or heterocyclyl, each of which may be substituted, or hydrogen; R...
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6875778 |
Alkylene-tethered bis-nitroiminoimidazolidines, process for preparing the same, and insecticides containing the same
The present invention provides a novel alkylene-tethered bis-nitroiminoimidazolidine compound having superior insecticidal activity. The nitroimino imidazolidine compound is a...
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6867217 |
Substituted polycyclic aryl and heteroaryl pyridones useful for selective inhibition of the coagulation cascade
The invention relates to substituted polycyclic aryl and heteroaryl pyridone compounds useful as inhibitors of serine proteases of the coagulation cascade and compounds, compositions and methods...
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6838475 |
Imidazolidinones as NS3-serine protease inhibitors of hepatitis C virus
The present invention discloses novel imidazolidinones which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses...
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6833375 |
N-&lsqb 4-(heteroarylmethyl)phenyl&rsqb -heteroarylamines
The present invention is concerned with compounds of formula the N-oxides, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein R 1 is...
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6706711 |
Pyrazole derived kinase inhibitor
Described herein are compounds that are useful as protein kinase inhibitors having the formula: wherein R 1 , R 2 , T, n and Q are as described in the specification. The compounds are useful for...
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6683192 |
Small organic molecule regulators of cell proliferation
A compound represented in general formula (X) and (XI):
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6683097 |
Imidazole derivatives
Novel imidazole derivatives are disclosed. These compounds have a good affinity to the NMDA (N-methyl-D-aspartate)-receptor subtype selective blockers, which have a key function in modulating...
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6642379 |
Benzamide derivatives, insecticides for agricultural and horticultural use and usage thereof
Benzamide derivatives represented by the general formula (I): and insecticides for agricultural and horticultural use and usage thereof, wherein Z 1 is O or S; R is H, (substituted) alkyl, or...
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6576656 |
Oxindole derivative
An oxindole of Formula 1 or a prodrug thereof, or a pharmaceutically acceptable salt thereof is useful for growth hormone releaser: wherein R 1 , R 2 , R 3 and R 4 are independently hydrogen,...
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6566359 |
2,4,6-trimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid esters as neuroprotective drugs
A new series of derivatives of 2,4,6-trimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid and their synthesis have been discovered. Surprisingly, by modifying the substituent of the 3-carboxylic...
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6562861 |
Substituted cyclopentane and cyclopentene compounds useful as neuraminidase inhibitors
Compounds I-III wherein U is CH, O, or S; Z is mono- or di-substituted carbon; R is (CH2)nCO2H, (CH2)nSO3H, (CH2)nPO3H2, (CH2)nNO2, CH(SCH3)3, esters; R1 is H, hydroxyalkyl, aminoalkyl,...
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6562817 |
Tricyclic compound
The present invention provides a compound of the formula (I): wherein A ring, B ring and C ring are each independently optionally substituted aromatic carbocycle or optionally substituted 5-...
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6548519 |
Pyridoxine and pyridoxal analogues: novel uses
The invention provides pyridoxal and pyridoxine analogues, pharmaceutical compositions containing pyridoxine and pyridoxal analogues, and methods of administering pharmaceutical compositions...
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6534503 |
Melanocortin receptor-3 ligands to treat sexual dysfunction
Methods for treating sexual dysfunction, such as erectile dysfunction or sexual arousal disorder, with a compound having the generic formula X 1 —X 2 -(D)Phe-Arg-(D)Trp-X 3 . A particularly...
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