Matches 201 - 250 out of 319 < 1 2 3 4 5 6 7 >
Match Document Document Title
4882343 Biarylalkylimidazole derivatives as anti-depressants  
Certain 4(5)-(biarylethyl)imidazole derivatives are selectiv3 α 2 -adrenergic receptor blockers and are useful as anti-depressant agents.
4873238 2-Pyridinecarbothioamides and pharmaceutical compositions comprising the same  
There are provided gastric antiulcer and cytoprotective substituted N-phenyl-2-pyridinecarbothioamides. The process for their production and formulation is disclosed.
4870088 1-[1-aryl-1-hydroxy-2-azolyl-ethyl]-1-aryl-cyclopropane derivatives, and their fungicidal use thereof  
Compounds I ##STR1## where A equals t-butyl or a large number of (substituted) aromatics; Y equals azolyl; or Y equals --X--R 1 where X=oxygen or sulfur and R 1 equals (cyclo)alkyl or...
4863938 Pyridine derivatives and their use as nootropic agents  
Pyridine derivatives of the formula ##STR1## their tautomers and their salts, in which R 1 , R 2 , R 3 , R 4 , R 5 and n have the meanings given in the claims, can be used as active ingredients in...
4863947 N-aryl-3-aryl-4,5-dihydro-1H-pyrazole-1-carboxamides and methods of their production  
This invention relates to novel N-aryl-3-aryl-4,5-dihydro-1H-pyrazole-1-carboxamide compounds which are useful as pesticides, compositions containing those compounds, methods of controlling pests...
4857516 Coumaran derivatives and their pharmaceutical use  
A compound of the formula ##STR1## wherein R is a lower alkyl group, R 0 is hydrogen or an acyl group, R 1 and R 2 are lower alkyl groups which may optionally be substituted or wherein R 1 and...
4853395 Certain 3-carboxylate or 3-carbamyl-5-acyl-2-(1H)-pyridinones having cardiotonic properties  
Novel 5-acyl-2-(1H)pyridinones and their use as cardiotonic agents. Typical of the compounds is 5-acetyl-1,2-dihydro-6-methyl-2-oxo-3-pyridinecarbonitrile which is prepared by condensing anionic...
4851406 Heterocyclic-substituted indoles and pharmaceutical compositions containing them  
The present invention provides indole derivatives of the general formula: ##STR1## wherein R 1 is a hydrogen atom or an alkyl, alkenyl, cycloalkyl, cycloalkenyl, carboxyl, cyano, alkylcarbonyl,...
4845113 2-substituted -1,4-dihydropyridines and pharmaceutical compositions containing them  
Compounds of formula I ##STR1## wherein R is hydrogen or lower alkyl; R 1 is acetyl, benzoyl, cyano, nitro, carboxy, alkoxycarbonyl or aminocarbonyl groups; R 2 is an optionally substituted aryl...
4839348 1,4-dihydropyridines  
Dihydropyridines of formula I ##STR1## wherein R is hydrogen or lower alkyl; R 1 is a CN, NO 2 , COCH 3 , COPh group, a carboalkoxy or carboamide group; R 2 is an aromatic or heteroaromatic,...
4829075 Antimycotic 1,1-disubstituted cyclopropane derivatives  
Compounds I ##STR1## where A equals t-butyl, phenyl, biphenylyl, phenoxyphenyl, benzylphenyl, benzyloxyphenyl, phenylthiophenyl, phenylsulfinylphenyl, phenylsulfonylphenyl, naphthyl,...
4820842 2-substituted-1,4-dihydropyridines  
The present invention provides a process for preparing a 5-cyano-2-substituted-1,4-dihydropyridine compound having cardiovascular activity.
4818765 1,3-dithiolan-2-ylidenes their 1-oxides, pharmaceutical compositions, and methods of use thereof  
The invention relates to the use of ketenethioacetals of the formula ##STR1## in which R 1 represents aryl or heteroaryl, R 2 represents hydrogen, an optionally substituted hydrocarbon radical,...
4812467 N-(imidazolylmethyl)diphenylazomethines and compositions containing them  
A compound which is an N-(imidazolymethyl) diphenylazomethine derivative of the general formula (I) ##STR1## wherein R 1 is chlorine or methyl, X is a thio or sulphonyl group, and R 2 is a...
4810800 Novel imidazole dopamine beta hydroxylase inhibitors  
1,2-Disubstituted imidazoles useful as antihypertensive agents are described herein. The compounds are obtained from the appropriate 1-substituted imidazole which can be reacted with methyl oxalyl...
4806535 Imidazolylphenyl and 1,2,4-triazolylphenyl benzopyridazinone and pyridopyridazinone compounds and their use for increasing cardiatonic contractility  
This invention relates to imidazolylphenyl and 1,2,4-triazolylphenyl benzopyridazinone and pyridopyridazinone compounds of the formula ##STR1## wherein A is CH or N and not more than one of W, X, Y...
4806540 1-heteroaryl-4-aryl-pyrazole microbicides  
Novel microbicidally active 1-heteroaryl-4-arylpyrazole derivatives of the formulae (I) and/or (1A) ##STR1## in which R represents hydrogen or alkyl, R 1 represents halogen, hydroxyl,...
4788190 2,4,4-tri- and 2,2,4,4-tetra substituted-1,3-dioxolane antifungal, antiallergy compounds  
Novel 1,3-dioxolane compounds useful as antifungal and antiallergy agents and represented by the formula ##STR1## wherein Ar is thienyl, pyridyl, biphenyl, phenyl or phenyl substituted by one or...
4784958 1,4-dihydropyridine derivatives and 1,4-dihydroquinoline derivatives radioactively labelled with .sup.125 I, their preparation, and their use in testing medicaments  
A simple method for preparing highly radioactive 1,4-dihydropyridine and 1,4-dihydroquinoline derivatives labelled with 125 I enables a specific radioactivity of approx. 2200 to 8800 Ci/m Mole to...
4778817 Naphthyl imidazolyl compounds and pharmaceutical compositions  
Compounds of the formula I ##STR1## in which R 1 , R 2 and Y have the indicated meanings, their physiologically tolerated acid addition salts, and a process for the preparation of these compounds...
4769380 Cardiotonic 5-benzoyl-1,2-dihydro-2-oxo-3-pyridinecarboxylates  
Novel 3-carboxy- and 3-carbalkoxy-5-benzoyl-2(1H)-pyridinones as well as the pharmaeutically acceptable salts thereof are cardiotonic agents useful in the treatment of heart failure.
4760151 Dithioketo pyrrolopyrroles  
Compounds of formula (1) ##STR1## wherein A and B are identical or different alkyl, aralkyl or cycloalkyl groups or carbocyclic or heterocyclic aromatic radicals, R 1 and R 2 are hydrogen atoms...
4751309 Methine dyes and preparation thereof  
Methine dyes (I) which conform in one of their tautomeric forms to the general formula ##STR1## where Y 1 is in both or either case an electron-attracting group and the other Y 1 is hydrogen, ...
4745120 3-pyridyl compounds and use as thromboxane synthetase inhibitors  
The present invention relates to new pyridines substituted in the 3-position, of the formula ##STR1## and to a process for their preparation. The compounds bring about specific inhibition of...
4742068 Dihydropyridine compounds having 1,4,4-trisubstitution useful as antihypertensive agents  
Dihydropyridine compounds having 1,4,4-trisubstitution of the following formula (I): ##STR1## wherein R is one of --COR 3 , R 3 being a group such as phenyl or benzyl; R 4 where R 4 is a...
4731364 Dihydrobenzo(B)thiophenes and pharmaceutical compositions thereof useful as antifungals  
2-Alkyl-, 2-alkenyl- and 2-alkynyl-2,3-dihydro-2-(1H-azolyl(C 1 -C 2 )alkyl)benzo[b]thiophenes especially 2-alkyl-, 2-alkenyl- and...
4731370 Pyridyl ester containing 1,4-dihydropyridine derivatives and salts thereof and pharmaceutical composition containing the same  
This invention relates to a novel 1,4-dihydropyridine derivative of the formula ##STR1## wherein R2 is pyridyl, or a salt thereof. These compounds have a vasodilating activity and a platelet...
4731371 Certain 5-acyl-1,2-dihydro-2-oxo-3-pyridinecarbonitriles which are useful as cardiotonic agents  
Novel 5-acyl-2-(1H)pyridinones and their use as cardiotonic agents. Typical of the compounds is 5-acetyl-1,2-dihydro-6-methyl-2-oxo-3-pyridinecarbonitrile which is prepared by condensing anionic...
4723014 Process for the preparation of 2-substituted-1,4-dihydropyridines  
The present invention provides a process for preparing a 2-substituted-1,4-dihydropyridine by providing a regiospecific bromine containing intermediate which is then reacted with a nucleophile to...
4713387 Vasodilating and platelet aggregation inhibiting 1,4 dihydropyridines with an imidazolyl or pyridyl containing ester  
This invention relates to a 1,4-dihydropyridine derivative of the formula ##STR1## wherein Y represents an oxygen or sulfur atom or a vinylene group, Z represents an oxygen or sulfur atom or an...
4699914 Imidazole group containing 2(1H)-pyridones and method for treating heart insufficiencies in humans  
The present invention is directed to new, an imidazole group containing 2(1H)-pyridones of formula I ##STR1## salts thereof and process for treating congestive heart failure in humans.
4692531 Substituted 3,4-diamino-1,2,5-thiadiazoles having histamine H.sub.2 -receptor antagonist activity  
Histamine H 2 -receptor antagonists of the formula ##STR1## wherein A, m, Z, n and R 1 are as defined herein, and their nontoxic pharmaceutically acceptable salts are novel anti-ulcer agents...
4678796 2-alkylidene derivatives of 1,2,3,4-tetrahydropyridine-2,5-pyridine carboxylic acid dialkyl esters useful for treatment of cardiovascular disorders  
Novel 2-(2-alkoxy-2-oxoethylidene)-1,2,3,4-tetrahydro-6-methyl-4-[ 2-(substituted )phenyl]-3,5-pyridinedicarboxylic acid dialkyl ester derivatives having novel inotropic and hypotensive activity,...
4665080 Imidazolyl compounds and their use as medicaments  
The present invention relates to new ortho-, meta- and para-substituted imidazolylmethylstyrenes of the formula I ##STR1## and to a process for their preparation. The compounds according to the...
4663344 Anti-inflammatory and analgesic 3-hydroxybenzo[b]thiophene derivatives, compositions, and method of use therefor  
3-Hydroxybenzo[b]thiophene derivatives, such as 2-aralkyl, 2-alkyl and 2-alkenyl-3-hydroxybenzo[b]-thiophenes, were prepared by, among other methods, ring closure of...
4663341 Insecticidal n-aryl-3-aryl-4,5-dihydro-1h-pyrazole-1-carboxamides  
This invention relates to N-aryl-3-aryl-4,5-dihydro-1H-pyrazole-1-carboxamide compounds which are useful as pesticides, compositions containing those compounds, methods of controlling pests and...
4652572 2-(furanyl alkylamino or thienyl alkylamino or phenylalkylamino)-3-carboxy (or hydroxy)-pyridines  
This invention relates to 2-amino-3-hydroxy, and 3-carboxy pyridine derivatives, in which the amino group is substituted by a methylthioethyl, butyl or oxypropyl group bearing a terminal...
4649150 Antiulcerogenic amidine derivatives of 2-substituted 4-phenylimidazole  
Compounds of the formula ##STR1## wherein R represents substituents of various types; R 1 and R 2 are each independently hydrogen or lower alkyl; R 3 represents substituents of various...
4636518 Imidazole derivatives and pharmaceutical compositions  
Compounds of the general formula: ##STR1## and acid addition salts thereof; in which Ar and Ar 1 which may be the same or different, each represent an aromatic radical which may be substituted one...
4636519 Ketene S,S-acetal derivative, a process for manufacturing thereof and a method for curing mycosis by administering it  
A novel ketene S,S-acetal derivative which is useful as an antimycotic agent and an agricultural chemical of fungicidal, plant growth regulating or insecticidal properties represented by the...
4624958 Antiprotozoal 1,4-di(p-amidinophenyl)imidazoles  
Diamidines of the formula ##STR1## wherein X is a propylene, isobutylene, guanidine, pyrrole, tetrazole, imidazole or substituted imidazole group; and...
4613609 Antiarrhythmic imidazoliums  
The imidazolium salts described are useful as antiarrhythmic agents. A method of treating arrhythmia by increasing the refractoriness of cardiac tissue is provided as well as pharmaceutical...
4605661 Aromastase inhibiting α,α-diarylimidazole-4(5)-propionitriles, α,α-diarylimidazole-4(5)-propionamides, and 4(5)-(2,2-diarylethyl)imidazoles  
This invention provides a method of inhibiting aromatase and treating or preventing estrogen-dependent diseases in mammals by administering certain imidazole derivatives. Pharmaceutical...
4602022 N-imidazolyl derivatives of bicyclic compounds  
Compounds of the formula (I) ##STR1## wherein the symbol represents a single or a double bond; each of R 1 , R 2 , R 3 and R 4 , which may be the same or different is (a) hydrogen;...
4598077 Amidine derivatives and cardiotonic compositions  
Amidine derivatives of the formula ##STR1## wherein R 1 and R 2 , which may be the same or different, represent each a hydrogen atom or a lower alkyl group, or R 1 and R 2 together with an...
RE32154 Production of 2-(o-alkylthiophenyl)-1,3-diazocycloalkene hydrohalides  
Production of new 2-(o-alkylthiophenyl)-1,3-diazacycloalkene hydrohalides by reaction of a benzo-thietane-2-spiro-2'-(1',3'-diazacycloalkane) with an alkyl halide, and the new...
4569942 N,3-Disubstituted 2-oxindole-1-carboxamides as analgesic and antiinflammatory agents  
Certain 2-oxindole-1-carboxamide compounds having an acyl substituent at the 3-position, and also further substituted on the carboxamide nitrogen by an alkyl, cycloalkyl, phenyl or substituted...
4568751 5-Acyl-2-(1H)-pyridinones  
Novel 5-acyl-2-(1H)pyridinones and their use as cardiotonic agents. Typical of the compounds is 5-acetyl-1,2-dihydro-6-methyl-2-oxo-3-pyridinecarbonitrile which is prepared by condensing anionic...
4563446 Thromboxane synthetase inhibiting 3-(1-alkenyl) pyridines  
Novel compounds of the formula: ##STR1## wherein R 2 is an aromatic or heterocyclic group, which may optionally be substituted, R 2 is a methyl group, a hydroxymethyl group, a nitroxymethyl...
4548935 Dihydropyridine anti-ischaemic and anti-hypertensive agents, compositions and use  
Dihydropyridine anti-ischaemic and anti-hypertensive agents of the formula: ##STR1## and their pharmaceutically acceptable salts; wherein R is aryl or heteroaryl; R 1 and R 2 are each...
Matches 201 - 250 out of 319 < 1 2 3 4 5 6 7 >